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Rapid Bioorthogonal Chemistry Enables in Situ Modulation of the Stem Cell Behavior in 3D without External Triggers.

Hao Y, Song J, Ravikrishnan A, Dicker KT, Fowler EW, Zerdoum AB, Li Y, Zhang H, Rajasekaran AK, Fox JM, Jia X.

ACS Appl Mater Interfaces. 2018 Aug 8;10(31):26016-26027. doi: 10.1021/acsami.8b07632. Epub 2018 Jul 30.


Cellular interactions with hydrogel microfibers synthesized via interfacial tetrazine ligation.

Liu S, Moore AC, Zerdoum AB, Zhang H, Scinto SL, Zhang H, Gong L, Burris DL, Rajasekaran AK, Fox JM, Jia X.

Biomaterials. 2018 Oct;180:24-35. doi: 10.1016/j.biomaterials.2018.06.042. Epub 2018 Jul 4.


Cervical Vestibular Evoked Myogenic Potential in Hypoglossal Nerve Schwannoma: A Case Report.

Rajasekaran AK, Savardekar AR, Shivashankar NR.

J Am Acad Audiol. 2018 Feb;29(2):187-191. doi: 10.3766/jaaa.16012.


Biomimetic Hydrogels Incorporating Polymeric Cell-Adhesive Peptide To Promote the 3D Assembly of Tumoroids.

Hao Y, Zerdoum AB, Stuffer AJ, Rajasekaran AK, Jia X.

Biomacromolecules. 2016 Nov 14;17(11):3750-3760. Epub 2016 Oct 20.


Regulation of Epithelial-to-Mesenchymal Transition Using Biomimetic Fibrous Scaffolds.

Ravikrishnan A, Ozdemir T, Bah M, Baskerville KA, Shah SI, Rajasekaran AK, Jia X.

ACS Appl Mater Interfaces. 2016 Jul 20;8(28):17915-26. doi: 10.1021/acsami.6b05646. Epub 2016 Jul 5.


Carcinoma cells induce lumen filling and EMT in epithelial cells through soluble E-cadherin-mediated activation of EGFR.

Patil PU, D'Ambrosio J, Inge LJ, Mason RW, Rajasekaran AK.

J Cell Sci. 2015 Dec 1;128(23):4366-79. doi: 10.1242/jcs.173518. Epub 2015 Oct 19.


Physiologically Based Pharmacokinetic Modeling of Fluorescently Labeled Block Copolymer Nanoparticles for Controlled Drug Delivery in Leukemia Therapy.

Gilkey MJ, Krishnan V, Scheetz L, Jia X, Rajasekaran AK, Dhurjati PS.

CPT Pharmacometrics Syst Pharmacol. 2015 Mar;4(3):e00013. doi: 10.1002/psp4.13. Epub 2015 Mar 12.


CD19-Targeted Nanodelivery of Doxorubicin Enhances Therapeutic Efficacy in B-Cell Acute Lymphoblastic Leukemia.

Krishnan V, Xu X, Kelly D, Snook A, Waldman SA, Mason RW, Jia X, Rajasekaran AK.

Mol Pharm. 2015 Jun 1;12(6):2101-11. doi: 10.1021/acs.molpharmaceut.5b00071. Epub 2015 May 4.


Glucocorticoids suppress renal cell carcinoma progression by enhancing Na,K-ATPase beta-1 subunit expression.

Huynh TP, Barwe SP, Lee SJ, McSpadden R, Franco OE, Hayward SW, Damoiseaux R, Grubbs SS, Petrelli NJ, Rajasekaran AK.

PLoS One. 2015 Apr 2;10(4):e0122442. doi: 10.1371/journal.pone.0122442. eCollection 2015.


Gramicidin A: A New Mission for an Old Antibiotic.

David JM, Rajasekaran AK.

J Kidney Cancer VHL. 2015 Jan 18;2(1):15-24. doi: 10.15586/jkcvhl.2015.21. eCollection 2015.


Wilms' tumor protein induces an epithelial-mesenchymal hybrid differentiation state in clear cell renal cell carcinoma.

Sampson VB, David JM, Puig I, Patil PU, de Herreros AG, Thomas GV, Rajasekaran AK.

PLoS One. 2014 Jul 15;9(7):e102041. doi: 10.1371/journal.pone.0102041. eCollection 2014.


Gramicidin A blocks tumor growth and angiogenesis through inhibition of hypoxia-inducible factor in renal cell carcinoma.

David JM, Owens TA, Inge LJ, Bremner RM, Rajasekaran AK.

Mol Cancer Ther. 2014 Apr;13(4):788-99. doi: 10.1158/1535-7163.MCT-13-0891. Epub 2014 Feb 3.


Epigenetic silencing of Na,K-ATPase β 1 subunit gene ATP1B1 by methylation in clear cell renal cell carcinoma.

Selvakumar P, Owens TA, David JM, Petrelli NJ, Christensen BC, Lakshmikuttyamma A, Rajasekaran AK.

Epigenetics. 2014 Apr;9(4):579-86. doi: 10.4161/epi.27795. Epub 2014 Jan 22.


Clinical nanomedicine: a solution to the chemotherapy conundrum in pediatric leukemia therapy.

Krishnan V, Rajasekaran AK.

Clin Pharmacol Ther. 2014 Feb;95(2):168-78. doi: 10.1038/clpt.2013.174. Epub 2013 Sep 5. Review.


Gramicidin A induces metabolic dysfunction and energy depletion leading to cell death in renal cell carcinoma cells.

David JM, Owens TA, Barwe SP, Rajasekaran AK.

Mol Cancer Ther. 2013 Nov;12(11):2296-307. doi: 10.1158/1535-7163.MCT-13-0445. Epub 2013 Sep 4.


Dexamethasone-loaded block copolymer nanoparticles induce leukemia cell death and enhance therapeutic efficacy: a novel application in pediatric nanomedicine.

Krishnan V, Xu X, Barwe SP, Yang X, Czymmek K, Waldman SA, Mason RW, Jia X, Rajasekaran AK.

Mol Pharm. 2013 Jun 3;10(6):2199-210. doi: 10.1021/mp300350e. Epub 2012 Nov 29.


Na,K-ATPase β-subunit cis homo-oligomerization is necessary for epithelial lumen formation in mammalian cells.

Barwe SP, Skay A, McSpadden R, Huynh TP, Langhans SA, Inge LJ, Rajasekaran AK.

J Cell Sci. 2012 Dec 1;125(Pt 23):5711-20. doi: 10.1242/jcs.108795. Epub 2012 Oct 17.


Dishonorable discharge: the oncogenic roles of cleaved E-cadherin fragments.

David JM, Rajasekaran AK.

Cancer Res. 2012 Jun 15;72(12):2917-23. doi: 10.1158/0008-5472.CAN-11-3498. Epub 2012 Jun 1. Review.


Na,K-ATPase is a target of cigarette smoke and reduced expression predicts poor patient outcome of smokers with lung cancer.

Huynh TP, Mah V, Sampson VB, Chia D, Fishbein MC, Horvath S, Alavi M, Wu DC, Harper J, Sarafian T, Dubinett SM, Langhans SA, Goodglick L, Rajasekaran AK.

Am J Physiol Lung Cell Mol Physiol. 2012 Jun 1;302(11):L1150-8. doi: 10.1152/ajplung.00384.2010. Epub 2012 Feb 17.


Protein expression based multimarker analysis of breast cancer samples.

Presson AP, Yoon NK, Bagryanova L, Mah V, Alavi M, Maresh EL, Rajasekaran AK, Goodglick L, Chia D, Horvath S.

BMC Cancer. 2011 Jun 8;11:230. doi: 10.1186/1471-2407-11-230.


Soluble E-cadherin promotes cell survival by activating epidermal growth factor receptor.

Inge LJ, Barwe SP, D'Ambrosio J, Gopal J, Lu K, Ryazantsev S, Rajasekaran SA, Rajasekaran AK.

Exp Cell Res. 2011 Apr 1;317(6):838-48. doi: 10.1016/j.yexcr.2010.12.025. Epub 2011 Jan 4.


Na,K-ATPase subunits as markers for epithelial-mesenchymal transition in cancer and fibrosis.

Rajasekaran SA, Huynh TP, Wolle DG, Espineda CE, Inge LJ, Skay A, Lassman C, Nicholas SB, Harper JF, Reeves AE, Ahmed MM, Leatherman JM, Mullin JM, Rajasekaran AK.

Mol Cancer Ther. 2010 Jun;9(6):1515-24. doi: 10.1158/1535-7163.MCT-09-0832. Epub 2010 May 25.


Dysfunction of ouabain-induced cardiac contractility in mice with heart-specific ablation of Na,K-ATPase beta1-subunit.

Barwe SP, Jordan MC, Skay A, Inge L, Rajasekaran SA, Wolle D, Johnson CL, Neco P, Fang K, Rozengurt N, Goldhaber JI, Roos KP, Rajasekaran AK.

J Mol Cell Cardiol. 2009 Oct;47(4):552-60. doi: 10.1016/j.yjmcc.2009.07.018. Epub 2009 Aug 15.


Expression of Na,K-ATPase-beta(1) subunit increases uptake and sensitizes carcinoma cells to oxaliplatin.

Tummala R, Wolle D, Barwe SP, Sampson VB, Rajasekaran AK, Pendyala L.

Cancer Chemother Pharmacol. 2009 Nov;64(6):1187-94. doi: 10.1007/s00280-009-0985-x. Epub 2009 Mar 26.


Na,K-ATPase and epithelial tight junctions.

Rajasekaran SA, Rajasekaran AK.

Front Biosci (Landmark Ed). 2009 Jan 1;14:2130-48. Review.


Prostate-specific membrane antigen associates with anaphase-promoting complex and induces chromosomal instability.

Rajasekaran SA, Christiansen JJ, Schmid I, Oshima E, Ryazantsev S, Sakamoto K, Weinstein J, Rao NP, Rajasekaran AK.

Mol Cancer Ther. 2008 Jul;7(7):2142-51. doi: 10.1158/1535-7163.MCT-08-0005. Erratum in: Mol Cancer Ther. 2008 Sep;7(9):3122. Ryazantsev, Sergey [added].


alpha-Catenin overrides Src-dependent activation of beta-catenin oncogenic signaling.

Inge LJ, Rajasekaran SA, Wolle D, Barwe SP, Ryazantsev S, Ewing CM, Isaacs WB, Rajasekaran AK.

Mol Cancer Ther. 2008 Jun;7(6):1386-97. doi: 10.1158/1535-7163.MCT-07-2029.


Clinical trials of cancer therapies targeting prostate-specific membrane antigen.

Olson WC, Heston WD, Rajasekaran AK.

Rev Recent Clin Trials. 2007 Sep;2(3):182-90. Review.


Evidence for a potential tumor suppressor role for the Na,K-ATPase beta1-subunit.

Inge LJ, Rajasekaran SA, Yoshimoto K, Mischel PS, McBride W, Landaw E, Rajasekaran AK.

Histol Histopathol. 2008 Apr;23(4):459-67. doi: 10.14670/HH-23.459.


Interactions of tight junctions with membrane channels and transporters.

Rajasekaran SA, Beyenbach KW, Rajasekaran AK.

Biochim Biophys Acta. 2008 Mar;1778(3):757-69. Epub 2007 Nov 19. Review.


Na,K-adenosine triphosphatase alpha1-subunit predicts survival of renal clear cell carcinoma.

Seligson DB, Rajasekaran SA, Yu H, Liu X, Eeva M, Tze S, Ball W Jr, Horvath S, deKernion JB, Rajasekaran AK.

J Urol. 2008 Jan;179(1):338-45. Epub 2007 Nov 19.


Interaction of prostate specific membrane antigen with clathrin and the adaptor protein complex-2.

Goodman OB Jr, Barwe SP, Ritter B, McPherson PS, Vasko AJ, Keen JH, Nanus DM, Bander NH, Rajasekaran AK.

Int J Oncol. 2007 Nov;31(5):1199-203.


Preferential association of prostate cancer cells expressing prostate specific membrane antigen to bone marrow matrix.

Barwe SP, Maul RS, Christiansen JJ, Anilkumar G, Cooper CR, Kohn DB, Rajasekaran AK.

Int J Oncol. 2007 Apr;30(4):899-904.


Janus model of the Na,K-ATPase beta-subunit transmembrane domain: distinct faces mediate alpha/beta assembly and beta-beta homo-oligomerization.

Barwe SP, Kim S, Rajasekaran SA, Bowie JU, Rajasekaran AK.

J Mol Biol. 2007 Jan 19;365(3):706-14. Epub 2006 Oct 31.


Na-K-ATPase regulates tight junction permeability through occludin phosphorylation in pancreatic epithelial cells.

Rajasekaran SA, Barwe SP, Gopal J, Ryazantsev S, Schneeberger EE, Rajasekaran AK.

Am J Physiol Gastrointest Liver Physiol. 2007 Jan;292(1):G124-33. Epub 2006 Sep 7.


Reassessing epithelial to mesenchymal transition as a prerequisite for carcinoma invasion and metastasis.

Christiansen JJ, Rajasekaran AK.

Cancer Res. 2006 Sep 1;66(17):8319-26. Review.


Association of prostate-specific membrane antigen with caveolin-1 and its caveolae-dependent internalization in microvascular endothelial cells: implications for targeting to tumor vasculature.

Anilkumar G, Barwe SP, Christiansen JJ, Rajasekaran SA, Kohn DB, Rajasekaran AK.

Microvasc Res. 2006 Jul-Sep;72(1-2):54-61. Epub 2006 May 19.


Estrogen receptor-alpha binds p53 tumor suppressor protein directly and represses its function.

Liu W, Konduri SD, Bansal S, Nayak BK, Rajasekaran SA, Karuppayil SM, Rajasekaran AK, Das GM.

J Biol Chem. 2006 Apr 14;281(15):9837-40. Epub 2006 Feb 9.


Multiple functions of Na,K-ATPase in epithelial cells.

Rajasekaran SA, Barwe SP, Rajasekaran AK.

Semin Nephrol. 2005 Sep;25(5):328-34. Review.


N-glycosylation and microtubule integrity are involved in apical targeting of prostate-specific membrane antigen: implications for immunotherapy.

Christiansen JJ, Rajasekaran SA, Inge L, Cheng L, Anilkumar G, Bander NH, Rajasekaran AK.

Mol Cancer Ther. 2005 May;4(5):704-14.


Is prostate-specific membrane antigen a multifunctional protein?

Rajasekaran AK, Anilkumar G, Christiansen JJ.

Am J Physiol Cell Physiol. 2005 May;288(5):C975-81. Review.


Novel role for Na,K-ATPase in phosphatidylinositol 3-kinase signaling and suppression of cell motility.

Barwe SP, Anilkumar G, Moon SY, Zheng Y, Whitelegge JP, Rajasekaran SA, Rajasekaran AK.

Mol Biol Cell. 2005 Mar;16(3):1082-94. Epub 2004 Dec 22.


Renal clear-cell carcinoma: an ultrastructural study on the junctional complexes.

Kim G, Rajasekaran SA, Thomas G, Rosen EA, Landaw EM, Shintaku P, Lassman C, Said J, Rajasekaran AK.

Histol Histopathol. 2005 Jan;20(1):35-44. doi: 10.14670/HH-20.35.


Biological impediments to monoclonal antibody-based cancer immunotherapy.

Christiansen J, Rajasekaran AK.

Mol Cancer Ther. 2004 Nov;3(11):1493-501. Review.


HPAF-II, a cell culture model to study pancreatic epithelial cell structure and function.

Rajasekaran SA, Gopal J, Espineda C, Ryazantsev S, Schneeberger EE, Rajasekaran AK.

Pancreas. 2004 Oct;29(3):e77-83.


Na,K-ATPase beta1-subunit increases the translation efficiency of the alpha1-subunit in MSV-MDCK cells.

Rajasekaran SA, Gopal J, Willis D, Espineda C, Twiss JL, Rajasekaran AK.

Mol Biol Cell. 2004 Jul;15(7):3224-32. Epub 2004 May 7.


Repression of Na,K-ATPase beta1-subunit by the transcription factor snail in carcinoma.

Espineda CE, Chang JH, Twiss J, Rajasekaran SA, Rajasekaran AK.

Mol Biol Cell. 2004 Mar;15(3):1364-73. Epub 2003 Dec 29.

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