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Targeting Nicotinamide N-Methyltransferase and miR-449a in EGFR-TKI-Resistant Non-Small-Cell Lung Cancer Cells.

Bach DH, Kim D, Bae SY, Kim WK, Hong JY, Lee HJ, Rajasekaran N, Kwon S, Fan Y, Luu TT, Shin YK, Lee J, Lee SK.

Mol Ther Nucleic Acids. 2018 Jun 1;11:455-467. doi: 10.1016/j.omtn.2018.03.011. Epub 2018 Mar 29.


Evidence for a hyper-reductive redox in a sub-set of heart failure patients.

Sairam T, Patel AN, Subrahmanian M, Gopalan R, Pogwizd SM, Ramalingam S, Sankaran R, Rajasekaran NS.

J Transl Med. 2018 May 18;16(1):130. doi: 10.1186/s12967-018-1503-x.


Temporal partitioning of adaptive responses of the murine heart to fasting.

Brewer RA, Collins HE, Berry RD, Brahma MK, Tirado BA, Peliciari-Garcia RA, Stanley HL, Wende AR, Taegtmeyer H, Rajasekaran NS, Darley-Usmar V, Zhang J, Frank SJ, Chatham JC, Young ME.

Life Sci. 2018 Mar 15;197:30-39. doi: 10.1016/j.lfs.2018.01.031. Epub 2018 Feb 1.


Recurrent heat shock impairs the proliferation and differentiation of C2C12 myoblasts.

Bolus DJ, Shanmugam G, Narasimhan M, Rajasekaran NS.

Cell Stress Chaperones. 2018 May;23(3):399-410. doi: 10.1007/s12192-017-0851-4. Epub 2017 Oct 24.


Blueberry Metabolites Attenuate Lipotoxicity-Induced Endothelial Dysfunction.

Bharat D, Cavalcanti RRM, Petersen C, Begaye N, Cutler BR, Costa MMA, Ramos RKLG, Ferreira MR, Li Y, Bharath LP, Toolson E, Sebahar P, Looper RE, Jalili T, Rajasekaran NS, Jia Z, Symons JD, Anandh Babu PV.

Mol Nutr Food Res. 2018 Jan;62(2). doi: 10.1002/mnfr.201700601. Epub 2017 Dec 14.


Cardiac Aging - Benefits of Exercise, Nrf2 Activation and Antioxidant Signaling.

Narasimhan M, Rajasekaran NS.

Adv Exp Med Biol. 2017;999:231-255. doi: 10.1007/978-981-10-4307-9_13.


Excess ω-6 fatty acids influx in aging drives metabolic dysregulation, electrocardiographic alterations, and low-grade chronic inflammation.

Kain V, Ingle KA, Kachman M, Baum H, Shanmugam G, Rajasekaran NS, Young ME, Halade GV.

Am J Physiol Heart Circ Physiol. 2018 Feb 1;314(2):H160-H169. doi: 10.1152/ajpheart.00297.2017. Epub 2017 Oct 6.


A Universal Pattern in the Percolation and Dissipation of Protein Structural Perturbations.

Rajasekaran N, Sekhar A, Naganathan AN.

J Phys Chem Lett. 2017 Oct 5;8(19):4779-4784. doi: 10.1021/acs.jpclett.7b02021. Epub 2017 Sep 20.


Administration of low-dose combination anti-CTLA4, anti-CD137, and anti-OX40 into murine tumor or proximal to the tumor draining lymph node induces systemic tumor regression.

Hebb JPO, Mosley AR, Vences-Catalán F, Rajasekaran N, Rosén A, Ellmark P, Felsher DW.

Cancer Immunol Immunother. 2018 Jan;67(1):47-60. doi: 10.1007/s00262-017-2059-y. Epub 2017 Sep 13.


Polyamidoamine-Decorated Nanodiamonds as a Hybrid Gene Delivery Vector and siRNA Structural Characterization at the Charged Interfaces.

Lim DG, Rajasekaran N, Lee D, Kim NA, Jung HS, Hong S, Shin YK, Kang E, Jeong SH.

ACS Appl Mater Interfaces. 2017 Sep 20;9(37):31543-31556. doi: 10.1021/acsami.7b09624. Epub 2017 Sep 11.


Effect of HPV E6/E7 siRNA with Chemotherapeutic Agents on the Regulation of TP53/E2F Dynamic Behavior for Cell Fate Decisions.

Rajasekaran N, Jung HS, Bae SH, Chelakkot C, Hong S, Choi JS, Yim DS, Oh YK, Choi YL, Shin YK.

Neoplasia. 2017 Oct;19(10):735-749. doi: 10.1016/j.neo.2017.07.005. Epub 2017 Aug 24.


Identification of transcriptome signature for myocardial reductive stress.

Quiles JM, Narasimhan M, Mosbruger T, Shanmugam G, Crossman D, Rajasekaran NS.

Redox Biol. 2017 Oct;13:568-580. doi: 10.1016/j.redox.2017.07.013. Epub 2017 Jul 24.


Genetic disruption of the cardiomyocyte circadian clock differentially influences insulin-mediated processes in the heart.

McGinnis GR, Tang Y, Brewer RA, Brahma MK, Stanley HL, Shanmugam G, Rajasekaran NS, Rowe GC, Frank SJ, Wende AR, Abel ED, Taegtmeyer H, Litovsky S, Darley-Usmar V, Zhang J, Chatham JC, Young ME.

J Mol Cell Cardiol. 2017 Sep;110:80-95. doi: 10.1016/j.yjmcc.2017.07.005. Epub 2017 Jul 20.


Differential regulation of miRNA and mRNA expression in the myocardium of Nrf2 knockout mice.

Quiles JM, Narasimhan M, Shanmugam G, Milash B, Hoidal JR, Rajasekaran NS.

BMC Genomics. 2017 Jul 3;18(1):509. doi: 10.1186/s12864-017-3875-3. No abstract available.


A self-consistent structural perturbation approach for determining the magnitude and extent of allosteric coupling in proteins.

Rajasekaran N, Naganathan AN.

Biochem J. 2017 Jul 6;474(14):2379-2388. doi: 10.1042/BCJ20170304.


Chronic Endurance Exercise Impairs Cardiac Structure and Function in Middle-Aged Mice with Impaired Nrf2 Signaling.

Shanmugam G, Narasimhan M, Conley RL, Sairam T, Kumar A, Mason RP, Sankaran R, Hoidal JR, Rajasekaran NS.

Front Physiol. 2017 May 3;8:268. doi: 10.3389/fphys.2017.00268. eCollection 2017.


Intestinal Epithelial Cell-Specific Deletion of PLD2 Alleviates DSS-Induced Colitis by Regulating Occludin.

Chelakkot C, Ghim J, Rajasekaran N, Choi JS, Kim JH, Jang MH, Shin YK, Suh PG, Ryu SH.

Sci Rep. 2017 May 8;7(1):1573. doi: 10.1038/s41598-017-01797-y.


Constitutive activation of Nrf2 induces a stable reductive state in the mouse myocardium.

Shanmugam G, Narasimhan M, Tamowski S, Darley-Usmar V, Rajasekaran NS.

Redox Biol. 2017 Aug;12:937-945. doi: 10.1016/j.redox.2017.04.038. Epub 2017 May 3.


A General Mechanism for the Propagation of Mutational Effects in Proteins.

Rajasekaran N, Suresh S, Gopi S, Raman K, Naganathan AN.

Biochemistry. 2017 Jan 10;56(1):294-305. doi: 10.1021/acs.biochem.6b00798. Epub 2016 Dec 27.


Upregulation of SMAD4 by MZF1 inhibits migration of human gastric cancer cells.

Lee JH, Kim SS, Lee HS, Hong S, Rajasekaran N, Wang LH, Choi JS, Shin YK.

Int J Oncol. 2017 Jan;50(1):272-282. doi: 10.3892/ijo.2016.3793. Epub 2016 Dec 6.


A biphasic effect of TNF-α in regulation of the Keap1/Nrf2 pathway in cardiomyocytes.

Shanmugam G, Narasimhan M, Sakthivel R, Kumar R R, Davidson C, Palaniappan S, Claycomb WW, Hoidal JR, Darley-Usmar VM, Rajasekaran NS.

Redox Biol. 2016 Oct;9:77-89. doi: 10.1016/j.redox.2016.06.004. Epub 2016 Jun 27.


Exercise, Nrf2 and Antioxidant Signaling in Cardiac Aging.

Narasimhan M, Rajasekaran NS.

Front Physiol. 2016 Jun 17;7:241. doi: 10.3389/fphys.2016.00241. eCollection 2016. Review.


Nuclear Factor-Erythroid-2-Related Factor 2 in Aging and Lung Fibrosis.

Swamy SM, Rajasekaran NS, Thannickal VJ.

Am J Pathol. 2016 Jul;186(7):1712-23. doi: 10.1016/j.ajpath.2016.02.022. Review.


Redox biology and the interface between bioenergetics, autophagy and circadian control of metabolism.

Wende AR, Young ME, Chatham J, Zhang J, Rajasekaran NS, Darley-Usmar VM.

Free Radic Biol Med. 2016 Nov;100:94-107. doi: 10.1016/j.freeradbiomed.2016.05.022. Epub 2016 May 27. Review.


Strategic Combinations: The Future of Oncolytic Virotherapy with Reovirus.

Zhao X, Chester C, Rajasekaran N, He Z, Kohrt HE.

Mol Cancer Ther. 2016 May;15(5):767-73. doi: 10.1158/1535-7163.MCT-15-0695. Epub 2016 Apr 14. Review.


Evaluation of the effect of diminished pulsatility as seen in continuous flow ventricular assist devices on arterial endothelial cell phenotype and function.

Patibandla PK, Rajasekaran NS, Shelar SB, Giridharan GA, Litovsky SH, Sethu P.

J Heart Lung Transplant. 2016 Jul;35(7):930-2. doi: 10.1016/j.healun.2016.03.008. Epub 2016 Mar 22. No abstract available.


Quantifying Protein Disorder through Measures of Excess Conformational Entropy.

Rajasekaran N, Gopi S, Narayan A, Naganathan AN.

J Phys Chem B. 2016 May 19;120(19):4341-50. doi: 10.1021/acs.jpcb.6b00658. Epub 2016 May 4.


Abrogation of Nrf2 impairs antioxidant signaling and promotes atrial hypertrophy in response to high-intensity exercise stress.

Kumar RR, Narasimhan M, Shanmugam G, Hong J, Devarajan A, Palaniappan S, Zhang J, Halade GV, Darley-Usmar VM, Hoidal JR, Rajasekaran NS.

J Transl Med. 2016 Apr 5;14:86. doi: 10.1186/s12967-016-0839-3.


Harnessing the innate immune system to treat cancer: enhancement of antibody-dependent cellular cytotoxicity with anti-CD137 Ab.

Yonezawa A, Chester C, Rajasekaran N, Kohrt HE.

Chin Clin Oncol. 2016 Feb;5(1):5. doi: 10.3978/j.issn.2304-3865.2016.02.05. Review. No abstract available.


Disruption of nuclear factor (erythroid-derived-2)-like 2 antioxidant signaling: a mechanism for impaired activation of stem cells and delayed regeneration of skeletal muscle.

Shelar SB, Narasimhan M, Shanmugam G, Litovsky SH, Gounder SS, Karan G, Arulvasu C, Kensler TW, Hoidal JR, Darley-Usmar VM, Rajasekaran NS.

FASEB J. 2016 May;30(5):1865-79. doi: 10.1096/fj.201500153. Epub 2016 Feb 2.


Redox Signaling and the Cardiovascular and Skeletal Muscle System.

Gomes AV, Rajasekaran NS, Pi X.

Oxid Med Cell Longev. 2015;2015:849095. doi: 10.1155/2015/849095. Epub 2015 Oct 7. No abstract available.


Employing Digital Droplet PCR to Detect BRAF V600E Mutations in Formalin-fixed Paraffin-embedded Reference Standard Cell Lines.

Rajasekaran N, Oh MR, Kim SS, Kim SE, Kim YD, Choi HJ, Byun B, Shin YK.

J Vis Exp. 2015 Oct 8;(104). doi: 10.3791/53190.


Correction: KEAP1-NRF2 signalling and autophagy in protection against oxidative and reductive proteotoxicity.

Dodson M, Redmann M, Rajasekaran NS, Darley-Usmar V, Zhang J.

Biochem J. 2015 Nov 1;471(3):431. doi: 10.1042/BJ4710431. No abstract available.


Energetic and topological determinants of a phosphorylation-induced disorder-to-order protein conformational switch.

Gopi S, Rajasekaran N, Singh A, Ranu S, Naganathan AN.

Phys Chem Chem Phys. 2015 Nov 7;17(41):27264-9. doi: 10.1039/c5cp04765j.


Human Papillomavirus: Current and Future RNAi Therapeutic Strategies for Cervical Cancer.

Jung HS, Rajasekaran N, Ju W, Shin YK.

J Clin Med. 2015 May 21;4(5):1126-55. doi: 10.3390/jcm4051126. Review.


KEAP1-NRF2 signalling and autophagy in protection against oxidative and reductive proteotoxicity.

Dodson M, Redmann M, Rajasekaran NS, Darley-Usmar V, Zhang J.

Biochem J. 2015 Aug 1;469(3):347-55. doi: 10.1042/BJ20150568. Review. Erratum in: Biochem J. 2015 Nov 1;471(3):431.


Human Papillomavirus E6/E7-Specific siRNA Potentiates the Effect of Radiotherapy for Cervical Cancer in Vitro and in Vivo.

Jung HS, Rajasekaran N, Song SY, Kim YD, Hong S, Choi HJ, Kim YS, Choi JS, Choi YL, Shin YK.

Int J Mol Sci. 2015 May 29;16(6):12243-60. doi: 10.3390/ijms160612243.


Immunological Basis for Rapid Progression of Diabetes in Older NOD Mouse Recipients Post BM-HSC Transplantation.

Wang N, Rajasekaran N, Hou T, Macaubas C, Mellins ED.

PLoS One. 2015 May 28;10(5):e0128494. doi: 10.1371/journal.pone.0128494. eCollection 2015.


Nickel elution properties of contemporary interatrial shunt closure devices.

Verma DR, Khan MF, Tandar A, Rajasekaran NS, Neuharth R, Patel AN, Muhlestein JB, Badger RS.

J Invasive Cardiol. 2015 Feb;27(2):99-104.


Enhancement of antibody-dependent cell mediated cytotoxicity: a new era in cancer treatment.

Rajasekaran N, Chester C, Yonezawa A, Zhao X, Kohrt HE.

Immunotargets Ther. 2015 May 15;4:91-100. doi: 10.2147/ITT.S61292. eCollection 2015. Review.


Reduced locomotor activity correlates with increased severity of arthritis in a mouse model of antibody-induced arthritis.

Rajasekaran N, Tran R, Pascual C, Xie X, Mellins ED.

Open J Rheumatol Autoimmune Dis. 2014 Feb 1;4(1):62-68.


Reductive potential - a savior turns stressor in protein aggregation cardiomyopathy.

Narasimhan M, Rajasekaran NS.

Biochim Biophys Acta. 2015 Jan;1852(1):53-60. doi: 10.1016/j.bbadis.2014.11.010. Epub 2014 Nov 15. Review.


The MHC class II cofactor HLA-DM interacts with Ig in B cells.

Macmillan H, Strohman MJ, Ayyangar S, Jiang W, Rajasekaran N, Spura A, Hessell AJ, Madec AM, Mellins ED.

J Immunol. 2014 Sep 15;193(6):2641-2650. doi: 10.4049/jimmunol.1400075. Epub 2014 Aug 6.


Heme-mediated SPI-C induction promotes monocyte differentiation into iron-recycling macrophages.

Haldar M, Kohyama M, So AY, Kc W, Wu X, Briseño CG, Satpathy AT, Kretzer NM, Arase H, Rajasekaran NS, Wang L, Egawa T, Igarashi K, Baltimore D, Murphy TL, Murphy KM.

Cell. 2014 Mar 13;156(6):1223-1234. doi: 10.1016/j.cell.2014.01.069.


Nrf2 deficiency promotes apoptosis and impairs PAX7/MyoD expression in aging skeletal muscle cells.

Narasimhan M, Hong J, Atieno N, Muthusamy VR, Davidson CJ, Abu-Rmaileh N, Richardson RS, Gomes AV, Hoidal JR, Rajasekaran NS.

Free Radic Biol Med. 2014 Jun;71:402-14. doi: 10.1016/j.freeradbiomed.2014.02.023. Epub 2014 Mar 6.


Effect of Alpinia calcarata on glucose uptake in diabetic rats-an in vitro and in vivo model.

Rajasekar R, Manokaran K, Rajasekaran N, Duraisamy G, Kanakasabapathi D.

J Diabetes Metab Disord. 2014 Feb 6;13(1):33. doi: 10.1186/2251-6581-13-33.


Collagenase-3 (MMP-13) deficiency protects C57BL/6 mice from antibody-induced arthritis.

Singh A, Rajasekaran N, Hartenstein B, Szabowski S, Gajda M, Angel P, Bräuer R, Illges H.

Arthritis Res Ther. 2013;15(6):R222.


Transgene expression in various organs post BM-HSC transplantation.

Wang N, Rajasekaran N, Hou T, Mellins ED.

Stem Cell Res. 2014 Jan;12(1):209-21. doi: 10.1016/j.scr.2013.10.010. Epub 2013 Nov 2.


Comparison of transduction efficiency among various lentiviruses containing GFP reporter in bone marrow hematopoietic stem cell transplantation.

Wang N, Rajasekaran N, Hou T, Lisowski L, Mellins ED.

Exp Hematol. 2013 Nov;41(11):934-43. doi: 10.1016/j.exphem.2013.07.002. Epub 2013 Aug 14.


The NADPH metabolic network regulates human αB-crystallin cardiomyopathy and reductive stress in Drosophila melanogaster.

Xie HB, Cammarato A, Rajasekaran NS, Zhang H, Suggs JA, Lin HC, Bernstein SI, Benjamin IJ, Golic KG.

PLoS Genet. 2013 Jun;9(6):e1003544. doi: 10.1371/journal.pgen.1003544. Epub 2013 Jun 20.

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