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Items: 1 to 50 of 65

1.

Preclinical Efficacy and Safety Comparison of CD3 Bispecific and ADC Modalities Targeting BCMA for the Treatment of Multiple Myeloma.

Panowski SH, Kuo TC, Zhang Y, Chen A, Geng T, Aschenbrenner L, Kamperschroer C, Pascua E, Chen W, Delaria K, Farias S, Bateman M, Dushin RG, Chin SM, Van Blarcom TJ, Yeung YA, Lindquist KC, Chunyk AG, Kuang B, Han B, Mirsky M, Pardo I, Buetow B, Martin TG, Wolf JL, Shelton D, Rajpal A, Strop P, Chaparro-Riggers J, Sasu BJ.

Mol Cancer Ther. 2019 Aug 21. pii: molcanther.0007.2019. doi: 10.1158/1535-7163.MCT-19-0007. [Epub ahead of print]

PMID:
31434693
2.

Preclinical Evaluation of Allogeneic CAR T Cells Targeting BCMA for the Treatment of Multiple Myeloma.

Sommer C, Boldajipour B, Kuo TC, Bentley T, Sutton J, Chen A, Geng T, Dong H, Galetto R, Valton J, Pertel T, Juillerat A, Gariboldi A, Pascua E, Brown C, Chin SM, Sai T, Ni Y, Duchateau P, Smith J, Rajpal A, Van Blarcom T, Chaparro-Riggers J, Sasu BJ.

Mol Ther. 2019 Jun 5;27(6):1126-1138. doi: 10.1016/j.ymthe.2019.04.001. Epub 2019 Apr 8.

PMID:
31005597
3.

Optimal design, anti-tumour efficacy and tolerability of anti-CXCR4 antibody drug conjugates.

Costa MJ, Kudaravalli J, Ma JT, Ho WH, Delaria K, Holz C, Stauffer A, Chunyk AG, Zong Q, Blasi E, Buetow B, Tran TT, Lindquist K, Dorywalska M, Rajpal A, Shelton DL, Strop P, Liu SH.

Sci Rep. 2019 Feb 21;9(1):2443. doi: 10.1038/s41598-019-38745-x.

4.

RN765C, a low affinity EGFR antibody drug conjugate with potent anti-tumor activity in preclinical solid tumor models.

Wong OK, Tran TT, Ho WH, Casas MG, Au M, Bateman M, Lindquist KC, Rajpal A, Shelton DL, Strop P, Liu SH.

Oncotarget. 2018 Sep 11;9(71):33446-33458. doi: 10.18632/oncotarget.26002. eCollection 2018 Sep 11.

5.

Epitope Mapping Using Yeast Display and Next Generation Sequencing.

Van Blarcom T, Rossi A, Foletti D, Sundar P, Pitts S, Melton Z, Telman D, Zhao L, Cheung WL, Berka J, Zhai W, Strop P, Pons J, Rajpal A, Chaparro-Riggers J.

Methods Mol Biol. 2018;1785:89-118. doi: 10.1007/978-1-4939-7841-0_7.

PMID:
29714014
6.

Clopidogrel-Induced Insulin Autoimmune Syndrome: A Newly Recognized Cause of Hypoglycemia in a Patient Without Diabetes.

Rajpal A, Kassem LS, Moscoso-Cordero M, Arafah BM.

J Endocr Soc. 2017 Aug 28;1(9):1217-1223. doi: 10.1210/js.2017-00316. eCollection 2017 Sep 1.

7.

The Value of Perioperative Levels of ACTH, DHEA, and DHEA-S and Tumor Size in Predicting Recurrence of Cushing Disease.

El Asmar N, Rajpal A, Selman WR, Arafah BM.

J Clin Endocrinol Metab. 2018 Feb 1;103(2):477-485. doi: 10.1210/jc.2017-01797.

PMID:
29244084
8.

Productive common light chain libraries yield diverse panels of high affinity bispecific antibodies.

Van Blarcom T, Lindquist K, Melton Z, Cheung WL, Wagstrom C, McDonough D, Valle Oseguera C, Ding S, Rossi A, Potluri S, Sundar P, Pitts S, Sirota M, Galindo Casas M, Yan Y, Jones J, Roe-Zurz Z, Srivatsa Srinivasan S, Zhai W, Pons J, Rajpal A, Chaparro-Riggers J.

MAbs. 2018 Feb/Mar;10(2):256-268. doi: 10.1080/19420862.2017.1406570. Epub 2017 Dec 14.

9.

The impact of peri-operative dexamethasone administration on the normal hypothalamic pituitary adrenal response to major surgical procedures.

El-Sibai K, Rajpal A, Al-Aridi R, Selman WR, Arafah BM.

Endocrine. 2017 Oct;58(1):134-142. doi: 10.1007/s12020-017-1398-y. Epub 2017 Sep 1.

PMID:
28865040
10.

Perioperative hypothalamic pituitary adrenal function in patients with silent corticotroph adenomas.

Cheres AF, ElAsmar N, Rajpal A, Selman WR, Arafah BM.

Pituitary. 2017 Aug;20(4):471-476. doi: 10.1007/s11102-017-0809-7.

PMID:
28528397
11.

Improved Lysosomal Trafficking Can Modulate the Potency of Antibody Drug Conjugates.

DeVay RM, Delaria K, Zhu G, Holz C, Foletti D, Sutton J, Bolton G, Dushin R, Bee C, Pons J, Rajpal A, Liang H, Shelton D, Liu SH, Strop P.

Bioconjug Chem. 2017 Apr 19;28(4):1102-1114. doi: 10.1021/acs.bioconjchem.7b00013. Epub 2017 Feb 13.

PMID:
28151644
12.

Germline-encoded neutralization of a Staphylococcus aureus virulence factor by the human antibody repertoire.

Yeung YA, Foletti D, Deng X, Abdiche Y, Strop P, Glanville J, Pitts S, Lindquist K, Sundar PD, Sirota M, Hasa-Moreno A, Pham A, Melton Witt J, Ni I, Pons J, Shelton D, Rajpal A, Chaparro-Riggers J.

Nat Commun. 2016 Nov 18;7:13376. doi: 10.1038/ncomms13376.

13.

RN927C, a Site-Specific Trop-2 Antibody-Drug Conjugate (ADC) with Enhanced Stability, Is Highly Efficacious in Preclinical Solid Tumor Models.

Strop P, Tran TT, Dorywalska M, Delaria K, Dushin R, Wong OK, Ho WH, Zhou D, Wu A, Kraynov E, Aschenbrenner L, Han B, O'Donnell CJ, Pons J, Rajpal A, Shelton DL, Liu SH.

Mol Cancer Ther. 2016 Nov;15(11):2698-2708. Epub 2016 Aug 31.

14.

Modulation of P2X3 and P2X2/3 Receptors by Monoclonal Antibodies.

Shcherbatko A, Foletti D, Poulsen K, Strop P, Zhu G, Hasa-Moreno A, Melton Witt J, Loo C, Krimm S, Pios A, Yu J, Brown C, Lee JK, Stroud R, Rajpal A, Shelton D.

J Biol Chem. 2016 Jun 3;291(23):12254-70. doi: 10.1074/jbc.M116.722330. Epub 2016 Apr 20.

15.

Engineering Highly Potent and Selective Microproteins against Nav1.7 Sodium Channel for Treatment of Pain.

Shcherbatko A, Rossi A, Foletti D, Zhu G, Bogin O, Galindo Casas M, Rickert M, Hasa-Moreno A, Bartsevich V, Crameri A, Steiner AR, Henningsen R, Gill A, Pons J, Shelton DL, Rajpal A, Strop P.

J Biol Chem. 2016 Jul 1;291(27):13974-86. doi: 10.1074/jbc.M116.725978. Epub 2016 Apr 22.

16.

Molecular Basis of Valine-Citrulline-PABC Linker Instability in Site-Specific ADCs and Its Mitigation by Linker Design.

Dorywalska M, Dushin R, Moine L, Farias SE, Zhou D, Navaratnam T, Lui V, Hasa-Moreno A, Casas MG, Tran TT, Delaria K, Liu SH, Foletti D, O'Donnell CJ, Pons J, Shelton DL, Rajpal A, Strop P.

Mol Cancer Ther. 2016 May;15(5):958-70. doi: 10.1158/1535-7163.MCT-15-1004. Epub 2016 Mar 4.

17.

Contamination level of four priority phthalates in North Indian wastewater treatment plants and their fate in sequencing batch reactor systems.

Gani KM, Rajpal A, Kazmi AA.

Environ Sci Process Impacts. 2016 Mar;18(3):406-16. doi: 10.1039/c5em00583c.

PMID:
26923228
18.

Production of soluble and active microbial transglutaminase in Escherichia coli for site-specific antibody drug conjugation.

Rickert M, Strop P, Lui V, Melton-Witt J, Farias SE, Foletti D, Shelton D, Pons J, Rajpal A.

Protein Sci. 2016 Feb;25(2):442-55. doi: 10.1002/pro.2833. Epub 2015 Dec 26.

19.

Effect of dexmedetomidine as an adjuvant to levobupivacaine in supraclavicular brachial plexus block: A randomized double-blind prospective study.

Kaur H, Singh G, Rani S, Gupta KK, Kumar M, Rajpal AS, Aggarwal S.

J Anaesthesiol Clin Pharmacol. 2015 Jul-Sep;31(3):333-8. doi: 10.4103/0970-9185.161668.

20.

Site-Dependent Degradation of a Non-Cleavable Auristatin-Based Linker-Payload in Rodent Plasma and Its Effect on ADC Efficacy.

Dorywalska M, Strop P, Melton-Witt JA, Hasa-Moreno A, Farias SE, Galindo Casas M, Delaria K, Lui V, Poulsen K, Sutton J, Bolton G, Zhou D, Moine L, Dushin R, Tran TT, Liu SH, Rickert M, Foletti D, Shelton DL, Pons J, Rajpal A.

PLoS One. 2015 Jul 10;10(7):e0132282. doi: 10.1371/journal.pone.0132282. eCollection 2015.

21.

Site-specific conjugation improves therapeutic index of antibody drug conjugates with high drug loading.

Strop P, Delaria K, Foletti D, Witt JM, Hasa-Moreno A, Poulsen K, Casas MG, Dorywalska M, Farias S, Pios A, Lui V, Dushin R, Zhou D, Navaratnam T, Tran TT, Sutton J, Lindquist KC, Han B, Liu SH, Shelton DL, Pons J, Rajpal A.

Nat Biotechnol. 2015 Jul;33(7):694-6. doi: 10.1038/nbt.3274. No abstract available.

PMID:
26154005
22.

The neonatal Fc receptor (FcRn) binds independently to both sites of the IgG homodimer with identical affinity.

Abdiche YN, Yeung YA, Chaparro-Riggers J, Barman I, Strop P, Chin SM, Pham A, Bolton G, McDonough D, Lindquist K, Pons J, Rajpal A.

MAbs. 2015;7(2):331-43. doi: 10.1080/19420862.2015.1008353.

23.

Effect of attachment site on stability of cleavable antibody drug conjugates.

Dorywalska M, Strop P, Melton-Witt JA, Hasa-Moreno A, Farias SE, Galindo Casas M, Delaria K, Lui V, Poulsen K, Loo C, Krimm S, Bolton G, Moine L, Dushin R, Tran TT, Liu SH, Rickert M, Foletti D, Shelton DL, Pons J, Rajpal A.

Bioconjug Chem. 2015 Apr 15;26(4):650-9. doi: 10.1021/bc5005747. Epub 2015 Feb 20.

PMID:
25643134
24.

Precise and efficient antibody epitope determination through library design, yeast display and next-generation sequencing.

Van Blarcom T, Rossi A, Foletti D, Sundar P, Pitts S, Bee C, Melton Witt J, Melton Z, Hasa-Moreno A, Shaughnessy L, Telman D, Zhao L, Cheung WL, Berka J, Zhai W, Strop P, Chaparro-Riggers J, Shelton DL, Pons J, Rajpal A.

J Mol Biol. 2015 Mar 27;427(6 Pt B):1513-1534. doi: 10.1016/j.jmb.2014.09.020. Epub 2014 Oct 2.

PMID:
25284753
25.

A comparative study for pathogen removal using different filter media during vermifiltration.

Arora S, Rajpal A, Kumar T, Bhargava R, Kazmi AA.

Water Sci Technol. 2014;70(6):996-1003. doi: 10.2166/wst.2014.318.

PMID:
25259487
26.

Pathogen removal during wastewater treatment by vermifiltration.

Arora S, Rajpal A, Kumar T, Bhargava R, Kazmi AA.

Environ Technol. 2014 Sep-Oct;35(17-20):2493-9.

PMID:
25145204
27.

Human responses to influenza vaccination show seroconversion signatures and convergent antibody rearrangements.

Jackson KJ, Liu Y, Roskin KM, Glanville J, Hoh RA, Seo K, Marshall EL, Gurley TC, Moody MA, Haynes BF, Walter EB, Liao HX, Albrecht RA, García-Sastre A, Chaparro-Riggers J, Rajpal A, Pons J, Simen BB, Hanczaruk B, Dekker CL, Laserson J, Koller D, Davis MM, Fire AZ, Boyd SD.

Cell Host Microbe. 2014 Jul 9;16(1):105-14. doi: 10.1016/j.chom.2014.05.013. Epub 2014 Jun 26.

28.

Antibacterial and enzymatic activity of microbial community during wastewater treatment by pilot scale vermifiltration system.

Arora S, Rajpal A, Bhargava R, Pruthi V, Bhatia A, Kazmi AA.

Bioresour Technol. 2014 Aug;166:132-41. doi: 10.1016/j.biortech.2014.05.041. Epub 2014 May 21.

PMID:
24907572
29.

High-throughput epitope binning assays on label-free array-based biosensors can yield exquisite epitope discrimination that facilitates the selection of monoclonal antibodies with functional activity.

Abdiche YN, Miles A, Eckman J, Foletti D, Van Blarcom TJ, Yeung YA, Pons J, Rajpal A.

PLoS One. 2014 Mar 20;9(3):e92451. doi: 10.1371/journal.pone.0092451. eCollection 2014.

30.

Chemically coupled microwave and ultrasonic pre-hydrolysis of pulp and paper mill waste-activated sludge: effect on sludge solubilisation and anaerobic digestion.

Tyagi VK, Lo SL, Rajpal A.

Environ Sci Pollut Res Int. 2014 May;21(9):6205-17. doi: 10.1007/s11356-013-2426-y. Epub 2014 Feb 1.

PMID:
24488518
31.

Mass spectrometric characterization of transglutaminase based site-specific antibody-drug conjugates.

Farias SE, Strop P, Delaria K, Galindo Casas M, Dorywalska M, Shelton DL, Pons J, Rajpal A.

Bioconjug Chem. 2014 Feb 19;25(2):240-50. doi: 10.1021/bc4003794. Epub 2014 Jan 8.

PMID:
24359082
32.

Determining the binding affinity of therapeutic monoclonal antibodies towards their native unpurified antigens in human serum.

Bee C, Abdiche YN, Pons J, Rajpal A.

PLoS One. 2013 Nov 6;8(11):e80501. doi: 10.1371/journal.pone.0080501. eCollection 2013.

33.

Effects of transaldolase exchange on estimates of gluconeogenesis in type 2 diabetes.

Rajpal A, Dube S, Carvalho F, Simoes AR, Figueiredo A, Basu A, Jones J, Basu R.

Am J Physiol Endocrinol Metab. 2013 Aug 15;305(4):E465-74. doi: 10.1152/ajpendo.00245.2013. Epub 2013 Jun 4.

34.

Location matters: site of conjugation modulates stability and pharmacokinetics of antibody drug conjugates.

Strop P, Liu SH, Dorywalska M, Delaria K, Dushin RG, Tran TT, Ho WH, Farias S, Casas MG, Abdiche Y, Zhou D, Chandrasekaran R, Samain C, Loo C, Rossi A, Rickert M, Krimm S, Wong T, Chin SM, Yu J, Dilley J, Chaparro-Riggers J, Filzen GF, O'Donnell CJ, Wang F, Myers JS, Pons J, Shelton DL, Rajpal A.

Chem Biol. 2013 Feb 21;20(2):161-7. doi: 10.1016/j.chembiol.2013.01.010.

35.

Mechanism of action and in vivo efficacy of a human-derived antibody against Staphylococcus aureus α-hemolysin.

Foletti D, Strop P, Shaughnessy L, Hasa-Moreno A, Casas MG, Russell M, Bee C, Wu S, Pham A, Zeng Z, Pons J, Rajpal A, Shelton D.

J Mol Biol. 2013 May 27;425(10):1641-54. doi: 10.1016/j.jmb.2013.02.008. Epub 2013 Feb 13.

PMID:
23416200
36.

Experiences with a novel policy for managing conflicts of interest of guideline developers: a descriptive qualitative study.

Neumann I, Karl R, Rajpal A, Akl EA, Guyatt GH.

Chest. 2013 Aug;144(2):398-404. doi: 10.1378/chest.12-2390.

PMID:
23412682
37.

High-affinity IgG antibodies develop naturally in Ig-knockout rats carrying germline human IgH/Igκ/Igλ loci bearing the rat CH region.

Osborn MJ, Ma B, Avis S, Binnie A, Dilley J, Yang X, Lindquist K, Ménoret S, Iscache AL, Ouisse LH, Rajpal A, Anegon I, Neuberger MS, Buelow R, Brüggemann M.

J Immunol. 2013 Feb 15;190(4):1481-90. doi: 10.4049/jimmunol.1203041. Epub 2013 Jan 9. Erratum in: J Immunol. 2013 Jun 15;190(12):6707.

38.

A method for integrative structure determination of protein-protein complexes.

Schneidman-Duhovny D, Rossi A, Avila-Sakar A, Kim SJ, Velázquez-Muriel J, Strop P, Liang H, Krukenberg KA, Liao M, Kim HM, Sobhanifar S, Dötsch V, Rajpal A, Pons J, Agard DA, Cheng Y, Sali A.

Bioinformatics. 2012 Dec 15;28(24):3282-9. doi: 10.1093/bioinformatics/bts628. Epub 2012 Oct 23.

39.

Anti-IL-7 receptor-α reverses established type 1 diabetes in nonobese diabetic mice by modulating effector T-cell function.

Lee LF, Logronio K, Tu GH, Zhai W, Ni I, Mei L, Dilley J, Yu J, Rajpal A, Brown C, Appah C, Chin SM, Han B, Affolter T, Lin JC.

Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12674-9. doi: 10.1073/pnas.1203795109. Epub 2012 Jun 25. Erratum in: Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16393.

40.

Label-free epitope binning assays of monoclonal antibodies enable the identification of antigen heterogeneity.

Abdiche YN, Lindquist KC, Stone DM, Rajpal A, Pons J.

J Immunol Methods. 2012 Aug 31;382(1-2):101-16. doi: 10.1016/j.jim.2012.05.010. Epub 2012 May 17.

PMID:
22609372
41.

Exploring the dynamic range of the kinetic exclusion assay in characterizing antigen-antibody interactions.

Bee C, Abdiche YN, Stone DM, Collier S, Lindquist KC, Pinkerton AC, Pons J, Rajpal A.

PLoS One. 2012;7(4):e36261. doi: 10.1371/journal.pone.0036261. Epub 2012 Apr 30.

42.

Generating bispecific human IgG1 and IgG2 antibodies from any antibody pair.

Strop P, Ho WH, Boustany LM, Abdiche YN, Lindquist KC, Farias SE, Rickert M, Appah CT, Pascua E, Radcliffe T, Sutton J, Chaparro-Riggers J, Chen W, Casas MG, Chin SM, Wong OK, Liu SH, Vergara G, Shelton D, Rajpal A, Pons J.

J Mol Biol. 2012 Jul 13;420(3):204-19. doi: 10.1016/j.jmb.2012.04.020. Epub 2012 Apr 25.

PMID:
22543237
43.

Increasing serum half-life and extending cholesterol lowering in vivo by engineering antibody with pH-sensitive binding to PCSK9.

Chaparro-Riggers J, Liang H, DeVay RM, Bai L, Sutton JE, Chen W, Geng T, Lindquist K, Casas MG, Boustany LM, Brown CL, Chabot J, Gomes B, Garzone P, Rossi A, Strop P, Shelton D, Pons J, Rajpal A.

J Biol Chem. 2012 Mar 30;287(14):11090-7. doi: 10.1074/jbc.M111.319764. Epub 2012 Jan 31.

44.

Naive antibody gene-segment frequencies are heritable and unaltered by chronic lymphocyte ablation.

Glanville J, Kuo TC, von Büdingen HC, Guey L, Berka J, Sundar PD, Huerta G, Mehta GR, Oksenberg JR, Hauser SL, Cox DR, Rajpal A, Pons J.

Proc Natl Acad Sci U S A. 2011 Dec 13;108(50):20066-71. doi: 10.1073/pnas.1107498108. Epub 2011 Nov 28.

45.

Proprotein convertase substilisin/kexin type 9 antagonism reduces low-density lipoprotein cholesterol in statin-treated hypercholesterolemic nonhuman primates.

Liang H, Chaparro-Riggers J, Strop P, Geng T, Sutton JE, Tsai D, Bai L, Abdiche Y, Dilley J, Yu J, Wu S, Chin SM, Lee NA, Rossi A, Lin JC, Rajpal A, Pons J, Shelton DL.

J Pharmacol Exp Ther. 2012 Feb;340(2):228-36. doi: 10.1124/jpet.111.187419. Epub 2011 Oct 21.

PMID:
22019884
46.

Synthetic antibodies designed on natural sequence landscapes.

Zhai W, Glanville J, Fuhrmann M, Mei L, Ni I, Sundar PD, Van Blarcom T, Abdiche Y, Lindquist K, Strohner R, Telman D, Cappuccilli G, Finlay WJ, Van den Brulle J, Cox DR, Pons J, Rajpal A.

J Mol Biol. 2011 Sep 9;412(1):55-71. doi: 10.1016/j.jmb.2011.07.018. Epub 2011 Jul 23.

PMID:
21787786
47.

On site domestic organic waste treatment through vermitechnology using indigenous earthworm species.

Rajpal A, Bhargava R, Sasi SK, Chopra A.

Waste Manag Res. 2012 Mar;30(3):266-75. doi: 10.1177/0734242X11403798. Epub 2011 May 31.

PMID:
21628345
48.

Expanding the ProteOn XPR36 biosensor into a 36-ligand array expedites protein interaction analysis.

Abdiche YN, Lindquist KC, Pinkerton A, Pons J, Rajpal A.

Anal Biochem. 2011 Apr 1;411(1):139-51. doi: 10.1016/j.ab.2010.12.020. Epub 2010 Dec 17.

PMID:
21168382
49.

Precise determination of the diversity of a combinatorial antibody library gives insight into the human immunoglobulin repertoire.

Glanville J, Zhai W, Berka J, Telman D, Huerta G, Mehta GR, Ni I, Mei L, Sundar PD, Day GM, Cox D, Rajpal A, Pons J.

Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20216-21. doi: 10.1073/pnas.0909775106. Epub 2009 Oct 29.

50.

Bart's syndrome.

Rajpal A, Mishra R, Hajirnis K, Shah M, Nagpur N.

Indian J Dermatol. 2008;53(2):88-90. doi: 10.4103/0019-5154.41655.

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