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Items: 1 to 50 of 294

1.

First update of the International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes--Chapter 3: Porcine islet product manufacturing and release testing criteria.

Rayat GR, Gazda LS, Hawthorne WJ, Hering BJ, Hosking P, Matsumoto S, Rajotte RV.

Xenotransplantation. 2016 Jan-Feb;23(1):38-45. doi: 10.1111/xen.12225. Epub 2016 Feb 29.

PMID:
26923763
2.

Research-Focused Isolation of Human Islets From Donors With and Without Diabetes at the Alberta Diabetes Institute IsletCore.

Lyon J, Manning Fox JE, Spigelman AF, Kim R, Smith N, O'Gorman D, Kin T, Shapiro AM, Rajotte RV, MacDonald PE.

Endocrinology. 2016 Feb;157(2):560-9. doi: 10.1210/en.2015-1562. Epub 2015 Dec 11.

PMID:
26653569
3.

Transcript Expression Data from Human Islets Links Regulatory Signals from Genome-Wide Association Studies for Type 2 Diabetes and Glycemic Traits to Their Downstream Effectors.

van de Bunt M, Manning Fox JE, Dai X, Barrett A, Grey C, Li L, Bennett AJ, Johnson PR, Rajotte RV, Gaulton KJ, Dermitzakis ET, MacDonald PE, McCarthy MI, Gloyn AL.

PLoS Genet. 2015 Dec 1;11(12):e1005694. doi: 10.1371/journal.pgen.1005694. eCollection 2015 Dec.

4.

Porcine Islet-Specific Tolerance Induced by the Combination of Anti-LFA-1 and Anti-CD154 mAbs Is Dependent on PD-1.

Arefanian H, Tredget EB, Mok DC, Ramji Q, Rafati S, Rodriguez-Barbosa J, Korbutt GS, Rajotte RV, Gill RG, Rayat GR.

Cell Transplant. 2016;25(2):327-42. doi: 10.3727/096368915X688506. Epub 2015 Jun 23.

PMID:
26109574
5.

Human islet function following 20 years of cryogenic biobanking.

Manning Fox JE, Lyon J, Dai XQ, Wright RC, Hayward J, van de Bunt M, Kin T, Shapiro AM, McCarthy MI, Gloyn AL, Ungrin MD, Lakey JR, Kneteman NM, Warnock GL, Korbutt GS, Rajotte RV, MacDonald PE.

Diabetologia. 2015 Jul;58(7):1503-12. doi: 10.1007/s00125-015-3598-4. Epub 2015 May 1.

6.

Cyanidin-3-O-glucoside enhanced the function of syngeneic mouse islets transplanted under the kidney capsule or into the portal vein.

Cai H, Yang B, Xu Z, Zhang B, Xu B, Li X, Wu P, Chen K, Rajotte RV, Wu Y, Rayat GR.

Transplantation. 2015 Mar;99(3):508-14. doi: 10.1097/TP.0000000000000628.

PMID:
25680088
7.

Failure of neonatal B-cell tolerance induction by ABO-incompatible kidney grafts in piglets.

Jeyakanthan M, Zhou X, Tao K, Mengel M, Rajotte RV, Larsen I, West LJ.

Transplantation. 2013 Sep;96(6):519-28. doi: 10.1097/TP.0b013e31829b0840.

PMID:
23860083
8.

Protection of porcine islet xenografts in mice using sertoli cells and monoclonal antibodies.

Ramji QA, Bayrack K, Arefanian H, Marcet-Palacios M, Bleackley RC, Rajotte RV, Rayat GR.

Transplantation. 2011 Dec 27;92(12):1309-15. doi: 10.1097/TP.0b013e3182384ab0.

PMID:
22037619
9.

Lifelong stable human insulin expression in transgenic tilapia expressing a humanized tilapia insulin gene.

Hrytsenko O, Rayat GR, Xu BY, Krause R, Pohajdak B, Rajotte RV, Wright JR Jr.

Transgenic Res. 2011 Dec;20(6):1397-8. doi: 10.1007/s11248-011-9500-3. Epub 2011 Mar 11. No abstract available.

PMID:
21394514
10.

Short-term administrations of a combination of anti-LFA-1 and anti-CD154 monoclonal antibodies induce tolerance to neonatal porcine islet xenografts in mice.

Arefanian H, Tredget EB, Rajotte RV, Gill RG, Korbutt GS, Rayat GR.

Diabetes. 2010 Apr;59(4):958-66. doi: 10.2337/db09-0413. Epub 2010 Jan 19.

11.

Portal vein embolization with radiolabeled polyvinyl alcohol particles in a swine model: hepatic distribution and implications for pancreatic islet cell transplantation.

Owen RJ, Mercer JR, Al-Saif F, Molinari M, Ashforth RA, Rajotte RV, Conner-Spady B, Shapiro AM.

Cardiovasc Intervent Radiol. 2009 May;32(3):499-507. doi: 10.1007/s00270-009-9544-4. Epub 2009 Mar 28.

PMID:
19330373
12.

Prolonged survival of microencapsulated neonatal porcine islet xenografts in immune-competent mice without antirejection therapy.

Kobayashi T, Arefanian H, Harb G, Tredget EB, Rajotte RV, Korbutt GS, Rayat GR.

Cell Transplant. 2008;17(10-11):1243-56.

PMID:
19181218
13.

Epithelial cells within the human pancreas do not coexpress mesenchymal antigens: epithelial-mesenchymal transition is an artifact of cell culture.

Seeberger KL, Eshpeter A, Rajotte RV, Korbutt GS.

Lab Invest. 2009 Feb;89(2):110-21. doi: 10.1038/labinvest.2008.122. Epub 2008 Dec 15.

14.

Mouse pancreatic islets are resistant to indoleamine 2,3 dioxygenase-induced general control nonderepressible-2 kinase stress pathway and maintain normal viability and function.

Jalili RB, Forouzandeh F, Moeenrezakhanlou A, Rayat GR, Rajotte RV, Uludag H, Ghahary A.

Am J Pathol. 2009 Jan;174(1):196-205. doi: 10.2353/ajpath.2009.080539. Epub 2008 Dec 12.

15.

In vivo characterization of transplanted human embryonic stem cell-derived pancreatic endocrine islet cells.

Eshpeter A, Jiang J, Au M, Rajotte RV, Lu K, Lebkowski JS, Majumdar AS, Korbutt GS.

Cell Prolif. 2008 Dec;41(6):843-858. doi: 10.1111/j.1365-2184.2008.00564.x.

PMID:
19040565
16.

Monotherapy with anti-LFA-1 monoclonal antibody promotes long-term survival of rat islet xenografts.

Tredget EB, Arefanian H, Gill RG, Rajotte RV, Rayat GR.

Cell Transplant. 2008;17(6):599-608.

PMID:
18819248
17.

Sertoli cell line lacks the immunoprotective properties associated with primary Sertoli cells.

Dufour JM, Dass B, Halley KR, Korbutt GS, Dixon DE, Rajotte RV.

Cell Transplant. 2008;17(5):525-34.

PMID:
18714671
18.

Moving towards clinical application.

Rajotte RV.

Xenotransplantation. 2008 Mar-Apr;15(2):113-5. doi: 10.1111/j.1399-3089.2008.00466.x. No abstract available.

PMID:
18447883
19.

Isolation and assessment of islet quality.

Rajotte RV.

Xenotransplantation. 2008 Mar-Apr;15(2):93-5. doi: 10.1111/j.1399-3089.2008.00459.x. No abstract available.

PMID:
18447876
20.

Comparison of successful and unsuccessful islet/Sertoli cell cotransplant grafts in streptozotocin-induced diabetic mice.

Dufour JM, Lord SJ, Kin T, Rayat GR, Dixon DE, Bleackley RC, Korbutt GS, Rajotte RV.

Cell Transplant. 2008;16(10):1029-38.

PMID:
18351019
21.
22.

Comparison of Successful and Unsuccessful Islet/Sertoli Cell Cotransplant Grafts in Streptozotocin-Induced Diabetic Mice.

Dufour JM, Lord SJ, Kin T, Rayat GR, Dixon DE, Bleackley RC, Korbutt GS, Rajotte RV.

Cell Transplant. 2007 Nov;16(10):1029-1038. doi: 10.3727/000000007783472417.

PMID:
28866926
23.

Long-term graft function after allogeneic islet transplantation.

Lakey JR, Kin T, Warnock GL, Shapiro AM, Tsapogas P, Imes S, Korbutt GS, Kneteman NM, Rajotte RV, Ryan EA.

Cell Transplant. 2007;16(4):441-6.

PMID:
17658134
24.

Enriched human pancreatic ductal cultures obtained from selective death of acinar cells express pancreatic and duodenal homeobox gene-1 age-dependently.

Street CN, Lakey JR, Rajotte RV, Shapiro AM, Kieffer TJ, Lyon JG, Kin T, Korbutt GS.

Rev Diabet Stud. 2004 Summer;1(2):66-79. Epub 2004 Aug 10.

25.

Suppression of islet allogeneic immune response by indoleamine 2,3 dioxygenase-expressing fibroblasts.

Jalili RB, Rayat GR, Rajotte RV, Ghahary A.

J Cell Physiol. 2007 Oct;213(1):137-43.

PMID:
17477384
26.

Long-Term Graft Function after Allogeneic Islet Transplantation.

Lakey JRT, Kin T, Warnock GL, Shapiro AMJ, Tsapogas P, Imes S, Korbutt GS, Kneteman NM, Rajotte RV, Ryan EA.

Cell Transplant. 2007 Apr;16(4):441-446. doi: 10.3727/000000007783464849.

PMID:
28858603
27.

Diabetes induces rapid suppression of adaptive immunity followed by homeostatic T-cell proliferation.

Luo B, Chan WF, Lord SJ, Nanji SA, Rajotte RV, Shapiro AM, Anderson CC.

Scand J Immunol. 2007 Jan;65(1):22-31.

28.

Immune mechanisms associated with the rejection of encapsulated neonatal porcine islet xenografts.

Kobayashi T, Harb G, Rajotte RV, Korbutt GS, Mallett AG, Arefanian H, Mok D, Rayat GR.

Xenotransplantation. 2006 Nov;13(6):547-59.

PMID:
17059582
29.

Neonatal porcine islets exhibit natural resistance to hypoxia-induced apoptosis.

Emamaullee JA, Shapiro AM, Rajotte RV, Korbutt G, Elliott JF.

Transplantation. 2006 Oct 15;82(7):945-52.

PMID:
17038911
30.

Identification of a novel human granzyme B inhibitor secreted by cultured sertoli cells.

Sipione S, Simmen KC, Lord SJ, Motyka B, Ewen C, Shostak I, Rayat GR, Dufour JM, Korbutt GS, Rajotte RV, Bleackley RC.

J Immunol. 2006 Oct 15;177(8):5051-8.

31.

Glutaraldehyde-fixed bioprosthetic heart valve conduits calcify and fail from xenograft rejection.

Manji RA, Zhu LF, Nijjar NK, Rayner DC, Korbutt GS, Churchill TA, Rajotte RV, Koshal A, Ross DB.

Circulation. 2006 Jul 25;114(4):318-27. Epub 2006 Jul 10.

PMID:
16831988
32.

Long-term survival of neonatal porcine islets in nonhuman primates by targeting costimulation pathways.

Cardona K, Korbutt GS, Milas Z, Lyon J, Cano J, Jiang W, Bello-Laborn H, Hacquoil B, Strobert E, Gangappa S, Weber CJ, Pearson TC, Rajotte RV, Larsen CP.

Nat Med. 2006 Mar;12(3):304-6. Epub 2006 Feb 26.

PMID:
16501570
33.

Expansion of mesenchymal stem cells from human pancreatic ductal epithelium.

Seeberger KL, Dufour JM, Shapiro AM, Lakey JR, Rajotte RV, Korbutt GS.

Lab Invest. 2006 Feb;86(2):141-53.

34.

Development of an ectopic site for islet transplantation, using biodegradable scaffolds.

Dufour JM, Rajotte RV, Zimmerman M, Rezania A, Kin T, Dixon DE, Korbutt GS.

Tissue Eng. 2005 Sep-Oct;11(9-10):1323-31.

PMID:
16259588
35.

Islet auto-transplantation into an omental or splenic site results in a normal beta cell but abnormal alpha cell response to mild non-insulin-induced hypoglycemia.

Gustavson SM, Rajotte RV, Hunkeler D, Lakey JR, Edgerton DS, Neal DW, Snead WL, Penaloza AR, Cherrington AD.

Am J Transplant. 2005 Oct;5(10):2368-77.

36.

XIAP overexpression in human islets prevents early posttransplant apoptosis and reduces the islet mass needed to treat diabetes.

Emamaullee JA, Rajotte RV, Liston P, Korneluk RG, Lakey JR, Shapiro AM, Elliott JF.

Diabetes. 2005 Sep;54(9):2541-8.

37.

Decellularization reduces the immune response to aortic valve allografts in the rat.

Meyer SR, Nagendran J, Desai LS, Rayat GR, Churchill TA, Anderson CC, Rajotte RV, Lakey JR, Ross DB.

J Thorac Cardiovasc Surg. 2005 Aug;130(2):469-76.

38.

Reversal of diabetes in pancreatectomized pigs after transplantation of neonatal porcine islets.

Kin T, Korbutt GS, Kobayashi T, Dufour JM, Rajotte RV.

Diabetes. 2005 Apr;54(4):1032-9.

39.

The portal immunosuppressive storm: relevance to islet transplantation?

Shapiro AM, Gallant HL, Hao EG, Lakey JR, McCready T, Rajotte RV, Yatscoff RW, Kneteman NM.

Ther Drug Monit. 2005 Feb;27(1):35-7.

PMID:
15665744
40.

Neonatal porcine Sertoli cells inhibit human natural antibody-mediated lysis.

Dufour JM, Hamilton M, Rajotte RV, Korbutt GS.

Biol Reprod. 2005 May;72(5):1224-31. Epub 2005 Jan 19.

PMID:
15659703
41.

Islet graft assessment in the Edmonton Protocol: implications for predicting long-term clinical outcome.

Street CN, Lakey JR, Shapiro AM, Imes S, Rajotte RV, Ryan EA, Lyon JG, Kin T, Avila J, Tsujimura T, Korbutt GS.

Diabetes. 2004 Dec;53(12):3107-14.

42.

Improved survival of microencapsulated islets during in vitro culture and enhanced metabolic function following transplantation.

Korbutt GS, Mallett AG, Ao Z, Flashner M, Rajotte RV.

Diabetologia. 2004 Oct;47(10):1810-8. Epub 2004 Oct 23.

PMID:
15517151
43.

In-situ crosslinking thermoreversible polymers for cell entrapment.

Norrie B, Jalil A, Lakey JR, Rajotte RV, Uludag H.

Adv Exp Med Biol. 2004;553:19-28. No abstract available.

PMID:
15503444
44.

Reassessment of the vascularization of renal subcapsular islet grafts.

Kin T, Rajotte RV, Korbutt GS.

Pancreas. 2004 Oct;29(3):e59-63.

PMID:
15367895
45.

Increased apoptosis in porcine cardiac xenografts perfused with human ABO plasma containing the anti-B antibody.

Manji JS, Rajotte RV, Koshal A, Manji RA.

Xenotransplantation. 2004 Jul;11(4):378-9. No abstract available.

PMID:
15196134
46.

Human anti-A and anti-B antibodies interact with alphaGal antibody affecting xenograft survival.

Manji JS, Rajotte RV, Koshal A, Manji RA.

Xenotransplantation. 2004 Jul;11(4):376-7. No abstract available.

PMID:
15196133
47.

Porcine endogenous retroviral nucleic acid in peripheral tissues is associated with migration of porcine cells post islet transplant.

Binette TM, Seeberger KL, Lyon JG, Rajotte RV, Korbutt GS.

Am J Transplant. 2004 Jul;4(7):1051-60.

48.

Stem cell-based approaches to solving the problem of tissue supply for islet transplantation in type 1 diabetes.

Street CN, Sipione S, Helms L, Binette T, Rajotte RV, Bleackley RC, Korbutt GS.

Int J Biochem Cell Biol. 2004 Apr;36(4):667-83. Review.

PMID:
15010331
49.

Human O red blood cells and pig-to-human xenotransplantation.

Manji RA, Rajotte RV, Arvind K.

Xenotransplantation. 2004 Jan;11(1):107. No abstract available.

PMID:
14962300
50.

Metformin, but not leptin, regulates AMP-activated protein kinase in pancreatic islets: impact on glucose-stimulated insulin secretion.

Leclerc I, Woltersdorf WW, da Silva Xavier G, Rowe RL, Cross SE, Korbutt GS, Rajotte RV, Smith R, Rutter GA.

Am J Physiol Endocrinol Metab. 2004 Jun;286(6):E1023-31. Epub 2004 Feb 10.

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