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Items: 1 to 50 of 104

1.

Structural basis for the second step of group II intron splicing.

Chan RT, Peters JK, Robart AR, Wiryaman T, Rajashankar KR, Toor N.

Nat Commun. 2018 Nov 8;9(1):4676. doi: 10.1038/s41467-018-06678-0.

2.

Structure-based analysis of CysZ-mediated cellular uptake of sulfate.

Assur Sanghai Z, Liu Q, Clarke OB, Belcher-Dufrisne M, Wiriyasermkul P, Giese MH, Leal-Pinto E, Kloss B, Tabuso S, Love J, Punta M, Banerjee S, Rajashankar KR, Rost B, Logothetis D, Quick M, Hendrickson WA, Mancia F.

Elife. 2018 May 24;7. pii: e27829. doi: 10.7554/eLife.27829.

3.

Glucan Binding Protein C of Streptococcus mutans Mediates both Sucrose-Independent and Sucrose-Dependent Adherence.

Mieher JL, Larson MR, Schormann N, Purushotham S, Wu R, Rajashankar KR, Wu H, Deivanayagam C.

Infect Immun. 2018 Jun 21;86(7). pii: e00146-18. doi: 10.1128/IAI.00146-18. Print 2018 Jul.

4.

Fatty acyl recognition and transfer by an integral membrane S-acyltransferase.

Rana MS, Kumar P, Lee CJ, Verardi R, Rajashankar KR, Banerjee A.

Science. 2018 Jan 12;359(6372). pii: eaao6326. doi: 10.1126/science.aao6326.

5.

Structures and transport dynamics of a Campylobacter jejuni multidrug efflux pump.

Su CC, Yin L, Kumar N, Dai L, Radhakrishnan A, Bolla JR, Lei HT, Chou TH, Delmar JA, Rajashankar KR, Zhang Q, Shin YK, Yu EW.

Nat Commun. 2017 Aug 1;8(1):171. doi: 10.1038/s41467-017-00217-z.

6.

Crystal structures of the Burkholderia multivorans hopanoid transporter HpnN.

Kumar N, Su CC, Chou TH, Radhakrishnan A, Delmar JA, Rajashankar KR, Yu EW.

Proc Natl Acad Sci U S A. 2017 Jun 20;114(25):6557-6562. doi: 10.1073/pnas.1619660114. Epub 2017 Jun 5.

7.

Crystal structure of Aquifex aeolicus σN bound to promoter DNA and the structure of σN-holoenzyme.

Campbell EA, Kamath S, Rajashankar KR, Wu M, Darst SA.

Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):E1805-E1814. doi: 10.1073/pnas.1619464114. Epub 2017 Feb 21.

8.

PAM-Dependent Target DNA Recognition and Cleavage by C2c1 CRISPR-Cas Endonuclease.

Yang H, Gao P, Rajashankar KR, Patel DJ.

Cell. 2016 Dec 15;167(7):1814-1828.e12. doi: 10.1016/j.cell.2016.11.053.

9.

Structure and mechanism of human PrimPol, a DNA polymerase with primase activity.

Rechkoblit O, Gupta YK, Malik R, Rajashankar KR, Johnson RE, Prakash L, Prakash S, Aggarwal AK.

Sci Adv. 2016 Oct 21;2(10):e1601317. eCollection 2016 Oct.

10.

Structures of NS5 Methyltransferase from Zika Virus.

Coloma J, Jain R, Rajashankar KR, García-Sastre A, Aggarwal AK.

Cell Rep. 2016 Sep 20;16(12):3097-3102. doi: 10.1016/j.celrep.2016.08.091. Epub 2016 Sep 12.

11.

Type V CRISPR-Cas Cpf1 endonuclease employs a unique mechanism for crRNA-mediated target DNA recognition.

Gao P, Yang H, Rajashankar KR, Huang Z, Patel DJ.

Cell Res. 2016 Aug;26(8):901-13. doi: 10.1038/cr.2016.88. Epub 2016 Jul 22.

12.

Structure and function of the yeast listerin (Ltn1) conserved N-terminal domain in binding to stalled 60S ribosomal subunits.

Doamekpor SK, Lee JW, Hepowit NL, Wu C, Charenton C, Leonard M, Bengtson MH, Rajashankar KR, Sachs MS, Lima CD, Joazeiro CA.

Proc Natl Acad Sci U S A. 2016 Jul 19;113(29):E4151-60. doi: 10.1073/pnas.1605951113. Epub 2016 Jul 6.

13.

Structures of aminoarabinose transferase ArnT suggest a molecular basis for lipid A glycosylation.

Petrou VI, Herrera CM, Schultz KM, Clarke OB, Vendome J, Tomasek D, Banerjee S, Rajashankar KR, Belcher Dufrisne M, Kloss B, Kloppmann E, Rost B, Klug CS, Trent MS, Shapiro L, Mancia F.

Science. 2016 Feb 5;351(6273):608-12. doi: 10.1126/science.aad1172.

14.

Structure of the polyisoprenyl-phosphate glycosyltransferase GtrB and insights into the mechanism of catalysis.

Ardiccioni C, Clarke OB, Tomasek D, Issa HA, von Alpen DC, Pond HL, Banerjee S, Rajashankar KR, Liu Q, Guan Z, Li C, Kloss B, Bruni R, Kloppmann E, Rost B, Manzini MC, Shapiro L, Mancia F.

Nat Commun. 2016 Jan 5;7:10175. doi: 10.1038/ncomms10175.

15.

Structural basis for phosphatidylinositol-phosphate biosynthesis.

Clarke OB, Tomasek D, Jorge CD, Dufrisne MB, Kim M, Banerjee S, Rajashankar KR, Shapiro L, Hendrickson WA, Santos H, Mancia F.

Nat Commun. 2015 Oct 16;6:8505. doi: 10.1038/ncomms9505.

16.

Crystal structure of group II intron domain 1 reveals a template for RNA assembly.

Zhao C, Rajashankar KR, Marcia M, Pyle AM.

Nat Chem Biol. 2015 Dec;11(12):967-72. doi: 10.1038/nchembio.1949. Epub 2015 Oct 26.

17.

Structural Basis for the Regulation of the MmpL Transporters of Mycobacterium tuberculosis.

Delmar JA, Chou TH, Wright CC, Licon MH, Doh JK, Radhakrishnan A, Kumar N, Lei HT, Bolla JR, Rajashankar KR, Su CC, Purdy GE, Yu EW.

J Biol Chem. 2015 Nov 20;290(47):28559-74. doi: 10.1074/jbc.M115.683797. Epub 2015 Sep 22.

18.

Mechanism of MenE inhibition by acyl-adenylate analogues and discovery of novel antibacterial agents.

Matarlo JS, Evans CE, Sharma I, Lavaud LJ, Ngo SC, Shek R, Rajashankar KR, French JB, Tan DS, Tonge PJ.

Biochemistry. 2015 Oct 27;54(42):6514-6524. doi: 10.1021/acs.biochem.5b00966. Epub 2015 Oct 15.

19.

Crystal structure of the Mycobacterium tuberculosis transcriptional regulator Rv0302.

Chou TH, Delmar JA, Wright CC, Kumar N, Radhakrishnan A, Doh JK, Licon MH, Bolla JR, Lei HT, Rajashankar KR, Su CC, Purdy GE, Yu EW.

Protein Sci. 2015 Dec;24(12):1942-55. doi: 10.1002/pro.2802. Epub 2015 Sep 29.

20.

Global RNA Fold and Molecular Recognition for a pfl Riboswitch Bound to ZMP, a Master Regulator of One-Carbon Metabolism.

Ren A, Rajashankar KR, Patel DJ.

Structure. 2015 Aug 4;23(8):1375-1381. doi: 10.1016/j.str.2015.05.016. Epub 2015 Jun 25.

21.

Structure-function studies of histone H3/H4 tetramer maintenance during transcription by chaperone Spt2.

Chen S, Rufiange A, Huang H, Rajashankar KR, Nourani A, Patel DJ.

Genes Dev. 2015 Jun 15;29(12):1326-40. doi: 10.1101/gad.261115.115.

22.

X-ray structure of a mammalian stearoyl-CoA desaturase.

Bai Y, McCoy JG, Levin EJ, Sobrado P, Rajashankar KR, Fox BG, Zhou M.

Nature. 2015 Aug 13;524(7564):252-6. doi: 10.1038/nature14549. Epub 2015 Jun 22.

23.

Crystal structure of the Alcanivorax borkumensis YdaH transporter reveals an unusual topology.

Bolla JR, Su CC, Delmar JA, Radhakrishnan A, Kumar N, Chou TH, Long F, Rajashankar KR, Yu EW.

Nat Commun. 2015 Apr 20;6:6874. doi: 10.1038/ncomms7874.

24.

Structure and function of Neisseria gonorrhoeae MtrF illuminates a class of antimetabolite efflux pumps.

Su CC, Bolla JR, Kumar N, Radhakrishnan A, Long F, Delmar JA, Chou TH, Rajashankar KR, Shafer WM, Yu EW.

Cell Rep. 2015 Apr 7;11(1):61-70. doi: 10.1016/j.celrep.2015.03.003. Epub 2015 Mar 26.

25.

Structural basis for molecular discrimination by a 3',3'-cGAMP sensing riboswitch.

Ren A, Wang XC, Kellenberger CA, Rajashankar KR, Jones RA, Hammond MC, Patel DJ.

Cell Rep. 2015 Apr 7;11(1):1-12. doi: 10.1016/j.celrep.2015.03.004. Epub 2015 Mar 26. Erratum in: Cell Rep. 2015 Apr 28;11(4):671.

26.

In-line alignment and Mg²⁺ coordination at the cleavage site of the env22 twister ribozyme.

Ren A, Košutić M, Rajashankar KR, Frener M, Santner T, Westhof E, Micura R, Patel DJ.

Nat Commun. 2014 Nov 20;5:5534. doi: 10.1038/ncomms6534.

27.

Crystal structure of a eukaryotic group II intron lariat.

Robart AR, Chan RT, Peters JK, Rajashankar KR, Toor N.

Nature. 2014 Oct 9;514(7521):193-7. doi: 10.1038/nature13790. Epub 2014 Sep 24.

28.

Structural and functional insight into TAF1-TAF7, a subcomplex of transcription factor II D.

Bhattacharya S, Lou X, Hwang P, Rajashankar KR, Wang X, Gustafsson JÅ, Fletterick RJ, Jacobson RH, Webb P.

Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9103-8. doi: 10.1073/pnas.1408293111. Epub 2014 Jun 10.

29.

Structural basis for catalysis in a CDP-alcohol phosphotransferase.

Sciara G, Clarke OB, Tomasek D, Kloss B, Tabuso S, Byfield R, Cohn R, Banerjee S, Rajashankar KR, Slavkovic V, Graziano JH, Shapiro L, Mancia F.

Nat Commun. 2014 Jun 13;5:4068. doi: 10.1038/ncomms5068.

30.

Crystal structure of the Neisseria gonorrhoeae MtrD inner membrane multidrug efflux pump.

Bolla JR, Su CC, Do SV, Radhakrishnan A, Kumar N, Long F, Chou TH, Delmar JA, Lei HT, Rajashankar KR, Shafer WM, Yu EW.

PLoS One. 2014 Jun 5;9(6):e97903. doi: 10.1371/journal.pone.0097903. eCollection 2014.

31.

Crystal structure of the open state of the Neisseria gonorrhoeae MtrE outer membrane channel.

Lei HT, Chou TH, Su CC, Bolla JR, Kumar N, Radhakrishnan A, Long F, Delmar JA, Do SV, Rajashankar KR, Shafer WM, Yu EW.

PLoS One. 2014 Jun 5;9(6):e97475. doi: 10.1371/journal.pone.0097475. eCollection 2014.

32.

Neural migration. Structures of netrin-1 bound to two receptors provide insight into its axon guidance mechanism.

Xu K, Wu Z, Renier N, Antipenko A, Tzvetkova-Robev D, Xu Y, Minchenko M, Nardi-Dei V, Rajashankar KR, Himanen J, Tessier-Lavigne M, Nikolov DB.

Science. 2014 Jun 13;344(6189):1275-9. doi: 10.1126/science.1255149. Epub 2014 May 29.

33.

Crystal structure of the Campylobacter jejuni CmeC outer membrane channel.

Su CC, Radhakrishnan A, Kumar N, Long F, Bolla JR, Lei HT, Delmar JA, Do SV, Chou TH, Rajashankar KR, Zhang Q, Yu EW.

Protein Sci. 2014 Jul;23(7):954-61. doi: 10.1002/pro.2478. Epub 2014 May 6.

34.

Crystal structure of the transcriptional regulator Rv0678 of Mycobacterium tuberculosis.

Radhakrishnan A, Kumar N, Wright CC, Chou TH, Tringides ML, Bolla JR, Lei HT, Rajashankar KR, Su CC, Purdy GE, Yu EW.

J Biol Chem. 2014 Jun 6;289(23):16526-40. doi: 10.1074/jbc.M113.538959. Epub 2014 Apr 15.

35.

Crystal structure of yeast DNA polymerase ε catalytic domain.

Jain R, Rajashankar KR, Buku A, Johnson RE, Prakash L, Prakash S, Aggarwal AK.

PLoS One. 2014 Apr 14;9(4):e94835. doi: 10.1371/journal.pone.0094835. eCollection 2014.

36.

Crystal structure of the transcriptional regulator Rv1219c of Mycobacterium tuberculosis.

Kumar N, Radhakrishnan A, Wright CC, Chou TH, Lei HT, Bolla JR, Tringides ML, Rajashankar KR, Su CC, Purdy GE, Yu EW.

Protein Sci. 2014 Apr;23(4):423-32. doi: 10.1002/pro.2424. Epub 2014 Mar 10.

37.

Crystal structure of the receptor-binding domain from newly emerged Middle East respiratory syndrome coronavirus.

Chen Y, Rajashankar KR, Yang Y, Agnihothram SS, Liu C, Lin YL, Baric RS, Li F.

J Virol. 2013 Oct;87(19):10777-83. doi: 10.1128/JVI.01756-13. Epub 2013 Jul 31.

38.

Crystal structures of Lgr4 and its complex with R-spondin1.

Xu K, Xu Y, Rajashankar KR, Robev D, Nikolov DB.

Structure. 2013 Sep 3;21(9):1683-9. doi: 10.1016/j.str.2013.07.001. Epub 2013 Jul 25.

39.

Structural basis for angiopoietin-1-mediated signaling initiation.

Yu X, Seegar TC, Dalton AC, Tzvetkova-Robev D, Goldgur Y, Rajashankar KR, Nikolov DB, Barton WA.

Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7205-10. doi: 10.1073/pnas.1216890110. Epub 2013 Apr 16.

40.

New insights into the Hendra virus attachment and entry process from structures of the virus G glycoprotein and its complex with Ephrin-B2.

Xu K, Chan YP, Rajashankar KR, Khetawat D, Yan L, Kolev MV, Broder CC, Nikolov DB.

PLoS One. 2012;7(11):e48742. doi: 10.1371/journal.pone.0048742. Epub 2012 Nov 5.

41.

Structural and functional analysis of the transcriptional regulator Rv3066 of Mycobacterium tuberculosis.

Bolla JR, Do SV, Long F, Dai L, Su CC, Lei HT, Chen X, Gerkey JE, Murphy DC, Rajashankar KR, Zhang Q, Yu EW.

Nucleic Acids Res. 2012 Oct;40(18):9340-55. doi: 10.1093/nar/gks677. Epub 2012 Jul 19.

42.

Structural basis for receptor sharing and activation by interleukin-20 receptor-2 (IL-20R2) binding cytokines.

Logsdon NJ, Deshpande A, Harris BD, Rajashankar KR, Walter MR.

Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12704-9. doi: 10.1073/pnas.1117551109. Epub 2012 Jul 16.

43.

Charged amino acids (R83, E567, D617, E625, R669, and K678) of CusA are required for metal ion transport in the Cus efflux system.

Su CC, Long F, Lei HT, Bolla JR, Do SV, Rajashankar KR, Yu EW.

J Mol Biol. 2012 Sep 21;422(3):429-41. doi: 10.1016/j.jmb.2012.05.038. Epub 2012 Jun 6.

44.

Fluoride ion encapsulation by Mg2+ ions and phosphates in a fluoride riboswitch.

Ren A, Rajashankar KR, Patel DJ.

Nature. 2012 May 13;486(7401):85-9. doi: 10.1038/nature11152.

45.

Crystal structure of a group II intron in the pre-catalytic state.

Chan RT, Robart AR, Rajashankar KR, Pyle AM, Toor N.

Nat Struct Mol Biol. 2012 Apr 8;19(5):555-7. doi: 10.1038/nsmb.2270.

46.

Purification, crystallization and preliminary X-ray diffraction analysis of the IL-20-IL-20R1-IL-20R2 complex.

Logsdon NJ, Allen CE, Rajashankar KR, Walter MR.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Jan 1;68(Pt 1):89-92. doi: 10.1107/S1744309111049529. Epub 2011 Dec 24.

47.

Structural differences between the Streptococcus agalactiae housekeeping and pilus-specific sortases: SrtA and SrtC1.

Khare B, Krishnan V, Rajashankar KR, I-Hsiu H, Xin M, Ton-That H, Narayana SV.

PLoS One. 2011;6(8):e22995. doi: 10.1371/journal.pone.0022995. Epub 2011 Aug 30.

48.

Crystal structure of mouse coronavirus receptor-binding domain complexed with its murine receptor.

Peng G, Sun D, Rajashankar KR, Qian Z, Holmes KV, Li F.

Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10696-701. doi: 10.1073/pnas.1104306108. Epub 2011 Jun 13.

49.

Crystal structure of the C-terminal region of Streptococcus mutans antigen I/II and characterization of salivary agglutinin adherence domains.

Larson MR, Rajashankar KR, Crowley PJ, Kelly C, Mitchell TJ, Brady LJ, Deivanayagam C.

J Biol Chem. 2011 Jun 17;286(24):21657-66. doi: 10.1074/jbc.M111.231100. Epub 2011 Apr 19.

50.

Crystal structure of a phosphorylation-coupled saccharide transporter.

Cao Y, Jin X, Levin EJ, Huang H, Zong Y, Quick M, Weng J, Pan Y, Love J, Punta M, Rost B, Hendrickson WA, Javitch JA, Rajashankar KR, Zhou M.

Nature. 2011 May 5;473(7345):50-4. doi: 10.1038/nature09939. Epub 2011 Apr 6.

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