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Items: 38

1.

North American ginseng (Panax quinquefolius) suppresses β-adrenergic-dependent signalling, hypertrophy, and cardiac dysfunction.

Tang X, Gan XT, Rajapurohitam V, Huang CX, Xue J, Lui EM, Karmazyn M.

Can J Physiol Pharmacol. 2016 Dec;94(12):1325-1335. Epub 2016 Aug 17.

PMID:
27797280
2.

Cardiomyocyte Antihypertrophic Effect of Adipose Tissue Conditioned Medium from Rats and Its Abrogation by Obesity is Mediated by the Leptin to Adiponectin Ratio.

Bairwa SC, Rajapurohitam V, Gan XT, Mangat R, Proctor SD, Karmazyn M.

PLoS One. 2016 Jan 5;11(1):e0145992. doi: 10.1371/journal.pone.0145992. eCollection 2016.

3.

Myocardial Hypertrophic Remodeling and Impaired Left Ventricular Function in Mice with a Cardiac-Specific Deletion of Janus Kinase 2.

Gan XT, Rajapurohitam V, Xue J, Huang C, Bairwa S, Tang X, Chow JT, Liu MF, Chiu F, Sakamoto K, Wagner KU, Karmazyn M.

Am J Pathol. 2015 Dec;185(12):3202-10. doi: 10.1016/j.ajpath.2015.08.007.

4.

Identification of functional leptin receptors expressed in ventricular mitochondria.

Martinez-Abundis E, Rajapurohitam V, Gertler A, Karmazyn M.

Mol Cell Biochem. 2015 Oct;408(1-2):155-62. doi: 10.1007/s11010-015-2491-2. Epub 2015 Jun 30.

PMID:
26122392
5.

Early and transient sodium-hydrogen exchanger isoform 1 inhibition attenuates subsequent cardiac hypertrophy and heart failure following coronary artery ligation.

Kilić A, Huang CX, Rajapurohitam V, Madwed JB, Karmazyn M.

J Pharmacol Exp Ther. 2014 Dec;351(3):492-9. doi: 10.1124/jpet.114.217091. Epub 2014 Sep 12.

PMID:
25216745
6.

Probiotic administration attenuates myocardial hypertrophy and heart failure after myocardial infarction in the rat.

Gan XT, Ettinger G, Huang CX, Burton JP, Haist JV, Rajapurohitam V, Sidaway JE, Martin G, Gloor GB, Swann JR, Reid G, Karmazyn M.

Circ Heart Fail. 2014 May;7(3):491-9. doi: 10.1161/CIRCHEARTFAILURE.113.000978. Epub 2014 Mar 13.

PMID:
24625365
7.

The potential contribution of circulating and locally produced leptin to cardiac hypertrophy and failure.

Karmazyn M, Gan XT, Rajapurohitam V.

Can J Physiol Pharmacol. 2013 Nov;91(11):883-8. doi: 10.1139/cjpp-2013-0057. Epub 2013 May 8. Review.

PMID:
24117255
8.

Leptin as a cardiac pro-hypertrophic factor and its potential role in the development of heart failure.

Karmazyn M, Rajapurohitam V.

Curr Pharm Des. 2014;20(4):646-51. Review.

PMID:
23688017
9.

Leptin-induced cardiomyocyte hypertrophy reveals both calcium-dependent and calcium-independent/RhoA-dependent calcineurin activation and NFAT nuclear translocation.

Rajapurohitam V, Izaddoustdar F, Martinez-Abundis E, Karmazyn M.

Cell Signal. 2012 Dec;24(12):2283-90. doi: 10.1016/j.cellsig.2012.07.025. Epub 2012 Aug 15.

PMID:
22917533
10.

The obesity-related peptide leptin sensitizes cardiac mitochondria to calcium-induced permeability transition pore opening and apoptosis.

Martinez-Abundis E, Rajapurohitam V, Haist JV, Gan XT, Karmazyn M.

PLoS One. 2012;7(7):e41612. doi: 10.1371/journal.pone.0041612. Epub 2012 Jul 25.

11.

Ginseng reverses established cardiomyocyte hypertrophy and postmyocardial infarction-induced hypertrophy and heart failure.

Moey M, Gan XT, Huang CX, Rajapurohitam V, Martínez-Abundis E, Lui EM, Karmazyn M.

Circ Heart Fail. 2012 Jul 1;5(4):504-14. doi: 10.1161/CIRCHEARTFAILURE.112.967489. Epub 2012 May 10.

PMID:
22576957
12.

Role of NF-κB and p38 MAPK activation in mediating angiotensin II and endothelin-1-induced stimulation in leptin production and cardiomyocyte hypertrophy.

Rajapurohitam V, Kilic A, Javadov S, Karmazyn M.

Mol Cell Biochem. 2012 Jul;366(1-2):287-97. doi: 10.1007/s11010-012-1307-x. Epub 2012 Apr 20.

PMID:
22527934
13.

Ouabain increases iNOS-dependent nitric oxide generation which contributes to the hypertrophic effect of the glycoside: possible role of peroxynitrite formation.

Gan XT, Hunter JC, Huang C, Xue J, Rajapurohitam V, Javadov S, Karmazyn M.

Mol Cell Biochem. 2012 Apr;363(1-2):323-33. doi: 10.1007/s11010-011-1185-7. Epub 2011 Dec 10.

PMID:
22160804
15.

Ginseng inhibits cardiomyocyte hypertrophy and heart failure via NHE-1 inhibition and attenuation of calcineurin activation.

Guo J, Gan XT, Haist JV, Rajapurohitam V, Zeidan A, Faruq NS, Karmazyn M.

Circ Heart Fail. 2011 Jan;4(1):79-88. doi: 10.1161/CIRCHEARTFAILURE.110.957969. Epub 2010 Oct 22.

PMID:
20971938
16.

Expression of mitochondrial fusion-fission proteins during post-infarction remodeling: the effect of NHE-1 inhibition.

Javadov S, Rajapurohitam V, Kilić A, Hunter JC, Zeidan A, Said Faruq N, Escobales N, Karmazyn M.

Basic Res Cardiol. 2011 Jan;106(1):99-109. doi: 10.1007/s00395-010-0122-3. Epub 2010 Oct 1.

PMID:
20886221
17.

A novel chimeric natriuretic peptide reduces cardiomyocyte hypertrophy through the NHE-1-calcineurin pathway.

Kilic A, Rajapurohitam V, Sandberg SM, Zeidan A, Hunter JC, Said Faruq N, Lee CY, Burnett JC Jr, Karmazyn M.

Cardiovasc Res. 2010 Dec 1;88(3):434-42. doi: 10.1093/cvr/cvq254. Epub 2010 Aug 2.

18.

Differential AMPK phosphorylation sites associated with phenylephrine vs. antihypertrophic effects of adenosine agonists in neonatal rat ventricular myocytes.

Pang T, Rajapurohitam V, Cook MA, Karmazyn M.

Am J Physiol Heart Circ Physiol. 2010 May;298(5):H1382-90. doi: 10.1152/ajpheart.00424.2009. Epub 2010 Feb 26.

19.

Nitric oxide inhibits endothelin-1-induced neonatal cardiomyocyte hypertrophy via a RhoA-ROCK-dependent pathway.

Hunter JC, Zeidan A, Javadov S, Kilić A, Rajapurohitam V, Karmazyn M.

J Mol Cell Cardiol. 2009 Dec;47(6):810-8. doi: 10.1016/j.yjmcc.2009.09.012. Epub 2009 Sep 30.

PMID:
19799911
20.

Anti-hypertrophic effect of NHE-1 inhibition involves GSK-3beta-dependent attenuation of mitochondrial dysfunction.

Javadov S, Rajapurohitam V, Kilić A, Zeidan A, Choi A, Karmazyn M.

J Mol Cell Cardiol. 2009 Jun;46(6):998-1007. doi: 10.1016/j.yjmcc.2008.12.023. Epub 2009 Jan 20.

PMID:
19318234
21.

Signalling mechanisms underlying the metabolic and other effects of adipokines on the heart.

Karmazyn M, Purdham DM, Rajapurohitam V, Zeidan A.

Cardiovasc Res. 2008 Jul 15;79(2):279-86. doi: 10.1093/cvr/cvn115. Epub 2008 May 12. Review.

PMID:
18474523
22.

A neutralizing leptin receptor antibody mitigates hypertrophy and hemodynamic dysfunction in the postinfarcted rat heart.

Purdham DM, Rajapurohitam V, Zeidan A, Huang C, Gross GJ, Karmazyn M.

Am J Physiol Heart Circ Physiol. 2008 Jul;295(1):H441-6. doi: 10.1152/ajpheart.91537.2007. Epub 2008 May 9.

23.

NHE-1 inhibition-induced cardioprotection against ischaemia/reperfusion is associated with attenuation of the mitochondrial permeability transition.

Javadov S, Choi A, Rajapurohitam V, Zeidan A, Basnakian AG, Karmazyn M.

Cardiovasc Res. 2008 Jan 15;77(2):416-24. Epub 2007 Oct 18.

PMID:
18006455
24.

Leptin as a cardiac hypertrophic factor: a potential target for therapeutics.

Karmazyn M, Purdham DM, Rajapurohitam V, Zeidan A.

Trends Cardiovasc Med. 2007 Aug;17(6):206-11. Review.

PMID:
17662916
25.

Actin cytoskeleton dynamics promotes leptin-induced vascular smooth muscle hypertrophy via RhoA/ROCK- and phosphatidylinositol 3-kinase/protein kinase B-dependent pathways.

Zeidan A, Paylor B, Steinhoff KJ, Javadov S, Rajapurohitam V, Chakrabarti S, Karmazyn M.

J Pharmacol Exp Ther. 2007 Sep;322(3):1110-6. Epub 2007 Jun 11.

PMID:
17562852
26.

An autocrine role for leptin in mediating the cardiomyocyte hypertrophic effects of angiotensin II and endothelin-1.

Rajapurohitam V, Javadov S, Purdham DM, Kirshenbaum LA, Karmazyn M.

J Mol Cell Cardiol. 2006 Aug;41(2):265-74. Epub 2006 Jun 23.

PMID:
16806260
28.

Leptin induces vascular smooth muscle cell hypertrophy through angiotensin II- and endothelin-1-dependent mechanisms and mediates stretch-induced hypertrophy.

Zeidan A, Purdham DM, Rajapurohitam V, Javadov S, Chakrabarti S, Karmazyn M.

J Pharmacol Exp Ther. 2005 Dec;315(3):1075-84. Epub 2005 Sep 6.

PMID:
16144973
29.

Inhibition of phenylephrine induced hypertrophy in rat neonatal cardiomyocytes by the mitochondrial KATP channel opener diazoxide.

Xia Y, Rajapurohitam V, Cook MA, Karmazyn M.

J Mol Cell Cardiol. 2004 Nov;37(5):1063-7.

PMID:
15522283
30.

Inhibition of phenylephrine-induced cardiomyocyte hypertrophy by activation of multiple adenosine receptor subtypes.

Gan XT, Rajapurohitam V, Haist JV, Chidiac P, Cook MA, Karmazyn M.

J Pharmacol Exp Ther. 2005 Jan;312(1):27-34. Epub 2004 Sep 27.

PMID:
15452191
31.

Rat heart is a site of leptin production and action.

Purdham DM, Zou MX, Rajapurohitam V, Karmazyn M.

Am J Physiol Heart Circ Physiol. 2004 Dec;287(6):H2877-84. Epub 2004 Jul 29.

32.

The obesity-associated peptide leptin induces hypertrophy in neonatal rat ventricular myocytes.

Rajapurohitam V, Gan XT, Kirshenbaum LA, Karmazyn M.

Circ Res. 2003 Aug 22;93(4):277-9. Epub 2003 Jul 31.

PMID:
12893740
33.

Grey-lethal mutation induces severe malignant autosomal recessive osteopetrosis in mouse and human.

Chalhoub N, Benachenhou N, Rajapurohitam V, Pata M, Ferron M, Frattini A, Villa A, Vacher J.

Nat Med. 2003 Apr;9(4):399-406. Epub 2003 Mar 10.

PMID:
12627228
34.

Characterization of rat100, a 300-kilodalton ubiquitin-protein ligase induced in germ cells of the rat testis and similar to the Drosophila hyperplastic discs gene.

Oughtred R, Bedard N, Adegoke OA, Morales CR, Trasler J, Rajapurohitam V, Wing SS.

Endocrinology. 2002 Oct;143(10):3740-7.

PMID:
12239083
35.

Control of ubiquitination of proteins in rat tissues by ubiquitin conjugating enzymes and isopeptidases.

Rajapurohitam V, Bedard N, Wing SS.

Am J Physiol Endocrinol Metab. 2002 Apr;282(4):E739-45.

36.

The mouse osteopetrotic grey-lethal mutation induces a defect in osteoclast maturation/function.

Rajapurohitam V, Chalhoub N, Benachenhou N, Neff L, Baron R, Vacher J.

Bone. 2001 May;28(5):513-23.

PMID:
11344051
37.

Role of c-Src in the regulation of vascular contraction and Ca2+ signaling by angiotensin II in human vascular smooth muscle cells.

Touyz RM, Wu XH, He G, Park JB, Chen X, Vacher J, Rajapurohitam V, Schiffrin EL.

J Hypertens. 2001 Mar;19(3):441-9.

PMID:
11288814
38.

Activation of a UBC4-dependent pathway of ubiquitin conjugation during postnatal development of the rat testis.

Rajapurohitam V, Morales CR, El-Alfy M, Lefrançois S, Bedard N, Wing SS.

Dev Biol. 1999 Aug 1;212(1):217-28.

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