Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 45

1.

Biophysical Interactions of Direct AMPK Activators.

Kurumbail RG, West GM, Dharmarajan V, Borzilleri KA, Withka JM, Ward J, Reyes AR, Rajamohan F, Griffin PR, Calabrese MF.

Methods Mol Biol. 2018;1732:29-55. doi: 10.1007/978-1-4939-7598-3_3.

PMID:
29480467
2.

Optimization of Metabolic and Renal Clearance in a Series of Indole Acid Direct Activators of 5'-Adenosine Monophosphate-Activated Protein Kinase (AMPK).

Edmonds DJ, Kung DW, Kalgutkar AS, Filipski KJ, Ebner DC, Cabral S, Smith AC, Aspnes GE, Bhattacharya SK, Borzilleri KA, Brown JA, Calabrese MF, Caspers NL, Cokorinos EC, Conn EL, Dowling MS, Eng H, Feng B, Fernando DP, Genung NE, Herr M, Kurumbail RG, Lavergne SY, Lee EC, Li Q, Mathialagan S, Miller RA, Panteleev J, Polivkova J, Rajamohan F, Reyes AR, Salatto CT, Shavnya A, Thuma BA, Tu M, Ward J, Withka JM, Xiao J, Cameron KO.

J Med Chem. 2018 Mar 22;61(6):2372-2383. doi: 10.1021/acs.jmedchem.7b01641. Epub 2018 Feb 28.

PMID:
29466005
3.

Selective Activation of AMPK β1-Containing Isoforms Improves Kidney Function in a Rat Model of Diabetic Nephropathy.

Salatto CT, Miller RA, Cameron KO, Cokorinos E, Reyes A, Ward J, Calabrese MF, Kurumbail RG, Rajamohan F, Kalgutkar AS, Tess DA, Shavnya A, Genung NE, Edmonds DJ, Jatkar A, Maciejewski BS, Amaro M, Gandhok H, Monetti M, Cialdea K, Bollinger E, Kreeger JM, Coskran TM, Opsahl AC, Boucher GG, Birnbaum MJ, DaSilva-Jardine P, Rolph T.

J Pharmacol Exp Ther. 2017 May;361(2):303-311. doi: 10.1124/jpet.116.237925. Epub 2017 Mar 13.

PMID:
28289077
4.

Development of a high-throughput crystal structure-determination platform for JAK1 using a novel metal-chelator soaking system.

Caspers NL, Han S, Rajamohan F, Hoth LR, Geoghegan KF, Subashi TA, Vazquez ML, Kaila N, Cronin CN, Johnson E, Kurumbail RG.

Acta Crystallogr F Struct Biol Commun. 2016 Nov 1;72(Pt 11):840-845. Epub 2016 Oct 27.

5.

Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy.

Cameron KO, Kung DW, Kalgutkar AS, Kurumbail RG, Miller R, Salatto CT, Ward J, Withka JM, Bhattacharya SK, Boehm M, Borzilleri KA, Brown JA, Calabrese M, Caspers NL, Cokorinos E, Conn EL, Dowling MS, Edmonds DJ, Eng H, Fernando DP, Frisbie R, Hepworth D, Landro J, Mao Y, Rajamohan F, Reyes AR, Rose CR, Ryder T, Shavnya A, Smith AC, Tu M, Wolford AC, Xiao J.

J Med Chem. 2016 Sep 8;59(17):8068-81. doi: 10.1021/acs.jmedchem.6b00866. Epub 2016 Aug 20.

PMID:
27490827
6.

Development of a selective activity-based probe for glycosylated LIPA.

Schwaid AG, Ruangsiriluk W, Reyes AR, Cabral S, Rajamohan F, Tu M, Ward J, Carpino PA.

Bioorg Med Chem Lett. 2016 Apr 15;26(8):1993-6. doi: 10.1016/j.bmcl.2016.02.089. Epub 2016 Mar 2.

PMID:
26965858
7.

Probing the enzyme kinetics, allosteric modulation and activation of α1- and α2-subunit-containing AMP-activated protein kinase (AMPK) heterotrimeric complexes by pharmacological and physiological activators.

Rajamohan F, Reyes AR, Frisbie RK, Hoth LR, Sahasrabudhe P, Magyar R, Landro JA, Withka JM, Caspers NL, Calabrese MF, Ward J, Kurumbail RG.

Biochem J. 2016 Mar 1;473(5):581-92. doi: 10.1042/BJ20151051. Epub 2015 Dec 3.

8.

Expression and functional characterization of human lysosomal acid lipase gene (LIPA) mutation responsible for cholesteryl ester storage disease (CESD) phenotype.

Rajamohan F, Reyes AR, Ruangsiriluk W, Hoth LR, Han S, Caspers N, Tu M, Ward J, Kurumbail RG.

Protein Expr Purif. 2015 Jun;110:22-9. doi: 10.1016/j.pep.2014.12.009. Epub 2015 Jan 22.

PMID:
25620107
9.

Structural basis for AMPK activation: natural and synthetic ligands regulate kinase activity from opposite poles by different molecular mechanisms.

Calabrese MF, Rajamohan F, Harris MS, Caspers NL, Magyar R, Withka JM, Wang H, Borzilleri KA, Sahasrabudhe PV, Hoth LR, Geoghegan KF, Han S, Brown J, Subashi TA, Reyes AR, Frisbie RK, Ward J, Miller RA, Landro JA, Londregan AT, Carpino PA, Cabral S, Smith AC, Conn EL, Cameron KO, Qiu X, Kurumbail RG.

Structure. 2014 Aug 5;22(8):1161-1172. doi: 10.1016/j.str.2014.06.009. Epub 2014 Jul 24.

10.

Selectively targeting an inactive conformation of interleukin-2-inducible T-cell kinase by allosteric inhibitors.

Han S, Czerwinski RM, Caspers NL, Limburg DC, Ding W, Wang H, Ohren JF, Rajamohan F, McLellan TJ, Unwalla R, Choi C, Parikh MD, Seth N, Edmonds J, Phillips C, Shakya S, Li X, Spaulding V, Hughes S, Cook A, Robinson C, Mathias JP, Navratilova I, Medley QG, Anderson DR, Kurumbail RG, Aulabaugh A.

Biochem J. 2014 Jun 1;460(2):211-22. doi: 10.1042/BJ20131139.

PMID:
24593284
11.

Activation of AMP-activated protein kinase revealed by hydrogen/deuterium exchange mass spectrometry.

Landgraf RR, Goswami D, Rajamohan F, Harris MS, Calabrese MF, Hoth LR, Magyar R, Pascal BD, Chalmers MJ, Busby SA, Kurumbail RG, Griffin PR.

Structure. 2013 Nov 5;21(11):1942-53. doi: 10.1016/j.str.2013.08.023. Epub 2013 Sep 26.

12.

Biophysical and mechanistic insights into novel allosteric inhibitor of spleen tyrosine kinase.

Hall J, Aulabaugh A, Rajamohan F, Liu S, Kaila N, Wan ZK, Ryan M, Magyar R, Qiu X.

J Biol Chem. 2012 Mar 2;287(10):7717-27. doi: 10.1074/jbc.M111.311993. Epub 2012 Jan 4.

13.

Structure-guided inhibitor design for human acetyl-coenzyme A carboxylase by interspecies active site conversion.

Rajamohan F, Marr E, Reyes AR, Landro JA, Anderson MD, Corbett JW, Dirico KJ, Harwood JH, Tu M, Vajdos FF.

J Biol Chem. 2011 Dec 2;286(48):41510-9. doi: 10.1074/jbc.M111.275396. Epub 2011 Sep 27.

14.

Initiation of translation at an upstream non-AUG codon accounting for N-terminally extended minor forms of recombinant proteins expressed in insect cells.

Geoghegan KF, Feng X, Chang JS, Kelleher K, Wu PW, Lin L, Rajamohan F.

Protein Expr Purif. 2011 Mar;76(1):72-8. doi: 10.1016/j.pep.2010.09.015. Epub 2010 Oct 1.

PMID:
20888915
15.

Entrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymes.

Meng QJ, Maywood ES, Bechtold DA, Lu WQ, Li J, Gibbs JE, Dupré SM, Chesham JE, Rajamohan F, Knafels J, Sneed B, Zawadzke LE, Ohren JF, Walton KM, Wager TT, Hastings MH, Loudon AS.

Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15240-5. doi: 10.1073/pnas.1005101107. Epub 2010 Aug 9.

16.

Design of selective, ATP-competitive inhibitors of Akt.

Freeman-Cook KD, Autry C, Borzillo G, Gordon D, Barbacci-Tobin E, Bernardo V, Briere D, Clark T, Corbett M, Jakubczak J, Kakar S, Knauth E, Lippa B, Luzzio MJ, Mansour M, Martinelli G, Marx M, Nelson K, Pandit J, Rajamohan F, Robinson S, Subramanyam C, Wei L, Wythes M, Morris J.

J Med Chem. 2010 Jun 24;53(12):4615-22. doi: 10.1021/jm1003842. Erratum in: J Med Chem. 2010 Aug 12;53(15):5895.

PMID:
20481595
17.

Escherichia coli expression, purification and characterization of functional full-length recombinant alpha2beta2gamma3 heterotrimeric complex of human AMP-activated protein kinase.

Rajamohan F, Harris MS, Frisbie RK, Hoth LR, Geoghegan KF, Valentine JJ, Reyes AR, Landro JA, Qiu X, Kurumbail RG.

Protein Expr Purif. 2010 Oct;73(2):189-97. doi: 10.1016/j.pep.2010.04.022. Epub 2010 May 6.

PMID:
20451617
18.

Discovery of small molecule isozyme non-specific inhibitors of mammalian acetyl-CoA carboxylase 1 and 2.

Corbett JW, Freeman-Cook KD, Elliott R, Vajdos F, Rajamohan F, Kohls D, Marr E, Zhang H, Tong L, Tu M, Murdande S, Doran SD, Houser JA, Song W, Jones CJ, Coffey SB, Buzon L, Minich ML, Dirico KJ, Tapley S, McPherson RK, Sugarman E, Harwood HJ Jr, Esler W.

Bioorg Med Chem Lett. 2010 Apr 1;20(7):2383-8. doi: 10.1016/j.bmcl.2009.04.091. Epub 2009 Apr 24.

PMID:
20219367
19.

Selective inhibition of casein kinase 1 epsilon minimally alters circadian clock period.

Walton KM, Fisher K, Rubitski D, Marconi M, Meng QJ, Sládek M, Adams J, Bass M, Chandrasekaran R, Butler T, Griffor M, Rajamohan F, Serpa M, Chen Y, Claffey M, Hastings M, Loudon A, Maywood E, Ohren J, Doran A, Wager TT.

J Pharmacol Exp Ther. 2009 Aug;330(2):430-9. doi: 10.1124/jpet.109.151415. Epub 2009 May 19.

PMID:
19458106
20.

Alanine aminotransferase isoenzymes: molecular cloning and quantitative analysis of tissue expression in rats and serum elevation in liver toxicity.

Yang RZ, Park S, Reagan WJ, Goldstein R, Zhong S, Lawton M, Rajamohan F, Qian K, Liu L, Gong DW.

Hepatology. 2009 Feb;49(2):598-607. doi: 10.1002/hep.22657.

21.

Synthesis and structure based optimization of novel Akt inhibitors.

Lippa B, Pan G, Corbett M, Li C, Kauffman GS, Pandit J, Robinson S, Wei L, Kozina E, Marr ES, Borzillo G, Knauth E, Barbacci-Tobin EG, Vincent P, Troutman M, Baker D, Rajamohan F, Kakar S, Clark T, Morris J.

Bioorg Med Chem Lett. 2008 Jun 1;18(11):3359-63. doi: 10.1016/j.bmcl.2008.04.034. Epub 2008 Apr 15.

PMID:
18456494
22.

cDNA cloning, expression, purification, distribution, and characterization of biologically active canine alanine aminotransferase-1.

Rajamohan F, Nelms L, Joslin DL, Lu B, Reagan WJ, Lawton M.

Protein Expr Purif. 2006 Jul;48(1):81-9. Epub 2006 Jan 30.

PMID:
16495081
23.

Phosphorylation of serine residues in histidine-tag sequences attached to recombinant protein kinases: a cause of heterogeneity in mass and complications in function.

Du P, Loulakis P, Luo C, Mistry A, Simons SP, LeMotte PK, Rajamohan F, Rafidi K, Coleman KG, Geoghegan KF, Xie Z.

Protein Expr Purif. 2005 Dec;44(2):121-9.

PMID:
15946859
24.

High resolution X-ray structure and potent anti-HIV activity of recombinant dianthin antiviral protein.

Kurinov IV, Rajamohan F, Uckun FM.

Arzneimittelforschung. 2004;54(10):692-702.

PMID:
15553110
25.

Structure-based design and engineering of a nontoxic recombinant pokeweed antiviral protein with potent anti-human immunodeficiency virus activity.

Uckun FM, Rajamohan F, Pendergrass S, Ozer Z, Waurzyniak B, Mao C.

Antimicrob Agents Chemother. 2003 Mar;47(3):1052-61.

26.

Active center cleft residues of pokeweed antiviral protein mediate its high-affinity binding to the ribosomal protein L3.

Rajamohan F, Ozer Z, Mao C, Uckun FM.

Biochemistry. 2001 Aug 7;40(31):9104-14.

PMID:
11478877
27.
29.

Identification of the functional site in the mosquito larvicidal binary toxin of Bacillus sphaericus 1593M by site-directed mutagenesis.

Elangovan G, Shanmugavelu M, Rajamohan F, Dean DH, Jayaraman K.

Biochem Biophys Res Commun. 2000 Oct 5;276(3):1048-55.

PMID:
11027588
30.

Expression of biologically active recombinant pokeweed antiviral protein in methylotrophic yeast Pichia pastoris.

Rajamohan F, Doumbia SO, Engstrom CR, Pendergras SL, Maher DL, Uckun FM.

Protein Expr Purif. 2000 Mar;18(2):193-201.

PMID:
10686150
31.

Modeling and alanine scanning mutagenesis studies of recombinant pokeweed antiviral protein.

Rajamohan F, Pugmire MJ, Kurinov IV, Uckun FM.

J Biol Chem. 2000 Feb 4;275(5):3382-90.

32.
33.

Deguanylation of human immunodeficiency virus (HIV-1) RNA by recombinant pokeweed antiviral protein.

Rajamohan F, Kurinov IV, Venkatachalam TK, Uckun FM.

Biochem Biophys Res Commun. 1999 Sep 24;263(2):419-24.

PMID:
10491308
34.

High-level expression and purification of biologically active recombinant pokeweed antiviral protein.

Rajamohan F, Engstrom CR, Denton TJ, Engen LA, Kourinov I, Uckun FM.

Protein Expr Purif. 1999 Jul;16(2):359-68.

PMID:
10419833
35.

Pokeweed antiviral protein isoforms PAP-I, PAP-II, and PAP-III depurinate RNA of human immunodeficiency virus (HIV)-1.

Rajamohan F, Venkatachalam TK, Irvin JD, Uckun FM.

Biochem Biophys Res Commun. 1999 Jul 5;260(2):453-8.

PMID:
10403789
36.

Bacillus thuringiensis insecticidal proteins: molecular mode of action.

Rajamohan F, Lee MK, Dean DH.

Prog Nucleic Acid Res Mol Biol. 1998;60:1-27. Review.

PMID:
9594569
37.

Functional complementation of nontoxic mutant binary toxins of Bacillus sphaericus 1593M generated by site-directed mutagenesis.

Shanmugavelu M, Rajamohan F, Kathirvel M, Elangovan G, Dean DH, Jayaraman K.

Appl Environ Microbiol. 1998 Feb;64(2):756-9.

38.
39.

Probing the mechanism of action of Bacillus thuringiensis insecticidal proteins by site-directed mutagenesis--a minireview.

Dean DH, Rajamohan F, Lee MK, Wu SJ, Chen XJ, Alcantara E, Hussain SR.

Gene. 1996 Nov 7;179(1):111-7. Review.

PMID:
8955636
40.
42.
43.
44.

Supplemental Content

Loading ...
Support Center