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Items: 1 to 50 of 93

1.

Appropriation of GPIbα from platelet-derived extracellular vesicles supports monocyte recruitment in systemic inflammation.

Chimen M, Evryviadou A, Box CL, Harrison MJ, Hazeldine J, Dib LH, Kuravi SJ, Payne H, Price JMJ, Kavanagh D, Iqbal AJ, Lax S, Kalia N, Brill A, Thomas SG, Belli A, Crombie N, Adams RA, Evans SA, Deckmyn H, Lord JM, Harrison P, Watson SP, Nash GB, Rainger GE.

Haematologica. 2019 Aug 29. pii: haematol.2018.215145. doi: 10.3324/haematol.2018.215145. [Epub ahead of print]

2.

Cannabinoid receptor 2 deficiency exacerbates inflammation and neutrophil recruitment.

Kapellos TS, Taylor L, Feuerborn A, Valaris S, Hussain MT, Rainger GE, Greaves DR, Iqbal AJ.

FASEB J. 2019 May;33(5):6154-6167. doi: 10.1096/fj.201802524R. Epub 2019 Feb 25.

3.

Synthetic glycopolymers and natural fucoidans cause human platelet aggregation via PEAR1 and GPIbα.

Kardeby C, Fälker K, Haining EJ, Criel M, Lindkvist M, Barroso R, Påhlsson P, Ljungberg LU, Tengdelius M, Rainger GE, Watson S, Eble JA, Hoylaerts MF, Emsley J, Konradsson P, Watson SP, Sun Y, Grenegård M.

Blood Adv. 2019 Feb 12;3(3):275-287. doi: 10.1182/bloodadvances.2018024950.

4.

Tspan18 is a novel regulator of the Ca2+ channel Orai1 and von Willebrand factor release in endothelial cells.

Noy PJ, Gavin RL, Colombo D, Haining EJ, Reyat JS, Payne H, Thielmann I, Lokman AB, Neag G, Yang J, Lloyd T, Harrison N, Heath VL, Gardiner C, Whitworth KM, Robinson J, Koo CZ, Di Maio A, Harrison P, Lee SP, Michelangeli F, Kalia N, Rainger GE, Nieswandt B, Brill A, Watson SP, Tomlinson MG.

Haematologica. 2019 Sep;104(9):1892-1905. doi: 10.3324/haematol.2018.194241. Epub 2018 Dec 20.

5.

Ability of Platelet-Derived Extracellular Vesicles to Promote Neutrophil-Endothelial Cell Interactions.

Kuravi SJ, Harrison P, Rainger GE, Nash GB.

Inflammation. 2019 Feb;42(1):290-305. doi: 10.1007/s10753-018-0893-5.

6.

Signalling through Src family kinase isoforms is not redundant in models of thrombo-inflammatory vascular disease.

Harrison MJ, Chimen M, Hussain M, Iqbal AJ, Senis YA, Nash GB, Watson SP, Rainger GE.

J Cell Mol Med. 2018 Sep;22(9):4317-4327. doi: 10.1111/jcmm.13721. Epub 2018 Jul 4.

7.

Origin-Specific Adhesive Interactions of Mesenchymal Stem Cells with Platelets Influence Their Behavior After Infusion.

Sheriff L, Alanazi A, Ward LSC, Ward C, Munir H, Rayes J, Alassiri M, Watson SP, Newsome PN, Rainger GE, Kalia N, Frampton J, McGettrick HM, Nash GB.

Stem Cells. 2018 Jul;36(7):1062-1074. doi: 10.1002/stem.2811. Epub 2018 Mar 23.

8.

The Relationship Between Serum Interleukin-1α and Asymptomatic Infrarenal Abdominal Aortic Aneurysm Size, Morphology, and Growth Rates.

Ahmad M, Kuravi S, Hodson J, Rainger GE, Nash GB, Vohra RK, Bradbury AW.

Eur J Vasc Endovasc Surg. 2018 Jul;56(1):130-135. doi: 10.1016/j.ejvs.2018.01.015. Epub 2018 Feb 16.

9.

ADAM10-Interacting Tetraspanins Tspan5 and Tspan17 Regulate VE-Cadherin Expression and Promote T Lymphocyte Transmigration.

Reyat JS, Chimen M, Noy PJ, Szyroka J, Rainger GE, Tomlinson MG.

J Immunol. 2017 Jul 15;199(2):666-676. doi: 10.4049/jimmunol.1600713. Epub 2017 Jun 9.

10.

Mesenchymal Stromal Cells as Active Regulators of Lymphocyte Recruitment to Blood Vascular Endothelial Cells.

Mcgettrick HM, Ward LS, Rainger GE, Nash GB.

Methods Mol Biol. 2017;1591:121-142. doi: 10.1007/978-1-4939-6931-9_9.

PMID:
28349479
11.

Monocyte Subsets Coregulate Inflammatory Responses by Integrated Signaling through TNF and IL-6 at the Endothelial Cell Interface.

Chimen M, Yates CM, McGettrick HM, Ward LS, Harrison MJ, Apta B, Dib LH, Imhof BA, Harrison P, Nash GB, Rainger GE.

J Immunol. 2017 Apr 1;198(7):2834-2843. doi: 10.4049/jimmunol.1601281. Epub 2017 Feb 13.

12.

Fish oil supplements, longevity and aging.

de Magalhães JP, Müller M, Rainger GE, Steegenga W.

Aging (Albany NY). 2016 Aug;8(8):1578-82. doi: 10.18632/aging.101021.

13.

Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer.

Strong R, Miller RA, Antebi A, Astle CM, Bogue M, Denzel MS, Fernandez E, Flurkey K, Hamilton KL, Lamming DW, Javors MA, de Magalhães JP, Martinez PA, McCord JM, Miller BF, Müller M, Nelson JF, Ndukum J, Rainger GE, Richardson A, Sabatini DM, Salmon AB, Simpkins JW, Steegenga WT, Nadon NL, Harrison DE.

Aging Cell. 2016 Oct;15(5):872-84. doi: 10.1111/acel.12496. Epub 2016 Jun 16.

14.

TspanC8 Tetraspanins and A Disintegrin and Metalloprotease 10 (ADAM10) Interact via Their Extracellular Regions: EVIDENCE FOR DISTINCT BINDING MECHANISMS FOR DIFFERENT TspanC8 PROTEINS.

Noy PJ, Yang J, Reyat JS, Matthews AL, Charlton AE, Furmston J, Rogers DA, Rainger GE, Tomlinson MG.

J Biol Chem. 2016 Feb 12;291(7):3145-57. doi: 10.1074/jbc.M115.703058. Epub 2015 Dec 14.

15.

Inflammation drives thrombosis after Salmonella infection via CLEC-2 on platelets.

Hitchcock JR, Cook CN, Bobat S, Ross EA, Flores-Langarica A, Lowe KL, Khan M, Dominguez-Medina CC, Lax S, Carvalho-Gaspar M, Hubscher S, Rainger GE, Cobbold M, Buckley CD, Mitchell TJ, Mitchell A, Jones ND, Van Rooijen N, Kirchhofer D, Henderson IR, Adams DH, Watson SP, Cunningham AF.

J Clin Invest. 2015 Dec;125(12):4429-46. doi: 10.1172/JCI79070. Epub 2015 Nov 16.

16.

Homeostatic regulation of T cell trafficking by a B cell-derived peptide is impaired in autoimmune and chronic inflammatory disease.

Chimen M, McGettrick HM, Apta B, Kuravi SJ, Yates CM, Kennedy A, Odedra A, Alassiri M, Harrison M, Martin A, Barone F, Nayar S, Hitchcock JR, Cunningham AF, Raza K, Filer A, Copland DA, Dick AD, Robinson J, Kalia N, Walker LSK, Buckley CD, Nash GB, Narendran P, Rainger GE.

Nat Med. 2015 May;21(5):467-475. doi: 10.1038/nm.3842. Epub 2015 Apr 20.

17.

The roles of integrins in function of human neutrophils after their migration through endothelium into interstitial matrix.

Luo D, McGettrick HM, Stone PC, Rainger GE, Nash GB.

PLoS One. 2015 Feb 23;10(2):e0118593. doi: 10.1371/journal.pone.0118593. eCollection 2015.

18.

Analyzing the effects of stromal cells on the recruitment of leukocytes from flow.

Munir H, Rainger GE, Nash GB, McGettrick H.

J Vis Exp. 2015 Jan 7;(95):e52480. doi: 10.3791/52480.

19.

Podocytes regulate neutrophil recruitment by glomerular endothelial cells via IL-6-mediated crosstalk.

Kuravi SJ, McGettrick HM, Satchell SC, Saleem MA, Harper L, Williams JM, Rainger GE, Savage CO.

J Immunol. 2014 Jul 1;193(1):234-43. doi: 10.4049/jimmunol.1300229. Epub 2014 May 28.

20.

A zebrafish compound screen reveals modulation of neutrophil reverse migration as an anti-inflammatory mechanism.

Robertson AL, Holmes GR, Bojarczuk AN, Burgon J, Loynes CA, Chimen M, Sawtell AK, Hamza B, Willson J, Walmsley SR, Anderson SR, Coles MC, Farrow SN, Solari R, Jones S, Prince LR, Irimia D, Rainger GE, Kadirkamanathan V, Whyte MK, Renshaw SA.

Sci Transl Med. 2014 Feb 26;6(225):225ra29. doi: 10.1126/scitranslmed.3007672.

21.

Analysis of the effects of stromal cells on the migration of lymphocytes into and through inflamed tissue using 3-D culture models.

Jeffery HC, Buckley CD, Moss P, Rainger GE, Nash GB, McGettrick HM.

J Immunol Methods. 2013 Dec 31;400-401:45-57. doi: 10.1016/j.jim.2013.10.004. Epub 2013 Oct 16.

22.

Adhesion of tumor cells to matrices and endothelium.

Yates CM, McGettrick HM, Nash GB, Rainger GE.

Methods Mol Biol. 2014;1070:57-75. doi: 10.1007/978-1-4614-8244-4_5.

PMID:
24092432
23.

Crosstalk between mesenchymal stem cells and endothelial cells leads to downregulation of cytokine-induced leukocyte recruitment.

Luu NT, McGettrick HM, Buckley CD, Newsome PN, Rainger GE, Frampton J, Nash GB.

Stem Cells. 2013 Dec;31(12):2690-702. doi: 10.1002/stem.1511.

24.

The role of platelet-endothelial cell adhesion molecule-1 in atheroma formation varies depending on the site-specific hemodynamic environment.

Harrison M, Smith E, Ross E, Krams R, Segers D, Buckley CD, Nash GB, Rainger GE.

Arterioscler Thromb Vasc Biol. 2013 Apr;33(4):694-701. doi: 10.1161/ATVBAHA.112.300379. Epub 2013 Jan 31.

PMID:
23372062
25.

Integrin-substrate interactions underlying shear-induced inhibition of the inflammatory response of endothelial cells.

Luu NT, Glen KE, Egginton S, Rainger GE, Nash GB.

Thromb Haemost. 2013 Feb;109(2):298-308. doi: 10.1160/TH12-06-0400. Epub 2012 Dec 13.

PMID:
23238518
26.

PR3 and elastase alter PAR1 signaling and trigger vWF release via a calcium-independent mechanism from glomerular endothelial cells.

Tull SP, Bevins A, Kuravi SJ, Satchell SC, Al-Ani B, Young SP, Harper L, Williams JM, Rainger GE, Savage CO.

PLoS One. 2012;7(8):e43916. doi: 10.1371/journal.pone.0043916. Epub 2012 Aug 29.

27.

Neutrophil serine proteases mediate inflammatory cell recruitment by glomerular endothelium and progression towards dysfunction.

Kuravi SJ, Bevins A, Satchell SC, Harper L, Williams JM, Rainger GE, Savage CO, Tull SP.

Nephrol Dial Transplant. 2012 Dec;27(12):4331-8. doi: 10.1093/ndt/gfs180. Epub 2012 Jul 10.

PMID:
22785107
28.

Tissue stroma as a regulator of leukocyte recruitment in inflammation.

McGettrick HM, Butler LM, Buckley CD, Rainger GE, Nash GB.

J Leukoc Biol. 2012 Mar;91(3):385-400. doi: 10.1189/jlb.0911458. Epub 2012 Jan 6. Review.

PMID:
22227966
29.

Mesenchymal stem cells exhibit firm adhesion, crawling, spreading and transmigration across aortic endothelial cells: effects of chemokines and shear.

Chamberlain G, Smith H, Rainger GE, Middleton J.

PLoS One. 2011;6(9):e25663. doi: 10.1371/journal.pone.0025663. Epub 2011 Sep 28.

30.

Modulation of functional responses of endothelial cells linked to angiogenesis and inflammation by shear stress: differential effects of the mechanotransducer CD31.

Glen K, Luu NT, Ross E, Buckley CD, Rainger GE, Egginton S, Nash GB.

J Cell Physiol. 2012 Jun;227(6):2710-21. doi: 10.1002/jcp.23015.

PMID:
21898411
31.

Prostaglandin D2 regulates CD4+ memory T cell trafficking across blood vascular endothelium and primes these cells for clearance across lymphatic endothelium.

Ahmed SR, McGettrick HM, Yates CM, Buckley CD, Ratcliffe MJ, Nash GB, Rainger GE.

J Immunol. 2011 Aug 1;187(3):1432-9. doi: 10.4049/jimmunol.1100299. Epub 2011 Jun 29.

32.

The junctional adhesion molecule JAM-C regulates polarized transendothelial migration of neutrophils in vivo.

Woodfin A, Voisin MB, Beyrau M, Colom B, Caille D, Diapouli FM, Nash GB, Chavakis T, Albelda SM, Rainger GE, Meda P, Imhof BA, Nourshargh S.

Nat Immunol. 2011 Jun 26;12(8):761-9. doi: 10.1038/ni.2062.

33.

Endovascular aneurysm repair reverses the increased titer and the inflammatory activity of interleukin-1α in the serum of patients with abdominal aortic aneurysm.

Yates CM, Abdelhamid M, Adam DJ, Nash GB, Bradbury AW, Rainger GE.

J Vasc Surg. 2011 Aug;54(2):497-503. doi: 10.1016/j.jvs.2011.02.061. Epub 2011 May 28.

34.

Docosahexaenoic acid inhibits the adhesion of flowing neutrophils to cytokine stimulated human umbilical vein endothelial cells.

Yates CM, Tull SP, Madden J, Calder PC, Grimble RF, Nash GB, Rainger GE.

J Nutr. 2011 Jul;141(7):1331-4. doi: 10.3945/jn.111.139287. Epub 2011 May 25.

PMID:
21613456
35.

Editorial: Neutrophils live on a two-way street.

Mulero V, Sepulcre MP, Rainger GE, Buckley CD.

J Leukoc Biol. 2011 May;89(5):645-7. doi: 10.1189/jlb.0111013. No abstract available.

PMID:
21532050
36.

Endothelial cell-borne platelet bridges selectively recruit monocytes in human and mouse models of vascular inflammation.

Kuckleburg CJ, Yates CM, Kalia N, Zhao Y, Nash GB, Watson SP, Rainger GE.

Cardiovasc Res. 2011 Jul 1;91(1):134-41. doi: 10.1093/cvr/cvr040. Epub 2011 Feb 1.

PMID:
21285294
37.

Delay of migrating leukocytes by the basement membrane deposited by endothelial cells in long-term culture.

Burton VJ, Butler LM, McGettrick HM, Stone PC, Jeffery HC, Savage CO, Rainger GE, Nash GB.

Exp Cell Res. 2011 Feb 1;317(3):276-92. doi: 10.1016/j.yexcr.2010.10.022. Epub 2010 Nov 4.

38.

Stromal cells differentially regulate neutrophil and lymphocyte recruitment through the endothelium.

McGettrick HM, Buckley CD, Filer A, Rainger GE, Nash GB.

Immunology. 2010 Nov;131(3):357-70. doi: 10.1111/j.1365-2567.2010.03307.x.

39.

Responses of endothelial cells from different vessels to inflammatory cytokines and shear stress: evidence for the pliability of endothelial phenotype.

Luu NT, Rahman M, Stone PC, Rainger GE, Nash GB.

J Vasc Res. 2010;47(5):451-61. doi: 10.1159/000302613. Epub 2010 Mar 26.

40.

A role for the endothelial glycosaminoglycan hyaluronan in neutrophil recruitment by endothelial cells cultured for prolonged periods.

Butler LM, Rainger GE, Nash GB.

Exp Cell Res. 2009 Nov 15;315(19):3433-41. doi: 10.1016/j.yexcr.2009.08.012. Epub 2009 Aug 28.

41.

Omega-3 Fatty acids and inflammation: novel interactions reveal a new step in neutrophil recruitment.

Tull SP, Yates CM, Maskrey BH, O'Donnell VB, Madden J, Grimble RF, Calder PC, Nash GB, Rainger GE.

PLoS Biol. 2009 Aug;7(8):e1000177. doi: 10.1371/journal.pbio.1000177. Epub 2009 Aug 25.

42.

Fibroblasts from different sites may promote or inhibit recruitment of flowing lymphocytes by endothelial cells.

McGettrick HM, Smith E, Filer A, Kissane S, Salmon M, Buckley CD, Rainger GE, Nash GB.

Eur J Immunol. 2009 Jan;39(1):113-25. doi: 10.1002/eji.200838232.

43.

Direct observations of the kinetics of migrating T cells suggest active retention by endothelial cells with continual bidirectional migration.

McGettrick HM, Hunter K, Moss PA, Buckley CD, Rainger GE, Nash GB.

J Leukoc Biol. 2009 Jan;85(1):98-107. doi: 10.1189/jlb.0508301. Epub 2008 Oct 23.

44.

Altered monocyte CD44 expression in peripheral arterial disease is corrected by fish oil supplementation.

Madden J, Shearman CP, Dunn RL, Dastur ND, Tan RM, Nash GB, Rainger GE, Brunner A, Calder PC, Grimble RF.

Nutr Metab Cardiovasc Dis. 2009 May;19(4):247-52. doi: 10.1016/j.numecd.2008.06.011. Epub 2008 Sep 19.

PMID:
18804988
45.

A role for the integrin alpha6beta1 in the differential distribution of CD4 and CD8 T-cell subsets within the rheumatoid synovium.

Haworth O, Hardie DL, Burman A, Rainger GE, Eksteen B, Adams DH, Salmon M, Nash GB, Buckley CD.

Rheumatology (Oxford). 2008 Sep;47(9):1329-34. doi: 10.1093/rheumatology/ken263. Epub 2008 Jul 17.

46.

Mechanisms of the anti-inflammatory effects of hydroxyethyl starch demonstrated in a flow-based model of neutrophil recruitment by endothelial cells.

Matharu NM, Butler LM, Rainger GE, Gosling P, Vohra RK, Nash GB.

Crit Care Med. 2008 May;36(5):1536-42. doi: 10.1097/CCM.0b013e318169f19a.

PMID:
18434912
47.

Inflammatory responses of endothelial cells experiencing reduction in flow after conditioning by shear stress.

Matharu NM, McGettrick HM, Salmon M, Kissane S, Vohra RK, Rainger GE, Nash GB.

J Cell Physiol. 2008 Sep;216(3):732-41. doi: 10.1002/jcp.21457.

PMID:
18393276
48.

Dietary supplementation with fish oil modifies the ability of human monocytes to induce an inflammatory response.

Luu NT, Madden J, Calder PC, Grimble RF, Shearman CP, Chan T, Dastur N, Howell WM, Rainger GE, Nash GB.

J Nutr. 2007 Dec;137(12):2769-74.

PMID:
18029497
49.

Modulation of endothelial responses by the stromal microenvironment: effects on leucocyte recruitment.

McGettrick HM, Filer A, Rainger GE, Buckley CD, Nash GB.

Biochem Soc Trans. 2007 Nov;35(Pt 5):1161-2. Review.

PMID:
17956301
50.

JAM-C regulates unidirectional monocyte transendothelial migration in inflammation.

Bradfield PF, Scheiermann C, Nourshargh S, Ody C, Luscinskas FW, Rainger GE, Nash GB, Miljkovic-Licina M, Aurrand-Lions M, Imhof BA.

Blood. 2007 Oct 1;110(7):2545-55. Epub 2007 Jul 11.

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