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Items: 1 to 50 of 146

1.

p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors.

Carugo A, Minelli R, Sapio L, Soeung M, Carbone F, Robinson FS, Tepper J, Chen Z, Lovisa S, Svelto M, Amin S, Srinivasan S, Del Poggetto E, Loponte S, Puca F, Dey P, Malouf GG, Su X, Li L, Lopez-Terrada D, Rakheja D, Lazar AJ, Netto GJ, Rao P, Sgambato A, Maitra A, Tripathi DN, Walker CL, Karam JA, Heffernan TP, Viale A, Roberts CWM, Msaouel P, Tannir NM, Draetta GF, Genovese G.

Cancer Cell. 2019 Feb 11;35(2):204-220.e9. doi: 10.1016/j.ccell.2019.01.006.

PMID:
30753823
2.

Ascorbic acid-induced TET activation mitigates adverse hydroxymethylcytosine loss in renal cell carcinoma.

Shenoy N, Bhagat TD, Cheville J, Lohse C, Bhattacharyya S, Tischer A, Machha V, Gordon-Mitchell S, Choudhary G, Wong LF, Gross L, Ressigue E, Leibovich B, Boorjian SA, Steidl U, Wu X, Pradhan K, Gartrell B, Agarwal B, Pagliaro L, Suzuki M, Greally JM, Rakheja D, Thompson RH, Susztak K, Witzig T, Zou Y, Verma A.

J Clin Invest. 2019 Mar 4;130. pii: 98747. doi: 10.1172/JCI98747. eCollection 2019 Mar 4.

3.

Biochemical and Epigenetic Insights into L-2-Hydroxyglutarate, a Potential Therapeutic Target in Renal Cancer.

Shelar S, Shim EH, Brinkley GJ, Kundu A, Carobbio F, Poston T, Tan J, Parekh V, Benson D, Crossman DK, Buckhaults PJ, Rakheja D, Kirkman R, Sato Y, Ogawa S, Dutta S, Velu SE, Emberley E, Pan A, Chen J, Huang T, Absher D, Becker A, Kunick C, Sudarshan S.

Clin Cancer Res. 2018 Dec 15;24(24):6433-6446. doi: 10.1158/1078-0432.CCR-18-1727. Epub 2018 Aug 14.

PMID:
30108105
4.

Mutations in microRNA processing genes in Wilms tumors derepress the IGF2 regulator PLAG1.

Chen KS, Stroup EK, Budhipramono A, Rakheja D, Nichols-Vinueza D, Xu L, Stuart SH, Shukla AA, Fraire C, Mendell JT, Amatruda JF.

Genes Dev. 2018 Aug 1;32(15-16):996-1007. doi: 10.1101/gad.313783.118. Epub 2018 Jul 19.

5.

ACTG2-Associated Visceral Myopathy With Chronic Intestinal Pseudoobstruction, Intestinal Malrotation, Hypertrophic Pyloric Stenosis, Choledochal Cyst, and a Novel Missense Mutation.

Collins RRJ, Barth B, Megison S, Pfeifer CM, Rice LM, Harris S, Timmons CF, Rakheja D.

Int J Surg Pathol. 2019 Feb;27(1):77-83. doi: 10.1177/1066896918786586. Epub 2018 Jul 18.

PMID:
30019982
6.

Integrative Bayesian Analysis Identifies Rhabdomyosarcoma Disease Genes.

Xu L, Zheng Y, Liu J, Rakheja D, Singleterry S, Laetsch TW, Shern JF, Khan J, Triche TJ, Hawkins DS, Amatruda JF, Skapek SX.

Cell Rep. 2018 Jul 3;24(1):238-251. doi: 10.1016/j.celrep.2018.06.006.

7.

Loss of Dis3l2 partially phenocopies Perlman syndrome in mice and results in up-regulation of Igf2 in nephron progenitor cells.

Hunter RW, Liu Y, Manjunath H, Acharya A, Jones BT, Zhang H, Chen B, Ramalingam H, Hammer RE, Xie Y, Richardson JA, Rakheja D, Carroll TJ, Mendell JT.

Genes Dev. 2018 Jul 1;32(13-14):903-908. doi: 10.1101/gad.315804.118. Epub 2018 Jun 27.

8.

PAX3-FOXO1 transgenic zebrafish models identify HES3 as a mediator of rhabdomyosarcoma tumorigenesis.

Kendall GC, Watson S, Xu L, LaVigne CA, Murchison W, Rakheja D, Skapek SX, Tirode F, Delattre O, Amatruda JF.

Elife. 2018 Jun 5;7. pii: e33800. doi: 10.7554/eLife.33800.

9.

Subcutaneous Lobular Capillary Hemangioma Presenting as a Facial Mass.

Saadeh C, Ulualp SO, Rakheja D.

Case Rep Otolaryngol. 2018 May 8;2018:5973619. doi: 10.1155/2018/5973619. eCollection 2018.

10.

Myelodysplastic Syndrome and Sweet's Syndrome Are Associated with a Mutation in Isocitrate Dehydrogenase 1.

Snyder R, Libby T, Raciti P, Amin B, Jacobson M, Rakheja D, Fleming K, Bartenstein M, Zhu C, Goel S, Verma AK, Shastri A.

Anticancer Res. 2018 Apr;38(4):2201-2205.

PMID:
29599340
11.

EGF Receptor and mTORC1 Are Novel Therapeutic Targets in Nonseminomatous Germ Cell Tumors.

Chen KS, Fustino NJ, Shukla AA, Stroup EK, Budhipramono A, Ateek C, Stuart SH, Yamaguchi K, Kapur P, Frazier AL, Lum L, Looijenga LHJ, Laetsch TW, Rakheja D, Amatruda JF.

Mol Cancer Ther. 2018 May;17(5):1079-1089. doi: 10.1158/1535-7163.MCT-17-0137. Epub 2018 Feb 26.

PMID:
29483210
12.

Orbital Granulomatosis With Polyangiitis Mimicking IgG4-Related Disease in a 12-Year-Old Male.

Drobysheva A, Fuller J, Pfeifer CM, Rakheja D.

Int J Surg Pathol. 2018 Aug;26(5):453-458. doi: 10.1177/1066896917754252. Epub 2018 Jan 25.

PMID:
29366363
13.

Low-Grade Fibromyxoid Sarcoma With Striking Zonation.

Rakheja D, Seaward JR, Timmons CF.

Int J Surg Pathol. 2018 Jun;26(4):332-333. doi: 10.1177/1066896917742724. Epub 2017 Dec 6. No abstract available.

PMID:
29212404
14.

Convolutional Neural Network for Histopathological Analysis of Osteosarcoma.

Mishra R, Daescu O, Leavey P, Rakheja D, Sengupta A.

J Comput Biol. 2018 Mar;25(3):313-325. doi: 10.1089/cmb.2017.0153. Epub 2017 Oct 30.

PMID:
29083930
15.

Restoration of a denser myocardial capillary network after mechanical unloading of failing hearts in children with dilated cardiomyopathy.

Das BB, Rakheja D.

J Heart Lung Transplant. 2018 Jan;37(1):175-176. doi: 10.1016/j.healun.2017.09.018. Epub 2017 Sep 30. No abstract available.

PMID:
29055601
16.

Oncometabolites: A New Paradigm for Oncology, Metabolism, and the Clinical Laboratory.

Collins RRJ, Patel K, Putnam WC, Kapur P, Rakheja D.

Clin Chem. 2017 Dec;63(12):1812-1820. doi: 10.1373/clinchem.2016.267666. Epub 2017 Oct 16. Review.

17.

A Matter of Mushroom.

Ellington N, Wang J, Rakheja D.

Int J Surg Pathol. 2018 Apr;26(2):155-156. doi: 10.1177/1066896917728796. Epub 2017 Sep 1. No abstract available.

PMID:
28862081
18.

Targeted MAPK Pathway Inhibitors in Patients With Disseminated Pilocytic Astrocytomas.

Drobysheva A, Klesse LJ, Bowers DC, Rajaram V, Rakheja D, Timmons CF, Wang J, Koral K, Gargan L, Ramos E, Park JY.

J Natl Compr Canc Netw. 2017 Aug;15(8):978-982. doi: 10.6004/jnccn.2017.0139.

PMID:
28784858
19.

Measurement of Oncometabolites D-2-Hydroxyglutaric Acid and L-2-Hydroxyglutaric Acid.

Jones PM, Boriack R, Struys EA, Rakheja D.

Methods Mol Biol. 2017;1633:219-234. doi: 10.1007/978-1-4939-7142-8_14.

PMID:
28735490
20.

Reverse histologic remodeling after mechanical unloading of failing hearts in children with dilated cardiomyopathy.

Kasten J, Rakheja D, Zhang S, Thankavel P, Das BB.

J Heart Lung Transplant. 2017 Nov;36(11):1268-1271. doi: 10.1016/j.healun.2017.06.010. Epub 2017 Jun 23. No abstract available.

PMID:
28705646
21.

Omental Arteriopathy in Primary Atypical Hemolytic Uremic Syndrome.

Ellington N, Wolf MTF, Kasten J, Rakheja D.

Int J Surg Pathol. 2017 Sep;25(6):515-517. doi: 10.1177/1066896917699703. Epub 2017 Mar 22. No abstract available.

PMID:
28381151
22.

EGFR Exon 20 Insertion/Duplication Mutation in Fibrous Hamartoma of Infancy With Predominantly Pseudoangiomatous Pattern Mimicking Giant Cell Fibroblastoma.

Ellington N, Park JY, King K, Josephs S, Rakheja D.

Int J Surg Pathol. 2017 Aug;25(5):421-424. doi: 10.1177/1066896917698569. Epub 2017 Mar 16.

PMID:
28381148
23.

Prognostic value of tissue-based biomarker signature in clear cell renal cell carcinoma.

Haddad AQ, Luo JH, Krabbe LM, Darwish O, Gayed B, Youssef R, Kapur P, Rakheja D, Lotan Y, Sagalowsky A, Margulis V.

BJU Int. 2017 May;119(5):741-747. doi: 10.1111/bju.13776. Epub 2017 Feb 9.

24.

COMPUTER AIDED IMAGE SEGMENTATION AND CLASSIFICATION FOR VIABLE AND NON-VIABLE TUMOR IDENTIFICATION IN OSTEOSARCOMA.

Arunachalam HB, Mishra R, Armaselu B, Daescu O, Martinez M, Leavey P, Rakheja D, Cederberg K, Sengupta A, Ni'suilleabhain M.

Pac Symp Biocomput. 2017;22:195-206. doi: 10.1142/9789813207813_0020.

25.

Quantitative metabolic flux analysis reveals an unconventional pathway of fatty acid synthesis in cancer cells deficient for the mitochondrial citrate transport protein.

Jiang L, Boufersaoui A, Yang C, Ko B, Rakheja D, Guevara G, Hu Z, DeBerardinis RJ.

Metab Eng. 2017 Sep;43(Pt B):198-207. doi: 10.1016/j.ymben.2016.11.004. Epub 2016 Nov 14.

26.

Genomic analysis of hepatoblastoma identifies distinct molecular and prognostic subgroups.

Sumazin P, Chen Y, Treviño LR, Sarabia SF, Hampton OA, Patel K, Mistretta TA, Zorman B, Thompson P, Heczey A, Comerford S, Wheeler DA, Chintagumpala M, Meyers R, Rakheja D, Finegold MJ, Tomlinson G, Parsons DW, López-Terrada D.

Hepatology. 2017 Jan;65(1):104-121. doi: 10.1002/hep.28888. Epub 2016 Nov 29.

PMID:
27775819
27.

Hepatoblastoma modeling in mice places Nrf2 within a cancer field established by mutant β-catenin.

Comerford SA, Hinnant EA, Chen Y, Bansal H, Klapproth S, Rakheja D, Finegold MJ, Lopez-Terrada D, O'Donnell KA, Tomlinson GE, Hammer RE.

JCI Insight. 2016 Oct 6;1(16):e88549. doi: 10.1172/jci.insight.88549.

28.

Genetic inhibition of autophagy promotes p53 loss-of-heterozygosity and tumorigenesis.

Lee E, Wei Y, Zou Z, Tucker K, Rakheja D, Levine B, Amatruda JF.

Oncotarget. 2016 Oct 18;7(42):67919-67933. doi: 10.18632/oncotarget.12084.

29.

Possible progesterone-induced gestational activation of chromosomally integrated human herpesvirus 6B and transplacental transmission of activated human herpesvirus 6B.

Das BB, Rakheja D, Lacelle C, Sedlak RH, Gulve N, Chowdhury SR, Prusty BK.

J Heart Lung Transplant. 2016 Nov;35(11):1373-1376. doi: 10.1016/j.healun.2016.08.009. Epub 2016 Aug 20. No abstract available.

PMID:
27646062
30.

EGFR Exon 20 Insertion/Duplication Mutations Characterize Fibrous Hamartoma of Infancy.

Park JY, Cohen C, Lopez D, Ramos E, Wagenfuehr J, Rakheja D.

Am J Surg Pathol. 2016 Dec;40(12):1713-1718.

PMID:
27631514
31.

Preface to the column "Metabolism of Childhood Cancer".

Rakheja D.

Transl Pediatr. 2015 Jan;4(1):1-3. doi: 10.3978/j.issn.2224-4336.2015.02.02. No abstract available.

32.

p53 genes function to restrain mobile elements.

Wylie A, Jones AE, D'Brot A, Lu WJ, Kurtz P, Moran JV, Rakheja D, Chen KS, Hammer RE, Comerford SA, Amatruda JF, Abrams JM.

Genes Dev. 2016 Jan 1;30(1):64-77. doi: 10.1101/gad.266098.115. Epub 2015 Dec 23.

33.

Discordant intracellular and plasma D-2-hydroxyglutarate levels in a patient with IDH2 mutated angioimmunoblastic T-cell lymphoma.

Churchill H, Naina H, Boriack R, Rakheja D, Chen W.

Int J Clin Exp Pathol. 2015 Sep 1;8(9):11753-9. eCollection 2015.

34.

Recurrent internal tandem duplications of BCOR in clear cell sarcoma of the kidney.

Roy A, Kumar V, Zorman B, Fang E, Haines KM, Doddapaneni H, Hampton OA, White S, Bavle AA, Patel NR, Eldin KW, John Hicks M, Rakheja D, Leavey PJ, Skapek SX, Amatruda JF, Nuchtern JG, Chintagumpala MM, Wheeler DA, Plon SE, Sumazin P, Parsons DW.

Nat Commun. 2015 Nov 17;6:8891. doi: 10.1038/ncomms9891.

35.

A Novel Syndrome of Generalized Lipodystrophy Associated With Pilocytic Astrocytoma.

Patni N, Alves C, von Schnurbein J, Wabitsch M, Tannin G, Rakheja D, Garg A.

J Clin Endocrinol Metab. 2015 Oct;100(10):3603-6. doi: 10.1210/jc.2015-2476. Epub 2015 Aug 7.

36.

The importance of plasma D-2HG measurement in screening for IDH mutations in acute myeloid leukaemia.

McGehee E, Rakheja D, Oliver D, Chen W, Boriack R, Collins RH Jr.

Br J Haematol. 2016 Apr;173(2):323-6. doi: 10.1111/bjh.13598. Epub 2015 Jul 20. No abstract available.

PMID:
26195003
37.

D2HGDH regulates alpha-ketoglutarate levels and dioxygenase function by modulating IDH2.

Lin AP, Abbas S, Kim SW, Ortega M, Bouamar H, Escobedo Y, Varadarajan P, Qin Y, Sudderth J, Schulz E, Deutsch A, Mohan S, Ulz P, Neumeister P, Rakheja D, Gao X, Hinck A, Weintraub ST, DeBerardinis RJ, Sill H, Dahia PL, Aguiar RC.

Nat Commun. 2015 Jul 16;6:7768. doi: 10.1038/ncomms8768.

38.

Maternal high-fat diet is associated with impaired fetal lung development.

Mayor RS, Finch KE, Zehr J, Morselli E, Neinast MD, Frank AP, Hahner LD, Wang J, Rakheja D, Palmer BF, Rosenfeld CR, Savani RC, Clegg DJ.

Am J Physiol Lung Cell Mol Physiol. 2015 Aug 15;309(4):L360-8. doi: 10.1152/ajplung.00105.2015. Epub 2015 Jun 19.

39.

Increased plasma d-2-hydroxyglutarate in isocitrate dehydrogenase 2-mutated blastic plasmacytoid dendritic cell neoplasm.

Rakheja D, Fuda F, Vandergriff T, Boriack R, Medeiros BC, Frankel AE, Chen W.

Hum Pathol. 2015 Feb;46(2):322-6. doi: 10.1016/j.humpath.2014.10.013. Epub 2014 Nov 4.

PMID:
25481493
40.

Loss of PBRM1 and BAP1 expression is less common in non-clear cell renal cell carcinoma than in clear cell renal cell carcinoma.

Ho TH, Kapur P, Joseph RW, Serie DJ, Eckel-Passow JE, Parasramka M, Cheville JC, Wu KJ, Frenkel E, Rakheja D, Stefanius K, Brugarolas J, Parker AS.

Urol Oncol. 2015 Jan;33(1):23.e9-23.e14. doi: 10.1016/j.urolonc.2014.10.014. Epub 2014 Nov 24.

41.

Bap1 is essential for kidney function and cooperates with Vhl in renal tumorigenesis.

Wang SS, Gu YF, Wolff N, Stefanius K, Christie A, Dey A, Hammer RE, Xie XJ, Rakheja D, Pedrosa I, Carroll T, McKay RM, Kapur P, Brugarolas J.

Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16538-43. doi: 10.1073/pnas.1414789111. Epub 2014 Oct 30.

42.

Somatic mutations in DROSHA and DICER1 impair microRNA biogenesis through distinct mechanisms in Wilms tumours.

Rakheja D, Chen KS, Liu Y, Shukla AA, Schmid V, Chang TC, Khokhar S, Wickiser JE, Karandikar NJ, Malter JS, Mendell JT, Amatruda JF.

Nat Commun. 2014 Sep 5;2:4802. doi: 10.1038/ncomms5802.

43.

L-2-Hydroxyglutarate: an epigenetic modifier and putative oncometabolite in renal cancer.

Shim EH, Livi CB, Rakheja D, Tan J, Benson D, Parekh V, Kho EY, Ghosh AP, Kirkman R, Velu S, Dutta S, Chenna B, Rea SL, Mishur RJ, Li Q, Johnson-Pais TL, Guo L, Bae S, Wei S, Block K, Sudarshan S.

Cancer Discov. 2014 Nov;4(11):1290-8. doi: 10.1158/2159-8290.CD-13-0696. Epub 2014 Sep 2.

44.

Fibroepithelial polyp of the epiglottis.

Farzal Z, Ulualp SO, Rakheja D.

Am J Case Rep. 2014 Aug 14;15:340-2. doi: 10.12659/AJCR.890924.

45.

Lin28b is sufficient to drive liver cancer and necessary for its maintenance in murine models.

Nguyen LH, Robinton DA, Seligson MT, Wu L, Li L, Rakheja D, Comerford SA, Ramezani S, Sun X, Parikh MS, Yang EH, Powers JT, Shinoda G, Shah SP, Hammer RE, Daley GQ, Zhu H.

Cancer Cell. 2014 Aug 11;26(2):248-61. doi: 10.1016/j.ccr.2014.06.018.

46.

Oxidation of alpha-ketoglutarate is required for reductive carboxylation in cancer cells with mitochondrial defects.

Mullen AR, Hu Z, Shi X, Jiang L, Boroughs LK, Kovacs Z, Boriack R, Rakheja D, Sullivan LB, Linehan WM, Chandel NS, DeBerardinis RJ.

Cell Rep. 2014 Jun 12;7(5):1679-1690. doi: 10.1016/j.celrep.2014.04.037. Epub 2014 May 22.

47.

A 14-year-old boy with sore throat and tea-colored urine.

Cooper A, Rakheja D, Punaro M.

Pediatrics. 2014 May;133(5):e1377-80. doi: 10.1542/peds.2013-0466. Review.

48.

Loss of BAP1 protein expression is an independent marker of poor prognosis in patients with low-risk clear cell renal cell carcinoma.

Joseph RW, Kapur P, Serie DJ, Eckel-Passow JE, Parasramka M, Ho T, Cheville JC, Frenkel E, Rakheja D, Brugarolas J, Parker A.

Cancer. 2014 Apr 1;120(7):1059-67. doi: 10.1002/cncr.28521. Epub 2013 Dec 30. Erratum in: Cancer. 2014 Jun 1;120(11):1752-3.

49.

Analysis of induced pluripotent stem cells from a BRCA1 mutant family.

Soyombo AA, Wu Y, Kolski L, Rios JJ, Rakheja D, Chen A, Kehler J, Hampel H, Coughran A, Ross TS.

Stem Cell Reports. 2013 Oct 3;1(4):336-49. doi: 10.1016/j.stemcr.2013.08.004. eCollection 2013.

50.

Congenital hairy polyp of the palatopharyngeus muscle.

Christianson B, Ulualp SO, Koral K, Rakheja D, Deskin R.

Case Rep Otolaryngol. 2013;2013:374681. doi: 10.1155/2013/374681. Epub 2013 Jun 19.

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