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Items: 1 to 50 of 289

1.

Delayed Death by Plastid Inhibition in Apicomplexan Parasites.

Kennedy K, Crisafulli EM, Ralph SA.

Trends Parasitol. 2019 Oct;35(10):747-759. doi: 10.1016/j.pt.2019.07.010. Epub 2019 Aug 16. Review.

PMID:
31427248
2.

Alternative splicing is required for stage differentiation in malaria parasites.

Yeoh LM, Goodman CD, Mollard V, McHugh E, Lee VV, Sturm A, Cozijnsen A, McFadden GI, Ralph SA.

Genome Biol. 2019 Aug 1;20(1):151. doi: 10.1186/s13059-019-1756-6.

3.

Delayed death in the malaria parasite Plasmodium falciparum is caused by disruption of prenylation-dependent intracellular trafficking.

Kennedy K, Cobbold SA, Hanssen E, Birnbaum J, Spillman NJ, McHugh E, Brown H, Tilley L, Spielmann T, McConville MJ, Ralph SA.

PLoS Biol. 2019 Jul 18;17(7):e3000376. doi: 10.1371/journal.pbio.3000376. eCollection 2019 Jul.

4.

Plasmodium sexual differentiation: how to make a female.

Ralph SA, Cortés A.

Mol Microbiol. 2019 Jul 4. doi: 10.1111/mmi.14340. [Epub ahead of print]

PMID:
31271672
5.

Repurposing drugs as pro-oxidant redox modifiers to eliminate cancer stem cells and improve the treatment of advanced stage cancers.

Ralph SJ, Nozuhur S, ALHulais RA, Rodríguez-Enríquez S, Moreno-Sánchez R.

Med Res Rev. 2019 May 20. doi: 10.1002/med.21589. [Epub ahead of print] Review.

PMID:
31111530
6.

Estimation of Syringyl Units in Wood Lignins by FT-Raman Spectroscopy.

Agarwal UP, Ralph SA, Padmakshan D, Liu S, Foster CE.

J Agric Food Chem. 2019 Apr 17;67(15):4367-4374. doi: 10.1021/acs.jafc.8b06707. Epub 2019 Apr 9.

PMID:
30916944
7.

Alternative Splicing in Apicomplexan Parasites.

Yeoh LM, Lee VV, McFadden GI, Ralph SA.

MBio. 2019 Feb 19;10(1). pii: e02866-18. doi: 10.1128/mBio.02866-18. Review.

8.

3,3'-Disubstituted 5,5'-Bi(1,2,4-triazine) Derivatives with Potent in Vitro and in Vivo Antimalarial Activity.

Xue L, Shi DH, Harjani JR, Huang F, Beveridge JG, Dingjan T, Ban K, Diab S, Duffy S, Lucantoni L, Fletcher S, Chiu FCK, Blundell S, Ellis K, Ralph SA, Wirjanata G, Teguh S, Noviyanti R, Chavchich M, Creek D, Price RN, Marfurt J, Charman SA, Cuellar ME, Strasser JM, Dahlin JL, Walters MA, Edstein MD, Avery VM, Baell JB.

J Med Chem. 2019 Mar 14;62(5):2485-2498. doi: 10.1021/acs.jmedchem.8b01799. Epub 2019 Mar 5.

PMID:
30715882
9.
10.

Artemisinin kills malaria parasites by damaging proteins and inhibiting the proteasome.

Bridgford JL, Xie SC, Cobbold SA, Pasaje CFA, Herrmann S, Yang T, Gillett DL, Dick LR, Ralph SA, Dogovski C, Spillman NJ, Tilley L.

Nat Commun. 2018 Sep 18;9(1):3801. doi: 10.1038/s41467-018-06221-1.

11.

Integrative proteomics and bioinformatic prediction enable a high-confidence apicoplast proteome in malaria parasites.

Boucher MJ, Ghosh S, Zhang L, Lal A, Jang SW, Ju A, Zhang S, Wang X, Ralph SA, Zou J, Elias JE, Yeh E.

PLoS Biol. 2018 Sep 13;16(9):e2005895. doi: 10.1371/journal.pbio.2005895. eCollection 2018 Sep.

12.

Effect of structure variations on the quadruplex DNA binding ability of nickel Schiff base complexes.

Davis KJ, Assadawi NMO, Pham SQT, Birrento ML, Richardson C, Beck JL, Willis AC, Ralph SF.

Dalton Trans. 2018 Oct 2;47(38):13573-13591. doi: 10.1039/c8dt02727g.

PMID:
30206589
13.

Celecoxib inhibits mitochondrial O2 consumption, promoting ROS dependent death of murine and human metastatic cancer cells via the apoptotic signalling pathway.

Pritchard R, Rodríguez-Enríquez S, Pacheco-Velázquez SC, Bortnik V, Moreno-Sánchez R, Ralph S.

Biochem Pharmacol. 2018 Aug;154:318-334. doi: 10.1016/j.bcp.2018.05.013. Epub 2018 May 23.

PMID:
29800556
14.

High prevalence of anti-hepatitis A IgG in a cohort of UK HIV-negative men who have sex with men: implications for local hepatitis A vaccine policy.

Bhagey A, Foster K, Ralph S, Wardropper A, White C, Wholey V, Duncan S.

Int J STD AIDS. 2018 Sep;29(10):1007-1010. doi: 10.1177/0956462418770008. Epub 2018 May 10.

PMID:
29743003
15.

New cellulose crystallinity estimation method that differentiates between organized and crystalline phases.

Agarwal UP, Ralph SA, Reiner RS, Baez C.

Carbohydr Polym. 2018 Jun 15;190:262-270. doi: 10.1016/j.carbpol.2018.03.003. Epub 2018 Mar 5.

PMID:
29628247
16.

The cysteine protease dipeptidyl aminopeptidase 3 does not contribute to egress of Plasmodium falciparum from host red blood cells.

Ghosh S, Chisholm SA, Dans M, Lakkavaram A, Kennedy K, Ralph SA, Counihan NA, de Koning-Ward TF.

PLoS One. 2018 Mar 6;13(3):e0193538. doi: 10.1371/journal.pone.0193538. eCollection 2018.

17.

Use of antipsychotics and benzodiazepines for dementia: Time for action? What will be required before global de-prescribing?

Ralph SJ, Espinet AJ.

Dementia (London). 2019 Aug;18(6):2322-2339. doi: 10.1177/1471301217746769. Epub 2017 Dec 22. No abstract available.

PMID:
29271252
18.

Comparative transcriptomics of female and male gametocytes in Plasmodium berghei and the evolution of sex in alveolates.

Yeoh LM, Goodman CD, Mollard V, McFadden GI, Ralph SA.

BMC Genomics. 2017 Sep 18;18(1):734. doi: 10.1186/s12864-017-4100-0.

19.

Novel STAT binding elements mediate IL-6 regulation of MMP-1 and MMP-3.

Cutler SJ, Doecke JD, Ghazawi I, Yang J, Griffiths LR, Spring KJ, Ralph SJ, Mellick AS.

Sci Rep. 2017 Aug 17;7(1):8526. doi: 10.1038/s41598-017-08581-y.

20.

Chronic oedema in the community: an overview.

For-Szabo N, Ralph S.

Br J Community Nurs. 2017 Jun 2;22(6):266-270. doi: 10.12968/bjcn.2017.22.6.266. Review. No abstract available.

PMID:
28570107
21.

Carbon Nanotube Membranes: Synthesis, Properties, and Future Filtration Applications.

Rashid MH, Ralph SF.

Nanomaterials (Basel). 2017 May 1;7(5). pii: E99. doi: 10.3390/nano7050099. Review.

22.

Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis.

Wong W, Bai XC, Sleebs BE, Triglia T, Brown A, Thompson JK, Jackson KE, Hanssen E, Marapana DS, Fernandez IS, Ralph SA, Cowman AF, Scheres SHW, Baum J.

Nat Microbiol. 2017 Mar 13;2:17031. doi: 10.1038/nmicrobiol.2017.31.

23.

The Plasmodium rhoptry associated protein complex is important for parasitophorous vacuole membrane structure and intraerythrocytic parasite growth.

Ghosh S, Kennedy K, Sanders P, Matthews K, Ralph SA, Counihan NA, de Koning-Ward TF.

Cell Microbiol. 2017 Aug;19(8). doi: 10.1111/cmi.12733. Epub 2017 Mar 8.

PMID:
28205319
24.

Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles.

Williamson AE, Ylioja PM, Robertson MN, Antonova-Koch Y, Avery V, Baell JB, Batchu H, Batra S, Burrows JN, Bhattacharyya S, Calderon F, Charman SA, Clark J, Crespo B, Dean M, Debbert SL, Delves M, Dennis AS, Deroose F, Duffy S, Fletcher S, Giaever G, Hallyburton I, Gamo FJ, Gebbia M, Guy RK, Hungerford Z, Kirk K, Lafuente-Monasterio MJ, Lee A, Meister S, Nislow C, Overington JP, Papadatos G, Patiny L, Pham J, Ralph SA, Ruecker A, Ryan E, Southan C, Srivastava K, Swain C, Tarnowski MJ, Thomson P, Turner P, Wallace IM, Wells TN, White K, White L, Willis P, Winzeler EA, Wittlin S, Todd MH.

ACS Cent Sci. 2016 Oct 26;2(10):687-701. Epub 2016 Sep 14.

25.

Targeting Protein Translation in Organelles of the Apicomplexa.

Goodman CD, Pasaje CFA, Kennedy K, McFadden GI, Ralph SA.

Trends Parasitol. 2016 Dec;32(12):953-965. doi: 10.1016/j.pt.2016.09.011. Epub 2016 Oct 25. Review.

PMID:
27793563
26.

Best possible care at the end of life inside.

Ralph S.

Nurs Older People. 2016 Oct 28;28(9):15.

PMID:
27788646
27.

Penile ulceration: a rare manifestation of cutaneous crohn's successfully treated with subcutaneous methotrexate.

Bajaj V, Sripathy TK, Ralph S.

J Eur Acad Dermatol Venereol. 2016 Oct;30(10):e87-e88. doi: 10.1111/jdv.13334. Epub 2015 Sep 15. No abstract available.

PMID:
26373246
28.

Metabolomics-Based Screening of the Malaria Box Reveals both Novel and Established Mechanisms of Action.

Creek DJ, Chua HH, Cobbold SA, Nijagal B, MacRae JI, Dickerman BK, Gilson PR, Ralph SA, McConville MJ.

Antimicrob Agents Chemother. 2016 Oct 21;60(11):6650-6663. doi: 10.1128/AAC.01226-16. Print 2016 Nov.

29.

Large scale production of a mammalian cell derived quadrivalent hepatitis C virus like particle vaccine.

Earnest-Silveira L, Christiansen D, Herrmann S, Ralph SA, Das S, Gowans EJ, Torresi J.

J Virol Methods. 2016 Oct;236:87-92. doi: 10.1016/j.jviromet.2016.06.012. Epub 2016 Jun 29.

PMID:
27373602
30.

Artemisinin Action and Resistance in Plasmodium falciparum.

Tilley L, Straimer J, Gnädig NF, Ralph SA, Fidock DA.

Trends Parasitol. 2016 Sep;32(9):682-696. doi: 10.1016/j.pt.2016.05.010. Epub 2016 Jun 9. Review.

31.

Selective inhibition of apicoplast tryptophanyl-tRNA synthetase causes delayed death in Plasmodium falciparum.

Pasaje CF, Cheung V, Kennedy K, Lim EE, Baell JB, Griffin MD, Ralph SA.

Sci Rep. 2016 Jun 9;6:27531. doi: 10.1038/srep27531.

32.

The in vitro and in vivo antiviral properties of combined monoterpene alcohols against West Nile virus infection.

Pliego Zamora A, Edmonds JH, Reynolds MJ, Khromykh AA, Ralph SJ.

Virology. 2016 Aug;495:18-32. doi: 10.1016/j.virol.2016.04.021. Epub 2016 May 3.

33.

Characterization of a hepatitis C virus-like particle vaccine produced in a human hepatocyte-derived cell line.

Earnest-Silveira L, Chua B, Chin R, Christiansen D, Johnson D, Herrmann S, Ralph SA, Vercauteren K, Mesalam A, Meuleman P, Das S, Boo I, Drummer H, Bock CT, Gowans EJ, Jackson DC, Torresi J.

J Gen Virol. 2016 Aug;97(8):1865-76. doi: 10.1099/jgv.0.000493. Epub 2016 May 4.

PMID:
27147296
34.

Student midwives and paramedic students' experiences of shared learning in pre-hospital childbirth.

Feltham C, Foster J, Davidson T, Ralph S.

Nurse Educ Today. 2016 Jun;41:73-8. doi: 10.1016/j.nedt.2016.03.020. Epub 2016 Mar 31.

PMID:
27138486
35.

Trigonal prismatic metal complexes: a not so rare coordination geometry?

Alcock LJ, Cavigliasso G, Willis AC, Stranger R, Ralph SF.

Dalton Trans. 2016 May 31;45(22):9036-40. doi: 10.1039/c6dt01176d.

PMID:
27125359
36.

Identification of 4-O-5-Units in Softwood Lignins via Definitive Lignin Models and NMR.

Yue F, Lu F, Ralph S, Ralph J.

Biomacromolecules. 2016 Jun 13;17(6):1909-20. doi: 10.1021/acs.biomac.6b00256. Epub 2016 May 4.

PMID:
27078826
37.

Compact, 15 Gb/s electro-optic modulator through carrier accumulation in a hybrid Si/SiO(2)/Si microdisk.

Sodagar M, Hosseinnia AH, Isautier P, Moradinejad H, Ralph S, Eftekhar AA, Adibi A.

Opt Express. 2015 Nov 2;23(22):28306-15. doi: 10.1364/OE.23.028306.

PMID:
26561102
38.

Plasmodium falciparum glucose-6-phosphate dehydrogenase 6-phosphogluconolactonase is a potential drug target.

Allen SM, Lim EE, Jortzik E, Preuss J, Chua HH, MacRae JI, Rahlfs S, Haeussler K, Downton MT, McConville MJ, Becker K, Ralph SA.

FEBS J. 2015 Oct;282(19):3808-23. doi: 10.1111/febs.13380. Epub 2015 Aug 17.

39.

Metabolic Dysregulation Induced in Plasmodium falciparum by Dihydroartemisinin and Other Front-Line Antimalarial Drugs.

Cobbold SA, Chua HH, Nijagal B, Creek DJ, Ralph SA, McConville MJ.

J Infect Dis. 2016 Jan 15;213(2):276-86. doi: 10.1093/infdis/jiv372. Epub 2015 Jul 6.

PMID:
26150544
40.

Redox state influence on human galectin-1 function.

Yu X, Scott SA, Pritchard R, Houston TA, Ralph SJ, Blanchard H.

Biochimie. 2015 Sep;116:8-16. doi: 10.1016/j.biochi.2015.06.013. Epub 2015 Jun 24.

PMID:
26116885
41.

Frontiers in Nucleic Acid Nanotechnology.

Ralph SF.

Nanomaterials (Basel). 2015 May 8;5(2):750-754. doi: 10.3390/nano5020750.

42.

Development of a potent melanoma vaccine capable of stimulating CD8(+) T-cells independently of dendritic cells in a mouse model.

Powell KL, Stephens AS, Ralph SJ.

Cancer Immunol Immunother. 2015 Jul;64(7):861-72. doi: 10.1007/s00262-015-1695-3. Epub 2015 Apr 19.

PMID:
25893808
43.

A serine-arginine-rich (SR) splicing factor modulates alternative splicing of over a thousand genes in Toxoplasma gondii.

Yeoh LM, Goodman CD, Hall NE, van Dooren GG, McFadden GI, Ralph SA.

Nucleic Acids Res. 2015 May 19;43(9):4661-75. doi: 10.1093/nar/gkv311. Epub 2015 Apr 13.

44.

Immunomodulatory activity of Melaleuca alternifolia concentrate (MAC): inhibition of LPS-induced NF-κB activation and cytokine production in myeloid cell lines.

Low P, Clark AM, Chou TC, Chang TC, Reynolds M, Ralph SJ.

Int Immunopharmacol. 2015 May;26(1):257-64. doi: 10.1016/j.intimp.2015.03.034. Epub 2015 Apr 6.

PMID:
25858876
45.

Targeting and function of proteins mediating translation initiation in organelles of Plasmodium falciparum.

Haider A, Allen SM, Jackson KE, Ralph SA, Habib S.

Mol Microbiol. 2015 May;96(4):796-814. doi: 10.1111/mmi.12972. Epub 2015 Mar 16.

46.

Hitting the Bull's-Eye in Metastatic Cancers-NSAIDs Elevate ROS in Mitochondria, Inducing Malignant Cell Death.

Ralph SJ, Pritchard R, Rodríguez-Enríquez S, Moreno-Sánchez R, Ralph RK.

Pharmaceuticals (Basel). 2015 Feb 13;8(1):62-106. doi: 10.3390/ph8010062. Review.

47.

Tricin, a flavonoid monomer in monocot lignification.

Lan W, Lu F, Regner M, Zhu Y, Rencoret J, Ralph SA, Zakai UI, Morreel K, Boerjan W, Ralph J.

Plant Physiol. 2015 Apr;167(4):1284-95. doi: 10.1104/pp.114.253757. Epub 2015 Feb 9.

48.

Synthesis and characterisation of nickel Schiff base complexes containing the meso-1,2-diphenylethylenediamine moiety: selective interactions with a tetramolecular DNA quadruplex.

Davis KJ, Richardson C, Beck JL, Knowles BM, Guédin A, Mergny JL, Willis AC, Ralph SF.

Dalton Trans. 2015 Feb 21;44(7):3136-50. doi: 10.1039/c4dt02926g.

PMID:
25572696
49.

Advanced signaling technologies for high-speed digital fiber-optic links.

Stark AJ, Isautier P, Pan J, Pavan SK, Filer M, Tibuleac S, Lingle R Jr, de Salvo R, Ralph SE.

Appl Opt. 2014 Sep 1;53(25):5824-40. doi: 10.1364/AO.53.005824.

PMID:
25321383
50.

An investigation into the interactions of gold nanoparticles and anti-arthritic drugs with macrophages, and their reactivity towards thioredoxin reductase.

James LR, Xu ZQ, Sluyter R, Hawksworth EL, Kelso C, Lai B, Paterson DJ, de Jonge MD, Dixon NE, Beck JL, Ralph SF, Dillon CT.

J Inorg Biochem. 2015 Jan;142:28-38. doi: 10.1016/j.jinorgbio.2014.09.013. Epub 2014 Sep 28.

PMID:
25306263

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