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Items: 49


Identification of an Increased Alveolar Macrophage Subpopulation in Old Mice That Displays Unique Inflammatory Characteristics and Is Permissive to Mycobacterium tuberculosis Infection.

Lafuse WP, Rajaram MVS, Wu Q, Moliva JI, Torrelles JB, Turner J, Schlesinger LS.

J Immunol. 2019 Oct 15;203(8):2252-2264. doi: 10.4049/jimmunol.1900495. Epub 2019 Sep 11.


IFITM3 protects the heart during influenza virus infection.

Kenney AD, McMichael TM, Imas A, Chesarino NM, Zhang L, Dorn LE, Wu Q, Alfaour O, Amari F, Chen M, Zani A, Chemudupati M, Accornero F, Coppola V, Rajaram MVS, Yount JS.

Proc Natl Acad Sci U S A. 2019 Sep 10;116(37):18607-18612. doi: 10.1073/pnas.1900784116. Epub 2019 Aug 26.


Mycobacterium tuberculosis enhances macrophage P-glycoprotein (MDR1) expression and activity to promote intracellular survival during anti-TB drug treatment.

Wu Q, Hossfeld A, Gerberick A, Saljoughian N, Tiwari C, Mehra S, Ganesan LP, Wozniak DJ, Rajaram MVS.

J Infect Dis. 2019 Aug 14. pii: jiz405. doi: 10.1093/infdis/jiz405. [Epub ahead of print]


Aging heart and infection.

Headley C, Turner J, Rajaram MV.

Aging (Albany NY). 2019 Jul 25;11(14):4781-4782. doi: 10.18632/aging.102128. No abstract available.


The Lung Mucosa Environment in the Elderly Increases Host Susceptibility to Mycobacterium tuberculosis Infection.

Moliva JI, Duncan MA, Olmo-Fontánez A, Akhter A, Arnett E, Scordo JM, Ault R, Sasindran SJ, Azad AK, Montoya MJ, Reinhold-Larsson N, Rajaram MVS, Merrit RE, Lafuse WP, Zhang L, Wang SH, Beamer G, Wang Y, Proud K, Maselli DJ, Peters J, Weintraub ST, Turner J, Schlesinger LS, Torrelles JB.

J Infect Dis. 2019 Jul 2;220(3):514-523. doi: 10.1093/infdis/jiz138.


Nontuberculous mycobacterium M. avium infection predisposes aged mice to cardiac abnormalities and inflammation.

Headley CA, Gerberick A, Mehta S, Wu Q, Yu L, Fadda P, Khan M, Ganesan LP, Turner J, Rajaram MVS.

Aging Cell. 2019 Jun;18(3):e12926. doi: 10.1111/acel.12926. Epub 2019 Mar 4.


Novel Mechanistic Roles for Ankyrin-G in Cardiac Remodeling and Heart Failure.

Makara MA, Curran J, Lubbers ER, Murphy NP, Little SC, Musa H, Smith SA, Unudurthi SD, Rajaram MVS, Janssen PML, Boyden PA, Bradley EA, Hund TJ, Mohler PJ.

JACC Basic Transl Sci. 2018 Nov 12;3(5):675-689. doi: 10.1016/j.jacbts.2018.07.008. eCollection 2018 Oct.


Deletion of PPARγ in lung macrophages provides an immunoprotective response against M. tuberculosis infection in mice.

Guirado E, Rajaram MV, Chawla A, Daigle J, La Perle KM, Arnett E, Turner J, Schlesinger LS.

Tuberculosis (Edinb). 2018 Jul;111:170-177. doi: 10.1016/ Epub 2018 Jun 21.


Complement Receptor 3-Mediated Inhibition of Inflammasome Priming by Ras GTPase-Activating Protein During Francisella tularensis Phagocytosis by Human Mononuclear Phagocytes.

Hoang KV, Rajaram MVS, Curry HM, Gavrilin MA, Wewers MD, Schlesinger LS.

Front Immunol. 2018 Mar 26;9:561. doi: 10.3389/fimmu.2018.00561. eCollection 2018.


O-Mannosylation of Proteins Enables Histoplasma Yeast Survival at Mammalian Body Temperatures.

Garfoot AL, Goughenour KD, Wüthrich M, Rajaram MVS, Schlesinger LS, Klein BS, Rappleye CA.

MBio. 2018 Jan 2;9(1). pii: e02121-17. doi: 10.1128/mBio.02121-17.


M. tuberculosis-Initiated Human Mannose Receptor Signaling Regulates Macrophage Recognition and Vesicle Trafficking by FcRγ-Chain, Grb2, and SHP-1.

Rajaram MVS, Arnett E, Azad AK, Guirado E, Ni B, Gerberick AD, He LZ, Keler T, Thomas LJ, Lafuse WP, Schlesinger LS.

Cell Rep. 2017 Oct 3;21(1):126-140. doi: 10.1016/j.celrep.2017.09.034.


Mouse Liver Sinusoidal Endothelium Eliminates HIV-Like Particles from Blood at a Rate of 100 Million per Minute by a Second-Order Kinetic Process.

Mates JM, Yao Z, Cheplowitz AM, Suer O, Phillips GS, Kwiek JJ, Rajaram MV, Kim J, Robinson JM, Ganesan LP, Anderson CL.

Front Immunol. 2017 Jan 24;8:35. doi: 10.3389/fimmu.2017.00035. eCollection 2017.


Human Cystic Fibrosis Macrophages Have Defective Calcium-Dependent Protein Kinase C Activation of the NADPH Oxidase, an Effect Augmented by Burkholderia cenocepacia.

Assani K, Shrestha CL, Robledo-Avila F, Rajaram MV, Partida-Sanchez S, Schlesinger LS, Kopp BT.

J Immunol. 2017 Mar 1;198(5):1985-1994. doi: 10.4049/jimmunol.1502609. Epub 2017 Jan 16.


CD36-Mediated Uptake of Surfactant Lipids by Human Macrophages Promotes Intracellular Growth of Mycobacterium tuberculosis.

Dodd CE, Pyle CJ, Glowinski R, Rajaram MV, Schlesinger LS.

J Immunol. 2016 Dec 15;197(12):4727-4735. Epub 2016 Nov 9.


Corrigendum to the inextricable axis of targeted diagnostic imaging and therapy: An immunological natural history approach [Nucl Med Biol 43 (2016) 215-225].

Cope FO, Abbruzzese B, Sanders J, Metz W, Sturms K, Ralph D, Blue M, Zhang J, Bracci P, Bshara W, Behr S, Maurer T, Williams K, Walker J, Beverly A, Blay B, Damughatla A, Larsen M, Mountain C, Neylon E, Parcel K, Raghuraman K, Ricks K, Rose L, Sivakumar A, Streck N, Wang B, Wasco C, Williams A, Schlesinger LS, Azad A, Rajaram MVS, Jarjour W, Young N, Rosol T, McGrath M.

Nucl Med Biol. 2016 Dec;43(12):837. doi: 10.1016/j.nucmedbio.2016.10.001. No abstract available.


Cardiac Electrical and Structural Changes During Bacterial Infection: An Instructive Model to Study Cardiac Dysfunction in Sepsis.

Makara MA, Hoang KV, Ganesan LP, Crouser ED, Gunn JS, Turner J, Schlesinger LS, Mohler PJ, Rajaram MV.

J Am Heart Assoc. 2016 Sep 12;5(9). pii: e003820. doi: 10.1161/JAHA.116.003820.


Blood-Borne Lipopolysaccharide Is Rapidly Eliminated by Liver Sinusoidal Endothelial Cells via High-Density Lipoprotein.

Yao Z, Mates JM, Cheplowitz AM, Hammer LP, Maiseyeu A, Phillips GS, Wewers MD, Rajaram MV, Robinson JM, Anderson CL, Ganesan LP.

J Immunol. 2016 Sep 15;197(6):2390-9. doi: 10.4049/jimmunol.1600702. Epub 2016 Aug 17.


Targeting CBLB as a potential therapeutic approach for disseminated candidiasis.

Xiao Y, Tang J, Guo H, Zhao Y, Tang R, Ouyang S, Zeng Q, Rappleye CA, Rajaram MV, Schlesinger LS, Tao L, Brown GD, Langdon WY, Li BT, Zhang J.

Nat Med. 2016 Aug;22(8):906-14. doi: 10.1038/nm.4141. Epub 2016 Jul 18.


Correction: Fine Tuning Inflammation at the Front Door: Macrophage Complement Receptor 3-mediates Phagocytosis and Immune Suppression for Francisella tularensis.

Dai S, Rajaram MV, Curry HM, Leander R, Schlesinger LS.

PLoS Pathog. 2016 Mar 9;12(3):e1005504. doi: 10.1371/journal.ppat.1005504. eCollection 2016 Mar. No abstract available.


The inextricable axis of targeted diagnostic imaging and therapy: An immunological natural history approach.

Cope FO, Abbruzzese B, Sanders J, Metz W, Sturms K, Ralph D, Blue M, Zhang J, Bracci P, Bshara W, Behr S, Maurer T, Williams K, Walker J, Beverly A, Blay B, Damughatla A, Larsen M, Mountain C, Neylon E, Parcel K, Raghuraman K, Ricks K, Rose L, Sivakumar A, Streck N, Wang B, Wasco C, Schlesinger LS, Azad A, Rajaram MVS, Jarjour W, Young N, Rosol T, Williams A, McGrath M.

Nucl Med Biol. 2016 Mar;43(3):215-25. doi: 10.1016/j.nucmedbio.2015.11.007. Epub 2015 Dec 3. Review. Erratum in: Nucl Med Biol. 2016 Dec;43(12):837.


Scavenger receptor B1, the HDL receptor, is expressed abundantly in liver sinusoidal endothelial cells.

Ganesan LP, Mates JM, Cheplowitz AM, Avila CL, Zimmerer JM, Yao Z, Maiseyeu A, Rajaram MV, Robinson JM, Anderson CL.

Sci Rep. 2016 Feb 11;6:20646. doi: 10.1038/srep20646.


γ-Tilmanocept, a New Radiopharmaceutical Tracer for Cancer Sentinel Lymph Nodes, Binds to the Mannose Receptor (CD206).

Azad AK, Rajaram MV, Metz WL, Cope FO, Blue MS, Vera DR, Schlesinger LS.

J Immunol. 2015 Sep 1;195(5):2019-29. doi: 10.4049/jimmunol.1402005. Epub 2015 Jul 22.


Role for NOD2 in Mycobacterium tuberculosis-induced iNOS expression and NO production in human macrophages.

Landes MB, Rajaram MV, Nguyen H, Schlesinger LS.

J Leukoc Biol. 2015 Jun;97(6):1111-9. doi: 10.1189/jlb.3A1114-557R. Epub 2015 Mar 23.


Macrophage immunoregulatory pathways in tuberculosis.

Rajaram MV, Ni B, Dodd CE, Schlesinger LS.

Semin Immunol. 2014 Dec;26(6):471-85. doi: 10.1016/j.smim.2014.09.010. Epub 2014 Oct 30. Review.


Acetalated dextran encapsulated AR-12 as a host-directed therapy to control Salmonella infection.

Hoang KV, Borteh HM, Rajaram MV, Peine KJ, Curry H, Collier MA, Homsy ML, Bachelder EM, Gunn JS, Schlesinger LS, Ainslie KM.

Int J Pharm. 2014 Dec 30;477(1-2):334-43. doi: 10.1016/j.ijpharm.2014.10.022. Epub 2014 Oct 22.


Chemoproteomics reveals Toll-like receptor fatty acylation.

Chesarino NM, Hach JC, Chen JL, Zaro BW, Rajaram MV, Turner J, Schlesinger LS, Pratt MR, Hang HC, Yount JS.

BMC Biol. 2014 Nov 5;12:91. doi: 10.1186/s12915-014-0091-3.


Mycobacterium tuberculosis decreases human macrophage IFN-γ responsiveness through miR-132 and miR-26a.

Ni B, Rajaram MV, Lafuse WP, Landes MB, Schlesinger LS.

J Immunol. 2014 Nov 1;193(9):4537-47. doi: 10.4049/jimmunol.1400124. Epub 2014 Sep 24.


Exploitation of the Macrophage Mannose Receptor (CD206) in Infectious Disease Diagnostics and Therapeutics.

Azad AK, Rajaram MV, Schlesinger LS.

J Cytol Mol Biol. 2014 Jan 10;1(1). pii: 1000003.


Molecular composition of the alveolar lining fluid in the aging lung.

Moliva JI, Rajaram MV, Sidiki S, Sasindran SJ, Guirado E, Pan XJ, Wang SH, Ross P Jr, Lafuse WP, Schlesinger LS, Turner J, Torrelles JB.

Age (Dordr). 2014 Jun;36(3):9633. doi: 10.1007/s11357-014-9633-4. Epub 2014 Mar 3.


Estrogen modulation of endosome-associated toll-like receptor 8: an IFNα-independent mechanism of sex-bias in systemic lupus erythematosus.

Young NA, Wu LC, Burd CJ, Friedman AK, Kaffenberger BH, Rajaram MV, Schlesinger LS, James H, Shupnik MA, Jarjour WN.

Clin Immunol. 2014 Mar;151(1):66-77. doi: 10.1016/j.clim.2014.01.006. Epub 2014 Jan 24.


N-glycolylated peptidoglycan contributes to the immunogenicity but not pathogenicity of Mycobacterium tuberculosis.

Hansen JM, Golchin SA, Veyrier FJ, Domenech P, Boneca IG, Azad AK, Rajaram MV, Schlesinger LS, Divangahi M, Reed MB, Behr MA.

J Infect Dis. 2014 Apr 1;209(7):1045-54. doi: 10.1093/infdis/jit622. Epub 2013 Nov 21.


Type A Francisella tularensis acid phosphatases contribute to pathogenesis.

Mohapatra NP, Soni S, Rajaram MV, Strandberg KL, Gunn JS.

PLoS One. 2013;8(2):e56834. doi: 10.1371/journal.pone.0056834. Epub 2013 Feb 15.


Fine tuning inflammation at the front door: macrophage complement receptor 3-mediates phagocytosis and immune suppression for Francisella tularensis.

Dai S, Rajaram MV, Curry HM, Leander R, Schlesinger LS.

PLoS Pathog. 2013 Jan;9(1):e1003114. doi: 10.1371/journal.ppat.1003114. Epub 2013 Jan 24. Erratum in: PLoS Pathog. 2016 Mar;12(3):e1005504.


Novel estrogen target gene ZAS3 is overexpressed in systemic lupus erythematosus.

Young NA, Friedman AK, Kaffenberger B, Rajaram MV, Birmingham DJ, Rovin BH, Hebert LA, Schlesinger LS, Wu LC, Jarjour WN.

Mol Immunol. 2013 May;54(1):23-31. doi: 10.1016/j.molimm.2012.10.026. Epub 2012 Nov 22.


MiR-155 induction by microbes/microbial ligands requires NF-κB-dependent de novo protein synthesis.

Cremer TJ, Fatehchand K, Shah P, Gillette D, Patel H, Marsh RL, Besecker BY, Rajaram MV, Cormet-Boyaka E, Kanneganti TD, Schlesinger LS, Butchar JP, Tridandapani S.

Front Cell Infect Microbiol. 2012 Jun 1;2:73. doi: 10.3389/fcimb.2012.00073. eCollection 2012.


Pulmonary surfactant protein A and surfactant lipids upregulate IRAK-M, a negative regulator of TLR-mediated inflammation in human macrophages.

Nguyen HA, Rajaram MV, Meyer DA, Schlesinger LS.

Am J Physiol Lung Cell Mol Physiol. 2012 Oct 1;303(7):L608-16. doi: 10.1152/ajplung.00067.2012. Epub 2012 Aug 10.


Mycobacterium tuberculosis lipomannan blocks TNF biosynthesis by regulating macrophage MAPK-activated protein kinase 2 (MK2) and microRNA miR-125b.

Rajaram MV, Ni B, Morris JD, Brooks MN, Carlson TK, Bakthavachalu B, Schoenberg DR, Torrelles JB, Schlesinger LS.

Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):17408-13. doi: 10.1073/pnas.1112660108. Epub 2011 Oct 3.


Structural differences in lipomannans from pathogenic and nonpathogenic mycobacteria that impact CD1b-restricted T cell responses.

Torrelles JB, Sieling PA, Arcos J, Knaup R, Bartling C, Rajaram MV, Stenger S, Modlin RL, Schlesinger LS.

J Biol Chem. 2011 Oct 14;286(41):35438-46. doi: 10.1074/jbc.M111.232587. Epub 2011 Aug 22.


β-Glucans inhibit intracellular growth of Mycobacterium bovis BCG but not virulent Mycobacterium tuberculosis in human macrophages.

Betz BE, Azad AK, Morris JD, Rajaram MVS, Schlesinger LS.

Microb Pathog. 2011 Oct;51(4):233-242. doi: 10.1016/j.micpath.2011.06.006. Epub 2011 Jul 5.


NOD2 controls the nature of the inflammatory response and subsequent fate of Mycobacterium tuberculosis and M. bovis BCG in human macrophages.

Brooks MN, Rajaram MV, Azad AK, Amer AO, Valdivia-Arenas MA, Park JH, Núñez G, Schlesinger LS.

Cell Microbiol. 2011 Mar;13(3):402-18. doi: 10.1111/j.1462-5822.2010.01544.x. Epub 2010 Nov 24.


Mycobacterium tuberculosis activates human macrophage peroxisome proliferator-activated receptor gamma linking mannose receptor recognition to regulation of immune responses.

Rajaram MV, Brooks MN, Morris JD, Torrelles JB, Azad AK, Schlesinger LS.

J Immunol. 2010 Jul 15;185(2):929-42. doi: 10.4049/jimmunol.1000866. Epub 2010 Jun 16.


Francisella acid phosphatases inactivate the NADPH oxidase in human phagocytes.

Mohapatra NP, Soni S, Rajaram MV, Dang PM, Reilly TJ, El-Benna J, Clay CD, Schlesinger LS, Gunn JS.

J Immunol. 2010 May 1;184(9):5141-50. doi: 10.4049/jimmunol.0903413. Epub 2010 Mar 26.


Akt and SHIP modulate Francisella escape from the phagosome and induction of the Fas-mediated death pathway.

Rajaram MV, Butchar JP, Parsa KV, Cremer TJ, Amer A, Schlesinger LS, Tridandapani S.

PLoS One. 2009 Nov 20;4(11):e7919. doi: 10.1371/journal.pone.0007919.


Mannose receptor-dependent delay in phagosome maturation by Mycobacterium avium glycopeptidolipids.

Sweet L, Singh PP, Azad AK, Rajaram MV, Schlesinger LS, Schorey JS.

Infect Immun. 2010 Jan;78(1):518-26. doi: 10.1128/IAI.00257-09. Epub 2009 Oct 19.


Francisella gains a survival advantage within mononuclear phagocytes by suppressing the host IFNgamma response.

Parsa KV, Butchar JP, Rajaram MV, Cremer TJ, Gunn JS, Schlesinger LS, Tridandapani S.

Mol Immunol. 2008 Jul;45(12):3428-37. doi: 10.1016/j.molimm.2008.04.006. Epub 2008 Jun 2.


The tyrosine kinase Syk promotes phagocytosis of Francisella through the activation of Erk.

Parsa KV, Butchar JP, Rajaram MV, Cremer TJ, Tridandapani S.

Mol Immunol. 2008 May;45(10):3012-21. doi: 10.1016/j.molimm.2008.01.011. Epub 2008 Mar 4.


Francisella tularensis induces IL-23 production in human monocytes.

Butchar JP, Rajaram MV, Ganesan LP, Parsa KV, Clay CD, Schlesinger LS, Tridandapani S.

J Immunol. 2007 Apr 1;178(7):4445-54.


Akt/Protein kinase B modulates macrophage inflammatory response to Francisella infection and confers a survival advantage in mice.

Rajaram MV, Ganesan LP, Parsa KV, Butchar JP, Gunn JS, Tridandapani S.

J Immunol. 2006 Nov 1;177(9):6317-24.


Macrophage pro-inflammatory response to Francisella novicida infection is regulated by SHIP.

Parsa KV, Ganesan LP, Rajaram MV, Gavrilin MA, Balagopal A, Mohapatra NP, Wewers MD, Schlesinger LS, Gunn JS, Tridandapani S.

PLoS Pathog. 2006 Jul;2(7):e71.

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