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Items: 25


Characterization of a Novel Bispecific Antibody With Improved Conformational and Chemical Stability.

Manikwar P, Mulagapati SHR, Kasturirangan S, Moez K, Rainey GJ, Lobo B.

J Pharm Sci. 2019 Jul 6. pii: S0022-3549(19)30428-9. doi: 10.1016/j.xphs.2019.06.025. [Epub ahead of print]


Structure and biophysical characterization of the human full-length neurturin-GFRa2 complex: A role for heparan sulfate in signaling.

Sandmark J, Dahl G, Öster L, Xu B, Johansson P, Akerud T, Aagaard A, Davidsson P, Bigalke JM, Winzell MS, Rainey GJ, Roth RG.

J Biol Chem. 2018 Apr 13;293(15):5492-5508. doi: 10.1074/jbc.RA117.000820. Epub 2018 Feb 2.


A neutralizing antibody that blocks delivery of the enzymatic cargo of Clostridium difficile toxin TcdB into host cells.

Kroh HK, Chandrasekaran R, Zhang Z, Rosenthal K, Woods R, Jin X, Nyborg AC, Rainey GJ, Warrener P, Melnyk RA, Spiller BW, Lacy DB.

J Biol Chem. 2018 Jan 19;293(3):941-952. doi: 10.1074/jbc.M117.813428. Epub 2017 Nov 27.


Use of a neutralizing antibody helps identify structural features critical for binding of Clostridium difficile toxin TcdA to the host cell surface.

Kroh HK, Chandrasekaran R, Rosenthal K, Woods R, Jin X, Ohi MD, Nyborg AC, Rainey GJ, Warrener P, Spiller BW, Lacy DB.

J Biol Chem. 2017 Sep 1;292(35):14401-14412. doi: 10.1074/jbc.M117.781112. Epub 2017 Jul 13.


An antidote approach to reduce risk and broaden utility of antibody-based therapeutics.

Portnoff AD, Gao C, Borrok MJ, Gao X, Gao C, Rainey GJ.

J Biol Chem. 2017 May 19;292(20):8498-8506. doi: 10.1074/jbc.M117.775528. Epub 2017 Mar 3.


Targeted Fcγ Receptor (FcγR)-mediated Clearance by a Biparatopic Bispecific Antibody.

Kasturirangan S, Rainey GJ, Xu L, Wang X, Portnoff A, Chen T, Fazenbaker C, Zhong H, Bee J, Zeng Z, Jenne C, Wu H, Gao C.

J Biol Chem. 2017 Mar 10;292(10):4361-4370. doi: 10.1074/jbc.M116.770628. Epub 2017 Jan 18.


An anti-H5N1 influenza virus FcDART antibody is a highly efficacious therapeutic agent and prophylactic against H5N1 influenza virus infection.

Zanin M, Keck ZY, Rainey GJ, Lam CY, Boon AC, Rubrum A, Darnell D, Wong SS, Griffin Y, Xia J, Webster RG, Webby R, Johnson S, Foung S.

J Virol. 2015 Apr;89(8):4549-61. doi: 10.1128/JVI.00078-15. Epub 2015 Feb 11.


A multifunctional bispecific antibody protects against Pseudomonas aeruginosa.

DiGiandomenico A, Keller AE, Gao C, Rainey GJ, Warrener P, Camara MM, Bonnell J, Fleming R, Bezabeh B, Dimasi N, Sellman BR, Hilliard J, Guenther CM, Datta V, Zhao W, Gao C, Yu XQ, Suzich JA, Stover CK.

Sci Transl Med. 2014 Nov 12;6(262):262ra155. doi: 10.1126/scitranslmed.3009655.


A mammalian expression system for high throughput antibody screening.

Xu L, Jin X, Rainey GJ, Wu H, Gao C.

J Immunol Methods. 2013 Sep 30;395(1-2):45-53. doi: 10.1016/j.jim.2013.06.009. Epub 2013 Jul 4.


Application of dual affinity retargeting molecules to achieve optimal redirected T-cell killing of B-cell lymphoma.

Moore PA, Zhang W, Rainey GJ, Burke S, Li H, Huang L, Gorlatov S, Veri MC, Aggarwal S, Yang Y, Shah K, Jin L, Zhang S, He L, Zhang T, Ciccarone V, Koenig S, Bonvini E, Johnson S.

Blood. 2011 Apr 28;117(17):4542-51. doi: 10.1182/blood-2010-09-306449. Epub 2011 Feb 7.


Therapeutic control of B cell activation via recruitment of Fcgamma receptor IIb (CD32B) inhibitory function with a novel bispecific antibody scaffold.

Veri MC, Burke S, Huang L, Li H, Gorlatov S, Tuaillon N, Rainey GJ, Ciccarone V, Zhang T, Shah K, Jin L, Ning L, Minor T, Moore PA, Koenig S, Johnson S, Bonvini E.

Arthritis Rheum. 2010 Jul;62(7):1933-43. doi: 10.1002/art.27477.


A viral nanoparticle with dual function as an anthrax antitoxin and vaccine.

Manayani DJ, Thomas D, Dryden KA, Reddy V, Siladi ME, Marlett JM, Rainey GJ, Pique ME, Scobie HM, Yeager M, Young JA, Manchester M, Schneemann A.

PLoS Pathog. 2007 Oct 5;3(10):1422-31.


Anthrax toxin receptor 2 determinants that dictate the pH threshold of toxin pore formation.

Scobie HM, Marlett JM, Rainey GJ, Lacy DB, Collier RJ, Young JA.

PLoS One. 2007 Mar 28;2(3):e329.


Anthrax toxin receptor 2-dependent lethal toxin killing in vivo.

Scobie HM, Wigelsworth DJ, Marlett JM, Thomas D, Rainey GJ, Lacy DB, Manchester M, Collier RJ, Young JA.

PLoS Pathog. 2006 Oct;2(10):e111. Erratum in: PLoS Pathog. 2008 Oct;4(10).doi:10.1371/annotation/08c1bcf0-da65-4abd-97c7-5df86b1120b5.


Whole-cell voltage clamp measurements of anthrax toxin pore current.

Wolfe JT, Krantz BA, Rainey GJ, Young JA, Collier RJ.

J Biol Chem. 2005 Nov 25;280(47):39417-22. Epub 2005 Sep 23.


Receptor-specific requirements for anthrax toxin delivery into cells.

Rainey GJ, Wigelsworth DJ, Ryan PL, Scobie HM, Collier RJ, Young JA.

Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13278-83. Epub 2005 Sep 1.


Antitoxins: novel strategies to target agents of bioterrorism.

Rainey GJ, Young JA.

Nat Rev Microbiol. 2004 Sep;2(9):721-6. Review.


Mechanisms of avian retroviral host range extension.

Rainey GJ, Natonson A, Maxfield LF, Coffin JM.

J Virol. 2003 Jun;77(12):6709-19.


Human capillary morphogenesis protein 2 functions as an anthrax toxin receptor.

Scobie HM, Rainey GJ, Bradley KA, Young JA.

Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5170-4. Epub 2003 Apr 16.


Substrate sequence selection by retroviral integrase.

Zhou H, Rainey GJ, Wong SK, Coffin JM.

J Virol. 2001 Feb;75(3):1359-70.


Constitutive activation of STAT3 is associated with the acquisition of an interleukin 6-independent phenotype by murine plasmacytomas and hybridomas.

Rawat R, Rainey GJ, Thompson CD, Frazier-Jessen MR, Brown RT, Nordan RP.

Blood. 2000 Nov 15;96(10):3514-21.


Chromosomal and extrachromosomal instability of the cyclin D2 gene is induced by Myc overexpression.

Mai S, Hanley-Hyde J, Rainey GJ, Kuschak TI, Paul JT, Littlewood TD, Mischak H, Stevens LM, Henderson DW, Mushinski JF.

Neoplasia. 1999 Aug;1(3):241-52.


Myc-induced cyclin D2 genomic instability in murine B cell neoplasms.

Mushinski JF, Hanley-Hyde J, Rainey GJ, Kuschak TI, Taylor C, Fluri M, Stevens LM, Henderson DW, Mai S.

Curr Top Microbiol Immunol. 1999;246:183-9; discussion 190-2. Review. No abstract available.


Purification of the simian virus 40 (SV40) T antigen DNA-binding domain and characterization of its interactions with the SV40 origin.

Joo WS, Luo X, Denis D, Kim HY, Rainey GJ, Jones C, Sreekumar KR, Bullock PA.

J Virol. 1997 May;71(5):3972-85.

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