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Antimicrob Agents Chemother. 2000 Sep;44(9):2534-6.

Activities of imipenem and cephalosporins against clonally related strains of Escherichia coli hyperproducing chromosomal beta-lactamase and showing altered porin profiles.

Author information

1
Department of Microbiology, School of Medicine, Seville, Spain. lmartin@cica.es

Abstract

Forty clonally related clinical isolates of Escherichia coli from hospitalized patients were resistant to cefoxitin (MICs, >256 microg/ml) and ceftazidime (MICs, 32 to 256 microg/ml) and were intermediate or resistant to cefotaxime (MICs, 16 to 128 microg/ml) but susceptible to both cefepime (MICs, 0.5 to 2 microg/ml) and imipenem (MICs, 0.125 to 0.25 microg/ml). Resistance to beta-lactams was related to high-level production of AmpC beta-lactamase and loss of OmpF porin.

PMID:
10952609
PMCID:
PMC90099
DOI:
10.1128/aac.44.9.2534-2536.2000
[Indexed for MEDLINE]
Free PMC Article

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