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Items: 48


Contribution of D1R-expressing neurons of the dorsal dentate gyrus and Cav1.2 channels in extinction of cocaine conditioned place preference.

Burgdorf CE, Bavley CC, Fischer DK, Walsh AP, Martinez-Rivera A, Hackett JE, Zallar LJ, Ireton KE, Hofmann F, Hell JW, Huganir RL, Rajadhyaksha AM.

Neuropsychopharmacology. 2020 Jan 6. doi: 10.1038/s41386-019-0597-z. [Epub ahead of print]


Correction: Cocaine- and stress-primed reinstatement of drug-associated memories elicit differential behavioral and frontostriatal circuit activity patterns via recruitment of L-type Ca2+ channels.

Bavley CC, Fetcho RN, Burgdorf CE, Walsh AP, Fischer DK, Hall BS, Sayles NM, Contoreggi NH, Hackett JE, Antigua SA, Babij R, De Marco García NV, Kash TL, Milner TA, Liston C, Rajadhyaksha AM.

Mol Psychiatry. 2019 Dec 6. doi: 10.1038/s41380-019-0624-9. [Epub ahead of print]


Cocaine- and stress-primed reinstatement of drug-associated memories elicit differential behavioral and frontostriatal circuit activity patterns via recruitment of L-type Ca2+ channels.

Bavley CC, Fetcho RN, Burgdorf CE, Walsh AP, Fischer DK, Hall BS, Sayles NM, Contoreggi NH, Hackett JE, Antigua SA, Babij R, De Marco García NV, Kash TL, Milner TA, Liston C, Rajadhyaksha AM.

Mol Psychiatry. 2019 Sep 9. doi: 10.1038/s41380-019-0513-2. [Epub ahead of print] Erratum in: Mol Psychiatry. 2019 Dec 6;:.


Anxiety, the chicken or the egg of addiction: targeting G9a for the treatment of comorbid anxiety and cocaine addiction.

Bavley CC, Rajadhyaksha AM.

Neuropsychopharmacology. 2019 Jul;44(8):1345-1346. doi: 10.1038/s41386-019-0329-4. Epub 2019 Feb 13.


The L-type calcium channel blocker, isradipine, attenuates cue-induced cocaine-seeking by enhancing dopaminergic activity in the ventral tegmental area to nucleus accumbens pathway.

Addy NA, Nunes EJ, Hughley SM, Small KM, Baracz SJ, Haight JL, Rajadhyaksha AM.

Neuropsychopharmacology. 2018 Nov;43(12):2361-2372. doi: 10.1038/s41386-018-0080-2. Epub 2018 May 3.


Rescue of Learning and Memory Deficits in the Human Nonsyndromic Intellectual Disability Cereblon Knock-Out Mouse Model by Targeting the AMP-Activated Protein Kinase-mTORC1 Translational Pathway.

Bavley CC, Rice RC, Fischer DK, Fakira AK, Byrne M, Kosovsky M, Rizzo BK, Del Prete D, Alaedini A, Morón JA, Higgins JJ, D'Adamio L, Rajadhyaksha AM.

J Neurosci. 2018 Mar 14;38(11):2780-2795. doi: 10.1523/JNEUROSCI.0599-17.2018. Epub 2018 Feb 19.


Ligand-mediated protein degradation reveals functional conservation among sequence variants of the CUL4-type E3 ligase substrate receptor cereblon.

Akuffo AA, Alontaga AY, Metcalf R, Beatty MS, Becker A, McDaniel JM, Hesterberg RS, Goodheart WE, Gunawan S, Ayaz M, Yang Y, Karim MR, Orobello ME, Daniel K, Guida W, Yoder JA, Rajadhyaksha AM, Schönbrunn E, Lawrence HR, Lawrence NJ, Epling-Burnette PK.

J Biol Chem. 2018 Apr 20;293(16):6187-6200. doi: 10.1074/jbc.M117.816868. Epub 2018 Feb 15.


Correction: D-cycloserine improves synaptic transmission in an animal mode of Rett syndrome.

Na ES, De Jesús-Cortés H, Martinez-Rivera A, Kabir ZD, Wang J, Ramesh V, Onder Y, Rajadhyaksha AM, Monteggia LM, Pieper AA.

PLoS One. 2018 Jan 25;13(1):e0192057. doi: 10.1371/journal.pone.0192057. eCollection 2018.


Extinction of Contextual Cocaine Memories Requires Cav1.2 within D1R-Expressing Cells and Recruits Hippocampal Cav1.2-Dependent Signaling Mechanisms.

Burgdorf CE, Schierberl KC, Lee AS, Fischer DK, Van Kempen TA, Mudragel V, Huganir RL, Milner TA, Glass MJ, Rajadhyaksha AM.

J Neurosci. 2017 Dec 6;37(49):11894-11911. doi: 10.1523/JNEUROSCI.2397-17.2017. Epub 2017 Oct 31.


D-cycloserine improves synaptic transmission in an animal model of Rett syndrome.

Na ES, De Jesús-Cortés H, Martinez-Rivera A, Kabir ZD, Wang J, Ramesh V, Onder Y, Rajadhyaksha AM, Monteggia LM, Pieper AA.

PLoS One. 2017 Aug 16;12(8):e0183026. doi: 10.1371/journal.pone.0183026. eCollection 2017. Erratum in: PLoS One. 2018 Jan 25;13(1):e0192057.


Rescue of impaired sociability and anxiety-like behavior in adult cacna1c-deficient mice by pharmacologically targeting eIF2α.

Kabir ZD, Che A, Fischer DK, Rice RC, Rizzo BK, Byrne M, Glass MJ, De Marco Garcia NV, Rajadhyaksha AM.

Mol Psychiatry. 2017 Aug;22(8):1096-1109. doi: 10.1038/mp.2017.124. Epub 2017 Jun 6.


Altered reward sensitivity in female offspring of cocaine-exposed fathers.

Fischer DK, Rice RC, Martinez Rivera A, Donohoe M, Rajadhyaksha AM.

Behav Brain Res. 2017 Aug 14;332:23-31. doi: 10.1016/j.bbr.2017.05.054. Epub 2017 May 26.


From Gene to Behavior: L-Type Calcium Channel Mechanisms Underlying Neuropsychiatric Symptoms.

Kabir ZD, Martínez-Rivera A, Rajadhyaksha AM.

Neurotherapeutics. 2017 Jul;14(3):588-613. doi: 10.1007/s13311-017-0532-0. Review.


Genetic dissociation of morphine analgesia from hyperalgesia in mice.

Marrone GF, Le Rouzic V, Varadi A, Xu J, Rajadhyaksha AM, Majumdar S, Pan YX, Pasternak GW.

Psychopharmacology (Berl). 2017 Jun;234(12):1891-1900. doi: 10.1007/s00213-017-4600-2. Epub 2017 Mar 25.


Alternatively spliced mu opioid receptor C termini impact the diverse actions of morphine.

Xu J, Lu Z, Narayan A, Le Rouzic VP, Xu M, Hunkele A, Brown TG, Hoefer WF, Rossi GC, Rice RC, Martínez-Rivera A, Rajadhyaksha AM, Cartegni L, Bassoni DL, Pasternak GW, Pan YX.

J Clin Invest. 2017 Apr 3;127(4):1561-1573. doi: 10.1172/JCI88760. Epub 2017 Mar 20.


Cav1.2 channels mediate persistent chronic stress-induced behavioral deficits that are associated with prefrontal cortex activation of the p25/Cdk5-glucocorticoid receptor pathway.

Bavley CC, Fischer DK, Rizzo BK, Rajadhyaksha AM.

Neurobiol Stress. 2017 Feb 24;7:27-37. doi: 10.1016/j.ynstr.2017.02.004. eCollection 2017 Dec.


Enhancing VTA Cav1.3 L-type Ca2+ channel activity promotes cocaine and mood-related behaviors via overlapping AMPA receptor mechanisms in the nucleus accumbens.

Martínez-Rivera A, Hao J, Tropea TF, Giordano TP, Kosovsky M, Rice RC, Lee A, Huganir RL, Striessnig J, Addy NA, Han S, Rajadhyaksha AM.

Mol Psychiatry. 2017 Dec;22(12):1735-1745. doi: 10.1038/mp.2017.9. Epub 2017 Feb 14.


Cacna1c in the Prefrontal Cortex Regulates Depression-Related Behaviors via REDD1.

Kabir ZD, Lee AS, Burgdorf CE, Fischer DK, Rajadhyaksha AM, Mok E, Rizzo B, Rice RC, Singh K, Ota KT, Gerhard DM, Schierberl KC, Glass MJ, Duman RS, Rajadhyaksha AM.

Neuropsychopharmacology. 2017 Sep;42(10):2032-2042. doi: 10.1038/npp.2016.271. Epub 2016 Dec 6.


Cacna1c: Protecting young hippocampal neurons in the adult brain.

De Jesús-Cortés H, Rajadhyaksha AM, Pieper AA.

Neurogenesis (Austin). 2016 Sep 2;3(1):e1231160. eCollection 2016.


Sensory-Derived Glutamate Regulates Presynaptic Inhibitory Terminals in Mouse Spinal Cord.

Mende M, Fletcher EV, Belluardo JL, Pierce JP, Bommareddy PK, Weinrich JA, Kabir ZD, Schierberl KC, Pagiazitis JG, Mendelsohn AI, Francesconi A, Edwards RH, Milner TA, Rajadhyaksha AM, van Roessel PJ, Mentis GZ, Kaltschmidt JA.

Neuron. 2016 Jun 15;90(6):1189-1202. doi: 10.1016/j.neuron.2016.05.008. Epub 2016 Jun 2.


Energy deficit in parvalbumin neurons leads to circuit dysfunction, impaired sensory gating and social disability.

Inan M, Zhao M, Manuszak M, Karakaya C, Rajadhyaksha AM, Pickel VM, Schwartz TH, Goldstein PA, Manfredi G.

Neurobiol Dis. 2016 Sep;93:35-46. doi: 10.1016/j.nbd.2016.04.004. Epub 2016 Apr 20.


The Neuropsychiatric Disease-Associated Gene cacna1c Mediates Survival of Young Hippocampal Neurons.

Lee AS, De Jesús-Cortés H, Kabir ZD, Knobbe W, Orr M, Burgdorf C, Huntington P, McDaniel L, Britt JK, Hoffmann F, Brat DJ, Rajadhyaksha AM, Pieper AA.

eNeuro. 2016 Mar 31;3(2). pii: ENEURO.0006-16.2016. doi: 10.1523/ENEURO.0006-16.2016. eCollection 2016 Mar-Apr.


L-type Ca2+ channels in mood, cognition and addiction: integrating human and rodent studies with a focus on behavioural endophenotypes.

Kabir ZD, Lee AS, Rajadhyaksha AM.

J Physiol. 2016 Oct 15;594(20):5823-5837. doi: 10.1113/JP270673. Epub 2016 Apr 24. Review.


Lack of association between autism and anti-GM1 ganglioside antibody.

Moeller S, Lau NM, Green PH, Hellberg D, Higgins JJ, Rajadhyaksha AM, Alaedini A.

Neurology. 2013 Oct 29;81(18):1640-1. doi: 10.1212/WNL.0b013e3182a9f3dd. Epub 2013 Sep 25. No abstract available.


Autism and Lyme disease--reply.

Ajamian M, Rajadhyaksha AM, Alaedini A.

JAMA. 2013 Aug 28;310(8):857. doi: 10.1001/jama.2013.194768. No abstract available.


Markers of Celiac Disease and Gluten Sensitivity in Children with Autism.

Lau NM, Green PH, Taylor AK, Hellberg D, Ajamian M, Tan CZ, Kosofsky BE, Higgins JJ, Rajadhyaksha AM, Alaedini A.

PLoS One. 2013 Jun 18;8(6):e66155. doi: 10.1371/journal.pone.0066155. Print 2013.


Serologic markers of Lyme disease in children with autism.

Ajamian M, Kosofsky BE, Wormser GP, Rajadhyaksha AM, Alaedini A.

JAMA. 2013 May 1;309(17):1771-3. doi: 10.1001/jama.2013.618. No abstract available.


Selective genetic deletion of cacna1c in the mouse prefrontal cortex.

Lee AS, Gonzales KL, Lee A, Moosmang S, Hofmann F, Pieper AA, Rajadhyaksha AM.

Mol Psychiatry. 2012 Nov;17(11):1051. doi: 10.1038/mp.2012.149. No abstract available.


Forebrain elimination of cacna1c mediates anxiety-like behavior in mice.

Lee AS, Ra S, Rajadhyaksha AM, Britt JK, De Jesus-Cortes H, Gonzales KL, Lee A, Moosmang S, Hofmann F, Pieper AA, Rajadhyaksha AM.

Mol Psychiatry. 2012 Nov;17(11):1054-5. doi: 10.1038/mp.2012.71. Epub 2012 Jun 5. No abstract available.


Brain-derived neurotrophic factor genotype impacts the prenatal cocaine-induced mouse phenotype.

Kabir ZD, Lourenco F, Byrne ME, Katzman A, Lee F, Rajadhyaksha AM, Kosofsky BE.

Dev Neurosci. 2012;34(2-3):184-97. Epub 2012 May 8.


Enhanced dopamine D1 and BDNF signaling in the adult dorsal striatum but not nucleus accumbens of prenatal cocaine treated mice.

Tropea TF, Kabir ZD, Kaur G, Rajadhyaksha AM, Kosofsky BE.

Front Psychiatry. 2011 Dec 7;2:67. doi: 10.3389/fpsyt.2011.00067. eCollection 2011.


Behavioral characterization of cereblon forebrain-specific conditional null mice: a model for human non-syndromic intellectual disability.

Rajadhyaksha AM, Ra S, Kishinevsky S, Lee AS, Romanienko P, DuBoff M, Yang C, Zupan B, Byrne M, Daruwalla ZR, Mark W, Kosofsky BE, Toth M, Higgins JJ.

Behav Brain Res. 2012 Jan 15;226(2):428-34. doi: 10.1016/j.bbr.2011.09.039. Epub 2011 Oct 4.


Cav1.2 L-type Ca²⁺ channels mediate cocaine-induced GluA1 trafficking in the nucleus accumbens, a long-term adaptation dependent on ventral tegmental area Ca(v)1.3 channels.

Schierberl K, Hao J, Tropea TF, Ra S, Giordano TP, Xu Q, Garraway SM, Hofmann F, Moosmang S, Striessnig J, Inturrisi CE, Rajadhyaksha AM.

J Neurosci. 2011 Sep 21;31(38):13562-75. doi: 10.1523/JNEUROSCI.2315-11.2011.


Molecular switch from L-type Ca v 1.3 to Ca v 1.2 Ca2+ channel signaling underlies long-term psychostimulant-induced behavioral and molecular plasticity.

Giordano TP, Tropea TF, Satpute SS, Sinnegger-Brauns MJ, Striessnig J, Kosofsky BE, Rajadhyaksha AM.

J Neurosci. 2010 Dec 15;30(50):17051-62. doi: 10.1523/JNEUROSCI.2255-10.2010.


Mutations in FLVCR1 cause posterior column ataxia and retinitis pigmentosa.

Rajadhyaksha AM, Elemento O, Puffenberger EG, Schierberl KC, Xiang JZ, Putorti ML, Berciano J, Poulin C, Brais B, Michaelides M, Weleber RG, Higgins JJ.

Am J Hum Genet. 2010 Nov 12;87(5):643-54. doi: 10.1016/j.ajhg.2010.10.013.


Prenatal L-DOPA exposure produces lasting changes in brain dopamine content, cocaine-induced dopamine release and cocaine conditioned place preference.

Ren JQ, Jiang Y, Wang Z, McCarthy D, Rajadhyaksha AM, Tropea TF, Kosofsky BE, Bhide PG.

Neuropharmacology. 2011 Feb-Mar;60(2-3):295-302. doi: 10.1016/j.neuropharm.2010.09.012. Epub 2010 Sep 18.


Spinal mediators that may contribute selectively to antinociceptive tolerance but not other effects of morphine as revealed by deletion of GluR5.

Gregus AM, Inra CN, Giordano TP 3rd, Costa AC, Rajadhyaksha AM, Inturrisi CE.

Neuroscience. 2010 Aug 11;169(1):475-87. doi: 10.1016/j.neuroscience.2010.03.051. Epub 2010 Mar 29.


Temporal and spatial mouse brain expression of cereblon, an ionic channel regulator involved in human intelligence.

Higgins JJ, Tal AL, Sun X, Hauck SC, Hao J, Kosofosky BE, Rajadhyaksha AM.

J Neurogenet. 2010 Mar;24(1):18-26. doi: 10.3109/01677060903567849.


Deletion of the GluR5 subunit of kainate receptors affects cocaine sensitivity and preference.

Gregus AM, Tropea TF, Wang Y, Hauck SC, Costa AC, Rajadhyaksha AM, Inturrisi CE.

Neurosci Lett. 2010 Jan 14;468(3):186-9. doi: 10.1016/j.neulet.2009.10.071. Epub 2009 Oct 28.


Deletion of the glutamate receptor 5 subunit of kainate receptors affects the development of morphine tolerance.

Bogulavsky JJ, Gregus AM, Kim PT, Costa AC, Rajadhyaksha AM, Inturrisi CE.

J Pharmacol Exp Ther. 2009 Feb;328(2):579-87. doi: 10.1124/jpet.108.144121. Epub 2008 Oct 28.


Dysregulation of large-conductance Ca2+-activated K+ channel expression in nonsyndromal mental retardation due to a cereblon p.R419X mutation.

Higgins JJ, Hao J, Kosofsky BE, Rajadhyaksha AM.

Neurogenetics. 2008 Jul;9(3):219-23. doi: 10.1007/s10048-008-0128-2. Epub 2008 Apr 15.


NMDA receptors in the rat VTA: a critical site for social stress to intensify cocaine taking.

Covington HE 3rd, Tropea TF, Rajadhyaksha AM, Kosofsky BE, Miczek KA.

Psychopharmacology (Berl). 2008 Apr;197(2):203-16. Epub 2007 Dec 19.


Up-regulation of dopamine D(2)L mRNA levels in the ventral tegmental area and dorsal striatum of amphetamine-sensitized C57BL/6 mice: role of Ca(v)1.3 L-type Ca(2+) channels.

Giordano TP 3rd, Satpute SS, Striessnig J, Kosofsky BE, Rajadhyaksha AM.

J Neurochem. 2006 Nov;99(4):1197-206. Epub 2006 Oct 5.


Psychostimulants, Protein phosphorylation and Gene expression: a growing role of L-type calcium channels.

Rajadhyaksha AM, Kosofsky BE.

Cellscience. 2005 Jul 29;2(1):127-144. No abstract available.


Psychostimulants, L-type calcium channels, kinases, and phosphatases.

Rajadhyaksha AM, Kosofsky BE.

Neuroscientist. 2005 Oct;11(5):494-502. Review.

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