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Items: 35

1.

HDAC inhibition improves cardiopulmonary function in a feline model of diastolic dysfunction.

Wallner M, Eaton DM, Berretta RM, Liesinger L, Schittmayer M, Gindlhuber J, Wu J, Jeong MY, Lin YH, Borghetti G, Baker ST, Zhao H, Pfleger J, Blass S, Rainer PP, von Lewinski D, Bugger H, Mohsin S, Graier WF, Zirlik A, McKinsey TA, Birner-Gruenberger R, Wolfson MR, Houser SR.

Sci Transl Med. 2020 Jan 8;12(525). pii: eaay7205. doi: 10.1126/scitranslmed.aay7205.

PMID:
31915304
2.

Long-Term Prognostic Value of High-Sensitivity Troponin T Added to N-Terminal Pro Brain Natriuretic Peptide Plasma Levels Before Valve Replacement for Severe Aortic Stenosis.

Barbieri F, Senoner T, Adukauskaite A, Dobner S, Holfeld J, Semsroth S, Lambert T, Zweiker D, Theurl T, Rainer PP, Schmidt A, Feuchtner GM, Steinwender C, Hoppe UC, Hintringer F, Bauer A, Müller S, Grimm M, Pfeifer BE, Dichtl W.

Am J Cardiol. 2019 Dec 15;124(12):1932-1939. doi: 10.1016/j.amjcard.2019.09.014. Epub 2019 Sep 26.

PMID:
31699359
3.

Novel role of extracellular matrix protein 1 (ECM1) in cardiac aging and myocardial infarction.

Hardy SA, Mabotuwana NS, Murtha LA, Coulter B, Sanchez-Bezanilla S, Al-Omary MS, Senanayake T, Loering S, Starkey M, Lee RJ, Rainer PP, Hansbro PM, Boyle AJ.

PLoS One. 2019 Feb 21;14(2):e0212230. doi: 10.1371/journal.pone.0212230. eCollection 2019.

4.

Saxagliptin but Not Sitagliptin Inhibits CaMKII and PKC via DPP9 Inhibition in Cardiomyocytes.

Koyani CN, Trummer C, Shrestha N, Scheruebel S, Bourgeois B, Plastira I, Kickmaier S, Sourij H, Rainer PP, Madl T, Sattler W, Pelzmann B, Malle E, von Lewinski D.

Front Physiol. 2018 Nov 14;9:1622. doi: 10.3389/fphys.2018.01622. eCollection 2018.

5.

Reply: Elevated Cardiac Troponin T in Skeletal Myopathies: Skeletal TnT Cross-Reactivity and/or Cardiac TnT Expression?

Schmid J, Birner-Grünberger R, Quasthoff S, Binder JS, Rainer PP.

J Am Coll Cardiol. 2018 Jul 17;72(3):349-350. doi: 10.1016/j.jacc.2018.05.019. Epub 2018 Jul 9. No abstract available.

6.

A novel LMNA nonsense mutation causes two distinct phenotypes of cardiomyopathy with high risk of sudden cardiac death in a large five-generation family.

Glöcklhofer CR, Steinfurt J, Franke G, Hoppmann A, Glantschnig T, Perez-Feliz S, Alter S, Fischer J, Brunner M, Rainer PP, Köttgen A, Bode C, Odening KE.

Europace. 2018 Dec 1;20(12):2003-2013. doi: 10.1093/europace/euy127.

PMID:
29947763
7.

Elevated Cardiac Troponin T in Patients With Skeletal Myopathies.

Schmid J, Liesinger L, Birner-Gruenberger R, Stojakovic T, Scharnagl H, Dieplinger B, Asslaber M, Radl R, Beer M, Polacin M, Mair J, Szolar D, Berghold A, Quasthoff S, Binder JS, Rainer PP.

J Am Coll Cardiol. 2018 Apr 10;71(14):1540-1549. doi: 10.1016/j.jacc.2018.01.070.

8.

The Anti-Cancer Multikinase Inhibitor Sorafenib Impairs Cardiac Contractility by Reducing Phospholamban Phosphorylation and Sarcoplasmic Calcium Transients.

Schneider C, Wallner M, Kolesnik E, Herbst V, Mächler H, Pichler M, von Lewinski D, Sedej S, Rainer PP.

Sci Rep. 2018 Mar 28;8(1):5295. doi: 10.1038/s41598-018-23630-w.

9.

Desmin Phosphorylation Triggers Preamyloid Oligomers Formation and Myocyte Dysfunction in Acquired Heart Failure.

Rainer PP, Dong P, Sorge M, Fert-Bober J, Holewinski RJ, Wang Y, Foss CA, An SS, Baracca A, Solaini G, Glabe CG, Pomper MG, Van Eyk JE, Tomaselli GF, Paolocci N, Agnetti G.

Circ Res. 2018 May 11;122(10):e75-e83. doi: 10.1161/CIRCRESAHA.117.312082. Epub 2018 Feb 26.

10.

A New Murine Model of Chronic Kidney Disease-Mineral and Bone Disorder.

Frauscher B, Artinger K, Kirsch AH, Aringer I, Moschovaki-Filippidou F, Kétszeri M, Schabhüttl C, Rainer PP, Schmidt A, Stojakovic T, Fahrleitner-Pammer A, Rosenkranz AR, Eller P, Eller K.

Int J Endocrinol. 2017;2017:1659071. doi: 10.1155/2017/1659071. Epub 2017 Dec 14.

11.

Unfolding Cardiac Amyloidosis -From Pathophysiology to Cure.

Ablasser K, Verheyen N, Glantschnig T, Agnetti G, Rainer PP.

Curr Med Chem. 2019;26(16):2865-2878. doi: 10.2174/0929867325666180104153338. Review.

PMID:
29303069
12.

Dipeptidyl peptidase-4 independent cardiac dysfunction links saxagliptin to heart failure.

Koyani CN, Kolesnik E, Wölkart G, Shrestha N, Scheruebel S, Trummer C, Zorn-Pauly K, Hammer A, Lang P, Reicher H, Maechler H, Groschner K, Mayer B, Rainer PP, Sourij H, Sattler W, Malle E, Pelzmann B, von Lewinski D.

Biochem Pharmacol. 2017 Dec 1;145:64-80. doi: 10.1016/j.bcp.2017.08.021. Epub 2017 Aug 30.

13.

Nonmyocyte ERK1/2 signaling contributes to load-induced cardiomyopathy in Marfan mice.

Rouf R, MacFarlane EG, Takimoto E, Chaudhary R, Nagpal V, Rainer PP, Bindman JG, Gerber EE, Bedja D, Schiefer C, Miller KL, Zhu G, Myers L, Amat-Alarcon N, Lee DI, Koitabashi N, Judge DP, Kass DA, Dietz HC.

JCI Insight. 2017 Aug 3;2(15). pii: 91588. doi: 10.1172/jci.insight.91588. eCollection 2017 Aug 3.

14.

ST2 predicts survival in patients undergoing transcatheter aortic valve implantation.

Schmid J, Stojakovic T, Zweiker D, Scharnagl H, Maderthaner RD, Scherr D, Maier R, Schmidt A, März W, Binder JS, Rainer PP.

Int J Cardiol. 2017 Oct 1;244:87-92. doi: 10.1016/j.ijcard.2017.06.066. Epub 2017 Jun 19.

PMID:
28651919
15.

Istaroxime, a potential anticancer drug in prostate cancer, exerts beneficial functional effects in healthy and diseased human myocardium.

Wallner M, Khafaga M, Kolesnik E, Vafiadis A, Schwantzer G, Eaton DM, Curcic P, Köstenberger M, Knez I, Rainer PP, Pichler M, Pieske B, Lewinski DV.

Oncotarget. 2017 Jul 25;8(30):49264-49274. doi: 10.18632/oncotarget.17540.

16.

Typical STEMI: or not? Embolic left anterior descending artery occlusion, fulminant pulmonary embolism, and in-transit thrombus in a patent foramen ovale.

Maier R, Krumnikl J, Knez I, Rainer PP.

Eur Heart J. 2016 Oct 21;37(40):3114. Epub 2016 Jun 28. No abstract available.

PMID:
27354045
17.

Old dog, new tricks: novel cardiac targets and stress regulation by protein kinase G.

Rainer PP, Kass DA.

Cardiovasc Res. 2016 Jul 15;111(2):154-62. doi: 10.1093/cvr/cvw107. Epub 2016 Jun 13. Review.

18.

Profilin modulates sarcomeric organization and mediates cardiomyocyte hypertrophy.

Kooij V, Viswanathan MC, Lee DI, Rainer PP, Schmidt W, Kronert WA, Harding SE, Kass DA, Bernstein SI, Van Eyk JE, Cammarato A.

Cardiovasc Res. 2016 May 15;110(2):238-48. doi: 10.1093/cvr/cvw050. Epub 2016 Mar 7.

19.

Bidirectional cross-regulation between ErbB2 and β-adrenergic signalling pathways.

Sysa-Shah P, Tocchetti CG, Gupta M, Rainer PP, Shen X, Kang BH, Belmonte F, Li J, Xu Y, Guo X, Bedja D, Gao WD, Paolocci N, Rath R, Sawyer DB, Naga Prasad SV, Gabrielson K.

Cardiovasc Res. 2016 Mar 1;109(3):358-73. doi: 10.1093/cvr/cvv274. Epub 2015 Dec 21.

20.

Dual Labeling Biotin Switch Assay to Reduce Bias Derived From Different Cysteine Subpopulations: A Method to Maximize S-Nitrosylation Detection.

Chung HS, Murray CI, Venkatraman V, Crowgey EL, Rainer PP, Cole RN, Bomgarden RD, Rogers JC, Balkan W, Hare JM, Kass DA, Van Eyk JE.

Circ Res. 2015 Oct 23;117(10):846-57. doi: 10.1161/CIRCRESAHA.115.307336. Epub 2015 Sep 3.

21.

Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease.

Lee DI, Zhu G, Sasaki T, Cho GS, Hamdani N, Holewinski R, Jo SH, Danner T, Zhang M, Rainer PP, Bedja D, Kirk JA, Ranek MJ, Dostmann WR, Kwon C, Margulies KB, Van Eyk JE, Paulus WJ, Takimoto E, Kass DA.

Nature. 2015 Mar 26;519(7544):472-6. doi: 10.1038/nature14332. Epub 2015 Mar 18.

22.

Precardiac deletion of Numb and Numblike reveals renewal of cardiac progenitors.

Shenje LT, Andersen P, Uosaki H, Fernandez L, Rainer PP, Cho GS, Lee DI, Zhong W, Harvey RP, Kass DA, Kwon C.

Elife. 2014 Apr 24;3:e02164. doi: 10.7554/eLife.02164.

23.

Cardiomyocyte-specific transforming growth factor β suppression blocks neutrophil infiltration, augments multiple cytoprotective cascades, and reduces early mortality after myocardial infarction.

Rainer PP, Hao S, Vanhoutte D, Lee DI, Koitabashi N, Molkentin JD, Kass DA.

Circ Res. 2014 Apr 11;114(8):1246-57. doi: 10.1161/CIRCRESAHA.114.302653. Epub 2014 Feb 26.

24.

Combined TRPC3 and TRPC6 blockade by selective small-molecule or genetic deletion inhibits pathological cardiac hypertrophy.

Seo K, Rainer PP, Shalkey Hahn V, Lee DI, Jo SH, Andersen A, Liu T, Xu X, Willette RN, Lepore JJ, Marino JP Jr, Birnbaumer L, Schnackenberg CG, Kass DA.

Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1551-6. doi: 10.1073/pnas.1308963111. Epub 2014 Jan 22. Erratum in: Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):6115.

25.

Hyperactive adverse mechanical stress responses in dystrophic heart are coupled to transient receptor potential canonical 6 and blocked by cGMP-protein kinase G modulation.

Seo K, Rainer PP, Lee DI, Hao S, Bedja D, Birnbaumer L, Cingolani OH, Kass DA.

Circ Res. 2014 Feb 28;114(5):823-32. doi: 10.1161/CIRCRESAHA.114.302614. Epub 2014 Jan 21.

26.

HNO enhances SERCA2a activity and cardiomyocyte function by promoting redox-dependent phospholamban oligomerization.

Sivakumaran V, Stanley BA, Tocchetti CG, Ballin JD, Caceres V, Zhou L, Keceli G, Rainer PP, Lee DI, Huke S, Ziolo MT, Kranias EG, Toscano JP, Wilson GM, O'Rourke B, Kass DA, Mahaney JE, Paolocci N.

Antioxid Redox Signal. 2013 Oct 10;19(11):1185-97. doi: 10.1089/ars.2012.5057.

27.

Bile acids induce arrhythmias in human atrial myocardium--implications for altered serum bile acid composition in patients with atrial fibrillation.

Rainer PP, Primessnig U, Harenkamp S, Doleschal B, Wallner M, Fauler G, Stojakovic T, Wachter R, Yates A, Groschner K, Trauner M, Pieske BM, von Lewinski D.

Heart. 2013 Nov;99(22):1685-92. doi: 10.1136/heartjnl-2013-304163. Epub 2013 Jul 26.

PMID:
23894089
28.

A swinging pacemaker lead promoting endocarditis and severe tricuspid regurgitation.

Rainer PP, Schmidt A, Anelli-Monti M, Kleinert R, Pieske BM, Maier RM.

J Am Coll Cardiol. 2012 Jun 5;59(23):e45. doi: 10.1016/j.jacc.2011.10.908. No abstract available.

29.

Sunitinib causes dose-dependent negative functional effects on myocardium and cardiomyocytes.

Rainer PP, Doleschal B, Kirk JA, Sivakumaran V, Saad Z, Groschner K, Maechler H, Hoefler G, Bauernhofer T, Samonigg H, Hutterer G, Kass DA, Pieske B, von Lewinski D, Pichler M.

BJU Int. 2012 Nov;110(10):1455-62. doi: 10.1111/j.1464-410X.2012.11134.x. Epub 2012 Apr 17.

30.

Cardiac fibrosis in human transplanted hearts is mainly driven by cells of intracardiac origin.

Pichler M, Rainer PP, Schauer S, Hoefler G.

J Am Coll Cardiol. 2012 Mar 13;59(11):1008-16. doi: 10.1016/j.jacc.2011.11.036.

31.

Dependence of β3-adrenergic signaling on the adipokine leptin in cardiac myocytes.

Larson JE, Rainer PP, Watts VL, Yang R, Miller KL, Phan A, Barouch LA.

Int J Obes (Lond). 2012 Jun;36(6):876-9. doi: 10.1038/ijo.2011.137. Epub 2011 Jul 19.

PMID:
21772246
32.

Case report: Hyperbaric oxygen in the treatment of puff adder (Bitis arietans) bite.

Rainer PP, Kaufmann P, Smolle-Juettner FM, Krejs GJ.

Undersea Hyperb Med. 2010 Nov-Dec;37(6):395-8.

PMID:
21226389
33.

Esophageal ulceration mimicking malignancy in a patient with severe kyphoscoliosis.

Rainer PP, Eherer A, Langner C, Graninger WB, Spreizer C, Weber K.

Endoscopy. 2010;42 Suppl 2:E119-20. doi: 10.1055/s-0029-1243991. Epub 2010 Mar 19. No abstract available.

PMID:
20306403
34.

Functional effects of glucose transporters in human ventricular myocardium.

von Lewinski D, Gasser R, Rainer PP, Huber MS, Wilhelm B, Roessl U, Haas T, Wasler A, Grimm M, Bisping E, Pieske B.

Eur J Heart Fail. 2010 Feb;12(2):106-13. doi: 10.1093/eurjhf/hfp191.

35.

Glucose-transporter-mediated positive inotropic effects in human myocardium of diabetic and nondiabetic patients.

von Lewinski D, Rainer PP, Gasser R, Huber MS, Khafaga M, Wilhelm B, Haas T, Mächler H, Rössl U, Pieske B.

Metabolism. 2010 Jul;59(7):1020-8. doi: 10.1016/j.metabol.2009.10.025. Epub 2009 Dec 31.

PMID:
20045149

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