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Items: 6


Preclinical Pharmacokinetics of Fosciclopirox, a Novel Treatment of Urothelial Cancers, in Rats and Dogs.

Weir SJ, Wood R, Schorno K, Brinker AE, Ramamoorthy P, Heppert K, Rajewski L, Tanol M, Ham T, McKenna MJ, McCulloch W, Dalton M, Reed GA, Jensen RA, Baltezor MJ, Anant S, Taylor JA 3rd.

J Pharmacol Exp Ther. 2019 Aug;370(2):148-159. doi: 10.1124/jpet.119.257972. Epub 2019 May 21.


Targeted inhibition of histone deacetylase leads to suppression of Ewing sarcoma tumor growth through an unappreciated EWS-FLI1/HDAC3/HSP90 signaling axis.

Ma Y, Baltezor M, Rajewski L, Crow J, Samuel G, Staggs VS, Chastain KM, Toretsky JA, Weir SJ, Godwin AK.

J Mol Med (Berl). 2019 Jul;97(7):957-972. doi: 10.1007/s00109-019-01782-0. Epub 2019 Apr 25.


Evaluation of intravenous and subcutaneous administration of a novel, excipient-free, nanoparticulate formulation of paclitaxel in dogs with spontaneously occurring neoplasia.

Selting KA, Bechtel SM, Espinosa J, Henry CJ, Tate D, Bryan JN, Rajewski L, Flesner BK, Decedue C, Baltezor M.

Vet Comp Oncol. 2018 Dec;16(4):650-657. doi: 10.1111/vco.12435. Epub 2018 Sep 4.


Tyr1-ψ[( Z)CF═CH]-Gly2 Fluorinated Peptidomimetic Improves Distribution and Metabolism Properties of Leu-Enkephalin.

Altman RA, Sharma KK, Rajewski LG, Toren PC, Baltezor MJ, Pal M, Karad SN.

ACS Chem Neurosci. 2018 Jul 18;9(7):1735-1742. doi: 10.1021/acschemneuro.8b00085. Epub 2018 Apr 19.


Oral ciclopirox olamine displays biological activity in a phase I study in patients with advanced hematologic malignancies.

Minden MD, Hogge DE, Weir SJ, Kasper J, Webster DA, Patton L, Jitkova Y, Hurren R, Gronda M, Goard CA, Rajewski LG, Haslam JL, Heppert KE, Schorno K, Chang H, Brandwein JM, Gupta V, Schuh AC, Trudel S, Yee KW, Reed GA, Schimmer AD.

Am J Hematol. 2014 Apr;89(4):363-8. doi: 10.1002/ajh.23640. Epub 2014 Mar 3.


The repositioning of the anti-fungal agent ciclopirox olamine as a novel therapeutic agent for the treatment of haematologic malignancy.

Weir SJ, Patton L, Castle K, Rajewski L, Kasper J, Schimmer AD.

J Clin Pharm Ther. 2011 Apr;36(2):128-34. doi: 10.1111/j.1365-2710.2010.01172.x. Epub 2010 Aug 24.


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