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Items: 1 to 50 of 478

1.

TET enzymes control antibody production and shape the mutational landscape in germinal centre B cells.

Schoeler K, Aufschnaiter A, Messner S, Derudder E, Herzog S, Villunger A, Rajewsky K, Labi V.

FEBS J. 2019 May 23. doi: 10.1111/febs.14934. [Epub ahead of print]

PMID:
31120187
2.

Enhancement of Precise Gene Editing by the Association of Cas9 With Homologous Recombination Factors.

Tran NT, Bashir S, Li X, Rossius J, Chu VT, Rajewsky K, Kühn R.

Front Genet. 2019 Apr 30;10:365. doi: 10.3389/fgene.2019.00365. eCollection 2019.

3.

BCR-dependent lineage plasticity in mature B cells.

Graf R, Seagal J, Otipoby KL, Lam KP, Ayoub S, Zhang B, Sander S, Chu VT, Rajewsky K.

Science. 2019 Feb 15;363(6428):748-753. doi: 10.1126/science.aau8475.

PMID:
30765568
4.

sgRNA Sequence Motifs Blocking Efficient CRISPR/Cas9-Mediated Gene Editing.

Graf R, Li X, Chu VT, Rajewsky K.

Cell Rep. 2019 Jan 29;26(5):1098-1103.e3. doi: 10.1016/j.celrep.2019.01.024.

5.

The c-Myc/miR17-92/PTEN Axis Tunes PI3K Activity to Control Expression of Recombination Activating Genes in Early B Cell Development.

Benhamou D, Labi V, Getahun A, Benchetrit E, Dowery R, Rajewsky K, Cambier JC, Melamed D.

Front Immunol. 2018 Nov 22;9:2715. doi: 10.3389/fimmu.2018.02715. eCollection 2018.

6.

A novel allele for inducible Cre expression in germinal center B cells.

Weber T, Seagal J, Winkler W, Wirtz T, Chu VT, Rajewsky K.

Eur J Immunol. 2019 Jan;49(1):192-194. doi: 10.1002/eji.201847863. Epub 2018 Nov 20.

PMID:
30359469
7.

Nuclear FOXO1 promotes lymphomagenesis in germinal center B cells.

Kabrani E, Chu VT, Tasouri E, Sommermann T, Baßler K, Ulas T, Zenz T, Bullinger L, Schultze JL, Rajewsky K, Sander S.

Blood. 2018 Dec 20;132(25):2670-2683. doi: 10.1182/blood-2018-06-856203. Epub 2018 Oct 17.

PMID:
30333121
8.

Postnatal DNA demethylation and its role in tissue maturation.

Reizel Y, Sabag O, Skversky Y, Spiro A, Steinberg B, Bernstein D, Wang A, Kieckhaefer J, Li C, Pikarsky E, Levin-Klein R, Goren A, Rajewsky K, Kaestner KH, Cedar H.

Nat Commun. 2018 May 23;9(1):2040. doi: 10.1038/s41467-018-04456-6.

9.

Erratum: Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells.

Van Chu T, Weber T, Wefers B, Wurst W, Sander S, Rajewsky K, Kühn R.

Nat Biotechnol. 2018 Feb 6;36(2):196. doi: 10.1038/nbt0218-196d. No abstract available.

PMID:
29406513
10.

Signaling by the Epstein-Barr virus LMP1 protein induces potent cytotoxic CD4+ and CD8+ T cell responses.

Choi IK, Wang Z, Ke Q, Hong M, Qian Y, Zhao X, Liu Y, Kim HJ, Ritz J, Cantor H, Rajewsky K, Wucherpfennig KW, Zhang B.

Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E686-E695. doi: 10.1073/pnas.1713607115. Epub 2018 Jan 8.

11.

A novel conditional Aire allele enables cell-specific ablation of the immune tolerance regulator Aire.

Dobeš J, Edenhofer F, Vobořil M, Brabec T, Dobešová M, Čepková A, Klein L, Rajewsky K, Filipp D.

Eur J Immunol. 2018 Mar;48(3):546-548. doi: 10.1002/eji.201747267. Epub 2017 Dec 27.

12.

CRISPR/Cas9-Mediated In Vitro Mutagenesis in GC-Like B Cells.

Chu VT, Graf R, Rajewsky K.

Methods Mol Biol. 2017;1623:135-145. doi: 10.1007/978-1-4939-7095-7_12.

PMID:
28589354
13.

The B-cell receptor controls fitness of MYC-driven lymphoma cells via GSK3β inhibition.

Varano G, Raffel S, Sormani M, Zanardi F, Lonardi S, Zasada C, Perucho L, Petrocelli V, Haake A, Lee AK, Bugatti M, Paul U, Van Anken E, Pasqualucci L, Rabadan R, Siebert R, Kempa S, Ponzoni M, Facchetti F, Rajewsky K, Casola S.

Nature. 2017 Jun 8;546(7657):302-306. doi: 10.1038/nature22353. Epub 2017 May 31.

PMID:
28562582
14.

George Klein: 1925-2016.

Rajewsky K.

Proc Natl Acad Sci U S A. 2017 Mar 28;114(13):3275-3277. doi: 10.1073/pnas.1702501114. Epub 2017 Mar 13. No abstract available.

15.

EBI2 Is Highly Expressed in Multiple Sclerosis Lesions and Promotes Early CNS Migration of Encephalitogenic CD4 T Cells.

Wanke F, Moos S, Croxford AL, Heinen AP, Gräf S, Kalt B, Tischner D, Zhang J, Christen I, Bruttger J, Yogev N, Tang Y, Zayoud M, Israel N, Karram K, Reißig S, Lacher SM, Reichhold C, Mufazalov IA, Ben-Nun A, Kuhlmann T, Wettschureck N, Sailer AW, Rajewsky K, Casola S, Waisman A, Kurschus FC.

Cell Rep. 2017 Jan 31;18(5):1270-1284. doi: 10.1016/j.celrep.2017.01.020.

16.

miRNAs Are Essential for the Regulation of the PI3K/AKT/FOXO Pathway and Receptor Editing during B Cell Maturation.

Coffre M, Benhamou D, Rieß D, Blumenberg L, Snetkova V, Hines MJ, Chakraborty T, Bajwa S, Jensen K, Chong MMW, Getu L, Silverman GJ, Blelloch R, Littman DR, Calado D, Melamed D, Skok JA, Rajewsky K, Koralov SB.

Cell Rep. 2016 Nov 22;17(9):2271-2285. doi: 10.1016/j.celrep.2016.11.006.

17.

Mouse model for acute Epstein-Barr virus infection.

Wirtz T, Weber T, Kracker S, Sommermann T, Rajewsky K, Yasuda T.

Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):13821-13826. Epub 2016 Nov 16.

18.

Efficient CRISPR-mediated mutagenesis in primary immune cells using CrispRGold and a C57BL/6 Cas9 transgenic mouse line.

Chu VT, Graf R, Wirtz T, Weber T, Favret J, Li X, Petsch K, Tran NT, Sieweke MH, Berek C, Kühn R, Rajewsky K.

Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):12514-12519. Epub 2016 Oct 11.

19.

A c-Myc/miR17-92/Pten Axis Controls PI3K-Mediated Positive and Negative Selection in B Cell Development and Reconstitutes CD19 Deficiency.

Benhamou D, Labi V, Novak R, Dai I, Shafir-Alon S, Weiss A, Gaujoux R, Arnold R, Shen-Orr SS, Rajewsky K, Melamed D.

Cell Rep. 2016 Jul 12;16(2):419-431. doi: 10.1016/j.celrep.2016.05.084. Epub 2016 Jun 23.

20.

MiR-150 Controls B Cell Differentiation by Targeting the Transcription Factor c-Myb.

Xiao C, Calado DP, Galler G, Thai TH, Patterson HC, Wang J, Rajewsky N, Bender TP, Rajewsky K.

Cell. 2016 May 5;165(4):1027. doi: 10.1016/j.cell.2016.04.056. No abstract available.

21.

Canonical NF-κB signaling is uniquely required for the long-term persistence of functional mature B cells.

Derudder E, Herzog S, Labi V, Yasuda T, Köchert K, Janz M, Villunger A, Schmidt-Supprian M, Rajewsky K.

Proc Natl Acad Sci U S A. 2016 May 3;113(18):5065-70. doi: 10.1073/pnas.1604529113. Epub 2016 Apr 20.

22.

Tissue-specific DNA demethylation is required for proper B-cell differentiation and function.

Orlanski S, Labi V, Reizel Y, Spiro A, Lichtenstein M, Levin-Klein R, Koralov SB, Skversky Y, Rajewsky K, Cedar H, Bergman Y.

Proc Natl Acad Sci U S A. 2016 May 3;113(18):5018-23. doi: 10.1073/pnas.1604365113. Epub 2016 Apr 18.

23.

Survival of Igα-Deficient Mature B Cells Requires BAFF-R Function.

Levit-Zerdoun E, Becker M, Pohlmeyer R, Wilhelm I, Maity PC, Rajewsky K, Reth M, Hobeika E.

J Immunol. 2016 Mar 1;196(5):2348-60. doi: 10.4049/jimmunol.1501707. Epub 2016 Feb 3.

24.

miR-23∼27∼24 clusters control effector T cell differentiation and function.

Cho S, Wu CJ, Yasuda T, Cruz LO, Khan AA, Lin LL, Nguyen DT, Miller M, Lee HM, Kuo ML, Broide DH, Rajewsky K, Rudensky AY, Lu LF.

J Exp Med. 2016 Feb 8;213(2):235-49. doi: 10.1084/jem.20150990. Epub 2016 Feb 1.

25.

Immunological memory: lessons from the past and a look to the future.

Farber DL, Netea MG, Radbruch A, Rajewsky K, Zinkernagel RM.

Nat Rev Immunol. 2016 Feb;16(2):124-8. doi: 10.1038/nri.2016.13. Review.

PMID:
26831526
26.

Efficient generation of Rosa26 knock-in mice using CRISPR/Cas9 in C57BL/6 zygotes.

Chu VT, Weber T, Graf R, Sommermann T, Petsch K, Sack U, Volchkov P, Rajewsky K, Kühn R.

BMC Biotechnol. 2016 Jan 16;16:4. doi: 10.1186/s12896-016-0234-4.

27.

FOXO1 couples metabolic activity and growth state in the vascular endothelium.

Wilhelm K, Happel K, Eelen G, Schoors S, Oellerich MF, Lim R, Zimmermann B, Aspalter IM, Franco CA, Boettger T, Braun T, Fruttiger M, Rajewsky K, Keller C, Brüning JC, Gerhardt H, Carmeliet P, Potente M.

Nature. 2016 Jan 14;529(7585):216-20. doi: 10.1038/nature16498. Epub 2016 Jan 6.

28.

PI3 Kinase and FOXO1 Transcription Factor Activity Differentially Control B Cells in the Germinal Center Light and Dark Zones.

Sander S, Chu VT, Yasuda T, Franklin A, Graf R, Calado DP, Li S, Imami K, Selbach M, Di Virgilio M, Bullinger L, Rajewsky K.

Immunity. 2015 Dec 15;43(6):1075-86. doi: 10.1016/j.immuni.2015.10.021. Epub 2015 Nov 24.

29.

Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma.

Finkin S, Yuan D, Stein I, Taniguchi K, Weber A, Unger K, Browning JL, Goossens N, Nakagawa S, Gunasekaran G, Schwartz ME, Kobayashi M, Kumada H, Berger M, Pappo O, Rajewsky K, Hoshida Y, Karin M, Heikenwalder M, Ben-Neriah Y, Pikarsky E.

Nat Immunol. 2015 Dec;16(12):1235-44. doi: 10.1038/ni.3290. Epub 2015 Oct 26.

30.

Gab1 and Mapk Signaling Are Essential in the Hair Cycle and Hair Follicle Stem Cell Quiescence.

Akilli Öztürk Ö, Pakula H, Chmielowiec J, Qi J, Stein S, Lan L, Sasaki Y, Rajewsky K, Birchmeier W.

Cell Rep. 2015 Oct 20;13(3):561-572. doi: 10.1016/j.celrep.2015.09.015. Epub 2015 Oct 8.

31.

The B-cell antigen receptor integrates adaptive and innate immune signals.

Otipoby KL, Waisman A, Derudder E, Srinivasan L, Franklin A, Rajewsky K.

Proc Natl Acad Sci U S A. 2015 Sep 29;112(39):12145-50. doi: 10.1073/pnas.1516428112. Epub 2015 Sep 14.

32.

A Rapid Embryonic Stem Cell-Based Mouse Model for B-cell Lymphomas Driven by Epstein-Barr Virus Protein LMP1.

Ba Z, Meng FL, Gostissa M, Huang PY, Ke Q, Wang Z, Dao MN, Fujiwara Y, Rajewsky K, Zhang B, Alt FW.

Cancer Immunol Res. 2015 Jun;3(6):641-9. doi: 10.1158/2326-6066.CIR-15-0058. Epub 2015 May 1.

33.

An oncogenic role for alternative NF-κB signaling in DLBCL revealed upon deregulated BCL6 expression.

Zhang B, Calado DP, Wang Z, Fröhler S, Köchert K, Qian Y, Koralov SB, Schmidt-Supprian M, Sasaki Y, Unitt C, Rodig S, Chen W, Dalla-Favera R, Alt FW, Pasqualucci L, Rajewsky K.

Cell Rep. 2015 May 5;11(5):715-26. doi: 10.1016/j.celrep.2015.03.059. Epub 2015 Apr 23.

34.

The Herzenberg lecture: how to make a B-1 cell?

Rajewsky K.

Ann N Y Acad Sci. 2015 Dec;1362:6-7. doi: 10.1111/nyas.12767. Epub 2015 Apr 24.

PMID:
25912787
35.

Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells.

Chu VT, Weber T, Wefers B, Wurst W, Sander S, Rajewsky K, Kühn R.

Nat Biotechnol. 2015 May;33(5):543-8. doi: 10.1038/nbt.3198. Epub 2015 Mar 24. Erratum in: Nat Biotechnol. 2018 Feb 6;36(2):196.

PMID:
25803306
36.

The DNA deamination model of somatic antibody diversification.

Rajewsky K.

J Immunol. 2015 Mar 1;194(5):2041-2. doi: 10.4049/jimmunol.1403252. No abstract available.

37.

VH replacement in primary immunoglobulin repertoire diversification.

Sun A, Novobrantseva TI, Coffre M, Hewitt SL, Jensen K, Skok JA, Rajewsky K, Koralov SB.

Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):E458-66. doi: 10.1073/pnas.1418001112. Epub 2015 Jan 21.

38.

TET proteins and 5-methylcytosine oxidation in hematological cancers.

Ko M, An J, Pastor WA, Koralov SB, Rajewsky K, Rao A.

Immunol Rev. 2015 Jan;263(1):6-21. doi: 10.1111/imr.12239. Review.

39.

Mapping of transcription factor motifs in active chromatin identifies IRF5 as key regulator in classical Hodgkin lymphoma.

Kreher S, Bouhlel MA, Cauchy P, Lamprecht B, Li S, Grau M, Hummel F, Köchert K, Anagnostopoulos I, Jöhrens K, Hummel M, Hiscott J, Wenzel SS, Lenz P, Schneider M, Küppers R, Scheidereit C, Giefing M, Siebert R, Rajewsky K, Lenz G, Cockerill PN, Janz M, Dörken B, Bonifer C, Mathas S.

Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):E4513-22. doi: 10.1073/pnas.1406985111. Epub 2014 Oct 6.

40.

STAT3 activation in Th17 and Th22 cells controls IL-22-mediated epithelial host defense during infectious colitis.

Backert I, Koralov SB, Wirtz S, Kitowski V, Billmeier U, Martini E, Hofmann K, Hildner K, Wittkopf N, Brecht K, Waldner M, Rajewsky K, Neurath MF, Becker C, Neufert C.

J Immunol. 2014 Oct 1;193(7):3779-91. doi: 10.4049/jimmunol.1303076. Epub 2014 Sep 3.

41.

B-cell expansion and lymphomagenesis induced by chronic CD40 signaling is strictly dependent on CD19.

Hojer C, Frankenberger S, Strobl LJ, Feicht S, Djermanovic K, Jagdhuber F, Hömig-Hölzel C, Ferch U, Ruland J, Rajewsky K, Zimber-Strobl U.

Cancer Res. 2014 Aug 15;74(16):4318-28. doi: 10.1158/0008-5472.CAN-13-3274. Epub 2014 Jun 17.

42.

Generation of memory B cells inside and outside germinal centers.

Takemori T, Kaji T, Takahashi Y, Shimoda M, Rajewsky K.

Eur J Immunol. 2014 May;44(5):1258-64. doi: 10.1002/eji.201343716. Epub 2014 Apr 10. Review.

43.

Shp2/MAPK signaling controls goblet/paneth cell fate decisions in the intestine.

Heuberger J, Kosel F, Qi J, Grossmann KS, Rajewsky K, Birchmeier W.

Proc Natl Acad Sci U S A. 2014 Mar 4;111(9):3472-7. doi: 10.1073/pnas.1309342111. Epub 2014 Feb 18.

44.

Michael S. Neuberger 1953-2013.

Rajewsky K.

Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):2862-3. doi: 10.1073/pnas.1401334111. Epub 2014 Feb 14. No abstract available.

45.

Activation of MAPK overrides the termination of myelin growth and replaces Nrg1/ErbB3 signals during Schwann cell development and myelination.

Sheean ME, McShane E, Cheret C, Walcher J, Müller T, Wulf-Goldenberg A, Hoelper S, Garratt AN, Krüger M, Rajewsky K, Meijer D, Birchmeier W, Lewin GR, Selbach M, Birchmeier C.

Genes Dev. 2014 Feb 1;28(3):290-303. doi: 10.1101/gad.230045.113.

46.

Skewed B cell differentiation affects lymphoid organogenesis but not T cell-mediated autoimmunity.

Colombo E, Tentorio P, Musio S, Rajewsky K, Pedotti R, Casola S, Farina C.

Clin Exp Immunol. 2014 Apr;176(1):58-65. doi: 10.1111/cei.12250.

47.

Studying Epstein-Barr virus pathologies and immune surveillance by reconstructing EBV infection in mice.

Yasuda T, Wirtz T, Zhang B, Wunderlich T, Schmidt-Supprian M, Sommermann T, Rajewsky K.

Cold Spring Harb Symp Quant Biol. 2013;78:259-63. doi: 10.1101/sqb.2013.78.020222. Epub 2013 Nov 15.

PMID:
24241423
48.

Negative selection, not receptor editing, is a physiological response of autoreactive thymocytes.

Kreslavsky T, Kim HJ, Koralov SB, Ghitza D, Buch T, Cantor H, Rajewsky K, von Boehmer H.

J Exp Med. 2013 Sep 23;210(10):1911-8. doi: 10.1084/jem.20130876. Epub 2013 Aug 26.

49.

T cell-derived IL-17 mediates epithelial changes in the airway and drives pulmonary neutrophilia.

Fogli LK, Sundrud MS, Goel S, Bajwa S, Jensen K, Derudder E, Sun A, Coffre M, Uyttenhove C, Van Snick J, Schmidt-Supprian M, Rao A, Grunig G, Durbin J, Casola S, Rajewsky K, Koralov SB.

J Immunol. 2013 Sep 15;191(6):3100-11. doi: 10.4049/jimmunol.1301360. Epub 2013 Aug 21. Erratum in: J Immunol. 2013 Nov 15;191(10):5318. Casola, Stefano S [corrected to Casola, Stefano].

50.

MicroRNA-17~92 plays a causative role in lymphomagenesis by coordinating multiple oncogenic pathways.

Jin HY, Oda H, Lai M, Skalsky RL, Bethel K, Shepherd J, Kang SG, Liu WH, Sabouri-Ghomi M, Cullen BR, Rajewsky K, Xiao C.

EMBO J. 2013 Aug 28;32(17):2377-91. doi: 10.1038/emboj.2013.178. Epub 2013 Aug 6.

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