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Items: 1 to 50 of 104

1.

Associations between clinical characteristics and the development of multiple organ failure after severe burns in adult patients.

Ogura A, Tsurumi A, Que YA, Almpani M, Zheng H, Tompkins RG, Ryan CM, Rahme LG.

Burns. 2019 Nov 2. pii: S0305-4179(18)30327-9. doi: 10.1016/j.burns.2019.02.014. [Epub ahead of print]

PMID:
31690472
2.

Editorial: Beyond Antimicrobials: Non-traditional Approaches to Combating Multidrug-Resistant Bacteria.

Kirienko NV, Rahme L, Cho YH.

Front Cell Infect Microbiol. 2019 Oct 11;9:343. doi: 10.3389/fcimb.2019.00343. eCollection 2019. No abstract available.

3.

Pseudomonas aeruginosa Quorum Sensing Molecule Alters Skeletal Muscle Protein Homeostasis by Perturbing the Antioxidant Defense System.

Bandyopadhaya A, Tzika AA, Rahme LG.

MBio. 2019 Oct 1;10(5). pii: e02211-19. doi: 10.1128/mBio.02211-19.

4.

Designed Small-Molecule Inhibitors of the Anthranilyl-CoA Synthetase PqsA Block Quinolone Biosynthesis in Pseudomonas aeruginosa.

Ji C, Sharma I, Pratihar D, Hudson LL, Maura D, Guney T, Rahme LG, Pesci EC, Coleman JP, Tan DS.

ACS Chem Biol. 2019 Jun 21;14(6):1380. doi: 10.1021/acschembio.9b00298. Epub 2019 May 14. No abstract available.

5.

Targeting bacterial quorum sensing shows promise in improving intestinal barrier function following burn‑site infection.

Adiliaghdam F, Almpani M, Gharedaghi MH, Najibi M, Hodin RA, Rahme LG.

Mol Med Rep. 2019 May;19(5):4057-4066. doi: 10.3892/mmr.2019.10071. Epub 2019 Mar 21.

6.

Magnetization transfer contrast MRI in GFP‑tagged live bacteria.

Righi V, Starkey M, Dai G, Rahme LG, Tzika AA.

Mol Med Rep. 2019 Jan;19(1):617-621. doi: 10.3892/mmr.2018.9669. Epub 2018 Nov 19.

PMID:
30483743
7.

Effects of a small, volatile bacterial molecule on Pseudomonas aeruginosa bacteria using whole cell high-resolution magic angle spinning nuclear magnetic resonance spectroscopy and genomics.

Righi V, Constantinou C, Kesarwani M, Rahme LG, Tzika AA.

Int J Mol Med. 2018 Oct;42(4):2129-2136. doi: 10.3892/ijmm.2018.3760. Epub 2018 Jul 6.

8.

Molecular Insights into Function and Competitive Inhibition of Pseudomonas aeruginosa Multiple Virulence Factor Regulator.

Kitao T, Lepine F, Babloudi S, Walte F, Steinbacher S, Maskos K, Blaesse M, Negri M, Pucci M, Zahler B, Felici A, Rahme LG.

MBio. 2018 Jan 16;9(1). pii: e02158-17. doi: 10.1128/mBio.02158-17.

9.

Animal Models for Pseudomonas aeruginosa Quorum Sensing Studies.

Maura D, Bandyopadhaya A, Rahme LG.

Methods Mol Biol. 2018;1673:227-241. doi: 10.1007/978-1-4939-7309-5_18.

10.

Pharmacological Inhibition of the Pseudomonas aeruginosa MvfR Quorum-Sensing System Interferes with Biofilm Formation and Potentiates Antibiotic-Mediated Biofilm Disruption.

Maura D, Rahme LG.

Antimicrob Agents Chemother. 2017 Nov 22;61(12). pii: e01362-17. doi: 10.1128/AAC.01362-17. Print 2017 Dec.

11.

NF-κBp50 and HDAC1 Interaction Is Implicated in the Host Tolerance to Infection Mediated by the Bacterial Quorum Sensing Signal 2-Aminoacetophenone.

Bandyopadhaya A, Tsurumi A, Rahme LG.

Front Microbiol. 2017 Jun 30;8:1211. doi: 10.3389/fmicb.2017.01211. eCollection 2017.

12.

In-depth Profiling of MvfR-Regulated Small Molecules in Pseudomonas aeruginosa after Quorum Sensing Inhibitor Treatment.

Allegretta G, Maurer CK, Eberhard J, Maura D, Hartmann RW, Rahme L, Empting M.

Front Microbiol. 2017 May 24;8:924. doi: 10.3389/fmicb.2017.00924. eCollection 2017.

13.

Polypharmacology Approaches against the Pseudomonas aeruginosa MvfR Regulon and Their Application in Blocking Virulence and Antibiotic Tolerance.

Maura D, Drees SL, Bandyopadhaya A, Kitao T, Negri M, Starkey M, Lesic B, Milot S, Déziel E, Zahler R, Pucci M, Felici A, Fetzner S, Lépine F, Rahme LG.

ACS Chem Biol. 2017 May 19;12(5):1435-1443. doi: 10.1021/acschembio.6b01139. Epub 2017 Apr 12.

PMID:
28379691
14.

Pseudomonas aeruginosa Alginate Overproduction Promotes Coexistence with Staphylococcus aureus in a Model of Cystic Fibrosis Respiratory Infection.

Limoli DH, Whitfield GB, Kitao T, Ivey ML, Davis MR Jr, Grahl N, Hogan DA, Rahme LG, Howell PL, O'Toole GA, Goldberg JB.

MBio. 2017 Mar 21;8(2). pii: e00186-17. doi: 10.1128/mBio.00186-17.

15.

Bioanalysis of Pseudomonas aeruginosa alkyl quinolone signalling molecules in infected mouse tissue using LC-MS/MS; and its application to a pharmacodynamic evaluation of MvfR inhibition.

Turnpenny P, Padfield A, Barton P, Teague J, Rahme LG, Pucci MJ, Zahler R, Rubio A.

J Pharm Biomed Anal. 2017 May 30;139:44-53. doi: 10.1016/j.jpba.2017.02.034. Epub 2017 Feb 28.

PMID:
28273650
16.

TNF-α/IL-10 Ratio Correlates with Burn Severity and May Serve as a Risk Predictor of Increased Susceptibility to Infections.

Tsurumi A, Que YA, Ryan CM, Tompkins RG, Rahme LG.

Front Public Health. 2016 Oct 5;4:216. eCollection 2016.

17.

Considerations and caveats in anti-virulence drug development.

Maura D, Ballok AE, Rahme LG.

Curr Opin Microbiol. 2016 Oct;33:41-46. doi: 10.1016/j.mib.2016.06.001. Epub 2016 Jun 16. Review.

18.

A quorum-sensing signal promotes host tolerance training through HDAC1-mediated epigenetic reprogramming.

Bandyopadhaya A, Tsurumi A, Maura D, Jeffrey KL, Rahme LG.

Nat Microbiol. 2016 Oct 3;1:16174. doi: 10.1038/nmicrobiol.2016.174.

19.

Evidence for Direct Control of Virulence and Defense Gene Circuits by the Pseudomonas aeruginosa Quorum Sensing Regulator, MvfR.

Maura D, Hazan R, Kitao T, Ballok AE, Rahme LG.

Sci Rep. 2016 Sep 28;6:34083. doi: 10.1038/srep34083.

20.

Designed Small-Molecule Inhibitors of the Anthranilyl-CoA Synthetase PqsA Block Quinolone Biosynthesis in Pseudomonas aeruginosa.

Ji C, Sharma I, Pratihar D, Hudson LL, Maura D, Guney T, Rahme LG, Pesci EC, Coleman JP, Tan DS.

ACS Chem Biol. 2016 Nov 18;11(11):3061-3067. Epub 2016 Sep 22. Erratum in: ACS Chem Biol. 2019 Jun 21;14(6):1380.

21.

Bacterial-excreted small volatile molecule 2-aminoacetophenone induces oxidative stress and apoptosis in murine skeletal muscle.

Bandyopadhaya A, Constantinou C, Psychogios N, Ueki R, Yasuhara S, Martyn JA, Wilhelmy J, Mindrinos M, Rahme LG, Tzika AA.

Int J Mol Med. 2016 Apr;37(4):867-78. doi: 10.3892/ijmm.2016.2487. Epub 2016 Feb 12.

22.

Auto Poisoning of the Respiratory Chain by a Quorum-Sensing-Regulated Molecule Favors Biofilm Formation and Antibiotic Tolerance.

Hazan R, Que YA, Maura D, Strobel B, Majcherczyk PA, Hopper LR, Wilbur DJ, Hreha TN, Barquera B, Rahme LG.

Curr Biol. 2016 Jan 25;26(2):195-206. doi: 10.1016/j.cub.2015.11.056. Epub 2016 Jan 14.

23.

In vivo high-resolution magic angle spinning magnetic and electron paramagnetic resonance spectroscopic analysis of mitochondria-targeted peptide in Drosophila melanogaster with trauma-induced thoracic injury.

Constantinou C, Apidianakis Y, Psychogios N, Righi V, Mindrinos MN, Khan N, Swartz HM, Szeto HH, Tompkins RG, Rahme LG, Tzika AA.

Int J Mol Med. 2016 Feb;37(2):299-308. doi: 10.3892/ijmm.2015.2426. Epub 2015 Dec 8.

24.

Do standard burn mortality formulae work on a population of severely burned children and adults?

Tsurumi A, Que YA, Yan S, Tompkins RG, Rahme LG, Ryan CM.

Burns. 2015 Aug;41(5):935-45. doi: 10.1016/j.burns.2015.03.017. Epub 2015 Apr 25.

PMID:
25922299
25.

Identification of anti-virulence compounds that disrupt quorum-sensing regulated acute and persistent pathogenicity.

Starkey M, Lepine F, Maura D, Bandyopadhaya A, Lesic B, He J, Kitao T, Righi V, Milot S, Tzika A, Rahme L.

PLoS Pathog. 2014 Aug 21;10(8):e1004321. doi: 10.1371/journal.ppat.1004321. eCollection 2014 Aug.

26.

Prediction of multiple infections after severe burn trauma: a prospective cohort study.

Yan S, Tsurumi A, Que YA, Ryan CM, Bandyopadhaya A, Morgan AA, Flaherty PJ, Tompkins RG, Rahme LG.

Ann Surg. 2015 Apr;261(4):781-92. doi: 10.1097/SLA.0000000000000759.

27.

Assessing Pseudomonas aeruginosa Persister/antibiotic tolerant cells.

Hazan R, Maura D, Que YA, Rahme LG.

Methods Mol Biol. 2014;1149:699-707. doi: 10.1007/978-1-4939-0473-0_54.

28.

Assessing Pseudomonas virulence with the nonmammalian host model: Arabidopsis thaliana.

Baldini RL, Starkey M, Rahme LG.

Methods Mol Biol. 2014;1149:689-97. doi: 10.1007/978-1-4939-0473-0_53.

PMID:
24818943
29.

In vivo high-resolution magic angle spinning proton NMR spectroscopy of Drosophila melanogaster flies as a model system to investigate mitochondrial dysfunction in Drosophila GST2 mutants.

Righi V, Apidianakis Y, Psychogios N, Rahme LG, Tompkins RG, Tzika AA.

Int J Mol Med. 2014 Jul;34(1):327-33. doi: 10.3892/ijmm.2014.1757. Epub 2014 Apr 24.

PMID:
24789699
30.

Live-cell high resolution magic angle spinning magnetic resonance spectroscopy for in vivo analysis of Pseudomonas aeruginosa metabolomics.

Righi V, Constantinou C, Kesarwani M, Rahme LG, Tzika AA.

Biomed Rep. 2013 Sep;1(5):707-712. Epub 2013 Jul 22.

31.

A quorum sensing small volatile molecule promotes antibiotic tolerance in bacteria.

Que YA, Hazan R, Strobel B, Maura D, He J, Kesarwani M, Panopoulos P, Tsurumi A, Giddey M, Wilhelmy J, Mindrinos MN, Rahme LG.

PLoS One. 2013 Dec 19;8(12):e80140. doi: 10.1371/journal.pone.0080140. eCollection 2013.

32.

The end of an old hypothesis: the pseudomonas signaling molecules 4-hydroxy-2-alkylquinolines derive from fatty acids, not 3-ketofatty acids.

Dulcey CE, Dekimpe V, Fauvelle DA, Milot S, Groleau MC, Doucet N, Rahme LG, Lépine F, Déziel E.

Chem Biol. 2013 Dec 19;20(12):1481-91. doi: 10.1016/j.chembiol.2013.09.021. Epub 2013 Nov 14.

33.

A small volatile bacterial molecule triggers mitochondrial dysfunction in murine skeletal muscle.

Tzika AA, Constantinou C, Bandyopadhaya A, Psychogios N, Lee S, Mindrinos M, Martyn JA, Tompkins RG, Rahme LG.

PLoS One. 2013 Sep 30;8(9):e74528. doi: 10.1371/journal.pone.0074528. eCollection 2013.

34.

Skeletal muscle mitochondrial uncoupling in a murine cancer cachexia model.

Tzika AA, Fontes-Oliveira CC, Shestov AA, Constantinou C, Psychogios N, Righi V, Mintzopoulos D, Busquets S, Lopez-Soriano FJ, Milot S, Lepine F, Mindrinos MN, Rahme LG, Argiles JM.

Int J Oncol. 2013 Sep;43(3):886-94. doi: 10.3892/ijo.2013.1998. Epub 2013 Jun 28.

PMID:
23817738
35.

Mitochondria-targeted antioxidant promotes recovery of skeletal muscle mitochondrial function after burn trauma assessed by in vivo 31P nuclear magnetic resonance and electron paramagnetic resonance spectroscopy.

Righi V, Constantinou C, Mintzopoulos D, Khan N, Mupparaju SP, Rahme LG, Swartz HM, Szeto HH, Tompkins RG, Tzika AA.

FASEB J. 2013 Jun;27(6):2521-30. doi: 10.1096/fj.12-220764. Epub 2013 Mar 12.

36.

Genomic responses in mouse models poorly mimic human inflammatory diseases.

Seok J, Warren HS, Cuenca AG, Mindrinos MN, Baker HV, Xu W, Richards DR, McDonald-Smith GP, Gao H, Hennessy L, Finnerty CC, López CM, Honari S, Moore EE, Minei JP, Cuschieri J, Bankey PE, Johnson JL, Sperry J, Nathens AB, Billiar TR, West MA, Jeschke MG, Klein MB, Gamelli RL, Gibran NS, Brownstein BH, Miller-Graziano C, Calvano SE, Mason PH, Cobb JP, Rahme LG, Lowry SF, Maier RV, Moldawer LL, Herndon DN, Davis RW, Xiao W, Tompkins RG; Inflammation and Host Response to Injury, Large Scale Collaborative Research Program.

Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3507-12. doi: 10.1073/pnas.1222878110. Epub 2013 Feb 11.

37.

The quorum sensing volatile molecule 2-amino acetophenon modulates host immune responses in a manner that promotes life with unwanted guests.

Bandyopadhaya A, Kesarwani M, Que YA, He J, Padfield K, Tompkins R, Rahme LG.

PLoS Pathog. 2012;8(11):e1003024. doi: 10.1371/journal.ppat.1003024. Epub 2012 Nov 15.

38.

A method for high throughput determination of viable bacteria cell counts in 96-well plates.

Hazan R, Que YA, Maura D, Rahme LG.

BMC Microbiol. 2012 Nov 13;12:259. doi: 10.1186/1471-2180-12-259.

39.

Imaging C-Fos Gene Expression in Burns Using Lipid Coated Spion Nanoparticles.

Papagiannaros A, Righi V, Day GG, Rahme LG, Liu PK, Fischman AJ, Tompkins RG, Tzika AA.

Adv J Mol Imaging. 2012 Oct;2(4):31-37.

40.

Purification, crystallization and preliminary X-ray diffraction analysis of the C-terminal fragment of the MvfR protein from Pseudomonas aeruginosa.

Kefala K, Kotsifaki D, Providaki M, Kapetaniou EG, Rahme L, Kokkinidis M.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Jun 1;68(Pt 6):695-7. doi: 10.1107/S1744309112016661. Epub 2012 May 23.

41.

Honey's Ability to Counter Bacterial Infections Arises from Both Bactericidal Compounds and QS Inhibition.

Wang R, Starkey M, Hazan R, Rahme LG.

Front Microbiol. 2012 Apr 11;3:144. doi: 10.3389/fmicb.2012.00144. eCollection 2012.

42.

Immune response to bacteria induces dissemination of Ras-activated Drosophila hindgut cells.

Bangi E, Pitsouli C, Rahme LG, Cagan R, Apidianakis Y.

EMBO Rep. 2012 Jun 1;13(6):569-76. doi: 10.1038/embor.2012.44.

43.

An ex vivo bacteriologic study comparing antiseptic techniques for natural orifice translumenal endoscopic surgery (NOTES) via the gastrointestinal tract.

Ryou M, Hazan R, Rahme L, Thompson CC.

Dig Dis Sci. 2012 Aug;57(8):2130-6. doi: 10.1007/s10620-012-2126-3. Epub 2012 Mar 24.

PMID:
22447433
44.

Down-regulation of glutatione S-transferase α 4 (hGSTA4) in the muscle of thermally injured patients is indicative of susceptibility to bacterial infection.

Apidianakis Y, Que YA, Xu W, Tegos GP, Zimniak P, Hamblin MR, Tompkins RG, Xiao W, Rahme LG.

FASEB J. 2012 Feb;26(2):730-7. doi: 10.1096/fj.11-192484. Epub 2011 Oct 28.

45.

A quorum sensing regulated small volatile molecule reduces acute virulence and promotes chronic infection phenotypes.

Kesarwani M, Hazan R, He J, Que YA, Apidianakis Y, Lesic B, Xiao G, Dekimpe V, Milot S, Deziel E, Lépine F, Rahme LG.

PLoS Pathog. 2011 Aug;7(8):e1002192. doi: 10.1371/journal.ppat.1002192. Epub 2011 Aug 4. Erratum in: PLoS Pathog. 2011 Aug;7(8). doi: 10.1371/annotation/a1b0d6de-c6b4-4a5f-97ac-d500fbde806f.

46.

Combining magnetic resonance spectroscopy and molecular genomics offers better accuracy in brain tumor typing and prediction of survival than either methodology alone.

Astrakas L, Blekas KD, Constantinou C, Andronesi OC, Mindrinos MN, Likas AC, Rahme LG, Black PM, Marcus KJ, Tzika AA.

Int J Oncol. 2011 Apr;38(4):1113-27. doi: 10.3892/ijo.2011.928. Epub 2011 Jan 27.

PMID:
21274507
47.

Production of Pseudomonas aeruginosa Intercellular Small Signaling Molecules in Human Burn Wounds.

Que YA, Hazan R, Ryan CM, Milot S, Lépine F, Lydon M, Rahme LG.

J Pathog. 2011;2011:549302. doi: 10.4061/2011/549302. Epub 2011 Mar 17.

48.

Drosophila melanogaster as a model for human intestinal infection and pathology.

Apidianakis Y, Rahme LG.

Dis Model Mech. 2011 Jan;4(1):21-30. doi: 10.1242/dmm.003970. Review.

49.

Nuclear magnetic resonance in conjunction with functional genomics suggests mitochondrial dysfunction in a murine model of cancer cachexia.

Constantinou C, Fontes de Oliveira CC, Mintzopoulos D, Busquets S, He J, Kesarwani M, Mindrinos M, Rahme LG, Argilés JM, Tzika AA.

Int J Mol Med. 2011 Jan;27(1):15-24. doi: 10.3892/ijmm.2010.557. Epub 2010 Nov 10.

50.

Combined off-resonance imaging and T2 relaxation in the rotating frame for positive contrast MR imaging of infection in a murine burn model.

Andronesi OC, Mintzopoulos D, Righi V, Psychogios N, Kesarwani M, He J, Yasuhara S, Dai G, Rahme LG, Tzika AA.

J Magn Reson Imaging. 2010 Nov;32(5):1172-83. doi: 10.1002/jmri.22349. Erratum in: J Magn Reson Imaging. 2011 Jan;33(1):256. Righi, Valeria [added].

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