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Items: 1 to 50 of 63

1.
2.

Small-molecule antagonists of the immune checkpoint pathways: concept to clinic.

Sasikumar PG, Ramachandra M.

Future Med Chem. 2017 Aug;9(12):1305-1308. doi: 10.4155/fmc-2017-0107. Epub 2017 Aug 3. No abstract available.

PMID:
28771036
3.

Simulation study of Hemodynamic in Bifurcations for Cerebral Arteriovenous Malformation using Electrical Analogy.

Kiran Kumar Y, Mehta SB, Ramachandra M.

J Biomed Phys Eng. 2017 Jun 1;7(2):143-154. eCollection 2017 Jun.

4.

The Multi-kinase Inhibitor Debio 0617B Reduces Maintenance and Self-renewal of Primary Human AML CD34+ Stem/Progenitor Cells.

Murone M, Radpour R, Attinger A, Chessex AV, Huguenin AL, Schürch CM, Banz Y, Sengupta S, Aguet M, Rigotti S, Bachhav Y, Massière F, Ramachandra M, McAllister A, Riether C.

Mol Cancer Ther. 2017 Aug;16(8):1497-1510. doi: 10.1158/1535-7163.MCT-16-0889. Epub 2017 May 3.

PMID:
28468777
5.

Numerical modeling of vessel geometry to measure hemodynamics parameters non-invasively in cerebral arteriovenous malformation.

Kumar YK, Mehta SB, Ramachandra M.

Biomed Mater Eng. 2016;27(6):613-631. doi: 10.3233/BME-161613.

PMID:
28234245
6.

Computer simulation of Cerebral Arteriovenous Malformation-validation analysis of hemodynamics parameters.

Kumar YK, Mehta SB, Ramachandra M.

PeerJ. 2017 Jan 26;5:e2724. doi: 10.7717/peerj.2724. eCollection 2017.

7.

Anti-PD-L1 peptide improves survival in sepsis.

Shindo Y, McDonough JS, Chang KC, Ramachandra M, Sasikumar PG, Hotchkiss RS.

J Surg Res. 2017 Feb;208:33-39. doi: 10.1016/j.jss.2016.08.099. Epub 2016 Sep 8.

8.

Urogenital function in robotic vs laparoscopic rectal cancer surgery: a comparative study.

Panteleimonitis S, Ahmed J, Ramachandra M, Farooq M, Harper M, Parvaiz A.

Int J Colorectal Dis. 2017 Feb;32(2):241-248. doi: 10.1007/s00384-016-2682-7. Epub 2016 Oct 21.

9.

Debio 0617B Inhibits Growth of STAT3-Driven Solid Tumors through Combined Inhibition of JAK, SRC, and Class III/V Receptor Tyrosine Kinases.

Murone M, Vaslin Chessex A, Attinger A, Ramachandra R, Shetty SJ, Daginakatte G, Sengupta S, Marappan S, Dhodheri S, Rigotti S, Bachhav Y, Brienza S, Traxler P, Lang M, Aguet M, Zoete V, Michielin O, Nicholas C, Johnson FM, Ramachandra M, McAllister A.

Mol Cancer Ther. 2016 Oct;15(10):2334-2343. Epub 2016 Jul 20.

10.

Structure-guided discovery of 2-aryl/pyridin-2-yl-1H-indole derivatives as potent and selective hepsin inhibitors.

Goswami R, Wohlfahrt G, Törmäkangas O, Moilanen A, Lakshminarasimhan A, Nagaraj J, Arumugam KN, Mukherjee S, Chacko AR, Krishnamurthy NR, Jaleel M, Palakurthy RK, Samiulla DS, Ramachandra M.

Bioorg Med Chem Lett. 2015 Nov 15;25(22):5309-14. doi: 10.1016/j.bmcl.2015.09.042. Epub 2015 Sep 21.

PMID:
26421993
11.

Deregulated hepsin protease activity confers oncogenicity by concomitantly augmenting HGF/MET signalling and disrupting epithelial cohesion.

Tervonen TA, Belitškin D, Pant SM, Englund JI, Marques E, Ala-Hongisto H, Nevalaita L, Sihto H, Heikkilä P, Leidenius M, Hewitson K, Ramachandra M, Moilanen A, Joensuu H, Kovanen PE, Poso A, Klefström J.

Oncogene. 2016 Apr 7;35(14):1832-46. doi: 10.1038/onc.2015.248. Epub 2015 Jul 13.

PMID:
26165838
12.

AFN-1252 is a potent inhibitor of enoyl-ACP reductase from Burkholderia pseudomallei--Crystal structure, mode of action, and biological activity.

Rao KN, Lakshminarasimhan A, Joseph S, Lekshmi SU, Lau MS, Takhi M, Sreenivas K, Nathan S, Yusof R, Abd Rahman N, Ramachandra M, Antony T, Subramanya H.

Protein Sci. 2015 May;24(5):832-40. doi: 10.1002/pro.2655. Epub 2015 Apr 2.

13.

Discovery of O-(3-carbamimidoylphenyl)-l-serine amides as matriptase inhibitors using a fragment-linking approach.

Goswami R, Wohlfahrt G, Mukherjee S, Ghadiyaram C, Nagaraj J, Satyam LK, Subbarao K, Gopinath S, Krishnamurthy NR, Subramanya HS, Ramachandra M.

Bioorg Med Chem Lett. 2015 Feb 1;25(3):616-20. doi: 10.1016/j.bmcl.2014.12.008. Epub 2014 Dec 17.

PMID:
25556099
14.

3-alkoxy-pyrrolo[1,2-b]pyrazolines as selective androgen receptor modulators with ideal physicochemical properties for transdermal administration.

Ullrich T, Sasmal S, Boorgu V, Pasagadi S, Cheera S, Rajagopalan S, Bhumireddy A, Shashikumar D, Chelur S, Belliappa C, Pandit C, Krishnamurthy N, Mukherjee S, Ramanathan A, Ghadiyaram C, Ramachandra M, Santos PG, Lagu B, Bock MG, Perrone MH, Weiler S, Keller H.

J Med Chem. 2014 Sep 11;57(17):7396-411. doi: 10.1021/jm5009049. Epub 2014 Aug 26.

PMID:
25121964
15.

Discovery of azetidine based ene-amides as potent bacterial enoyl ACP reductase (FabI) inhibitors.

Takhi M, Sreenivas K, Reddy CK, Munikumar M, Praveena K, Sudheer P, Rao BN, Ramakanth G, Sivaranjani J, Mulik S, Reddy YR, Narasimha Rao K, Pallavi R, Lakshminarasimhan A, Panigrahi SK, Antony T, Abdullah I, Lee YK, Ramachandra M, Yusof R, Rahman NA, Subramanya H.

Eur J Med Chem. 2014 Sep 12;84:382-94. doi: 10.1016/j.ejmech.2014.07.036. Epub 2014 Jul 11.

PMID:
25036796
16.

Discovery of Pyridyl Bis(oxy)dibenzimidamide Derivatives as Selective Matriptase Inhibitors.

Goswami R, Mukherjee S, Wohlfahrt G, Ghadiyaram C, Nagaraj J, Chandra BR, Sistla RK, Satyam LK, Samiulla DS, Moilanen A, Subramanya HS, Ramachandra M.

ACS Med Chem Lett. 2013 Oct 7;4(12):1152-7. doi: 10.1021/ml400213v. eCollection 2013 Dec 12.

17.

Structure-guided discovery of 1,3,5 tri-substituted benzenes as potent and selective matriptase inhibitors exhibiting in vivo antitumor efficacy.

Goswami R, Mukherjee S, Ghadiyaram C, Wohlfahrt G, Sistla RK, Nagaraj J, Satyam LK, Subbarao K, Palakurthy RK, Gopinath S, Krishnamurthy NR, Ikonen T, Moilanen A, Subramanya HS, Kallio P, Ramachandra M.

Bioorg Med Chem. 2014 Jun 15;22(12):3187-203. doi: 10.1016/j.bmc.2014.04.013. Epub 2014 Apr 18.

PMID:
24794746
18.

Discovery of 7-azaindole based anaplastic lymphoma kinase (ALK) inhibitors: wild type and mutant (L1196M) active compounds with unique binding mode.

Gummadi VR, Rajagopalan S, Looi CY, Paydar M, Renukappa GA, Ainan BR, Krishnamurthy NR, Panigrahi SK, Mahasweta K, Raghuramachandran S, Rajappa M, Ramanathan A, Lakshminarasimhan A, Ramachandra M, Wong PF, Mustafa MR, Nanduri S, Hosahalli S.

Bioorg Med Chem Lett. 2013 Sep 1;23(17):4911-8. doi: 10.1016/j.bmcl.2013.06.071. Epub 2013 Jul 4.

PMID:
23880539
19.

Discovery of indole tetrafluorophenoxymethylketone-based potent novel small molecule inhibitors of caspase-3.

Samiulla DS, Naidu A, Rao GV, Ramachandra M.

Org Med Chem Lett. 2012 Jul 16;2(1):27. doi: 10.1186/2191-2858-2-27.

20.

Evaluation of the effects of Mitragyna speciosa alkaloid extract on cytochrome P450 enzymes using a high throughput assay.

Kong WM, Chik Z, Ramachandra M, Subramaniam U, Aziddin RE, Mohamed Z.

Molecules. 2011 Aug 29;16(9):7344-56. doi: 10.3390/molecules16097344.

21.

Isolated prostatic utricle.

Ramachandra M, Bendre PS, Redkar RG, Taide DV.

J Indian Assoc Pediatr Surg. 2009 Oct;14(4):228-9. doi: 10.4103/0971-9261.59610.

22.

Synthesis and bioactivity of novel caffeic acid esters from Zuccagnia punctata.

Ramachandra MS, Subbaraju GV.

J Asian Nat Prod Res. 2006 Dec;8(8):683-8.

PMID:
17145655
23.
24.

Matching complementing functions of transformed cells with stable expression of selected viral genes for production of E1-deleted adenovirus vectors.

Howe JA, Pelka P, Antelman D, Wilson C, Cornell D, Hancock W, Ramachandra M, Avanzini J, Horn M, Wills K, Sutjipto S, Ralston R.

Virology. 2006 Feb 5;345(1):220-30. Epub 2005 Oct 24.

25.

Synthesis and biological evaluation of polyhydroxycurcuminoids.

Venkateswarlu S, Ramachandra MS, Subbaraju GV.

Bioorg Med Chem. 2005 Dec 1;13(23):6374-80. Epub 2005 Aug 19.

PMID:
16112582
26.

Inefficient killing of quiescent human epithelial cells by replicating adenoviruses: potential implications for their use as oncolytic agents.

Vaillancourt MT, Atencio I, Quijano E, Howe JA, Ramachandra M.

Cancer Gene Ther. 2005 Aug;12(8):691-8.

PMID:
15877084
27.

Synthesis of microfolicoumarin, a constituent of Cedrelopsis microfoliata.

Ramachandra MS, Venkateswarlu S, Subbaraju GV.

Biosci Biotechnol Biochem. 2004 Sep;68(9):1995-7.

28.

Acute hepatotoxicity of oncolytic adenoviruses in mouse models is associated with expression of wild-type E1a and induction of TNF-alpha.

Engler H, Machemer T, Philopena J, Wen SF, Quijano E, Ramachandra M, Tsai V, Ralston R.

Virology. 2004 Oct 10;328(1):52-61.

29.
30.

Pharmacologic indicators of antitumor efficacy for oncolytic virotherapy.

Demers GW, Johnson DE, Tsai V, Wen SF, Quijano E, Machemer T, Philopena J, Ramachandra M, Howe JA, Shabram P, Ralston R, Engler H.

Cancer Res. 2003 Jul 15;63(14):4003-8.

31.

Restoration of transforming growth factor Beta signaling by functional expression of smad4 induces anoikis.

Ramachandra M, Atencio I, Rahman A, Vaillancourt M, Zou A, Avanzini J, Wills K, Bookstein R, Shabram P.

Cancer Res. 2002 Nov 1;62(21):6045-51.

32.

Re-engineering adenovirus regulatory pathways to enhance oncolytic specificity and efficacy.

Ramachandra M, Rahman A, Zou A, Vaillancourt M, Howe JA, Antelman D, Sugarman B, Demers GW, Engler H, Johnson D, Shabram P.

Nat Biotechnol. 2001 Nov;19(11):1035-41.

PMID:
11689848
33.

Enhanced apoptotic activity of a p53 variant in tumors resistant to wild-type p53 treatment.

Atencio IA, Avanzini JB, Johnson D, Neuteboom S, Vaillancourt MT, Nielsen LL, Hajian G, Sutjipto S, Sugarman BJ, Philopena J, McAllister DL, Beltran JC, Nodelman M, Ramachandra M, Wills KN.

Mol Ther. 2001 Jul;4(1):5-12.

34.

Selective expression of nonsecreted interferon by an adenoviral vector confers antiproliferative and antiviral properties and causes reduction of tumor growth in nude mice.

Ahmed CM, Wills KN, Sugarman BJ, Johnson DE, Ramachandra M, Nagabhushan TL, Howe JA.

J Interferon Cytokine Res. 2001 Jun;21(6):399-408.

PMID:
11440637
35.

Specific depletion of human anti-adenovirus antibodies facilitates transduction in an in vivo model for systemic gene therapy.

Rahman A, Tsai V, Goudreau A, Shinoda JY, Wen SF, Ramachandra M, Ralston R, Maneval D, LaFace D, Shabram P.

Mol Ther. 2001 May;3(5 Pt 1):768-78.

36.

Synthesis of 1,7-bis(4-hydroxypenyl)-4-hydroxy-1,3-heptadiene-5-one, an antiplatelet diarylheptanoid from Alpinia blepharocalyx K. schum.

Venkateswarlu S, Ramachandra MS, Rambabu M, Subbaraju GV.

J Asian Nat Prod Res. 2000;2(2):111-20.

PMID:
11252676
37.

Calpain inhibitor 1 activates p53-dependent apoptosis in tumor cell lines.

Atencio IA, Ramachandra M, Shabram P, Demers GW.

Cell Growth Differ. 2000 May;11(5):247-53.

38.

Effect of ABC transporters on HIV-1 infection: inhibition of virus production by the MDR1 transporter.

Lee CG, Ramachandra M, Jeang KT, Martin MA, Pastan I, Gottesman MM.

FASEB J. 2000 Mar;14(3):516-22.

PMID:
10698967
39.

Functional characterization of glycosylation-deficient human P-glycoprotein using a vaccinia virus expression system.

Gribar JJ, Ramachandra M, Hrycyna CA, Dey S, Ambudkar SV.

J Membr Biol. 2000 Feb 1;173(3):203-14.

PMID:
10667916
40.

Both ATP sites of human P-glycoprotein are essential but not symmetric.

Hrycyna CA, Ramachandra M, Germann UA, Cheng PW, Pastan I, Gottesman MM.

Biochemistry. 1999 Oct 19;38(42):13887-99.

PMID:
10529234
41.

Adenovirus-mediated gene transfer of MMAC1/PTEN to glioblastoma cells inhibits S phase entry by the recruitment of p27Kip1 into cyclin E/CDK2 complexes.

Cheney IW, Neuteboom ST, Vaillancourt MT, Ramachandra M, Bookstein R.

Cancer Res. 1999 May 15;59(10):2318-23.

42.

Biochemical, cellular, and pharmacological aspects of the multidrug transporter.

Ambudkar SV, Dey S, Hrycyna CA, Ramachandra M, Pastan I, Gottesman MM.

Annu Rev Pharmacol Toxicol. 1999;39:361-98. Review.

PMID:
10331089
43.

P-glycoprotein plays an insignificant role in the presentation of antigenic peptides to CD8+ T cells.

Russ G, Ramachandra M, Hrycyna CA, Gottesman MM, Pastan I, Bennink JR, Yewdell JW.

Cancer Res. 1998 Oct 15;58(20):4688-93.

44.

Functional expression of human P-glycoprotein from plasmids using vaccinia virus-bacteriophage T7 RNA polymerase system.

Hrycyna CA, Ramachandra M, Pastan I, Gottesman MM.

Methods Enzymol. 1998;292:456-73. No abstract available.

PMID:
9711574
45.

Recombinant vaccinia virus vectors for functional expression of P-glycoprotein in mammalian cells.

Ramachandra M, Gottesman MM, Pastan I.

Methods Enzymol. 1998;292:441-55. No abstract available.

PMID:
9711573
46.

Photoaffinity labeling of human P-glycoprotein: effect of modulator interaction and ATP hydrolysis on substrate binding.

Dey S, Ramachandra M, Pastan I, Gottesman MM, Ambudkar SV.

Methods Enzymol. 1998;292:318-28. No abstract available.

PMID:
9711564
47.
48.

Human P-glycoprotein exhibits reduced affinity for substrates during a catalytic transition state.

Ramachandra M, Ambudkar SV, Chen D, Hrycyna CA, Dey S, Gottesman MM, Pastan I.

Biochemistry. 1998 Apr 7;37(14):5010-9.

PMID:
9538020
49.

HIV-1 protease inhibitors are substrates for the MDR1 multidrug transporter.

Lee CG, Gottesman MM, Cardarelli CO, Ramachandra M, Jeang KT, Ambudkar SV, Pastan I, Dey S.

Biochemistry. 1998 Mar 17;37(11):3594-601.

PMID:
9530286
50.

Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein.

Dey S, Ramachandra M, Pastan I, Gottesman MM, Ambudkar SV.

Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10594-9.

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