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Items: 1 to 50 of 369

1.

Role of TREM2 in Alzheimer's disease and its consequences on β-amyloid, Tau and neurofibrillary tangles.

Singh AK, Mishra G, Maurya A, Awasthi R, Kumari K, Thakur A, Rai A, Rai GK, Sharma B, Kulkarni GT, Singh SK.

Curr Alzheimer Res. 2019 Sep 2. doi: 10.2174/1567205016666190903102822. [Epub ahead of print]

PMID:
31481003
2.

Room-Temperature, Copper-Free Sonogashira Reactions Facilitated by Air-Stable, Monoligated Precatalyst [DTBNpP] Pd(crotyl)Cl.

Pohida K, Maloney DJ, Mott BT, Rai G.

ACS Omega. 2018 Oct 10;3(10):12985-12998. doi: 10.1021/acsomega.8b01868. eCollection 2018 Oct 31.

3.

Targeting Glycolysis through Inhibition of Lactate Dehydrogenase Impairs Tumor Growth in Preclinical Models of Ewing Sarcoma.

Yeung C, Gibson AE, Issaq SH, Oshima N, Baumgart JT, Edessa LD, Rai G, Urban DJ, Johnson MS, Benavides GA, Squadrito GL, Yohe ME, Lei H, Eldridge S, Hamre J 3rd, Dowdy T, Ruiz-Rodado V, Lita A, Mendoza A, Shern JF, Larion M, Helman LJ, Stott GM, Krishna MC, Hall MD, Darley-Usmar V, Neckers LM, Heske CM.

Cancer Res. 2019 Oct 1;79(19):5060-5073. doi: 10.1158/0008-5472.CAN-19-0217. Epub 2019 Aug 20.

PMID:
31431459
4.

Berberine: A plant derived alkaloid with therapeutic potential to combat Alzheimer's disease.

Singh AK, Singh SK, Nandi MK, Mishra G, Maurya A, Rai A, Rai GK, Awasthi R, Sharma B, Kulkarni GT.

Cent Nerv Syst Agents Med Chem. 2019 Aug 20. doi: 10.2174/1871524919666190820160053. [Epub ahead of print]

PMID:
31429696
5.

Epidemiology of urinary tract infection and antimicrobial resistance in a pediatric hospital in Nepal.

Ganesh R, Shrestha D, Bhattachan B, Rai G.

BMC Infect Dis. 2019 May 14;19(1):420. doi: 10.1186/s12879-019-3997-0.

6.

Effect of Segmental Thoracic Epidural Block on Pancreatitisinduced Organ Dysfunction: A Preliminary Study.

Tyagi A, Gupta YR, Das S, Rai G, Gupta A.

Indian J Crit Care Med. 2019 Feb;23(2):89-94. doi: 10.5005/jp-journals-10071-23123.

7.

Intestinal parasitic infections among public and private schoolchildren of Kathmandu, Nepal: prevalence and associated risk factors.

Shrestha J, Bhattachan B, Rai G, Park EY, Rai SK.

BMC Res Notes. 2019 Mar 29;12(1):192. doi: 10.1186/s13104-019-4225-0.

8.

Gamma irradiation protect the developing wheat endosperm from oxidative damage by balancing the trade-off between the defence network and grains quality.

Kumar RR, Hasija S, Goswami S, Tasleem M, Sakhare A, Kumar S, Bakshi S, Jambhulkar S, Rai GK, Singh B, Singh GP, Pathak H, Viswanathan C, Praveen S.

Ecotoxicol Environ Saf. 2019 Jun 15;174:637-648. doi: 10.1016/j.ecoenv.2019.03.020. Epub 2019 Mar 12.

PMID:
30875557
9.

Diarrheal disease outbreak in Gaidatar village of Rautahat District, Nepal.

Rai KR, Mukhiya RK, Thapa S, Rai G, Kc S, Thapa PM, Shrestha P, Rai SK.

BMC Res Notes. 2019 Mar 8;12(1):124. doi: 10.1186/s13104-019-4156-9.

10.

KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance.

Hinohara K, Wu HJ, Sébastien Vigneau, McDonald TO, Igarashi KJ, Yamamoto KN, Madsen T, Fassl A, Egri SB, Papanastasiou M, Ding L, Peluffo G, Cohen O, Kales SC, Lal-Nag M, Rai G, Maloney DJ, Jadhav A, Simeonov A, Wagle N, Brown M, Meissner A, Sicinski P, Jaffe JD, Jeselsohn R, Gimelbrant AA, Michor F, Polyak K.

Cancer Cell. 2019 Feb 11;35(2):330-332. doi: 10.1016/j.ccell.2019.01.012. No abstract available.

11.

Thrombocytosis as a Predictor of Serious Bacterial Infection in Febrile Infants.

Mishra D, Das AK, Chapagain RH, Jha NK, Rai GK.

J Nepal Health Res Counc. 2019 Jan 28;16(41):401-404.

PMID:
30739929
12.

Risk of early postoperative acute kidney injury with stroke volume variation-guided tetrastarch versus Ringer's lactate.

Tyagi A, Verma G, Luthra A, Lahan S, Das S, Rai G, Sethi AK.

Saudi J Anaesth. 2019 Jan-Mar;13(1):9-15. doi: 10.4103/sja.SJA_410_18.

13.

Emergency brachial artery ligation for ruptured infected pseudoaneurysm of haemodialysis access is a possible option.

Bishnoi AK, Rai G, Kamath GS, Vishnu R, Kumar V, Joshi H, Prabhu R, Soni LP, Nasser A.

J Vasc Access. 2019 Sep;20(5):471-474. doi: 10.1177/1129729818813265. Epub 2018 Nov 29.

PMID:
30486731
14.

KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance.

Hinohara K, Wu HJ, Vigneau S, McDonald TO, Igarashi KJ, Yamamoto KN, Madsen T, Fassl A, Egri SB, Papanastasiou M, Ding L, Peluffo G, Cohen O, Kales SC, Lal-Nag M, Rai G, Maloney DJ, Jadhav A, Simeonov A, Wagle N, Brown M, Meissner A, Sicinski P, Jaffe JD, Jeselsohn R, Gimelbrant AA, Michor F, Polyak K.

Cancer Cell. 2018 Dec 10;34(6):939-953.e9. doi: 10.1016/j.ccell.2018.10.014. Epub 2018 Nov 21. Erratum in: Cancer Cell. 2019 Feb 11;35(2):330-332.

PMID:
30472020
15.

Quantitative proteomic analysis reveals novel stress-associated active proteins (SAAPs) and pathways involved in modulating tolerance of wheat under terminal heat.

Kumar RR, Singh K, Ahuja S, Tasleem M, Singh I, Kumar S, Grover M, Mishra D, Rai GK, Goswami S, Singh GP, Chinnusamy V, Rai A, Praveen S.

Funct Integr Genomics. 2019 Mar;19(2):329-348. doi: 10.1007/s10142-018-0648-2. Epub 2018 Nov 22.

PMID:
30465139
16.

Structure-Based Engineering of Irreversible Inhibitors against Histone Lysine Demethylase KDM5A.

Horton JR, Woodcock CB, Chen Q, Liu X, Zhang X, Shanks J, Rai G, Mott BT, Jansen DJ, Kales SC, Henderson MJ, Cyr M, Pohida K, Hu X, Shah P, Xu X, Jadhav A, Maloney DJ, Hall MD, Simeonov A, Fu H, Vertino PM, Cheng X.

J Med Chem. 2018 Dec 13;61(23):10588-10601. doi: 10.1021/acs.jmedchem.8b01219. Epub 2018 Nov 15.

17.

Burden of Chronic Dermatophytosis in a Tertiary Care Hospital: Interaction of Fungal Virulence and Host Immunity.

Tigga RA, Das S, Bhattacharya SN, Saha R, Pandhi D, Datt S, Rai G.

Mycopathologia. 2018 Dec;183(6):951-959. doi: 10.1007/s11046-018-0303-4. Epub 2018 Nov 1.

PMID:
30386967
18.

Hospital based surveillance and molecular characterization of rotavirus in children less than 5 years of age with acute gastroenteritis in Nepal.

Sherchand JB, Thakali O, Sherchan JB, Bhandari D, Tandukar S, Paudel KP, Shrestha BM, Rayamajhi A, Rai GK.

Vaccine. 2018 Dec 14;36(51):7841-7845. doi: 10.1016/j.vaccine.2018.07.044. Epub 2018 Oct 29.

PMID:
30385057
19.

Inhibition of spinal 15-LOX-1 attenuates TLR4-dependent, nonsteroidal anti-inflammatory drug-unresponsive hyperalgesia in male rats.

Gregus AM, Buczynski MW, Dumlao DS, Norris PC, Rai G, Simeonov A, Maloney DJ, Jadhav A, Xu Q, Wei SC, Fitzsimmons BL, Dennis EA, Yaksh TL.

Pain. 2018 Dec;159(12):2620-2629. doi: 10.1097/j.pain.0000000000001373.

PMID:
30130298
20.

KDM5 histone demethylases repress immune response via suppression of STING.

Wu L, Cao J, Cai WL, Lang SM, Horton JR, Jansen DJ, Liu ZZ, Chen JF, Zhang M, Mott BT, Pohida K, Rai G, Kales SC, Henderson MJ, Hu X, Jadhav A, Maloney DJ, Simeonov A, Zhu S, Iwasaki A, Hall MD, Cheng X, Shadel GS, Yan Q.

PLoS Biol. 2018 Aug 6;16(8):e2006134. doi: 10.1371/journal.pbio.2006134. eCollection 2018 Aug.

21.

Nicotine preloading for smoking cessation: the Preloading RCT.

Aveyard P, Lindson N, Tearne S, Adams R, Ahmed K, Alekna R, Banting M, Healy M, Khan S, Rai G, Wood C, Anderson EC, Ataya-Williams A, Attwood A, Easey K, Fluharty M, Freuler T, Hurse M, Khouja J, Lacey L, Munafò M, Lycett D, McEwen A, Coleman T, Dickinson A, Lewis S, Orton S, Perdue J, Randall C, Anderson R, Bisal N, Hajek P, Homsey C, McRobbie HJ, Myers-Smith K, Phillips A, Przulj D, Li J, Coyle D, Coyle K, Pokhrel S.

Health Technol Assess. 2018 Aug;22(41):1-84. doi: 10.3310/hta22410.

22.

Candida auris in critically ill patients: Emerging threat in intensive care unit of hospitals.

Das S, Rai G, Tigga RA, Srivastava S, Singh PK, Sharma R, Datt S, Singh NP, Dar SA.

J Mycol Med. 2018 Sep;28(3):514-518. doi: 10.1016/j.mycmed.2018.06.005. Epub 2018 Jul 2.

PMID:
30042047
23.

Candida auris colonization in an immunocompetent patient: A new threat in medical ICU.

Das S, Tigga R, Rai G, Singh PK, Datt S, Tyagi A, Singh NP.

Med Mycol Case Rep. 2018 May 10;21:54-56. doi: 10.1016/j.mmcr.2018.05.004. eCollection 2018 Sep.

24.

A widely-applicable high-throughput cellular thermal shift assay (CETSA) using split Nano Luciferase.

Martinez NJ, Asawa RR, Cyr MG, Zakharov A, Urban DJ, Roth JS, Wallgren E, Klumpp-Thomas C, Coussens NP, Rai G, Yang SM, Hall MD, Marugan JJ, Simeonov A, Henderson MJ.

Sci Rep. 2018 Jun 21;8(1):9472. doi: 10.1038/s41598-018-27834-y.

25.

Characterization of novel heat-responsive transcription factor (TaHSFA6e) gene involved in regulation of heat shock proteins (HSPs) - A key member of heat stress-tolerance network of wheat.

Kumar RR, Goswami S, Singh K, Dubey K, Rai GK, Singh B, Singh S, Grover M, Mishra D, Kumar S, Bakshi S, Rai A, Pathak H, Chinnusamy V, Praveen S.

J Biotechnol. 2018 Aug 10;279:1-12. doi: 10.1016/j.jbiotec.2018.05.008. Epub 2018 May 7.

PMID:
29746879
26.

Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors.

Rohde JM, Brimacombe KR, Liu L, Pacold ME, Yasgar A, Cheff DM, Lee TD, Rai G, Baljinnyam B, Li Z, Simeonov A, Hall MD, Shen M, Sabatini DM, Boxer MB.

Bioorg Med Chem. 2018 May 1;26(8):1727-1739. doi: 10.1016/j.bmc.2018.02.016. Epub 2018 Feb 27.

27.

Insights into the Action of Inhibitor Enantiomers against Histone Lysine Demethylase 5A.

Horton JR, Liu X, Wu L, Zhang K, Shanks J, Zhang X, Rai G, Mott BT, Jansen DJ, Kales SC, Henderson MJ, Pohida K, Fang Y, Hu X, Jadhav A, Maloney DJ, Hall MD, Simeonov A, Fu H, Vertino PM, Yan Q, Cheng X.

J Med Chem. 2018 Apr 12;61(7):3193-3208. doi: 10.1021/acs.jmedchem.8b00261. Epub 2018 Mar 23.

28.

Phenotypic and functional profile of Th17 and Treg cells in allergic fungal sinusitis.

Rai G, Das S, Ansari MA, Singh PK, Gupta N, Sharma S, Akhter N, Ramachandran VG, Haque S, Dar SA.

Int Immunopharmacol. 2018 Apr;57:55-61. doi: 10.1016/j.intimp.2018.02.009. Epub 2018 Feb 22.

PMID:
29475096
29.

Serum Interleukin-6 Levels in Children with Febrile Seizures.

Gupta S, Aggarwal A, Faridi MM, Rai G, Das S, Kotru M.

Indian Pediatr. 2018 May 15;55(5):411-413. Epub 2018 Feb 9.

30.

Association between visual inspection of the cervix with acetic acid examination and high-risk human papillomavirus infection, Chlamydia trachomatis, Neisseria gonorrhoeae and Trichomonas vaginalis in Papua New Guinea.

Vallely AJ, Toliman PJ, Ryan C, Rai G, Wapling J, Gabuzzi J, Kumbia A, Kombuk B, Kombati Z, Vallely LM, Kelly-Hanku A, Wand H, Tabrizi SN, Mola GDL, Kaldor JM.

Aust N Z J Obstet Gynaecol. 2018 Oct;58(5):576-581. doi: 10.1111/ajo.12783. Epub 2018 Jan 30.

PMID:
29380356
31.

Performance of syndromic management for the detection and treatment of genital Chlamydia trachomatis, Neisseria gonorrhoeae and Trichomonas vaginalis among women attending antenatal, well woman and sexual health clinics in Papua New Guinea: a cross-sectional study.

Vallely LM, Toliman P, Ryan C, Rai G, Wapling J, Gabuzzi J, Allen J, Opa C, Munnull G, Kaima P, Kombuk B, Kumbia A, Kombati Z, Law G, Kelly-Hanku A, Wand H, Siba PM, Mola GDL, Kaldor JM, Vallely AJ.

BMJ Open. 2017 Dec 29;7(12):e018630. doi: 10.1136/bmjopen-2017-018630.

32.

FcɛR1α gene polymorphism shows association with high IgE and anti-FcɛR1α in Chronic Rhinosinusitis with Nasal Polyposis.

Dar SA, Rai G, Ansari MA, Akhter N, Gupta N, Sharma S, Haque S, Ramachandran VG, Wahid M, Rudramurthy SM, Chakrabarti A, Das S.

J Cell Biochem. 2018 May;119(5):4142-4149. doi: 10.1002/jcb.26619. Epub 2018 Jan 22.

PMID:
29243845
33.

Serum Cytokine Profile in Patients with Chronic Rhinosinusitis with Nasal Polyposis Infected by Aspergillus flavus.

Rai G, Ansari MA, Dar SA, Datt S, Gupta N, Sharma S, Haque S, Ramachandran VG, Mazumdar A, Rudramurthy S, Chakrabarti A, Das S.

Ann Lab Med. 2018 Mar;38(2):125-131. doi: 10.3343/alm.2018.38.2.125.

34.

Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH).

Rai G, Brimacombe KR, Mott BT, Urban DJ, Hu X, Yang SM, Lee TD, Cheff DM, Kouznetsova J, Benavides GA, Pohida K, Kuenstner EJ, Luci DK, Lukacs CM, Davies DR, Dranow DM, Zhu H, Sulikowski G, Moore WJ, Stott GM, Flint AJ, Hall MD, Darley-Usmar VM, Neckers LM, Dang CV, Waterson AG, Simeonov A, Jadhav A, Maloney DJ.

J Med Chem. 2017 Nov 22;60(22):9184-9204. doi: 10.1021/acs.jmedchem.7b00941. Epub 2017 Nov 9.

35.

Effectiveness of community pharmacies in improving seasonal influenza uptake-an evaluation using the Donabedian framework.

Rai GK, Wood A.

J Public Health (Oxf). 2018 Jun 1;40(2):359-365. doi: 10.1093/pubmed/fdx078.

PMID:
29106582
36.

Challenges in culture-negative cases of Madurella mycetomatis: A case report re-accentuating PCR as an essential diagnostic tool.

K S, Das S, Pandhi D, Rai G, Ansari MA, Gupta C, Haque S, Dar SA.

J Mycol Med. 2017 Dec;27(4):577-581. doi: 10.1016/j.mycmed.2017.09.004. Epub 2017 Nov 6.

PMID:
29102309
37.

Biochemical Defense Response: Characterizing the Plasticity of Source and Sink in Spring Wheat under Terminal Heat Stress.

Kumar RR, Goswami S, Shamim M, Mishra U, Jain M, Singh K, Singh JP, Dubey K, Singh S, Rai GK, Singh GP, Pathak H, Chinnusamy V, Praveen S.

Front Plant Sci. 2017 Sep 20;8:1603. doi: 10.3389/fpls.2017.01603. eCollection 2017.

38.

Detection of Cryptosporidium parvum and Cyclospora cayetanensis infections among people living in a slum area in Kathmandu valley, Nepal.

Bhattachan B, Sherchand JB, Tandukar S, Dhoubhadel BG, Gauchan L, Rai G.

BMC Res Notes. 2017 Sep 7;10(1):464. doi: 10.1186/s13104-017-2779-2.

39.

Parallel Chemistry Approach to Identify Novel Nuclear Receptor Ligands Based on the GW0742 Scaffold.

Teske KA, Rai G, Nandhikonda P, Sidhu PS, Feleke B, Simeonov A, Yasgar A, Jadhav A, Maloney DJ, Arnold LA.

ACS Comb Sci. 2017 Oct 9;19(10):646-656. doi: 10.1021/acscombsci.7b00066. Epub 2017 Sep 5.

40.

Development of a real-time loop-mediated isothermal amplification assay for detection of Burkholderia mallei.

Pal V, Saxena A, Singh S, Goel AK, Kumar JS, Parida MM, Rai GP.

Transbound Emerg Dis. 2018 Feb;65(1):e32-e39. doi: 10.1111/tbed.12665. Epub 2017 Jun 25.

PMID:
28649808
41.

Prevalence and risk factors of Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis and other sexually transmissible infections among women attending antenatal clinics in three provinces in Papua New Guinea: a cross-sectional survey.

Vallely LM, Toliman P, Ryan C, Rai G, Wapling J, Tomado C, Huliafi S, Munnull G, Rarau P, Phuanukoonnon S, Wand H, Siba P, Mola GDL, Kaldor JM, Vallely AJ.

Sex Health. 2016 Oct;13(5):420-427. doi: 10.1071/SH15227.

PMID:
28636866
42.

When Sterile Processing Goes Down: An Economic Analysis of Alternative Strategies for Supporting the Service.

Mittenzwei SE, Topkoff JL, Bessesen MT, Porter CA, Rai GS, Branch-Elliman W.

Infect Control Hosp Epidemiol. 2017 Aug;38(8):1002-1004. doi: 10.1017/ice.2017.104. Epub 2017 Jun 19.

PMID:
28625181
43.

Comparative Study of GeneXpert MTB/RIF Assay and Multiplex PCR Assay for Direct Detection of Mycobacterium tuberculosis in Suspected Pulmonary Tuberculosis Patients.

Sah AK, Joshi B, Khadka DK, Gupta BP, Adhikari A, Singh SK, Rai G, Vaidya GS, Rajbhandari R, Pant B, Rai SK.

Curr Microbiol. 2017 Sep;74(9):1026-1032. doi: 10.1007/s00284-017-1279-x. Epub 2017 Jun 13.

PMID:
28612135
44.

Transfersomes as versatile and flexible nano-vesicular carriers in skin cancer therapy: the state of the art.

Rai S, Pandey V, Rai G.

Nano Rev Exp. 2017 Jun 7;8(1):1325708. doi: 10.1080/20022727.2017.1325708. eCollection 2017. Review.

45.

Exploring the heat-responsive chaperones and microsatellite markers associated with terminal heat stress tolerance in developing wheat.

Kumar RR, Goswami S, Shamim M, Dubey K, Singh K, Singh S, Kala YK, Niraj RRK, Sakhrey A, Singh GP, Grover M, Singh B, Rai GK, Rai AK, Chinnusamy V, Praveen S.

Funct Integr Genomics. 2017 Nov;17(6):621-640. doi: 10.1007/s10142-017-0560-1. Epub 2017 Jun 1.

PMID:
28573536
46.

Evaluation of growth inhibitory response of Resveratrol and Salinomycin combinations against triple negative breast cancer cells.

Rai G, Suman S, Mishra S, Shukla Y.

Biomed Pharmacother. 2017 May;89:1142-1151. doi: 10.1016/j.biopha.2017.02.110. Epub 2017 Mar 12.

PMID:
28298074
47.

The Southeastern Asian house mouse (Mus musculus castaneus Linn.) as a new passenger host for Cryptococcus neoformans var. grubii molecular type VNI.

Singh K, Rani J, Neelabh, Rai GK, Singh M.

Med Mycol. 2017 Nov 1;55(8):820-827. doi: 10.1093/mmy/myx001.

PMID:
28204573
48.

Interleukin-6-174G > C (rs1800795) polymorphism distribution and its association with rheumatoid arthritis: A case-control study and meta-analysis.

Dar SA, Haque S, Mandal RK, Singh T, Wahid M, Jawed A, Panda AK, Akhter N, Lohani M, Areeshi MY, Rai G, Datt S, Bhattacharya SN, Ramachandran VG, Das S.

Autoimmunity. 2017 May;50(3):158-169. doi: 10.1080/08916934.2016.1261833. Epub 2016 Dec 23.

PMID:
28010120
49.

WITHDRAWN: Designing and computational validation of microarray probe sets for the diagnosis of viruses of non-human vertebrates.

Rai GK, Lawrence R.

Mol Cell Probes. 2018 Apr;38:60. doi: 10.1016/j.mcp.2016.12.004. Epub 2016 Dec 15. No abstract available.

PMID:
27989424
50.

RNA-seq Analysis Reveals Unique Transcriptome Signatures in Systemic Lupus Erythematosus Patients with Distinct Autoantibody Specificities.

Rai R, Chauhan SK, Singh VV, Rai M, Rai G.

PLoS One. 2016 Nov 11;11(11):e0166312. doi: 10.1371/journal.pone.0166312. eCollection 2016.

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