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Items: 1 to 50 of 186

1.

CLL intraclonal fractions exhibit established and recently acquired patterns of DNA methylation.

Bartholdy BA, Wang X, Yan XJ, Pascual M, Fan M, Barrientos J, Allen SL, Martinez-Climent JA, Rai KR, Chiorazzi N, Scharff MD, Roa S.

Blood Adv. 2020 Mar 10;4(5):893-905. doi: 10.1182/bloodadvances.2019000817.

2.

Intestinal Parasitic Infections among Prison Inmates in Kathmandu Nepal.

Shrestha P, Shrestha D, Magar DT, Rai G, Rai KR, Rai SK.

J Nepal Health Res Counc. 2019 Nov 14;17(3):382-387. doi: 10.33314/jnhrc.v17i3.2015.

PMID:
31735936
3.

Developmental subtypes assessed by DNA methylation-iPLEX forecast the natural history of chronic lymphocytic leukemia.

Giacopelli B, Zhao Q, Ruppert AS, Agyeman A, Weigel C, Wu YZ, Gerber MM, Rabe KG, Larson MC, Lu J, Blachly JS, Rogers KA, Wierda WG, Brown JR, Rai KR, Keating M, Rassenti LZ, Kipps TJ, Zenz T, Shanafelt TD, Kay NE, Abruzzo LV, Coombes KR, Woyach JA, Byrd JC, Oakes CC.

Blood. 2019 Aug 22;134(8):688-698. doi: 10.1182/blood.2019000490. Epub 2019 Jul 10.

4.

Growth dynamics in naturally progressing chronic lymphocytic leukaemia.

Gruber M, Bozic I, Leshchiner I, Livitz D, Stevenson K, Rassenti L, Rosebrock D, Taylor-Weiner A, Olive O, Goyetche R, Fernandes SM, Sun J, Stewart C, Wong A, Cibulskis C, Zhang W, Reiter JG, Gerold JM, Gribben JG, Rai KR, Keating MJ, Brown JR, Neuberg D, Kipps TJ, Nowak MA, Getz G, Wu CJ.

Nature. 2019 Jun;570(7762):474-479. doi: 10.1038/s41586-019-1252-x. Epub 2019 May 29.

5.

Identification of lncRNA-155 encoded by MIR155HG as a novel regulator of innate immunity against influenza A virus infection.

Maarouf M, Chen B, Chen Y, Wang X, Rai KR, Zhao Z, Liu S, Li Y, Xiao M, Chen JL.

Cell Microbiol. 2019 Aug;21(8):e13036. doi: 10.1111/cmi.13036. Epub 2019 May 29.

PMID:
31045320
6.

Diarrheal disease outbreak in Gaidatar village of Rautahat District, Nepal.

Rai KR, Mukhiya RK, Thapa S, Rai G, Kc S, Thapa PM, Shrestha P, Rai SK.

BMC Res Notes. 2019 Mar 8;12(1):124. doi: 10.1186/s13104-019-4156-9.

7.

Chronic lymphocytic leukemia (CLL) treatment: So many choices, such great options.

Sharma S, Rai KR.

Cancer. 2019 May 1;125(9):1432-1440. doi: 10.1002/cncr.31931. Epub 2019 Feb 26. Review.

PMID:
30807655
8.

Chylothorax in Patients with Chronic Lymphocytic Leukemia: A Case Series.

Sammartino D, Khanijo S, Koenig S, Katsetos JF, Tufano A, Rai KR, Barrientos JC.

J Hematol (Brossard). 2018 Jan;7(1):14-18. doi: 10.14740/jh339w.

9.

Immune Ecosystem of Virus-Infected Host Tissues.

Maarouf M, Rai KR, Goraya MU, Chen JL.

Int J Mol Sci. 2018 May 6;19(5). pii: E1379. doi: 10.3390/ijms19051379. Review.

10.

iwCLL guidelines for diagnosis, indications for treatment, response assessment, and supportive management of CLL.

Hallek M, Cheson BD, Catovsky D, Caligaris-Cappio F, Dighiero G, Döhner H, Hillmen P, Keating M, Montserrat E, Chiorazzi N, Stilgenbauer S, Rai KR, Byrd JC, Eichhorst B, O'Brien S, Robak T, Seymour JF, Kipps TJ.

Blood. 2018 Jun 21;131(25):2745-2760. doi: 10.1182/blood-2017-09-806398. Epub 2018 Mar 14.

PMID:
29540348
11.

Somatic CLL mutations occur at multiple distinct hematopoietic maturation stages: documentation and cautionary note regarding cell fraction purity.

Marsilio S, Khiabanian H, Fabbri G, Vergani S, Scuoppo C, Montserrat E, Shpall EJ, Hadigol M, Marin P, Rai KR, Rabadan R, Devereux S, Pasqualucci L, Chiorazzi N.

Leukemia. 2018 Apr;32(4):1041-1044. doi: 10.1038/leu.2017.343. Epub 2017 Dec 5. No abstract available.

12.

Leukemia-cell proliferation and disease progression in patients with early stage chronic lymphocytic leukemia.

Murphy EJ, Neuberg DS, Rassenti LZ, Hayes G, Redd R, Emson C, Li K, Brown JR, Wierda WG, Turner S, Greaves AW, Zent CS, Byrd JC, McConnel C, Barrientos J, Kay N, Hellerstein MK, Chiorazzi N, Kipps TJ, Rai KR.

Leukemia. 2017 Jun;31(6):1348-1354. doi: 10.1038/leu.2017.34. Epub 2017 Jan 24.

13.

Binding of CLL subset 4 B-cell receptor immunoglobulins to viable human memory B lymphocytes requires a distinctive IGKV somatic mutation.

Catera R, Liu Y, Gao C, Yan XJ, Magli A, Allen SL, Kolitz JE, Rai KR, Chu CC, Feizi T, Stamatopoulos K, Chiorazzi N.

Mol Med. 2017 Mar;23:1-12. doi: 10.2119/molmed.2017.00003. Epub 2017 Jan 12.

14.

Consensus guidelines for the diagnosis and management of patients with classic hairy cell leukemia.

Grever MR, Abdel-Wahab O, Andritsos LA, Banerji V, Barrientos J, Blachly JS, Call TG, Catovsky D, Dearden C, Demeter J, Else M, Forconi F, Gozzetti A, Ho AD, Johnston JB, Jones J, Juliusson G, Kraut E, Kreitman RJ, Larratt L, Lauria F, Lozanski G, Montserrat E, Parikh SA, Park JH, Polliack A, Quest GR, Rai KR, Ravandi F, Robak T, Saven A, Seymour JF, Tadmor T, Tallman MS, Tam C, Tiacci E, Troussard X, Zent CS, Zenz T, Zinzani PL, Falini B.

Blood. 2017 Feb 2;129(5):553-560. doi: 10.1182/blood-2016-01-689422. Epub 2016 Nov 30.

15.

Combinations of idelalisib with rituximab and/or bendamustine in patients with recurrent indolent non-Hodgkin lymphoma.

de Vos S, Wagner-Johnston ND, Coutre SE, Flinn IW, Schreeder MT, Fowler NH, Sharman JP, Boccia RV, Barrientos JC, Rai KR, Boyd TE, Furman RR, Kim Y, Godfrey WR, Leonard JP.

Blood Adv. 2016 Nov 30;1(2):122-131. doi: 10.1182/bloodadvances.2016000976. eCollection 2016 Dec 13.

16.

High-level ROR1 associates with accelerated disease progression in chronic lymphocytic leukemia.

Cui B, Ghia EM, Chen L, Rassenti LZ, DeBoever C, Widhopf GF 2nd, Yu J, Neuberg DS, Wierda WG, Rai KR, Kay NE, Brown JR, Jones JA, Gribben JG, Frazer KA, Kipps TJ.

Blood. 2016 Dec 22;128(25):2931-2940. doi: 10.1182/blood-2016-04-712562. Epub 2016 Nov 4.

17.

Chronic lymphocytic leukemia immunoglobulins display bacterial reactivity that converges and diverges from auto-/poly-reactivity and IGHV mutation status.

Hatzi K, Catera R, Moreno Atanasio C, Fischetti VA, Allen SL, Kolitz JE, Rai KR, Chu CC, Chiorazzi N.

Clin Immunol. 2016 Nov;172:44-51. doi: 10.1016/j.clim.2016.08.020. Epub 2016 Aug 29.

PMID:
27586592
18.

Chronic lymphocytic leukemia cells diversify and differentiate in vivo via a nonclassical Th1-dependent, Bcl-6-deficient process.

Patten PE, Ferrer G, Chen SS, Simone R, Marsilio S, Yan XJ, Gitto Z, Yuan C, Kolitz JE, Barrientos J, Allen SL, Rai KR, MacCarthy T, Chu CC, Chiorazzi N.

JCI Insight. 2016 Apr 7;1(4). pii: e86288.

19.

Chronic lymphocytic leukemia (CLL)-Then and now.

Rai KR, Jain P.

Am J Hematol. 2016 Mar;91(3):330-40. doi: 10.1002/ajh.24282. Review.

20.

BTK inhibition results in impaired CXCR4 chemokine receptor surface expression, signaling and function in chronic lymphocytic leukemia.

Chen SS, Chang BY, Chang S, Tong T, Ham S, Sherry B, Burger JA, Rai KR, Chiorazzi N.

Leukemia. 2016 Apr;30(4):833-43. doi: 10.1038/leu.2015.316. Epub 2015 Nov 9.

21.

Identification and characterization of distinct IL-17F expression patterns and signaling pathways in chronic lymphocytic leukemia and normal B lymphocytes.

Sherry B, Jain P, Chiu PY, Leung L, Allen SL, Kolitz JE, Rai KR, Barrientos J, Liang S, Hawtin R, Chiorazzi N.

Immunol Res. 2015 Dec;63(1-3):216-27. doi: 10.1007/s12026-015-8722-5.

22.

Subcutaneous injections of low doses of humanized anti-CD20 veltuzumab: a phase I study in chronic lymphocytic leukemia.

Kalaycio ME, George Negrea O, Allen SL, Rai KR, Abbasi RM, Horne H, Wegener WA, Goldenberg DM.

Leuk Lymphoma. 2016;57(4):803-11. doi: 10.3109/10428194.2015.1085531. Epub 2015 Oct 19.

PMID:
26389849
23.

Targeting Mutant BRAF in Relapsed or Refractory Hairy-Cell Leukemia.

Tiacci E, Park JH, De Carolis L, Chung SS, Broccoli A, Scott S, Zaja F, Devlin S, Pulsoni A, Chung YR, Cimminiello M, Kim E, Rossi D, Stone RM, Motta G, Saven A, Varettoni M, Altman JK, Anastasia A, Grever MR, Ambrosetti A, Rai KR, Fraticelli V, Lacouture ME, Carella AM, Levine RL, Leoni P, Rambaldi A, Falzetti F, Ascani S, Capponi M, Martelli MP, Park CY, Pileri SA, Rosen N, Foà R, Berger MF, Zinzani PL, Abdel-Wahab O, Falini B, Tallman MS.

N Engl J Med. 2015 Oct 29;373(18):1733-47. doi: 10.1056/NEJMoa1506583. Epub 2015 Sep 9.

24.

A seven-gene expression panel distinguishing clonal expansions of pre-leukemic and chronic lymphocytic leukemia B cells from normal B lymphocytes.

McCarthy BA, Yancopoulos S, Tipping M, Yan XJ, Wang XP, Bennett F, Li W, Lesser M, Paul S, Boyle E, Moreno C, Catera R, Messmer BT, Cutrona G, Ferrarini M, Kolitz JE, Allen SL, Rai KR, Rawstron AC, Chiorazzi N.

Immunol Res. 2015 Dec;63(1-3):90-100. doi: 10.1007/s12026-015-8688-3.

PMID:
26318878
25.

Cytoplasmic myosin-exposed apoptotic cells appear with caspase-3 activation and enhance CLL cell viability.

Cui X, Zhang L, Magli AR, Catera R, Yan XJ, Griffin DO, Rothstein TL, Barrientos J, Kolitz JE, Allen SL, Rai KR, Chiorazzi N, Chu CC.

Leukemia. 2016 Jan;30(1):74-85. doi: 10.1038/leu.2015.204. Epub 2015 Jul 29.

26.
27.

Augmenting NF-κB in poor-risk CLL: A general paradigm for other cancers?

Tuveson D, Rai KR.

J Exp Med. 2015 Jun 1;212(6):830-1. doi: 10.1084/jem.2126insight4. No abstract available.

28.

Rewiring of sIgM-Mediated Intracellular Signaling through the CD180 Toll-like Receptor.

Porakishvili N, Vispute K, Steele AJ, Rajakaruna N, Kulikova N, Tsertsvadze T, Nathwani A, Damle RN, Clark EA, Rai KR, Chiorazzi N, Lydyard PM.

Mol Med. 2015 Apr;21(1):46-57. doi: 10.2119/molmed.2014.00265. Epub 2015 Jan 14.

29.

Validation of ZAP-70 methylation and its relative significance in predicting outcome in chronic lymphocytic leukemia.

Claus R, Lucas DM, Ruppert AS, Williams KE, Weng D, Patterson K, Zucknick M, Oakes CC, Rassenti LZ, Greaves AW, Geyer S, Wierda WG, Brown JR, Gribben JG, Barrientos JC, Rai KR, Kay NE, Kipps TJ, Shields P, Zhao W, Grever MR, Plass C, Byrd JC.

Blood. 2014 Jul 3;124(1):42-8. doi: 10.1182/blood-2014-02-555722. Epub 2014 May 27. Erratum in: Blood. 2014 Sep 11;124(11):1848.

30.

Lenalidomide and rituximab for the initial treatment of patients with chronic lymphocytic leukemia: a multicenter clinical-translational study from the chronic lymphocytic leukemia research consortium.

James DF, Werner L, Brown JR, Wierda WG, Barrientos JC, Castro JE, Greaves A, Johnson AJ, Rassenti LZ, Rai KR, Neuberg D, Kipps TJ.

J Clin Oncol. 2014 Jul 1;32(19):2067-73. doi: 10.1200/JCO.2013.51.5890. Epub 2014 May 27.

31.

Movement toward optimization of CLL therapy.

Rai KR, Barrientos JC.

N Engl J Med. 2014 Mar 20;370(12):1160-2. doi: 10.1056/NEJMe1400599. No abstract available.

PMID:
24645950
32.

IGHV1-69 B cell chronic lymphocytic leukemia antibodies cross-react with HIV-1 and hepatitis C virus antigens as well as intestinal commensal bacteria.

Hwang KK, Trama AM, Kozink DM, Chen X, Wiehe K, Cooper AJ, Xia SM, Wang M, Marshall DJ, Whitesides J, Alam M, Tomaras GD, Allen SL, Rai KR, McKeating J, Catera R, Yan XJ, Chu CC, Kelsoe G, Liao HX, Chiorazzi N, Haynes BF.

PLoS One. 2014 Mar 10;9(3):e90725. doi: 10.1371/journal.pone.0090725. eCollection 2014.

33.

Study of medically important Vibrios in the sewage of Katmandu Valley, Nepal.

Rai KR, Rai SK, Bhatt DR, Kurokuwa M, Ono K, Magar DT.

Nepal Med Coll J. 2012 Sep;14(3):212-5.

PMID:
24047018
34.

Peptides that bind specifically to an antibody from a chronic lymphocytic leukemia clone expressing unmutated immunoglobulin variable region genes.

Liu Y, Higgins CD, Overstreet CM, Rai KR, Chiorazzi N, Lai JR.

Mol Med. 2013 Aug 28;19:245-52. doi: 10.2119/molmed.2013.00082.

35.

Association between B-cell receptor responsiveness and disease progression in B-cell chronic lymphocytic leukemia: results from single cell network profiling studies.

Cesano A, Perbellini O, Evensen E, Chu CC, Cioffi F, Ptacek J, Damle RN, Chignola R, Cordeiro J, Yan XJ, Hawtin RE, Nichele I, Ware JR, Cavallini C, Lovato O, Zanotti R, Rai KR, Chiorazzi N, Pizzolo G, Scupoli MT.

Haematologica. 2013 Apr;98(4):626-34. doi: 10.3324/haematol.2012.071910. Epub 2012 Nov 9.

36.

IGHV-unmutated and IGHV-mutated chronic lymphocytic leukemia cells produce activation-induced deaminase protein with a full range of biologic functions.

Patten PE, Chu CC, Albesiano E, Damle RN, Yan XJ, Kim D, Zhang L, Magli AR, Barrientos J, Kolitz JE, Allen SL, Rai KR, Roa S, Mongini PK, MacCarthy T, Scharff MD, Chiorazzi N.

Blood. 2012 Dec 6;120(24):4802-11. doi: 10.1182/blood-2012-08-449744. Epub 2012 Oct 15.

37.

Overview of recent developments in chronic lymphocytic leukemia.

Jain P, Rai KR.

South Asian J Cancer. 2012 Oct;1(2):84-9. doi: 10.4103/2278-330X.103721. Review.

38.

The impact of initial fludarabine therapy on transformation to Richter syndrome or prolymphocytic leukemia in patients with chronic lymphocytic leukemia: analysis of an intergroup trial (CALGB 9011).

Solh M, Rai KR, Peterson BL, Kolitz JE, Appelbaum FR, Tallman MS, Belch A, Larson RA, Morrison VA.

Leuk Lymphoma. 2013 Feb;54(2):252-4. doi: 10.3109/10428194.2012.710327. Epub 2012 Sep 8.

39.

T-cell independent, B-cell receptor-mediated induction of telomerase activity differs among IGHV mutation-based subgroups of chronic lymphocytic leukemia patients.

Damle RN, Temburni S, Banapour T, Paul S, Mongini PK, Allen SL, Kolitz JE, Rai KR, Chiorazzi N.

Blood. 2012 Sep 20;120(12):2438-49. Epub 2012 Aug 8.

40.

Novel targeted agents and the need to refine clinical end points in chronic lymphocytic leukemia.

Cheson BD, Byrd JC, Rai KR, Kay NE, O'Brien SM, Flinn IW, Wiestner A, Kipps TJ.

J Clin Oncol. 2012 Aug 10;30(23):2820-2. doi: 10.1200/JCO.2012.43.3748. Epub 2012 Jul 9. No abstract available.

41.

Fludarabine versus chlorambucil: is the debate over?

Rai KR, Hollweg A.

Clin Lymphoma Myeloma Leuk. 2011 Jun;11 Suppl 1:S7-9. doi: 10.1016/j.clml.2011.04.007. Epub 2011 May 7.

PMID:
22035752
42.

Th17 and non-Th17 interleukin-17-expressing cells in chronic lymphocytic leukemia: delineation, distribution, and clinical relevance.

Jain P, Javdan M, Feger FK, Chiu PY, Sison C, Damle RN, Bhuiya TA, Sen F, Abruzzo LV, Burger JA, Rosenwald A, Allen SL, Kolitz JE, Rai KR, Chiorazzi N, Sherry B.

Haematologica. 2012 Apr;97(4):599-607. doi: 10.3324/haematol.2011.047316. Epub 2011 Nov 4.

43.

Study of parasitic infection among children of Sukumbasi Basti in Kathmandu valley.

Thapa Magar D, Rai SK, Lekhak B, Rai KR.

Nepal Med Coll J. 2011 Mar;13(1):7-10.

PMID:
21991692
44.

Intraclonal complexity in chronic lymphocytic leukemia: fractions enriched in recently born/divided and older/quiescent cells.

Calissano C, Damle RN, Marsilio S, Yan XJ, Yancopoulos S, Hayes G, Emson C, Murphy EJ, Hellerstein MK, Sison C, Kaufman MS, Kolitz JE, Allen SL, Rai KR, Ivanovic I, Dozmorov IM, Roa S, Scharff MD, Li W, Chiorazzi N.

Mol Med. 2011;17(11-12):1374-82. doi: 10.2119/molmed.2011.00360. Epub 2011 Sep 23.

45.

Torque teno virus 10 isolated by genome amplification techniques from a patient with concomitant chronic lymphocytic leukemia and polycythemia vera.

Chu CC, Zhang L, Dhayalan A, Agagnina BM, Magli AR, Fraher G, Didier S, Johnson LP, Kennedy WJ, Damle RN, Yan XJ, Patten PE, Teichberg S, Koduru P, Kolitz JE, Allen SL, Rai KR, Chiorazzi N.

Mol Med. 2011;17(11-12):1338-48. doi: 10.2119/molmed.2010.00110. Epub 2011 Sep 21.

46.

Identification of outcome-correlated cytokine clusters in chronic lymphocytic leukemia.

Yan XJ, Dozmorov I, Li W, Yancopoulos S, Sison C, Centola M, Jain P, Allen SL, Kolitz JE, Rai KR, Chiorazzi N, Sherry B.

Blood. 2011 Nov 10;118(19):5201-10. doi: 10.1182/blood-2011-03-342436. Epub 2011 Sep 12.

47.

Advances in the clinical staging of chronic lymphocytic leukemia.

Rai KR, Jain P.

Clin Chem. 2011 Dec;57(12):1771-2. doi: 10.1373/clinchem.2010.159004. Epub 2011 Aug 11. No abstract available.

PMID:
21836079
48.

Accurate reporting of adverse events in chronic lymphocytic leukemia and non-Hodgkin lymphoma.

Cheson BD, Rai KR, Friedberg JW.

Clin Adv Hematol Oncol. 2011 Jul;9(7 Suppl 15):1-11. Review.

PMID:
22361879
49.

CD180 functions in activation, survival and cycling of B chronic lymphocytic leukaemia cells.

Porakishvili N, Memon A, Vispute K, Kulikova N, Clark EA, Rai KR, Nathwani A, Damle RN, Chiorazzi N, Lydyard PM.

Br J Haematol. 2011 May;153(4):486-98. doi: 10.1111/j.1365-2141.2011.08605.x. Epub 2011 Mar 28.

PMID:
21443749
50.

A novel adoptive transfer model of chronic lymphocytic leukemia suggests a key role for T lymphocytes in the disease.

Bagnara D, Kaufman MS, Calissano C, Marsilio S, Patten PE, Simone R, Chum P, Yan XJ, Allen SL, Kolitz JE, Baskar S, Rader C, Mellstedt H, Rabbani H, Lee A, Gregersen PK, Rai KR, Chiorazzi N.

Blood. 2011 May 19;117(20):5463-72. doi: 10.1182/blood-2010-12-324210. Epub 2011 Mar 8.

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