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Central Sensitization, N-methyl-D-aspartate Receptors, and Human Experimental Pain Models: Bridging the Gap between Target Discovery and Drug Development.

Raja SN, Sivanesan E, Guan Y.

Anesthesiology. 2019 Jun 14. doi: 10.1097/ALN.0000000000002808. [Epub ahead of print] No abstract available.


Modulation of Spinal Nociceptive Transmission by Sub-Sensory Threshold Spinal Cord Stimulation in Rats After Nerve Injury.

Yang F, Duan W, Huang Q, Chen Z, Ford N, Gao X, Sivanesan E, Sarma SV, Vera-Portocarrero LP, Linderoth B, Raja SN, Guan Y.

Neuromodulation. 2019 Jun 4. doi: 10.1111/ner.12975. [Epub ahead of print]


The IASP classification of chronic pain for ICD-11: chronic neuropathic pain.

Scholz J, Finnerup NB, Attal N, Aziz Q, Baron R, Bennett MI, Benoliel R, Cohen M, Cruccu G, Davis KD, Evers S, First M, Giamberardino MA, Hansson P, Kaasa S, Korwisi B, Kosek E, Lavandʼhomme P, Nicholas M, Nurmikko T, Perrot S, Raja SN, Rice ASC, Rowbotham MC, Schug S, Simpson DM, Smith BH, Svensson P, Vlaeyen JWS, Wang SJ, Barke A, Rief W, Treede RD; Classification Committee of the Neuropathic Pain Special Interest Group (NeuPSIG).

Pain. 2019 Jan;160(1):53-59. doi: 10.1097/j.pain.0000000000001365.


Supraspinal Mechanisms of Spinal Cord Stimulation for Modulation of Pain: Five Decades of Research and Prospects for the Future.

Sivanesan E, Maher DP, Raja SN, Linderoth B, Guan Y.

Anesthesiology. 2019 Apr;130(4):651-665. doi: 10.1097/ALN.0000000000002353.


The Impact of Electrical Charge Delivery on Inhibition of Mechanical Hypersensitivity in Nerve-Injured Rats by Sub-Sensory Threshold Spinal Cord Stimulation.

Chen Z, Huang Q, Yang F, Shi C, Sivanesan E, Liu S, Chen X, Sarma SV, Vera-Portocarrero LP, Linderoth B, Raja SN, Guan Y.

Neuromodulation. 2019 Feb;22(2):163-171. doi: 10.1111/ner.12910. Epub 2018 Dec 17.


RNA-seq of spinal cord from nerve-injured rats after spinal cord stimulation.

Stephens KE, Chen Z, Sivanesan E, Raja SN, Linderoth B, Taverna SD, Guan Y.

Mol Pain. 2018 Jan-Dec;14:1744806918817429. doi: 10.1177/1744806918817429. Epub 2018 Nov 19.


Massively parallel fabrication of crack-defined gold break junctions featuring sub-3 nm gaps for molecular devices.

Dubois V, Raja SN, Gehring P, Caneva S, van der Zant HSJ, Niklaus F, Stemme G.

Nat Commun. 2018 Aug 24;9(1):3433. doi: 10.1038/s41467-018-05785-2.


Neuropathic pain clinical trials: factors associated with decreases in estimated drug efficacy.

Finnerup NB, Haroutounian S, Baron R, Dworkin RH, Gilron I, Haanpaa M, Jensen TS, Kamerman PR, McNicol E, Moore A, Raja SN, Andersen NT, Sena ES, Smith BH, Rice ASC, Attal N.

Pain. 2018 Nov;159(11):2339-2346. doi: 10.1097/j.pain.0000000000001340. Review.


Oligomerization of MrgC11 and μ-opioid receptors in sensory neurons enhances morphine analgesia.

He SQ, Xu Q, Tiwari V, Yang F, Anderson M, Chen Z, Grenald SA, Raja SN, Dong X, Guan Y.

Sci Signal. 2018 Jun 19;11(535). pii: eaao3134. doi: 10.1126/scisignal.aao3134.


Differential expression of voltage-gated sodium channels in afferent neurons renders selective neural block by ionic direct current.

Yang F, Anderson M, He S, Stephens K, Zheng Y, Chen Z, Raja SN, Aplin F, Guan Y, Fridman G.

Sci Adv. 2018 Apr 11;4(4):eaaq1438. doi: 10.1126/sciadv.aaq1438. eCollection 2018 Apr.


Peripherally Acting μ-Opioid Receptor Agonists Attenuate Ongoing Pain-associated Behavior and Spontaneous Neuronal Activity after Nerve Injury in Rats.

Tiwari V, Anderson M, Yang F, Tiwari V, Zheng Q, He SQ, Zhang T, Shu B, Chen X, Grenald SA, Stephens KE, Chen Z, Dong X, Raja SN, Guan Y.

Anesthesiology. 2018 Jun;128(6):1220-1236. doi: 10.1097/ALN.0000000000002191.


Microscopic mechanisms of deformation transfer in high dynamic range branched nanoparticle deformation sensors.

Raja SN, Ye X, Jones MR, Lin L, Govindjee S, Ritchie RO.

Nat Commun. 2018 Mar 20;9(1):1155. doi: 10.1038/s41467-018-03396-5.


Spinal Cord Stimulation: Clinical Efficacy and Potential Mechanisms.

Sdrulla AD, Guan Y, Raja SN.

Pain Pract. 2018 Nov;18(8):1048-1067. doi: 10.1111/papr.12692. Epub 2018 Apr 23. Review.


Aspiring Pain Practitioners in India: Assessing Challenges and Building Opportunities.

Bhatnagar S, Patel A, Raja SN.

Indian J Palliat Care. 2018 Jan-Mar;24(1):93-97. doi: 10.4103/IJPC.IJPC_148_17.


Atomic Resolution Imaging of Nanoscale Chemical Expansion in PrxCe1-xO2-δ during In Situ Heating.

Swallow JG, Lee JK, Defferriere T, Hughes GM, Raja SN, Tuller HL, Warner JH, Van Vliet KJ.

ACS Nano. 2018 Feb 27;12(2):1359-1372. doi: 10.1021/acsnano.7b07732. Epub 2018 Jan 25.


Overexpression of µ-Opioid Receptors in Peripheral Afferents, but Not in Combination with Enkephalin, Decreases Neuropathic Pain Behavior and Enhances Opioid Analgesia in Mouse.

Klein AH, Mohammad HK, Ali R, Peper B, Wilson SP, Raja SN, Ringkamp M, Sweitzer S.

Anesthesiology. 2018 May;128(5):967-983. doi: 10.1097/ALN.0000000000002063.


NeuPSIG: investing in solutions to the growing global challenge of neuropathic pain.

Smith BH, Raja SN.

Br J Anaesth. 2017 Oct 1;119(4):705-708. doi: 10.1093/bja/aex276. No abstract available.


Annealing and polycrystallinity effects on the thermal conductivity of supported CVD graphene monolayers.

Raja SN, Osenberg D, Choi K, Park HG, Poulikakos D.

Nanoscale. 2017 Oct 19;9(40):15515-15524. doi: 10.1039/c7nr05346k.


Improving Pain Management and Long-Term Outcomes Following High-Energy Orthopaedic Trauma (Pain Study).

Castillo RC, Raja SN, Frey KP, Vallier HA, Tornetta P 3rd, Jaeblon T, Goff BJ, Gottschalk A, Scharfstein DO, OʼToole RV; METRC.

J Orthop Trauma. 2017 Apr;31 Suppl 1:S71-S77. doi: 10.1097/BOT.0000000000000793. Erratum in: J Orthop Trauma. 2017 Sep;31(9):e308.


The Potential Role of Sensory Testing, Skin Biopsy, and Functional Brain Imaging as Biomarkers in Chronic Pain Clinical Trials: IMMPACT Considerations.

Smith SM, Dworkin RH, Turk DC, Baron R, Polydefkis M, Tracey I, Borsook D, Edwards RR, Harris RE, Wager TD, Arendt-Nielsen L, Burke LB, Carr DB, Chappell A, Farrar JT, Freeman R, Gilron I, Goli V, Haeussler J, Jensen T, Katz NP, Kent J, Kopecky EA, Lee DA, Maixner W, Markman JD, McArthur JC, McDermott MP, Parvathenani L, Raja SN, Rappaport BA, Rice ASC, Rowbotham MC, Tobias JK, Wasan AD, Witter J.

J Pain. 2017 Jul;18(7):757-777. doi: 10.1016/j.jpain.2017.02.429. Epub 2017 Feb 27. Review.


Targeting human Mas-related G protein-coupled receptor X1 to inhibit persistent pain.

Li Z, Tseng PY, Tiwari V, Xu Q, He SQ, Wang Y, Zheng Q, Han L, Wu Z, Blobaum AL, Cui Y, Tiwari V, Sun S, Cheng Y, Huang-Lionnet JH, Geng Y, Xiao B, Peng J, Hopkins C, Raja SN, Guan Y, Dong X.

Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):E1996-E2005. doi: 10.1073/pnas.1615255114. Epub 2017 Feb 21.


Neuropathic pain.

Colloca L, Ludman T, Bouhassira D, Baron R, Dickenson AH, Yarnitsky D, Freeman R, Truini A, Attal N, Finnerup NB, Eccleston C, Kalso E, Bennett DL, Dworkin RH, Raja SN.

Nat Rev Dis Primers. 2017 Feb 16;3:17002. doi: 10.1038/nrdp.2017.2. Review.


Characterizing Photon Reabsorption in Quantum Dot-Polymer Composites for Use as Displacement Sensors.

Koc MA, Raja SN, Hanson LA, Nguyen SC, Borys NJ, Powers AS, Wu S, Takano K, Swabeck JK, Olshansky JH, Lin L, Ritchie RO, Alivisatos AP.

ACS Nano. 2017 Feb 28;11(2):2075-2084. doi: 10.1021/acsnano.6b08277. Epub 2017 Jan 26.


Reporting of Design Features and Analysis Details in Randomized Clinical Trials of Procedural Treatments for Cancer Pain: An ACTTION Systematic Review.

Rothstein D, Kitt RA, Smith SM, Abdi S, Engle MP, McDermott MP, Raja SN, Turk DC, Dworkin RH, Gewandter JS.

Reg Anesth Pain Med. 2017 May/Jun;42(3):392-399. doi: 10.1097/AAP.0000000000000553. Review.


Tracking Nanoparticle Diffusion and Interaction during Self-Assembly in a Liquid Cell.

Powers AS, Liao HG, Raja SN, Bronstein ND, Alivisatos AP, Zheng H.

Nano Lett. 2017 Jan 11;17(1):15-20. doi: 10.1021/acs.nanolett.6b02972. Epub 2016 Dec 20.


Encapsulation of Perovskite Nanocrystals into Macroscale Polymer Matrices: Enhanced Stability and Polarization.

Raja SN, Bekenstein Y, Koc MA, Fischer S, Zhang D, Lin L, Ritchie RO, Yang P, Alivisatos AP.

ACS Appl Mater Interfaces. 2016 Dec 28;8(51):35523-35533. doi: 10.1021/acsami.6b09443. Epub 2016 Dec 19.


Activation of cannabinoid CB1 receptor contributes to suppression of spinal nociceptive transmission and inhibition of mechanical hypersensitivity by Aβ-fiber stimulation.

Yang F, Xu Q, Shu B, Tiwari V, He SQ, Vera-Portocarrero LP, Dong X, Linderoth B, Raja SN, Wang Y, Guan Y.

Pain. 2016 Nov;157(11):2582-2593.


Reporting of cross-over clinical trials of analgesic treatments for chronic pain: Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks systematic review and recommendations.

Gewandter JS, McDermott MP, McKeown A, Hoang K, Iwan K, Kralovic S, Rothstein D, Gilron I, Katz NP, Raja SN, Senn S, Smith SM, Turk DC, Dworkin RH.

Pain. 2016 Nov;157(11):2544-2551. Review.


Deconstructing Chronic Low Back Pain in the Older Adult-Step by Step Evidence and Expert-Based Recommendations for Evaluation and Treatment: Part X: Sacroiliac Joint Syndrome.

Polsunas PJ, Sowa G, Fritz JM, Gentili A, Morone NE, Raja SN, Rodriguez E, Schmader K, Scholten JD, Weiner DK.

Pain Med. 2016 Sep;17(9):1638-47. doi: 10.1093/pm/pnw151.


Surface Chemical Tuning of Phonon and Electron Transport in Free-Standing Silicon Nanowire Arrays.

Pan Y, Tao Y, Qin G, Fedoryshyn Y, Raja SN, Hu M, Degen CL, Poulikakos D.

Nano Lett. 2016 Oct 12;16(10):6364-6370. Epub 2016 Sep 6.


Adverse Event Reporting in Clinical Trials of Intravenous and Invasive Pain Treatments: An ACTTION Systematic Review.

Williams MR, McKeown A, Pressman Z, Hunsinger M, Lee K, Coplan P, Gilron I, Katz NP, McDermott MP, Raja SN, Rappaport BA, Rowbotham MC, Turk DC, Dworkin RH, Smith SM.

J Pain. 2016 Nov;17(11):1137-1149. doi: 10.1016/j.jpain.2016.07.006. Epub 2016 Aug 12. Review.


Mechanisms of Local Stress Sensing in Multifunctional Polymer Films Using Fluorescent Tetrapod Nanocrystals.

Raja SN, Zherebetskyy D, Wu S, Ercius P, Powers A, Olson AC, Du DX, Lin L, Govindjee S, Wang LW, Xu T, Alivisatos AP, Ritchie RO.

Nano Lett. 2016 Aug 10;16(8):5060-7. doi: 10.1021/acs.nanolett.6b01907. Epub 2016 Jul 19.


Neuropathic pain: an updated grading system for research and clinical practice.

Finnerup NB, Haroutounian S, Kamerman P, Baron R, Bennett DL, Bouhassira D, Cruccu G, Freeman R, Hansson P, Nurmikko T, Raja SN, Rice AS, Serra J, Smith BH, Treede RD, Jensen TS.

Pain. 2016 Aug;157(8):1599-606. doi: 10.1097/j.pain.0000000000000492. Review.


Mas-Related G Protein-Coupled Receptors Offer Potential New Targets for Pain Therapy.

Tiwari V, Tiwari V, He S, Zhang T, Raja SN, Dong X, Guan Y.

Adv Exp Med Biol. 2016;904:87-103. doi: 10.1007/978-94-017-7537-3_7. Review.


Activation of Peripheral μ-opioid Receptors by Dermorphin [D-Arg2, Lys4] (1-4) Amide Leads to Modality-preferred Inhibition of Neuropathic Pain.

Tiwari V, Yang F, He SQ, Shechter R, Zhang C, Shu B, Zhang T, Tiwari V, Wang Y, Dong X, Guan Y, Raja SN.

Anesthesiology. 2016 Mar;124(3):706-20. doi: 10.1097/ALN.0000000000000993.


Research design considerations for single-dose analgesic clinical trials in acute pain: IMMPACT recommendations.

Cooper SA, Desjardins PJ, Turk DC, Dworkin RH, Katz NP, Kehlet H, Ballantyne JC, Burke LB, Carragee E, Cowan P, Croll S, Dionne RA, Farrar JT, Gilron I, Gordon DB, Iyengar S, Jay GW, Kalso EA, Kerns RD, McDermott MP, Raja SN, Rappaport BA, Rauschkolb C, Royal MA, Segerdahl M, Stauffer JW, Todd KH, Vanhove GF, Wallace MS, West C, White RE, Wu C.

Pain. 2016 Feb;157(2):288-301. doi: 10.1097/j.pain.0000000000000375. Review.


Structural diversity in binary superlattices self-assembled from polymer-grafted nanocrystals.

Ye X, Zhu C, Ercius P, Raja SN, He B, Jones MR, Hauwiller MR, Liu Y, Xu T, Alivisatos AP.

Nat Commun. 2015 Dec 2;6:10052. doi: 10.1038/ncomms10052.


Neuropathic pain phenotyping by international consensus (NeuroPPIC) for genetic studies: a NeuPSIG systematic review, Delphi survey, and expert panel recommendations.

van Hecke O, Kamerman PR, Attal N, Baron R, Bjornsdottir G, Bennett DL, Bennett MI, Bouhassira D, Diatchenko L, Freeman R, Freynhagen R, Haanpää M, Jensen TS, Raja SN, Rice AS, Seltzer Z, Thorgeirsson TE, Yarnitsky D, Smith BH.

Pain. 2015 Nov;156(11):2337-53. doi: 10.1097/j.pain.0000000000000335. Review. Erratum in: Pain. 2017 Jun;158(6):1180.


Effects of Combined Electrical Stimulation of the Dorsal Column and Dorsal Roots on Wide-Dynamic-Range Neuronal Activity in Nerve-Injured Rats.

Yang F, Zhang T, Tiwari V, Shu B, Zhang C, Wang Y, Vera-Portocarrero LP, Raja SN, Guan Y.

Neuromodulation. 2015 Oct;18(7):592-7; discussion 598. doi: 10.1111/ner.12341. Epub 2015 Aug 26.


The inhibition of high-voltage-activated calcium current by activation of MrgC11 involves phospholipase C-dependent mechanisms.

Li Z, He SQ, Tseng PY, Xu Q, Tiwari V, Yang F, Shu B, Zhang T, Tang Z, Raja SN, Wang Y, Dong X, Guan Y.

Neuroscience. 2015 Aug 6;300:393-403. doi: 10.1016/j.neuroscience.2015.05.043. Epub 2015 May 27.


Electrical stimulation of low-threshold afferent fibers induces a prolonged synaptic depression in lamina II dorsal horn neurons to high-threshold afferent inputs in mice.

Sdrulla AD, Xu Q, He SQ, Tiwari V, Yang F, Zhang C, Shu B, Shechter R, Raja SN, Wang Y, Dong X, Guan Y.

Pain. 2015 Jun;156(6):1008-17. doi: 10.1097/01.j.pain.0000460353.15460.a3.


Influence of three-dimensional nanoparticle branching on the Young's modulus of nanocomposites: Effect of interface orientation.

Raja SN, Olson AC, Limaye A, Thorkelsson K, Luong A, Lin L, Ritchie RO, Xu T, Alivisatos AP.

Proc Natl Acad Sci U S A. 2015 May 26;112(21):6533-8. doi: 10.1073/pnas.1421644112. Epub 2015 May 13.


Site-specific deposition of single gold nanoparticles by individual growth in electrohydrodynamically-printed attoliter droplet reactors.

Schneider J, Rohner P, Galliker P, Raja SN, Pan Y, Tiwari MK, Poulikakos D.

Nanoscale. 2015 Jun 7;7(21):9510-9. doi: 10.1039/c4nr06964a.


World Health Organization essential medicines lists: where are the drugs to treat neuropathic pain?

Kamerman PR, Wadley AL, Davis KD, Hietaharju A, Jain P, Kopf A, Meyer AC, Raja SN, Rice AS, Smith BH, Treede RD, Wiffen PJ.

Pain. 2015 May;156(5):793-7. doi: 10.1097/01.j.pain.0000460356.94374.a1. Review. No abstract available.


Research design considerations for chronic pain prevention clinical trials: IMMPACT recommendations.

Gewandter JS, Dworkin RH, Turk DC, Farrar JT, Fillingim RB, Gilron I, Markman JD, Oaklander AL, Polydefkis MJ, Raja SN, Robinson JP, Woolf CJ, Ziegler D, Ashburn MA, Burke LB, Cowan P, George SZ, Goli V, Graff OX, Iyengar S, Jay GW, Katz J, Kehlet H, Kitt RA, Kopecky EA, Malamut R, McDermott MP, Palmer P, Rappaport BA, Rauschkolb C, Steigerwald I, Tobias J, Walco GA.

Pain. 2015 Jul;156(7):1184-97. doi: 10.1097/j.pain.0000000000000191. Review.


Dynamic Pain Phenotypes are Associated with Spinal Cord Stimulation-Induced Reduction in Pain: A Repeated Measures Observational Pilot Study.

Campbell CM, Buenaver LF, Raja SN, Kiley KB, Swedberg LJ, Wacnik PW, Cohen SP, Erdek MA, Williams KA, Christo PJ.

Pain Med. 2015 Jul;16(7):1349-60. doi: 10.1111/pme.12732. Epub 2015 Mar 20.


Injury-specific promoters enhance herpes simplex virus-mediated gene therapy for treating neuropathic pain in rodents.

Smith SN, Paige C, Velazquez KT, Smith TP, Raja SN, Wilson SP, Sweitzer SM.

J Pain. 2015 Mar;16(3):283-90. doi: 10.1016/j.jpain.2014.12.007. Epub 2015 Jan 7.


Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis.

Finnerup NB, Attal N, Haroutounian S, McNicol E, Baron R, Dworkin RH, Gilron I, Haanpää M, Hansson P, Jensen TS, Kamerman PR, Lund K, Moore A, Raja SN, Rice AS, Rowbotham M, Sena E, Siddall P, Smith BH, Wallace M.

Lancet Neurol. 2015 Feb;14(2):162-73. doi: 10.1016/S1474-4422(14)70251-0. Epub 2015 Jan 7. Review.


Electrical stimulation of dorsal root entry zone attenuates wide-dynamic-range neuronal activity in rats.

Yang F, Zhang C, Xu Q, Tiwari V, He SQ, Wang Y, Dong X, Vera-Portocarrero LP, Wacnik PW, Raja SN, Guan Y.

Neuromodulation. 2015 Jan;18(1):33-40; discussion 40. doi: 10.1111/ner.12249. Epub 2014 Oct 10.

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