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Items: 1 to 50 of 67

1.

Malignant Transformation of a Desmoplastic Ameloblastoma to Squamous Cell Carcinoma: A Case Report.

Rais R, El-Mofty SK.

Head Neck Pathol. 2018 Jul 4. doi: 10.1007/s12105-018-0946-y. [Epub ahead of print]

PMID:
29974411
2.

Valproate augments Niraparib killing of tumor cells.

Booth L, Roberts JL, Rais R, Poklepovic A, Dent P.

Cancer Biol Ther. 2018 Jun 20. doi: 10.1080/15384047.2018.1472190. [Epub ahead of print]

PMID:
29923797
3.

NaV1.1 inhibition can reduce visceral hypersensitivity.

Salvatierra J, Castro J, Erickson A, Li Q, Braz J, Gilchrist J, Grundy L, Rychkov GY, Deiteren A, Rais R, King GF, Slusher BS, Basbaum A, Pasricha PJ, Brierley SM, Bosmans F.

JCI Insight. 2018 Jun 7;3(11). pii: 121000. doi: 10.1172/jci.insight.121000. [Epub ahead of print]

4.

N-Substituted Prodrugs of Mebendazole Provide Improved Aqueous Solubility and Oral Bioavailability in Mice and Dogs.

Zimmermann SC, Tichý T, Vávra J, Dash RP, Slusher CE, Gadiano AJ, Wu Y, Jančařík A, Tenora L, Monincová L, Prchalová E, Riggins GJ, Majer P, Slusher BS, Rais R.

J Med Chem. 2018 May 10;61(9):3918-3929. doi: 10.1021/acs.jmedchem.7b01792. Epub 2018 Apr 19.

PMID:
29648826
5.

Therapeutics discovery: From bench to first in-human trials.

Al-Hujaily EM, Khatlani T, Alehaideb Z, Ali R, Almuzaini B, Alrfaei BM, Iqbal J, Islam I, Malik S, Marwani BA, Massadeh S, Nehdi A, Alsomaie B, Debasi B, Bushnak I, Noibi S, Hussain S, Wajid WA, Armand JP, Gul S, Oyarzabal J, Rais R, Bountra C, Alaskar A, Knawy BA, Boudjelal M.

Biomed Rep. 2018 Mar;8(3):275-282. doi: 10.3892/br.2018.1052. Epub 2018 Jan 31.

6.

[Neratinib + Valproate] exposure permanently reduces ERBB1 and RAS expression in 4T1 mammary tumors and enhances M1 macrophage infiltration.

Booth L, Roberts JL, Rais R, Kirkwood J, Avogadri-Connors F, Cutler RE Jr, Lalani AS, Poklepovic A, Dent P.

Oncotarget. 2017 Dec 26;9(5):6062-6074. doi: 10.18632/oncotarget.23681. eCollection 2018 Jan 19.

7.

Glutamine metabolism via glutaminase 1 in autosomal-dominant polycystic kidney disease.

Soomro I, Sun Y, Li Z, Diggs L, Hatzivassiliou G, Thomas AG, Rais R, Slusher BS, Somlo S, Skolnik EY.

Nephrol Dial Transplant. 2018 Feb 5. doi: 10.1093/ndt/gfx349. [Epub ahead of print]

PMID:
29420817
8.

Pharmacokinetics of Intranasal versus Subcutaneous Insulin in the Mouse.

Nedelcovych MT, Gadiano AJ, Wu Y, Manning AA, Thomas AG, Khuder SS, Yoo SW, Xu J, McArthur JC, Haughey NJ, Volsky DJ, Rais R, Slusher BS.

ACS Chem Neurosci. 2018 Apr 18;9(4):809-816. doi: 10.1021/acschemneuro.7b00434. Epub 2018 Jan 4.

9.

Structure-Activity Relationship Studies on a Series of 3α-[Bis(4-fluorophenyl)methoxy]tropanes and 3α-[Bis(4-fluorophenyl)methylamino]tropanes As Novel Atypical Dopamine Transporter (DAT) Inhibitors for the Treatment of Cocaine Use Disorders.

Zou MF, Cao J, Abramyan AM, Kopajtic T, Zanettini C, Guthrie DA, Rais R, Slusher BS, Shi L, Loland CJ, Newman AH.

J Med Chem. 2017 Dec 28;60(24):10172-10187. doi: 10.1021/acs.jmedchem.7b01454. Epub 2017 Dec 11.

PMID:
29227643
10.

Atypical dopamine transporter inhibitors attenuate compulsive-like methamphetamine self-administration in rats.

Tunstall BJ, Ho CP, Cao J, Vendruscolo JCM, Schmeichel BE, Slack RD, Tanda G, Gadiano AJ, Rais R, Slusher BS, Koob GF, Newman AH, Vendruscolo LF.

Neuropharmacology. 2018 Mar 15;131:96-103. doi: 10.1016/j.neuropharm.2017.12.006. Epub 2017 Dec 5.

PMID:
29217282
11.

Evans Syndrome Complicated by Intratubular Hemoglobin Cast Nephropathy.

González I, Rais R, Gaut JP, Dehner LP.

Case Rep Pediatr. 2017;2017:5184587. doi: 10.1155/2017/5184587. Epub 2017 Oct 15.

12.

A review of bioanalytical quantitative methods for selected sphingosine 1-phosphate receptor modulators.

Dash RP, Srinivas NR, Rais R.

Biomed Chromatogr. 2018 Jan;32(1). doi: 10.1002/bmc.4109. Epub 2017 Nov 6. Review.

PMID:
28990207
13.

Chirality and neuropsychiatric drugs: an update on stereoselective disposition and clinical pharmacokinetics of bupropion.

Dash RP, Rais R, Srinivas NR.

Xenobiotica. 2018 Sep;48(9):945-957. doi: 10.1080/00498254.2017.1376765. Epub 2017 Oct 13.

PMID:
28876959
14.

Key Pharmacokinetic Essentials of Fixed-Dosed Combination Products: Case Studies and Perspectives.

Dash RP, Rais R, Srinivas NR.

Clin Pharmacokinet. 2018 Apr;57(4):419-426. doi: 10.1007/s40262-017-0589-2.

PMID:
28791593
15.

Enhanced Brain Delivery of 2-(Phosphonomethyl)pentanedioic Acid Following Intranasal Administration of Its γ-Substituted Ester Prodrugs.

Nedelcovych M, Dash RP, Tenora L, Zimmermann SC, Gadiano AJ, Garrett C, Alt J, Hollinger KR, Pommier E, Jančařík A, Rojas C, Thomas AG, Wu Y, Wozniak K, Majer P, Slusher BS, Rais R.

Mol Pharm. 2017 Oct 2;14(10):3248-3257. doi: 10.1021/acs.molpharmaceut.7b00231. Epub 2017 Aug 31.

16.

N-(Pivaloyloxy)alkoxy-carbonyl Prodrugs of the Glutamine Antagonist 6-Diazo-5-oxo-l-norleucine (DON) as a Potential Treatment for HIV Associated Neurocognitive Disorders.

Nedelcovych MT, Tenora L, Kim BH, Kelschenbach J, Chao W, Hadas E, Jančařík A, Prchalová E, Zimmermann SC, Dash RP, Gadiano AJ, Garrett C, Furtmüller G, Oh B, Brandacher G, Alt J, Majer P, Volsky DJ, Rais R, Slusher BS.

J Med Chem. 2017 Aug 24;60(16):7186-7198. doi: 10.1021/acs.jmedchem.7b00966. Epub 2017 Aug 14.

17.

Discovery of a para-Acetoxy-benzyl Ester Prodrug of a Hydroxamate-Based Glutamate Carboxypeptidase II Inhibitor as Oral Therapy for Neuropathic Pain.

Rais R, Vávra J, Tichý T, Dash RP, Gadiano AJ, Tenora L, Monincová L, Bařinka C, Alt J, Zimmermann SC, Slusher CE, Wu Y, Wozniak K, Majer P, Tsukamoto T, Slusher BS.

J Med Chem. 2017 Sep 28;60(18):7799-7809. doi: 10.1021/acs.jmedchem.7b00825. Epub 2017 Sep 18.

18.

Ponesimod, a selective sphingosine 1-phosphate (S1P1) receptor modulator for autoimmune diseases: review of clinical pharmacokinetics and drug disposition.

Dash RP, Rais R, Srinivas NR.

Xenobiotica. 2018 May;48(5):442-451. doi: 10.1080/00498254.2017.1329568. Epub 2017 May 30.

PMID:
28489480
19.

P-gp/ABCB1 exerts differential impacts on brain and fetal exposure to norbuprenorphine-Significance of zeitgeber time on pharmacokinetics.

Dash RP, Rais R.

Pharmacol Res. 2017 Jul;121:251-252. doi: 10.1016/j.phrs.2017.04.004. Epub 2017 Apr 8. No abstract available.

PMID:
28400151
20.

Property-Guided Synthesis of Aza-Tricyclic Indolines: Development of Gold Catalysis En Route.

Barbour PM, Wang W, Chang L, Pickard KL, Rais R, Slusher BS, Wang X.

Adv Synth Catal. 2016 Apr 28;358(9):1482-1490. doi: 10.1002/adsc.201501101. Epub 2016 Mar 3.

21.

Stereoselective and nonstereoselective pharmacokinetics of rabeprazole - an overview.

Dash RP, Rais R, Srinivas NR.

Xenobiotica. 2018 Apr;48(4):422-432. doi: 10.1080/00498254.2017.1307470. Epub 2017 Apr 6.

PMID:
28294690
22.

Local enema treatment to inhibit FOLH1/GCPII as a novel therapy for inflammatory bowel disease.

Date AA, Rais R, Babu T, Ortiz J, Kanvinde P, Thomas AG, Zimmermann SC, Gadiano AJ, Halpert G, Slusher BS, Ensign LM.

J Control Release. 2017 Oct 10;263:132-138. doi: 10.1016/j.jconrel.2017.01.036. Epub 2017 Jan 31.

23.

Novel and High Affinity 2-[(Diphenylmethyl)sulfinyl]acetamide (Modafinil) Analogues as Atypical Dopamine Transporter Inhibitors.

Cao J, Slack RD, Bakare OM, Burzynski C, Rais R, Slusher BS, Kopajtic T, Bonifazi A, Ellenberger MP, Yano H, He Y, Bi GH, Xi ZX, Loland CJ, Newman AH.

J Med Chem. 2016 Dec 8;59(23):10676-10691. Epub 2016 Nov 28.

24.

Discovery of 6-Diazo-5-oxo-l-norleucine (DON) Prodrugs with Enhanced CSF Delivery in Monkeys: A Potential Treatment for Glioblastoma.

Rais R, Jančařík A, Tenora L, Nedelcovych M, Alt J, Englert J, Rojas C, Le A, Elgogary A, Tan J, Monincová L, Pate K, Adams R, Ferraris D, Powell J, Majer P, Slusher BS.

J Med Chem. 2016 Sep 22;59(18):8621-33. doi: 10.1021/acs.jmedchem.6b01069. Epub 2016 Sep 6.

PMID:
27560860
25.

Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer.

Elgogary A, Xu Q, Poore B, Alt J, Zimmermann SC, Zhao L, Fu J, Chen B, Xia S, Liu Y, Neisser M, Nguyen C, Lee R, Park JK, Reyes J, Hartung T, Rojas C, Rais R, Tsukamoto T, Semenza GL, Hanes J, Slusher BS, Le A.

Proc Natl Acad Sci U S A. 2016 Sep 6;113(36):E5328-36. doi: 10.1073/pnas.1611406113. Epub 2016 Aug 24.

26.

FOLH1/GCPII is elevated in IBD patients, and its inhibition ameliorates murine IBD abnormalities.

Rais R, Jiang W, Zhai H, Wozniak KM, Stathis M, Hollinger KR, Thomas AG, Rojas C, Vornov JJ, Marohn M, Li X, Slusher BS.

JCI Insight. 2016 Aug 4;1(12). pii: e88634.

27.

Highly Selective Dopamine D3 Receptor (D3R) Antagonists and Partial Agonists Based on Eticlopride and the D3R Crystal Structure: New Leads for Opioid Dependence Treatment.

Kumar V, Bonifazi A, Ellenberger MP, Keck TM, Pommier E, Rais R, Slusher BS, Gardner E, You ZB, Xi ZX, Newman AH.

J Med Chem. 2016 Aug 25;59(16):7634-50. doi: 10.1021/acs.jmedchem.6b00860. Epub 2016 Aug 10.

28.

Still NAAG'ing After All These Years: The Continuing Pursuit of GCPII Inhibitors.

Vornov JJ, Hollinger KR, Jackson PF, Wozniak KM, Farah MH, Majer P, Rais R, Slusher BS.

Adv Pharmacol. 2016;76:215-55. doi: 10.1016/bs.apha.2016.01.007. Epub 2016 Mar 18. Review.

PMID:
27288079
29.

Oral administration of D-alanine in monkeys robustly increases plasma and cerebrospinal fluid levels but experimental D-amino acid oxidase inhibitors had minimal effect.

Rojas C, Alt J, Ator NA, Wilmoth H, Rais R, Hin N, DeVivo M, Popiolek M, Tsukamoto T, Slusher BS.

J Psychopharmacol. 2016 Sep;30(9):887-95. doi: 10.1177/0269881116652586. Epub 2016 Jun 10.

PMID:
27287825
30.

Unprecedented Binding Mode of Hydroxamate-Based Inhibitors of Glutamate Carboxypeptidase II: Structural Characterization and Biological Activity.

Novakova Z, Wozniak K, Jancarik A, Rais R, Wu Y, Pavlicek J, Ferraris D, Havlinova B, Ptacek J, Vavra J, Hin N, Rojas C, Majer P, Slusher BS, Tsukamoto T, Barinka C.

J Med Chem. 2016 May 26;59(10):4539-50. doi: 10.1021/acs.jmedchem.5b01806. Epub 2016 Apr 25.

PMID:
27074627
31.

D-Amino acid oxidase inhibitors based on the 5-hydroxy-1,2,4-triazin-6(1H)-one scaffold.

Hin N, Duvall B, Berry JF, Ferraris DV, Rais R, Alt J, Rojas C, Slusher BS, Tsukamoto T.

Bioorg Med Chem Lett. 2016 Apr 15;26(8):2088-91. doi: 10.1016/j.bmcl.2016.02.068. Epub 2016 Feb 23.

32.

Discovery of Orally Available Prodrugs of the Glutamate Carboxypeptidase II (GCPII) Inhibitor 2-Phosphonomethylpentanedioic Acid (2-PMPA).

Majer P, Jančařík A, Krečmerová M, Tichý T, Tenora L, Wozniak K, Wu Y, Pommier E, Ferraris D, Rais R, Slusher BS.

J Med Chem. 2016 Mar 24;59(6):2810-9. doi: 10.1021/acs.jmedchem.6b00062. Epub 2016 Mar 10.

PMID:
26930119
33.

D-Amino-Acid Oxidase Inhibition Increases D-Serine Plasma Levels in Mouse But not in Monkey or Dog.

Rojas C, Alt J, Ator NA, Thomas AG, Wu Y, Hin N, Wozniak K, Ferraris D, Rais R, Tsukamoto T, Slusher BS.

Neuropsychopharmacology. 2016 May;41(6):1610-9. doi: 10.1038/npp.2015.319. Epub 2015 Oct 16.

34.

6-Hydroxy-1,2,4-triazine-3,5(2H,4H)-dione Derivatives as Novel D-Amino Acid Oxidase Inhibitors.

Hin N, Duvall B, Ferraris D, Alt J, Thomas AG, Rais R, Rojas C, Wu Y, Wozniak KM, Slusher BS, Tsukamoto T.

J Med Chem. 2015 Sep 24;58(18):7258-72. doi: 10.1021/acs.jmedchem.5b00482. Epub 2015 Sep 3.

35.

High Affinity Dopamine D3 Receptor (D3R)-Selective Antagonists Attenuate Heroin Self-Administration in Wild-Type but not D3R Knockout Mice.

Boateng CA, Bakare OM, Zhan J, Banala AK, Burzynski C, Pommier E, Keck TM, Donthamsetti P, Javitch JA, Rais R, Slusher BS, Xi ZX, Newman AH.

J Med Chem. 2015 Aug 13;58(15):6195-213. doi: 10.1021/acs.jmedchem.5b00776. Epub 2015 Jul 23.

36.

Selective CNS Uptake of the GCP-II Inhibitor 2-PMPA following Intranasal Administration.

Rais R, Wozniak K, Wu Y, Niwa M, Stathis M, Alt J, Giroux M, Sawa A, Rojas C, Slusher BS.

PLoS One. 2015 Jul 7;10(7):e0131861. doi: 10.1371/journal.pone.0131861. eCollection 2015.

37.

Kinetic mechanism of Toxoplasma gondii adenosine kinase and the highly efficient utilization of adenosine.

Naguib FN, Rais RH, Al Safarjalani ON, el Kouni MH.

Comp Biochem Physiol B Biochem Mol Biol. 2015 Oct;188:63-9. doi: 10.1016/j.cbpb.2015.06.006. Epub 2015 Jun 23.

38.

Gastrointestinal delivery of propofol from fospropofol: its bioavailability and activity in rodents and human volunteers.

Wozniak KM, Vornov JJ, Mistry BM, Wu Y, Rais R, Slusher BS.

J Transl Med. 2015 May 29;13:170. doi: 10.1186/s12967-015-0526-9.

39.

Rheumatoid arthritis clinical features and management strategies at an urban tertiary facility in Pakistan.

Rais R, Saeed M, Haider R, Jassani Z, Riaz A, Perveen T.

J Pak Med Assoc. 2014 Dec;64(12):1435-7. Erratum in: J Pak Med Assoc. 2015 Feb;65(2):239.

40.

Using click chemistry toward novel 1,2,3-triazole-linked dopamine D3 receptor ligands.

Keck TM, Banala AK, Slack RD, Burzynski C, Bonifazi A, Okunola-Bakare OM, Moore M, Deschamps JR, Rais R, Slusher BS, Newman AH.

Bioorg Med Chem. 2015 Jul 15;23(14):4000-12. doi: 10.1016/j.bmc.2015.01.017. Epub 2015 Jan 17.

41.

Structure-Metabolism Relationships in the Glucuronidation of d-Amino Acid Oxidase Inhibitors.

Zimmermann SC, Rais R, Alt J, Burzynski C, Slusher BS, Tsukamoto T.

ACS Med Chem Lett. 2014 Oct 21;5(11):1251-3. doi: 10.1021/ml500335z. eCollection 2014 Nov 13.

42.

Regional brain distribution of translocator protein using [(11)C]DPA-713 PET in individuals infected with HIV.

Coughlin JM, Wang Y, Ma S, Yue C, Kim PK, Adams AV, Roosa HV, Gage KL, Stathis M, Rais R, Rojas C, McGlothan JL, Watkins CC, Sacktor N, Guilarte TR, Zhou Y, Sawa A, Slusher BS, Caffo B, Kassiou M, Endres CJ, Pomper MG.

J Neurovirol. 2014 Jun;20(3):219-32. doi: 10.1007/s13365-014-0239-5. Epub 2014 Feb 25.

43.

δ-Thiolactones as prodrugs of thiol-based glutamate carboxypeptidase II (GCPII) inhibitors.

Ferraris DV, Majer P, Ni C, Slusher CE, Rais R, Wu Y, Wozniak KM, Alt J, Rojas C, Slusher BS, Tsukamoto T.

J Med Chem. 2014 Jan 9;57(1):243-7. doi: 10.1021/jm401703a. Epub 2013 Dec 27.

44.

Bioanalytical method for evaluating the pharmacokinetics of the GCP-II inhibitor 2-phosphonomethyl pentanedioic acid (2-PMPA).

Rais R, Rojas C, Wozniak K, Wu Y, Zhao M, Tsukamoto T, Rudek MA, Slusher BS.

J Pharm Biomed Anal. 2014 Jan;88:162-9. doi: 10.1016/j.jpba.2013.08.028. Epub 2013 Aug 30.

45.

Pharmacokinetics and pharmacodynamics of the glutamate carboxypeptidase II inhibitor 2-MPPA show prolonged alleviation of neuropathic pain through an indirect mechanism.

Vornov JJ, Wozniak KM, Wu Y, Rojas C, Rais R, Slusher BS.

J Pharmacol Exp Ther. 2013 Sep;346(3):406-13. doi: 10.1124/jpet.113.205039. Epub 2013 Jun 17.

46.

Synthesis and SAR of 1-hydroxy-1H-benzo[d]imidazol-2(3H)-ones as Inhibitors of D-Amino Acid Oxidase.

Berry JF, Ferraris DV, Duvall B, Hin N, Rais R, Alt J, Thomas AG, Rojas C, Hashimoto K, Slusher BS, Tsukamoto T.

ACS Med Chem Lett. 2012 Oct 11;3(10):839-843. Epub 2012 Sep 16.

47.

Inhibition of glutamate carboxypeptidase II (GCPII) activity as a treatment for cognitive impairment in multiple sclerosis.

Rahn KA, Watkins CC, Alt J, Rais R, Stathis M, Grishkan I, Crainiceau CM, Pomper MG, Rojas C, Pletnikov MV, Calabresi PA, Brandt J, Barker PB, Slusher BS, Kaplin AI.

Proc Natl Acad Sci U S A. 2012 Dec 4;109(49):20101-6. doi: 10.1073/pnas.1209934109. Epub 2012 Nov 19.

48.

Design, synthesis, and pharmacological evaluation of bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide 3 (BPTES) analogs as glutaminase inhibitors.

Shukla K, Ferraris DV, Thomas AG, Stathis M, Duvall B, Delahanty G, Alt J, Rais R, Rojas C, Gao P, Xiang Y, Dang CV, Slusher BS, Tsukamoto T.

J Med Chem. 2012 Dec 13;55(23):10551-63. doi: 10.1021/jm301191p. Epub 2012 Nov 30.

49.

The orally active glutamate carboxypeptidase II inhibitor E2072 exhibits sustained nerve exposure and attenuates peripheral neuropathy.

Wozniak KM, Wu Y, Vornov JJ, Lapidus R, Rais R, Rojas C, Tsukamoto T, Slusher BS.

J Pharmacol Exp Ther. 2012 Dec;343(3):746-54. doi: 10.1124/jpet.112.197665. Epub 2012 Sep 17.

50.

Reversible disulfide formation of the glutamate carboxypeptidase II inhibitor E2072 results in prolonged systemic exposures in vivo.

Rais R, Hoover R, Wozniak K, Rudek MA, Tsukamoto T, Alt J, Rojas C, Slusher BS.

Drug Metab Dispos. 2012 Dec;40(12):2315-23. doi: 10.1124/dmd.112.046821. Epub 2012 Sep 4.

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