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Items: 1 to 50 of 199

1.

Mitochondrial methionyl N-formylation affects steady-state levels of oxidative phosphorylation complexes and their organization into supercomplexes.

Arguello T, Köhrer C, RajBhandary UL, Moraes CT.

J Biol Chem. 2018 Sep 28;293(39):15021-15032. doi: 10.1074/jbc.RA118.003838. Epub 2018 Aug 7.

2.

Identification of YbeY-Protein Interactions Involved in 16S rRNA Maturation and Stress Regulation in Escherichia coli.

Vercruysse M, Köhrer C, Shen Y, Proulx S, Ghosal A, Davies BW, RajBhandary UL, Walker GC.

MBio. 2016 Nov 8;7(6). pii: e01785-16. doi: 10.1128/mBio.01785-16.

3.

Corrigendum: Impaired protein translation in Drosophila models for Charcot-Marie-Tooth neuropathy caused by mutant tRNA synthetases.

Niehues S, Bussmann J, Steffes G, Erdmann I, Köhrer C, Sun L, Wagner M, Schäfer K, Wang G, Koerdt SN, Stum M, Jaiswal S, RajBhandary UL, Thomas U, Aberle H, Burgess RW, Yang XL, Dieterich D, Storkebaum E.

Nat Commun. 2016 Jan 21;7:10497. doi: 10.1038/ncomms10497. No abstract available.

4.

Essentiality of threonylcarbamoyladenosine (t(6)A), a universal tRNA modification, in bacteria.

Thiaville PC, El Yacoubi B, Köhrer C, Thiaville JJ, Deutsch C, Iwata-Reuyl D, Bacusmo JM, Armengaud J, Bessho Y, Wetzel C, Cao X, Limbach PA, RajBhandary UL, de Crécy-Lagard V.

Mol Microbiol. 2015 Dec;98(6):1199-221. doi: 10.1111/mmi.13209. Epub 2015 Oct 7.

5.

Impaired protein translation in Drosophila models for Charcot-Marie-Tooth neuropathy caused by mutant tRNA synthetases.

Niehues S, Bussmann J, Steffes G, Erdmann I, Köhrer C, Sun L, Wagner M, Schäfer K, Wang G, Koerdt SN, Stum M, Jaiswal S, RajBhandary UL, Thomas U, Aberle H, Burgess RW, Yang XL, Dieterich D, Storkebaum E.

Nat Commun. 2015 Jul 3;6:7520. doi: 10.1038/ncomms8520. Erratum in: Nat Commun. 2016;7:10497. Jaiswal, Sumit [Added].

6.

Nonsense suppression in archaea.

Bhattacharya A, Köhrer C, Mandal D, RajBhandary UL.

Proc Natl Acad Sci U S A. 2015 May 12;112(19):6015-20. doi: 10.1073/pnas.1501558112. Epub 2015 Apr 27.

7.

Biochemical characterization of pathogenic mutations in human mitochondrial methionyl-tRNA formyltransferase.

Sinha A, Köhrer C, Weber MH, Masuda I, Mootha VK, Hou YM, RajBhandary UL.

J Biol Chem. 2014 Nov 21;289(47):32729-41. doi: 10.1074/jbc.M114.610626. Epub 2014 Oct 6.

8.

The highly conserved bacterial RNase YbeY is essential in Vibrio cholerae, playing a critical role in virulence, stress regulation, and RNA processing.

Vercruysse M, Köhrer C, Davies BW, Arnold MF, Mekalanos JJ, RajBhandary UL, Walker GC.

PLoS Pathog. 2014 Jun 5;10(6):e1004175. doi: 10.1371/journal.ppat.1004175. eCollection 2014 Jun.

9.

Identification and codon reading properties of 5-cyanomethyl uridine, a new modified nucleoside found in the anticodon wobble position of mutant haloarchaeal isoleucine tRNAs.

Mandal D, Köhrer C, Su D, Babu IR, Chan CT, Liu Y, Söll D, Blum P, Kuwahara M, Dedon PC, Rajbhandary UL.

RNA. 2014 Feb;20(2):177-88. doi: 10.1261/rna.042358.113. Epub 2013 Dec 16.

10.

Life without tRNAIle-lysidine synthetase: translation of the isoleucine codon AUA in Bacillus subtilis lacking the canonical tRNA2Ile.

Köhrer C, Mandal D, Gaston KW, Grosjean H, Limbach PA, Rajbhandary UL.

Nucleic Acids Res. 2014 Feb;42(3):1904-15. doi: 10.1093/nar/gkt1009. Epub 2013 Nov 4.

11.

The structural basis for specific decoding of AUA by isoleucine tRNA on the ribosome.

Voorhees RM, Mandal D, Neubauer C, Köhrer C, RajBhandary UL, Ramakrishnan V.

Nat Struct Mol Biol. 2013 May;20(5):641-3. doi: 10.1038/nsmb.2545. Epub 2013 Mar 31.

12.

Conserved bacterial RNase YbeY plays key roles in 70S ribosome quality control and 16S rRNA maturation.

Jacob AI, Köhrer C, Davies BW, RajBhandary UL, Walker GC.

Mol Cell. 2013 Feb 7;49(3):427-38. doi: 10.1016/j.molcel.2012.11.025. Epub 2012 Dec 27.

13.

Har Gobind Khorana (1922-2011).

RajBhandary UL.

Nature. 2011 Dec 14;480(7377):322. doi: 10.1038/480322a. No abstract available.

PMID:
22170673
14.

Mutations in MTFMT underlie a human disorder of formylation causing impaired mitochondrial translation.

Tucker EJ, Hershman SG, Köhrer C, Belcher-Timme CA, Patel J, Goldberger OA, Christodoulou J, Silberstein JM, McKenzie M, Ryan MT, Compton AG, Jaffe JD, Carr SA, Calvo SE, RajBhandary UL, Thorburn DR, Mootha VK.

Cell Metab. 2011 Sep 7;14(3):428-34. doi: 10.1016/j.cmet.2011.07.010.

15.

Role of Escherichia coli YbeY, a highly conserved protein, in rRNA processing.

Davies BW, Köhrer C, Jacob AI, Simmons LA, Zhu J, Aleman LM, Rajbhandary UL, Walker GC.

Mol Microbiol. 2010 Oct;78(2):506-18. doi: 10.1111/j.1365-2958.2010.07351.x. Epub 2010 Sep 16.

16.

Agmatidine, a modified cytidine in the anticodon of archaeal tRNA(Ile), base pairs with adenosine but not with guanosine.

Mandal D, Köhrer C, Su D, Russell SP, Krivos K, Castleberry CM, Blum P, Limbach PA, Söll D, RajBhandary UL.

Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):2872-7. doi: 10.1073/pnas.0914869107. Epub 2010 Jan 26.

17.

Translation initiation from the ribosomal A site or the P site, dependent on the conformation of RNA pseudoknot I in dicistrovirus RNAs.

Kamoshita N, Nomoto A, RajBhandary UL.

Mol Cell. 2009 Jul 31;35(2):181-90. doi: 10.1016/j.molcel.2009.05.024.

18.

Aminoacyl-tRNAs, the bacterial cell envelope, and antibiotics.

RajBhandary UL, Söll D.

Proc Natl Acad Sci U S A. 2008 Apr 8;105(14):5285-6. doi: 10.1073/pnas.0801193105. Epub 2008 Apr 2. Review. No abstract available.

19.

The many applications of acid urea polyacrylamide gel electrophoresis to studies of tRNAs and aminoacyl-tRNA synthetases.

Köhrer C, Rajbhandary UL.

Methods. 2008 Feb;44(2):129-38. doi: 10.1016/j.ymeth.2007.10.006.

20.

Requirements for translation re-initiation in Escherichia coli: roles of initiator tRNA and initiation factors IF2 and IF3.

Yoo JH, RajBhandary UL.

Mol Microbiol. 2008 Mar;67(5):1012-26. doi: 10.1111/j.1365-2958.2008.06104.x. Epub 2008 Jan 21.

21.

Identification and characterization of a tRNA decoding the rare AUA codon in Haloarcula marismortui.

Köhrer C, Srinivasan G, Mandal D, Mallick B, Ghosh Z, Chakrabarti J, Rajbhandary UL.

RNA. 2008 Jan;14(1):117-26. Epub 2007 Nov 12.

22.

Site-specific incorporation of keto amino acids into functional G protein-coupled receptors using unnatural amino acid mutagenesis.

Ye S, Köhrer C, Huber T, Kazmi M, Sachdev P, Yan EC, Bhagat A, RajBhandary UL, Sakmar TP.

J Biol Chem. 2008 Jan 18;283(3):1525-33. Epub 2007 Nov 8.

23.

An evolved ribosome for genetic code expansion.

Köhrer C, RajBhandary UL.

Nat Biotechnol. 2007 Jul;25(7):745-6. No abstract available.

PMID:
17621298
24.

Role of group-conserved residues in the helical core of beta2-adrenergic receptor.

Chelikani P, Hornak V, Eilers M, Reeves PJ, Smith SO, RajBhandary UL, Khorana HG.

Proc Natl Acad Sci U S A. 2007 Apr 24;104(17):7027-32. Epub 2007 Apr 16.

25.

The genetic code - thawing the 'frozen accident'.

Söll D, RajBhandary UL.

J Biosci. 2006 Oct;31(4):459-63. Review. No abstract available.

26.

Early days of tRNA research: discovery, function, purification and sequence analysis.

RajBhandary UL, Köhrer C.

J Biosci. 2006 Oct;31(4):439-51. Review. No abstract available.

27.
28.

Two conformations of a crystalline human tRNA synthetase-tRNA complex: implications for protein synthesis.

Yang XL, Otero FJ, Ewalt KL, Liu J, Swairjo MA, Köhrer C, RajBhandary UL, Skene RJ, McRee DE, Schimmel P.

EMBO J. 2006 Jun 21;25(12):2919-29. Epub 2006 May 25.

29.

Opsin is present as dimers in COS1 cells: identification of amino acids at the dimeric interface.

Kota P, Reeves PJ, Rajbhandary UL, Khorana HG.

Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3054-9. Epub 2006 Feb 21.

31.

Light-driven activation of beta 2-adrenergic receptor signaling by a chimeric rhodopsin containing the beta 2-adrenergic receptor cytoplasmic loops.

Kim JM, Hwa J, Garriga P, Reeves PJ, RajBhandary UL, Khorana HG.

Biochemistry. 2005 Feb 22;44(7):2284-92.

PMID:
15709741
33.

Mycobacterium tuberculosis Rv2118c codes for a single-component homotetrameric m1A58 tRNA methyltransferase.

Varshney U, Ramesh V, Madabushi A, Gaur R, Subramanya HS, RajBhandary UL.

Nucleic Acids Res. 2004 Feb 11;32(3):1018-27. Print 2004.

34.

A possible approach to site-specific insertion of two different unnatural amino acids into proteins in mammalian cells via nonsense suppression.

Köhrer C, Yoo JH, Bennett M, Schaack J, RajBhandary UL.

Chem Biol. 2003 Nov;10(11):1095-102.

PMID:
14652077
35.

Initiator tRNA and its role in initiation of protein synthesis.

Mayer C, Stortchevoi A, Köhrer C, Varshney U, RajBhandary UL.

Cold Spring Harb Symp Quant Biol. 2001;66:195-206. Review. No abstract available.

PMID:
12762022
37.

Common location of determinants in initiator transfer RNAs for initiator-elongator discrimination in bacteria and in eukaryotes.

Stortchevoi A, Varshney U, RajBhandary UL.

J Biol Chem. 2003 May 16;278(20):17672-9. Epub 2003 Mar 13.

38.

Methanocaldococcus jannaschii prolyl-tRNA synthetase charges tRNA(Pro) with cysteine.

Ambrogelly A, Ahel I, Polycarpo C, Bunjun-Srihari S, Krett B, Jacquin-Becker C, Ruan B, Köhrer C, Stathopoulos C, RajBhandary UL, Söll D.

J Biol Chem. 2002 Sep 20;277(38):34749-54. Epub 2002 Jul 18.

40.
41.

Import of amber and ochre suppressor tRNAs into mammalian cells: a general approach to site-specific insertion of amino acid analogues into proteins.

Köhrer C, Xie L, Kellerer S, Varshney U, RajBhandary UL.

Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14310-5. Epub 2001 Nov 20.

42.

Altered discrimination of start codons and initiator tRNAs by mutant initiation factor 3.

O'Connor M, Gregory ST, Rajbhandary UL, Dahlberg AE.

RNA. 2001 Jul;7(7):969-78.

43.
44.
45.
46.

Initiation of protein synthesis in Saccharomyces cerevisiae mitochondria without formylation of the initiator tRNA.

Li Y, Holmes WB, Appling DR, RajBhandary UL.

J Bacteriol. 2000 May;182(10):2886-92.

47.

More surprises in translation: initiation without the initiator tRNA.

RajBhandary UL.

Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1325-7. No abstract available.

49.

Induced fit of a peptide loop of methionyl-tRNA formyltransferase triggered by the initiator tRNA substrate.

Ramesh V, Mayer C, Dyson MR, Gite S, RajBhandary UL.

Proc Natl Acad Sci U S A. 1999 Feb 2;96(3):875-80.

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