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In vivo identification of amyloid and mucin in basal cell carcinoma (BCC) with combined reflectance confocal microscopy (RCM)- optical coherence tomography (OCT) device and direct histopathological correlation.

Sahu A, Cordova M, Gill M, Alessi-Fox C, Navarrete-Dechent C, González S, Iftimia N, Rajadhyaksha M, Marghoob AA, Chen CJ.

J Am Acad Dermatol. 2019 Aug 30. pii: S0190-9622(19)32669-6. doi: 10.1016/j.jaad.2019.08.063. [Epub ahead of print] No abstract available.


Dupilumab shows long-term safety and efficacy in moderate-to-severe atopic dermatitis patients enrolled in a phase 3 open-label extension study.

Deleuran M, Thaçi D, Beck LA, de Bruin-Weller M, Blauvelt A, Forman S, Bissonnette R, Reich K, Soong W, Hussain I, Foley P, Hide M, Bouaziz JD, Gelfand JM, Sher L, Schuttelaar MLA, Wang C, Chen Z, Akinlade B, Gadkari A, Eckert L, Davis JD, Rajadhyaksha M, Staudinger H, Graham NMH, Pirozzi G, Ardeleanu M.

J Am Acad Dermatol. 2019 Jul 30. pii: S0190-9622(19)32465-X. doi: 10.1016/j.jaad.2019.07.074. [Epub ahead of print]


Ex Vivo Microscopy: A Promising Next-Generation Digital Microscopy Tool for Surgical Pathology Practice.

Krishnamurthy S, Brown JQ, Iftimia N, Levenson RM, Rajadhyaksha M.

Arch Pathol Lab Med. 2019 Sep;143(9):1058-1068. doi: 10.5858/arpa.2019-0058-RA. Epub 2019 Jul 11.


MEMS-in-the-lens architecture for a miniature high-NA laser scanning microscope.

Liu T, Rajadhyaksha M, Dickensheets DL.

Light Sci Appl. 2019 Jun 26;8:59. doi: 10.1038/s41377-019-0167-5. eCollection 2019.


Improvement of diagnostic confidence and management of equivocal skin lesions by integration of reflectance confocal microscopy in daily practice: prospective study in two referral skin cancer centers.

Yélamos O, Manubens E, Jain M, Chavez-Bourgeois M, Pulijal SV, Dusza SW, Marchetti MA, Barreiro A, Marino ML, Malvehy J, Cordova MA, Rossi AM, Rajadhyaksha M, Halpern AC, Puig S, Marghoob AA, Carrera C.

J Am Acad Dermatol. 2019 Jun 13. pii: S0190-9622(19)30969-7. doi: 10.1016/j.jaad.2019.05.101. [Epub ahead of print]


Reflectance confocal microscopy-guided carbon dioxide laser ablation of low-risk basal cell carcinomas: A prospective study.

Navarrete-Dechent C, Cordova M, Liopyris K, Yélamos O, Aleissa S, Hibler B, Sierra H, Sahu A, Blank N, Rajadhyaksha M, Rossi A.

J Am Acad Dermatol. 2019 Oct;81(4):984-988. doi: 10.1016/j.jaad.2019.06.014. Epub 2019 Jun 14.


Feasibility of a Video-Mosaicking Approach to Extend the Field-of-View For Reflectance Confocal Microscopy in the Oral Cavity In Vivo.

Peterson G, Zanoni DK, Ardigo M, Migliacci JC, Patel SG, Rajadhyaksha M.

Lasers Surg Med. 2019 May 8. doi: 10.1002/lsm.23090. [Epub ahead of print]


Can optical coherence tomography improve the management of basal cell carcinoma?

Navarrete-Dechent C, Rajadhyaksha M, Nehal KS.

Br J Dermatol. 2019 Mar;180(3):448-449. doi: 10.1111/bjd.17522. No abstract available.


Peri-operative delineation of non-melanoma skin cancer margins in vivo with handheld reflectance confocal microscopy and video-mosaicking.

Flores E, Yélamos O, Cordova M, Kose K, Phillips W, Lee EH, Rossi A, Nehal K, Rajadhyaksha M.

J Eur Acad Dermatol Venereol. 2019 Jun;33(6):1084-1091. doi: 10.1111/jdv.15491. Epub 2019 Mar 15.


hif-1 plays a role in hypoxia-induced gustatory plasticity of Caenorhabditis elegans.

Sorathia N, Chawda N, Saraki K, Rajadhyaksha MS, Hejmadi M.

Int J Neurosci. 2019 Sep;129(9):864-870. doi: 10.1080/00207454.2019.1576662. Epub 2019 Mar 20.


Evaluation of a Combined Reflectance Confocal Microscopy-Optical Coherence Tomography Device for Detection and Depth Assessment of Basal Cell Carcinoma.

Sahu A, Yélamos O, Iftimia N, Cordova M, Alessi-Fox C, Gill M, Maguluri G, Dusza SW, Navarrete-Dechent C, González S, Rossi AM, Marghoob AA, Rajadhyaksha M, Chen CJ.

JAMA Dermatol. 2018 Oct 1;154(10):1175-1183. doi: 10.1001/jamadermatol.2018.2446.


Evaluation of Bedside Diagnostic Accuracy, Learning Curve, and Challenges for a Novice Reflectance Confocal Microscopy Reader for Skin Cancer Detection In Vivo.

Jain M, Pulijal SV, Rajadhyaksha M, Halpern AC, Gonzalez S.

JAMA Dermatol. 2018 Aug 1;154(8):962-965. doi: 10.1001/jamadermatol.2018.1668. No abstract available.


Smartphone confocal microscopy for imaging cellular structures in human skin in vivo.

Freeman EE, Semeere A, Osman H, Peterson G, Rajadhyaksha M, González S, Martin JN, Anderson RR, Tearney GJ, Kang D.

Biomed Opt Express. 2018 Mar 26;9(4):1906-1915. doi: 10.1364/BOE.9.001906. eCollection 2018 Apr 1.


In vivo intraoral reflectance confocal microscopy of an amalgam tattoo.

Yélamos O, Cordova M, Peterson G, Pulitzer MP, Singh B, Rajadhyaksha M, DeFazio JL.

Dermatol Pract Concept. 2017 Oct 31;7(4):13-16. doi: 10.5826/dpc.0704a04. eCollection 2017 Oct.


Drug Target Interference in Immunogenicity Assays: Recommendations and Mitigation Strategies.

Zhong ZD, Clements-Egan A, Gorovits B, Maia M, Sumner G, Theobald V, Wu Y, Rajadhyaksha M.

AAPS J. 2017 Nov;19(6):1564-1575. doi: 10.1208/s12248-017-0148-7. Epub 2017 Oct 23.


Correlation of Handheld Reflectance Confocal Microscopy With Radial Video Mosaicing for Margin Mapping of Lentigo Maligna and Lentigo Maligna Melanoma.

Yélamos O, Cordova M, Blank N, Kose K, Dusza SW, Lee E, Rajadhyaksha M, Nehal KS, Rossi AM.

JAMA Dermatol. 2017 Dec 1;153(12):1278-1284. doi: 10.1001/jamadermatol.2017.3114.


Automated video-mosaicking approach for confocal microscopic imaging in vivo: an approach to address challenges in imaging living tissue and extend field of view.

Kose K, Gou M, Yélamos O, Cordova M, Rossi AM, Nehal KS, Flores ES, Camps O, Dy JG, Brooks DH, Rajadhyaksha M.

Sci Rep. 2017 Sep 7;7(1):10759. doi: 10.1038/s41598-017-11072-9.


Reflectance confocal microscopy-guided laser ablation of basal cell carcinomas: initial clinical experience.

Sierra H, Yélamos O, Cordova M, Chen CJ, Rajadhyaksha M.

J Biomed Opt. 2017 Aug;22(8):1-13. doi: 10.1117/1.JBO.22.8.085005.


Handheld optical coherence tomography-reflectance confocal microscopy probe for detection of basal cell carcinoma and delineation of margins.

Iftimia N, Yélamos O, Chen CJ, Maguluri G, Cordova MA, Sahu A, Park J, Fox W, Alessi-Fox C, Rajadhyaksha M.

J Biomed Opt. 2017 Jul 1;22(7):76006. doi: 10.1117/1.JBO.22.7.076006.


Handheld reflectance confocal microscopy to aid in the management of complex facial lentigo maligna.

Hibler BP, Yélamos O, Cordova M, Sierra H, Rajadhyaksha M, Nehal KS, Rossi AM.

Cutis. 2017 May;99(5):346-352.


Handheld Reflectance Confocal Microscopy for the Detection of Recurrent Extramammary Paget Disease.

Yélamos O, Hibler BP, Cordova M, Hollmann TJ, Kose K, Marchetti MA, Myskowski PL, Pulitzer MP, Rajadhyaksha M, Rossi AM, Jain M.

JAMA Dermatol. 2017 Jul 1;153(7):689-693. doi: 10.1001/jamadermatol.2017.0619.


Wide-field imaging combined with confocal microscopy using a miniature f/5 camera integrated within a high NA objective lens.

Dickensheets DL, Kreitinger S, Peterson G, Heger M, Rajadhyaksha M.

Opt Lett. 2017 Apr 1;42(7):1241-1244. doi: 10.1364/OL.42.001241.


Evaluation of breast tissue with confocal strip-mosaicking microscopy: a test approach emulating pathology-like examination.

Abeytunge S, Larson B, Peterson G, Morrow M, Rajadhyaksha M, Murray MP.

J Biomed Opt. 2017 Mar 1;22(3):34002. doi: 10.1117/1.JBO.22.3.034002.


Implementation of fluorescence confocal mosaicking microscopy by "early adopter" Mohs surgeons and dermatologists: recent progress.

Jain M, Rajadhyaksha M, Nehal K.

J Biomed Opt. 2017 Feb 1;22(2):24002. doi: 10.1117/1.JBO.22.2.024002.


Caenorhabditis elegans: A Model for Studying Human Pathogen Biology.

Sorathia N, Rajadhyaksha MS.

Recent Pat Biotechnol. 2016;10(2):217-225. Review.


Reflectance confocal microscopy of skin in vivo: From bench to bedside.

Rajadhyaksha M, Marghoob A, Rossi A, Halpern AC, Nehal KS.

Lasers Surg Med. 2017 Jan;49(1):7-19. doi: 10.1002/lsm.22600. Epub 2016 Oct 27. Review.


A Marked Poisson Process Driven Latent Shape Model for 3D Segmentation of Reflectance Confocal Microscopy Image Stacks of Human Skin.

Ghanta S, Jordan MI, Kose K, Brooks DH, Rajadhyaksha M, Dy JG.

IEEE Trans Image Process. 2017 Jan;26(1):172-184. doi: 10.1109/TIP.2016.2615291. Epub 2016 Oct 5.


In Vivo and Ex Vivo Confocal Microscopy for Dermatologic and Mohs Surgeons.

Longo C, Ragazzi M, Rajadhyaksha M, Nehal K, Bennassar A, Pellacani G, Malvehy Guilera J.

Dermatol Clin. 2016 Oct;34(4):497-504. doi: 10.1016/j.det.2016.05.012. Review.


Unsupervised delineation of stratum corneum using reflectance confocal microscopy and spectral clustering.

Bozkurt A, Kose K, Alessi-Fox C, Dy JG, Brooks DH, Rajadhyaksha M.

Skin Res Technol. 2017 May;23(2):176-185. doi: 10.1111/srt.12316. Epub 2016 Aug 12.


Miniature in vivo MEMS-based line-scanned dual-axis confocal microscope for point-of-care pathology.

Yin C, Glaser AK, Leigh SY, Chen Y, Wei L, Pillai PC, Rosenberg MC, Abeytunge S, Peterson G, Glazowski C, Sanai N, Mandella MJ, Rajadhyaksha M, Liu JT.

Biomed Opt Express. 2016 Jan 5;7(2):251-63. doi: 10.1364/BOE.7.000251. eCollection 2016 Feb 1.


Reflectance confocal microscopy features of mycosis fungoides and Sézary syndrome: correlation with histopathologic and T-cell receptor rearrangement studies.

Mancebo SE, Cordova M, Myskowski PL, Flores ES, Busam K, Jawed SI, Skripnik A, Rajadhyaksha M, Querfeld C.

J Cutan Pathol. 2016 Jun;43(6):505-15. doi: 10.1111/cup.12708. Epub 2016 Apr 8.


Quantitative molecular phenotyping with topically applied SERS nanoparticles for intraoperative guidance of breast cancer lumpectomy.

Wang Y, Kang S, Khan A, Ruttner G, Leigh SY, Murray M, Abeytunge S, Peterson G, Rajadhyaksha M, Dintzis S, Javid S, Liu JT.

Sci Rep. 2016 Feb 16;6:21242. doi: 10.1038/srep21242.


Dermoscopy-guided reflectance confocal microscopy of skin using high-NA objective lens with integrated wide-field color camera.

Dickensheets DL, Kreitinger S, Peterson G, Heger M, Rajadhyaksha M.

Proc SPIE Int Soc Opt Eng. 2016 Feb;9689. pii: 96890U. doi: 10.1117/12.2213332. Epub 2016 Feb 29.


Pre-existing Antibody: Biotherapeutic Modality-Based Review.

Gorovits B, Clements-Egan A, Birchler M, Liang M, Myler H, Peng K, Purushothama S, Rajadhyaksha M, Salazar-Fontana L, Sung C, Xue L.

AAPS J. 2016 Mar;18(2):311-20. doi: 10.1208/s12248-016-9878-1. Epub 2016 Jan 28. Review.


Carbon dioxide laser ablation of basal cell carcinoma with visual guidance by reflectance confocal microscopy: a proof-of-principle pilot study.

Hibler BP, Sierra H, Cordova M, Phillips W, Rajadhyaksha M, Nehal KS, Rossi AM.

Br J Dermatol. 2016 Jun;174(6):1359-64. doi: 10.1111/bjd.14414. Epub 2016 Apr 19.


Improving lesion localization when imaging with handheld reflectance confocal microscope.

Marino ML, Rogers T, Sierra Gil H, Rajadhyaksha M, Cordova MA, Marghoob AA.

Skin Res Technol. 2016 Nov;22(4):519-520. doi: 10.1111/srt.12280. Epub 2016 Jan 21. No abstract available.


In vivo confocal microscopy for the oral cavity: Current state of the field and future potential.

Maher NG, Collgros H, Uribe P, Ch'ng S, Rajadhyaksha M, Guitera P.

Oral Oncol. 2016 Mar;54:28-35. doi: 10.1016/j.oraloncology.2016.01.003. Epub 2016 Jan 16. Review.


Combined reflectance confocal microscopy-optical coherence tomography for delineation of basal cell carcinoma margins: an ex vivo study.

Iftimia N, Peterson G, Chang EW, Maguluri G, Fox W, Rajadhyaksha M.

J Biomed Opt. 2016 Jan;21(1):16006. doi: 10.1117/1.JBO.21.1.016006. No abstract available.


Novel approaches to imaging basal cell carcinoma.

Rossi AM, Sierra H, Rajadhyaksha M, Nehal K.

Future Oncol. 2015 Nov;11(22):3039-46. doi: 10.2217/fon.15.231. Epub 2015 Oct 15. Review.


Confocal imaging of carbon dioxide laser-ablated basal cell carcinomas: An ex-vivo study on the uptake of contrast agent and ablation parameters.

Sierra H, Damanpour S, Hibler B, Nehal K, Rossi A, Rajadhyaksha M.

Lasers Surg Med. 2016 Feb;48(2):133-9. doi: 10.1002/lsm.22415. Epub 2015 Sep 22.


Effects of blood processing and sample storage on the stability of biotherapeutics and anti-drug antibodies.

Andisik M, DeStefano L, Stefan C, Gathani M, Laurino K, Lai VCh, Rajadhyaksha M, Torri A, Shao W.

Bioanalysis. 2015;7(11):1325-35. doi: 10.4155/bio.15.66.


Mechanistic investigation of the preclinical pharmacokinetics and interspecies scaling of PF-05231023, a fibroblast growth factor 21-antibody protein conjugate.

Giragossian C, Vage C, Li J, Pelletier K, Piché-Nicholas N, Rajadhyaksha M, Liras J, Logan A, Calle RA, Weng Y.

Drug Metab Dispos. 2015 Jun;43(6):803-11. doi: 10.1124/dmd.114.061713. Epub 2015 Mar 24.


Intraoperative imaging during Mohs surgery with reflectance confocal microscopy: initial clinical experience.

Flores ES, Cordova M, Kose K, Phillips W, Rossi A, Nehal K, Rajadhyaksha M.

J Biomed Opt. 2015 Jun;20(6):61103. doi: 10.1117/1.JBO.20.6.061103.


Automated delineation of dermal-epidermal junction in reflectance confocal microscopy image stacks of human skin.

Kurugol S, Kose K, Park B, Dy JG, Brooks DH, Rajadhyaksha M.

J Invest Dermatol. 2015 Mar;135(3):710-717. doi: 10.1038/jid.2014.379. Epub 2014 Sep 3.


Confocal imaging-guided laser ablation of basal cell carcinomas: an ex vivo study.

Sierra H, Cordova M, Chen CJ, Rajadhyaksha M.

J Invest Dermatol. 2015 Feb;135(2):612-615. doi: 10.1038/jid.2014.371. Epub 2014 Sep 1. No abstract available.


Confocal microscopy-guided laser ablation for superficial and early nodular Basal cell carcinoma: a promising surgical alternative for superficial skin cancers.

Chen CS, Sierra H, Cordova M, Rajadhyaksha M.

JAMA Dermatol. 2014 Sep;150(9):994-8. doi: 10.1001/jamadermatol.2013.10225.


Evaluating ex vivo fluorescence confocal microscopy images of basal cell carcinomas in Mohs excised tissue.

Longo C, Rajadhyaksha M, Ragazzi M, Nehal K, Gardini S, Moscarella E, Lallas A, Zalaudek I, Piana S, Argenziano G, Pellacani G.

Br J Dermatol. 2014 Sep;171(3):561-70. doi: 10.1111/bjd.13070. Epub 2014 Aug 13.


Video-mosaicing of reflectance confocal images for examination of extended areas of skin in vivo.

Kose K, Cordova M, Duffy M, Flores ES, Brooks DH, Rajadhyaksha M.

Br J Dermatol. 2014 Nov;171(5):1239-41. doi: 10.1111/bjd.13050. Epub 2014 Oct 26. No abstract available.


Confocal microscopy to guide erbium:yttrium aluminum garnet laser ablation of basal cell carcinoma: an ex vivo feasibility study.

Sierra H, Larson BA, Chen CS, Rajadhyaksha M.

J Biomed Opt. 2013 Sep;18(9):095001. doi: 10.1117/1.JBO.18.9.095001.


2012 AAPS National Biotech Conference Open Forum: a perspective on the current state of immunogenicity prediction and risk management.

Rajadhyaksha M, Subramanyam M, Rup B.

AAPS J. 2013 Oct;15(4):1155-9. doi: 10.1208/s12248-013-9520-4. Epub 2013 Aug 30.

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