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Items: 1 to 50 of 203

1.

Effect of exchange of the cysteine molybdenum ligand with selenocysteine on the structure and function of the active site in human sulfite oxidase.

Reschke S, Niks D, Wilson H, Sigfridsson KG, Haumann M, Rajagopalan KV, Hille R, Leimkühler S.

Biochemistry. 2013 Nov 19;52(46):8295-303. doi: 10.1021/bi4008512. Epub 2013 Nov 7.

PMID:
24147957
2.

Structure-based alteration of substrate specificity and catalytic activity of sulfite oxidase from sulfite oxidation to nitrate reduction.

Qiu JA, Wilson HL, Rajagopalan KV.

Biochemistry. 2012 Feb 14;51(6):1134-47. doi: 10.1021/bi201206v. Epub 2012 Jan 30.

3.

Nature of halide binding to the molybdenum site of sulfite oxidase.

Pushie MJ, Doonan CJ, Wilson HL, Rajagopalan KV, George GN.

Inorg Chem. 2011 Oct 3;50(19):9406-13. doi: 10.1021/ic201030u. Epub 2011 Sep 6.

PMID:
21894921
4.

The History of the Discovery of the Molybdenum Cofactor and Novel Aspects of its Biosynthesis in Bacteria.

Leimkühler S, Wuebbens MM, Rajagopalan KV.

Coord Chem Rev. 2011 May 1;255(9-10):1129-1144.

5.

The structures of the C185S and C185A mutants of sulfite oxidase reveal rearrangement of the active site.

Qiu JA, Wilson HL, Pushie MJ, Kisker C, George GN, Rajagopalan KV.

Biochemistry. 2010 May 11;49(18):3989-4000. doi: 10.1021/bi1001954.

PMID:
20356030
6.

Structural studies of the molybdenum center of the pathogenic R160Q mutant of human sulfite oxidase by pulsed EPR spectroscopy and 17O and 33S labeling.

Astashkin AV, Johnson-Winters K, Klein EL, Feng C, Wilson HL, Rajagopalan KV, Raitsimring AM, Enemark JH.

J Am Chem Soc. 2008 Jul 2;130(26):8471-80. doi: 10.1021/ja801406f. Epub 2008 Jun 5.

7.

Studies of the Mo(V) Center of the Y343F Mutant of Human Sulfite Oxidase by Variable Frequency Pulsed EPR Spectroscopy.

Raitsimring AM, Astashkin AV, Feng C, Wilson HL, Rajagopalan KV, Enemark JH.

Inorganica Chim Acta. 2008 Mar 3;361(4):941-946.

8.

MoV electron paramagnetic resonance of sulfite oxidase revisited: the low-pH chloride signal.

Doonan CJ, Wilson HL, Bennett B, Prince RC, Rajagopalan KV, George GN.

Inorg Chem. 2008 Mar 17;47(6):2033-8. doi: 10.1021/ic7017083. Epub 2008 Feb 14.

9.

Layer-by-layer arrangement by protein-protein interaction of sulfite oxidase and cytochrome c catalyzing oxidation of sulfite.

Dronov R, Kurth DG, Möhwald H, Spricigo R, Leimkühler S, Wollenberger U, Rajagopalan KV, Scheller FW, Lisdat F.

J Am Chem Soc. 2008 Jan 30;130(4):1122-3. doi: 10.1021/ja0768690. Epub 2008 Jan 5. No abstract available.

PMID:
18177044
10.

Structure of the molybdenum site of Escherichia coli trimethylamine N-oxide reductase.

Zhang L, Nelson KJ, Rajagopalan KV, George GN.

Inorg Chem. 2008 Feb 4;47(3):1074-8. doi: 10.1021/ic701956f. Epub 2007 Dec 29.

PMID:
18163615
11.

Crystal structure of a molybdopterin synthase-precursor Z complex: insight into its sulfur transfer mechanism and its role in molybdenum cofactor deficiency.

Daniels JN, Wuebbens MM, Rajagopalan KV, Schindelin H.

Biochemistry. 2008 Jan 15;47(2):615-26. Epub 2007 Dec 20. Erratum in: Biochemistry. 2008 Mar 11;47(10):3315.

PMID:
18092812
12.

Modified active site coordination in a clinical mutant of sulfite oxidase.

Doonan CJ, Wilson HL, Rajagopalan KV, Garrett RM, Bennett B, Prince RC, George GN.

J Am Chem Soc. 2007 Aug 1;129(30):9421-8. Epub 2007 Jul 4. Erratum in: J Am Chem Soc. 2008 May 14;130(19):6298.

PMID:
17608478
13.

Interaction of product analogues with the active site of rhodobacter sphaeroides dimethyl sulfoxide reductase.

George GN, Nelson KJ, Harris HH, Doonan CJ, Rajagopalan KV.

Inorg Chem. 2007 Apr 16;46(8):3097-104. Epub 2007 Mar 16.

14.

Role of the C-terminal Gly-Gly motif of Escherichia coli MoaD, a molybdenum cofactor biosynthesis protein with a ubiquitin fold.

Schmitz J, Wuebbens MM, Rajagopalan KV, Leimkühler S.

Biochemistry. 2007 Jan 23;46(3):909-16.

PMID:
17223713
15.

Mutational analysis of Escherichia coli MoeA: two functional activities map to the active site cleft.

Nichols JD, Xiang S, Schindelin H, Rajagopalan KV.

Biochemistry. 2007 Jan 9;46(1):78-86.

16.

The G473D mutation impairs dimerization and catalysis in human sulfite oxidase.

Wilson HL, Wilkinson SR, Rajagopalan KV.

Biochemistry. 2006 Feb 21;45(7):2149-60.

PMID:
16475804
17.
18.

The pathogenic human sulfite oxidase mutants G473D and A208D are defective in intramolecular electron transfer.

Feng C, Wilson HL, Tollin G, Astashkin AV, Hazzard JT, Rajagopalan KV, Enemark JH.

Biochemistry. 2005 Oct 25;44(42):13734-43.

PMID:
16229463
19.

Structural insights into sulfite oxidase deficiency.

Karakas E, Wilson HL, Graf TN, Xiang S, Jaramillo-Busquets S, Rajagopalan KV, Kisker C.

J Biol Chem. 2005 Sep 30;280(39):33506-15. Epub 2005 Jul 27.

20.

Thermodynamic analysis of subunit interactions in Escherichia coli molybdopterin synthase.

Tong Y, Wuebbens MM, Rajagopalan KV, Fitzgerald MC.

Biochemistry. 2005 Feb 22;44(7):2595-601.

PMID:
15709772
21.

In vitro molybdenum ligation to molybdopterin using purified components.

Nichols JD, Rajagopalan KV.

J Biol Chem. 2005 Mar 4;280(9):7817-22. Epub 2005 Jan 4.

22.

Coordination chemistry at the molybdenum site of sulfite oxidase: redox-induced structural changes in the cysteine 207 to serine mutant.

George GN, Garrett RM, Prince RC, Rajagopalan KV.

Inorg Chem. 2004 Dec 27;43(26):8456-60.

PMID:
15606194
23.

Studies on the interaction of NADPH with Rhodobacter sphaeroides biotin sulfoxide reductase.

Nelson KJ, Rajagopalan KV.

Biochemistry. 2004 Sep 7;43(35):11226-37.

PMID:
15366932
24.

Evidence for the physiological role of a rhodanese-like protein for the biosynthesis of the molybdenum cofactor in humans.

Matthies A, Rajagopalan KV, Mendel RR, Leimkühler S.

Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):5946-51. Epub 2004 Apr 8.

25.

The role of tyrosine 343 in substrate binding and catalysis by human sulfite oxidase.

Wilson HL, Rajagopalan KV.

J Biol Chem. 2004 Apr 9;279(15):15105-13. Epub 2004 Jan 16.

26.

Essential role of conserved arginine 160 in intramolecular electron transfer in human sulfite oxidase.

Feng C, Wilson HL, Hurley JK, Hazzard JT, Tollin G, Rajagopalan KV, Enemark JH.

Biochemistry. 2003 Oct 28;42(42):12235-42.

PMID:
14567685
27.

The 1.2 A structure of the human sulfite oxidase cytochrome b(5) domain.

Rudolph MJ, Johnson JL, Rajagopalan KV, Kisker C.

Acta Crystallogr D Biol Crystallogr. 2003 Jul;59(Pt 7):1183-91. Epub 2003 Jun 27.

PMID:
12832761
28.

Mechanistic studies of human molybdopterin synthase reaction and characterization of mutants identified in group B patients of molybdenum cofactor deficiency.

Leimkuhler S, Freuer A, Araujo JA, Rajagopalan KV, Mendel RR.

J Biol Chem. 2003 Jul 11;278(28):26127-34. Epub 2003 May 5.

29.
30.

Structural studies of molybdopterin synthase provide insights into its catalytic mechanism.

Rudolph MJ, Wuebbens MM, Turque O, Rajagopalan KV, Schindelin H.

J Biol Chem. 2003 Apr 18;278(16):14514-22. Epub 2003 Feb 5.

31.
32.

Pulsed EPR studies of the exchangeable proton at the molybdenum center of dimethyl sulfoxide reductase.

Raitsimring AM, Astashkin AV, Feng C, Enemark JH, Nelson KJ, Rajagopalan KV.

J Biol Inorg Chem. 2003 Jan;8(1-2):95-104. Epub 2002 Aug 30.

PMID:
12459903
33.

Role of conserved tyrosine 343 in intramolecular electron transfer in human sulfite oxidase.

Feng C, Wilson HL, Hurley JK, Hazzard JT, Tollin G, Rajagopalan KV, Enemark JH.

J Biol Chem. 2003 Jan 31;278(5):2913-20. Epub 2002 Nov 6.

34.

Isolated sulfite oxidase deficiency: identification of 12 novel SUOX mutations in 10 patients.

Johnson JL, Coyne KE, Garrett RM, Zabot MT, Dorche C, Kisker C, Rajagopalan KV.

Hum Mutat. 2002 Jul;20(1):74.

PMID:
12112661
35.
36.

Escherichia coli MoeA and MogA. Function in metal incorporation step of molybdenum cofactor biosynthesis.

Nichols J, Rajagopalan KV.

J Biol Chem. 2002 Jul 12;277(28):24995-5000. Epub 2002 May 10.

37.

Isolated sulfite oxidase deficiency: mutation analysis and DNA-based prenatal diagnosis.

Johnson JL, Rajagopalan KV, Renier WO, Van der Burgt I, Ruitenbeek W.

Prenat Diagn. 2002 May;22(5):433-6.

PMID:
12001203
38.

Crystal structures of the active and alloxanthine-inhibited forms of xanthine dehydrogenase from Rhodobacter capsulatus.

Truglio JJ, Theis K, Leimkühler S, Rappa R, Rajagopalan KV, Kisker C.

Structure. 2002 Jan;10(1):115-25.

39.

Molybdopterin synthase mutations in a mild case of molybdenum cofactor deficiency.

Johnson JL, Coyne KE, Rajagopalan KV, Van Hove JL, Mackay M, Pitt J, Boneh A.

Am J Med Genet. 2001 Nov 22;104(2):169-73.

PMID:
11746050
40.

Mechanism of ubiquitin activation revealed by the structure of a bacterial MoeB-MoaD complex.

Lake MW, Wuebbens MM, Rajagopalan KV, Schindelin H.

Nature. 2001 Nov 15;414(6861):325-9.

PMID:
11713534
41.

Molybdopterin from molybdenum and tungsten enzymes.

Schindelin H, Kisker C, Rajagopalan KV.

Adv Protein Chem. 2001;58:47-94. Review. No abstract available.

PMID:
11665493
42.

The crystal structure of Escherichia coli MoeA and its relationship to the multifunctional protein gephyrin.

Xiang S, Nichols J, Rajagopalan KV, Schindelin H.

Structure. 2001 Apr 4;9(4):299-310.

43.
44.
45.
46.

Optimization of expression of human sulfite oxidase and its molybdenum domain.

Temple CA, Graf TN, Rajagopalan KV.

Arch Biochem Biophys. 2000 Nov 15;383(2):281-7.

PMID:
11185564
47.

Crystal structure of molybdopterin synthase and its evolutionary relationship to ubiquitin activation.

Rudolph MJ, Wuebbens MM, Rajagopalan KV, Schindelin H.

Nat Struct Biol. 2001 Jan;8(1):42-6.

PMID:
11135669
48.

In vitro incorporation of nascent molybdenum cofactor into human sulfite oxidase.

Leimkühler S, Rajagopalan KV.

J Biol Chem. 2001 Jan 19;276(3):1837-44. Epub 2000 Oct 20.

50.

The crystal structure of the Escherichia coli MobA protein provides insight into molybdopterin guanine dinucleotide biosynthesis.

Lake MW, Temple CA, Rajagopalan KV, Schindelin H.

J Biol Chem. 2000 Dec 22;275(51):40211-7.

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