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Items: 50


Clinical Molecular Marker Testing Data Capture to Promote Precision Medicine Research Within the Cancer Research Network.

Burnett-Hartman AN, Udaltsova N, Kushi LH, Neslund-Dudas C, Rahm AK, Pawloski PA, Corley DA, Knerr S, Feigelson HS, Hunter JE, Tabano DC, Epstein MM, Honda SA, Ter-Minassian M, Lynch JA, Lu CY.

JCO Clin Cancer Inform. 2019 Sep;3:1-10. doi: 10.1200/CCI.19.00026.


Trends in Use of Medical Imaging in US Health Care Systems and in Ontario, Canada, 2000-2016.

Smith-Bindman R, Kwan ML, Marlow EC, Theis MK, Bolch W, Cheng SY, Bowles EJA, Duncan JR, Greenlee RT, Kushi LH, Pole JD, Rahm AK, Stout NK, Weinmann S, Miglioretti DL.

JAMA. 2019 Sep 3;322(9):843-856. doi: 10.1001/jama.2019.11456.


Trends in Medical Imaging During Pregnancy in the United States and Ontario, Canada, 1996 to 2016.

Kwan ML, Miglioretti DL, Marlow EC, Aiello Bowles EJ, Weinmann S, Cheng SY, Deosaransingh KA, Chavan P, Moy LM, Bolch WE, Duncan JR, Greenlee RT, Kushi LH, Pole JD, Rahm AK, Stout NK, Smith-Bindman R; Radiation-Induced Cancers Study Team.

JAMA Netw Open. 2019 Jul 3;2(7):e197249. doi: 10.1001/jamanetworkopen.2019.7249.


Developing implementation strategies to improve uptake of guideline-recommended treatments for individuals with familial hypercholesterolemia: A protocol.

Jones LK, Gidding SS, Seaton TL, Goldberg A, Gregor C, Sturm AC, Brownson RC, Rahm AK, Williams MS.

Res Social Adm Pharm. 2019 Jun 15. pii: S1551-7411(19)30458-9. doi: 10.1016/j.sapharm.2019.06.006. [Epub ahead of print]


The Healthcare Systems Research Network (HCSRN) as an Environment for Dissemination and Implementation Research: A Case Study of Developing a Multi-Site Research Study in Precision Medicine.

Rahm AK, Ladd I, Burnett-Hartman AN, Epstein MM, Lowery JT, Lu CY, Pawloski PA, Sharaf RN, Liang SY, Hunter JE.

EGEMS (Wash DC). 2019 Apr 12;7(1):16. doi: 10.5334/egems.283.


Exome Sequencing-Based Screening for BRCA1/2 Expected Pathogenic Variants Among Adult Biobank Participants.

Manickam K, Buchanan AH, Schwartz MLB, Hallquist MLG, Williams JL, Rahm AK, Rocha H, Savatt JM, Evans AE, Butry LM, Lazzeri AL, Lindbuchler DM, Flansburg CN, Leeming R, Vogel VG, Lebo MS, Mason-Suares HM, Hoskinson DC, Abul-Husn NS, Dewey FE, Overton JD, Reid JG, Baras A, Willard HF, McCormick CZ, Krishnamurthy SB, Hartzel DN, Kost KA, Lavage DR, Sturm AC, Frisbie LR, Person TN, Metpally RP, Giovanni MA, Lowry LE, Leader JB, Ritchie MD, Carey DJ, Justice AE, Kirchner HL, Faucett WA, Williams MS, Ledbetter DH, Murray MF.

JAMA Netw Open. 2018 Sep 7;1(5):e182140. doi: 10.1001/jamanetworkopen.2018.2140.


Implementing universal Lynch syndrome screening (IMPULSS): protocol for a multi-site study to identify strategies to implement, adapt, and sustain genomic medicine programs in different organizational contexts.

Rahm AK, Cragun D, Hunter JE, Epstein MM, Lowery J, Lu CY, Pawloski PA, Sharaf RN, Liang SY, Burnett-Hartman AN, Gudgeon JM, Hao J, Snyder S, Gogoi R, Ladd I, Williams MS.

BMC Health Serv Res. 2018 Oct 30;18(1):824. doi: 10.1186/s12913-018-3636-2.


Inhibition of Histone Deacetylases Induces K+ Channel Remodeling and Action Potential Prolongation in HL-1 Atrial Cardiomyocytes.

Lugenbiel P, Govorov K, Rahm AK, Wieder T, Gramlich D, Syren P, Weiberg N, Seyler C, Katus HA, Thomas D.

Cell Physiol Biochem. 2018;49(1):65-77. doi: 10.1159/000492840. Epub 2018 Aug 22.


A Model for Genome-First Care: Returning Secondary Genomic Findings to Participants and Their Healthcare Providers in a Large Research Cohort.

Schwartz MLB, McCormick CZ, Lazzeri AL, Lindbuchler DM, Hallquist MLG, Manickam K, Buchanan AH, Rahm AK, Giovanni MA, Frisbie L, Flansburg CN, Davis FD, Sturm AC, Nicastro C, Lebo MS, Mason-Suares H, Mahanta LM, Carey DJ, Williams JL, Williams MS, Ledbetter DH, Faucett WA, Murray MF.

Am J Hum Genet. 2018 Sep 6;103(3):328-337. doi: 10.1016/j.ajhg.2018.07.009. Epub 2018 Aug 9.


Generation and Implementation of a Patient-Centered and Patient-Facing Genomic Test Report in the EHR.

Goehringer JM, Bonhag MA, Jones LK, Schmidlen T, Schwartz M, Rahm AK, Williams JL, Williams MS.

EGEMS (Wash DC). 2018 Jun 26;6(1):14. doi: 10.5334/egems.256.


Role of ion channels in heart failure and channelopathies.

Rahm AK, Lugenbiel P, Schweizer PA, Katus HA, Thomas D.

Biophys Rev. 2018 Aug;10(4):1097-1106. doi: 10.1007/s12551-018-0442-3. Epub 2018 Jul 17. Review.


Cardiovascular pharmacology of K2P17.1 (TASK-4, TALK-2) two-pore-domain K+ channels.

Staudacher I, Illg C, Chai S, Deschenes I, Seehausen S, Gramlich D, Müller ME, Wieder T, Rahm AK, Mayer C, Schweizer PA, Katus HA, Thomas D.

Naunyn Schmiedebergs Arch Pharmacol. 2018 Oct;391(10):1119-1131. doi: 10.1007/s00210-018-1535-z. Epub 2018 Jul 14.


Experience with Integrating Diagnostic Decision Support Software with Electronic Health Records: Benefits versus Risks of Information Sharing.

Segal MM, Rahm AK, Hulse NC, Wood G, Williams JL, Feldman L, Moore GJ, Gehrum D, Yefko M, Mayernick S, Gildersleeve R, Sunderland MC, Bleyl SB, Haug P, Williams MS.

EGEMS (Wash DC). 2017 Dec 6;5(1):23. doi: 10.5334/egems.244.


Patient-Centered Precision Health In A Learning Health Care System: Geisinger's Genomic Medicine Experience.

Williams MS, Buchanan AH, Davis FD, Faucett WA, Hallquist MLG, Leader JB, Martin CL, McCormick CZ, Meyer MN, Murray MF, Rahm AK, Schwartz MLB, Sturm AC, Wagner JK, Williams JL, Willard HF, Ledbetter DH.

Health Aff (Millwood). 2018 May;37(5):757-764. doi: 10.1377/hlthaff.2017.1557. Review.


Early cancer diagnoses through BRCA1/2 screening of unselected adult biobank participants.

Buchanan AH, Manickam K, Meyer MN, Wagner JK, Hallquist MLG, Williams JL, Rahm AK, Williams MS, Chen ZE, Shah CK, Garg TK, Lazzeri AL, Schwartz MLB, Lindbuchler DM, Fan AL, Leeming R, Servano PO 3rd, Smith AL, Vogel VG, Abul-Husn NS, Dewey FE, Lebo MS, Mason-Suares HM, Ritchie MD, Davis FD, Carey DJ, Feinberg DT, Faucett WA, Ledbetter DH, Murray MF.

Genet Med. 2018 Apr;20(5):554-558. doi: 10.1038/gim.2017.145. Epub 2017 Oct 26.


Impact of a Patient-Facing Enhanced Genomic Results Report to Improve Understanding, Engagement, and Communication.

Williams JL, Rahm AK, Zallen DT, Stuckey H, Fultz K, Fan AL, Bonhag M, Feldman L, Segal MM, Williams MS.

J Genet Couns. 2018 Apr;27(2):358-369. doi: 10.1007/s10897-017-0176-6. Epub 2017 Dec 4.


Control of cardiac chronotropic function in patients after heart transplantation: effects of ivabradine and metoprolol succinate on resting heart rate in the denervated heart.

Rivinius R, Helmschrott M, Ruhparwar A, Rahm AK, Darche FF, Thomas D, Bruckner T, Ehlermann P, Katus HA, Doesch AO.

Clin Res Cardiol. 2018 Feb;107(2):138-147. doi: 10.1007/s00392-017-1165-3. Epub 2017 Nov 2.


Chronic digitalis therapy in patients before heart transplantation is an independent risk factor for increased posttransplant mortality.

Rivinius R, Helmschrott M, Ruhparwar A, Rahm AK, Darche FF, Thomas D, Bruckner T, Ehlermann P, Katus HA, Doesch AO.

Ther Clin Risk Manag. 2017 Oct 13;13:1399-1407. doi: 10.2147/TCRM.S147062. eCollection 2017.


Latino Parents' Perceptions of Pediatric Weight Counseling Terms.

Knierim SD, Newcomer S, Castillo A, Rahm AK, Raghunath S, Clarke C, Wright L, Haemer M, Hambidge SJ.

Acad Pediatr. 2018 Apr;18(3):342-353. doi: 10.1016/j.acap.2017.09.006. Epub 2017 Sep 12.


Feasibility Study on Cardiac Arrhythmia Ablation Using High-Energy Heavy Ion Beams.

Lehmann HI, Graeff C, Simoniello P, Constantinescu A, Takami M, Lugenbiel P, Richter D, Eichhorn A, Prall M, Kaderka R, Fiedler F, Helmbrecht S, Fournier C, Erbeldinger N, Rahm AK, Rivinius R, Thomas D, Katus HA, Johnson SB, Parker KD, Debus J, Asirvatham SJ, Bert C, Durante M, Packer DL.

Sci Rep. 2016 Dec 20;6:38895. doi: 10.1038/srep38895.


Precision engagement: the PMI's success will depend on more than genomes and big data.

Wagner JK, Peltz-Rauchman C, Rahm AK, Johnson CC.

Genet Med. 2017 Jun;19(6):620-624. doi: 10.1038/gim.2016.165. Epub 2016 Oct 27.


Alternate Service Delivery Models in Cancer Genetic Counseling: A Mini-Review.

Buchanan AH, Rahm AK, Williams JL.

Front Oncol. 2016 May 13;6:120. doi: 10.3389/fonc.2016.00120. eCollection 2016. Review.


Therapeutic targeting of two-pore-domain potassium (K(2P)) channels in the cardiovascular system.

Wiedmann F, Schmidt C, Lugenbiel P, Staudacher I, Rahm AK, Seyler C, Schweizer PA, Katus HA, Thomas D.

Clin Sci (Lond). 2016 May;130(9):643-50. doi: 10.1042/CS20150533. Review.


Enhancing genomic laboratory reports: A qualitative analysis of provider review.

Williams JL, Rahm AK, Stuckey H, Green J, Feldman L, Zallen DT, Bonhag M, Segal MM, Fan AL, Williams MS.

Am J Med Genet A. 2016 May;170A(5):1134-41. doi: 10.1002/ajmg.a.37573. Epub 2016 Feb 3.


Enhancing genomic laboratory reports from the patients' view: A qualitative analysis.

Stuckey H, Williams JL, Fan AL, Rahm AK, Green J, Feldman L, Bonhag M, Zallen DT, Segal MM, Williams MS.

Am J Med Genet A. 2015 Oct;167A(10):2238-43. doi: 10.1002/ajmg.a.37174. Epub 2015 Jun 18.


Implementing an evidence-based breast cancer support and communication tool to newly diagnosed patients as standard care in two institutions.

Rahm AK, Hawkins RP, Dearing JW, Pingree S, Lomax JB, McDowell H, Morse EF, Barela B.

Transl Behav Med. 2015 Jun;5(2):198-206. doi: 10.1007/s13142-015-0305-4.


Latino parents' perceptions of weight terminology used in pediatric weight counseling.

Knierim SD, Rahm AK, Haemer M, Raghunath S, Martin C, Yang A, Clarke C, Hambidge SJ.

Acad Pediatr. 2015 Mar-Apr;15(2):210-7. doi: 10.1016/j.acap.2014.11.003. Epub 2014 Dec 20.


Facilitators and Barriers to Implementing Screening, Brief Intervention, and Referral to Treatment (SBIRT) in Primary Care in Integrated Health Care Settings.

Rahm AK, Boggs JM, Martin C, Price DW, Beck A, Backer TE, Dearing JW.

Subst Abus. 2015;36(3):281-8. doi: 10.1080/08897077.2014.951140. Epub 2014 Aug 15.


Collaboration of colorado cancer genetic counselors to integrate next generation sequencing panels into clinical practice.

Wolfe Schneider K, Anguiano A, Axell L, Barth C, Crow K, Gilstrap M, Hamlington BA, Lesh S, Mullineaux L, Rahm AK, Strait E, Freivogel M.

J Genet Couns. 2014 Aug;23(4):640-6. doi: 10.1007/s10897-014-9718-3. Epub 2014 May 1.


Functional characterization of zebrafish K2P18.1 (TRESK) two-pore-domain K+ channels.

Rahm AK, Wiedmann F, Gierten J, Schmidt C, Schweizer PA, Becker R, Katus HA, Thomas D.

Naunyn Schmiedebergs Arch Pharmacol. 2014 Mar;387(3):291-300. doi: 10.1007/s00210-013-0945-1. Epub 2013 Dec 6.


Underutilization of Lynch syndrome screening in a multisite study of patients with colorectal cancer.

Cross DS, Rahm AK, Kauffman TL, Webster J, Le AQ, Spencer Feigelson H, Alexander G, Meier P, Onitilo AA, Pawloski PA, Williams AE, Honda S, Daida Y, McCarty CA, Goddard KA; CERGEN study team.

Genet Med. 2013 Dec;15(12):933-40. doi: 10.1038/gim.2013.43. Epub 2013 May 2.


Biobanking for research: a survey of patient population attitudes and understanding.

Rahm AK, Wrenn M, Carroll NM, Feigelson HS.

J Community Genet. 2013 Oct;4(4):445-50. doi: 10.1007/s12687-013-0146-0. Epub 2013 Apr 20.


The influence of endoscopic vein harvesting on outcomes after coronary bypass grafting: a meta-analysis of 267,525 patients.

Sastry P, Rivinius R, Harvey R, Parker RA, Rahm AK, Thomas D, Nair S, Large SR.

Eur J Cardiothorac Surg. 2013 Dec;44(6):980-9. doi: 10.1093/ejcts/ezt121. Epub 2013 Mar 20. Review.


Utilization of HER2 genetic testing in a multi-institutional observational study.

Goddard KA, Bowles EJ, Feigelson HS, Habel LA, Alford SH, McCarty CA, Nekhlyudov L, Onitilo AA, Rahm AK, Webster JA.

Am J Manag Care. 2012 Nov;18(11):704-12.


Reliability of KRAS mutation testing in metastatic colorectal cancer patients across five laboratories.

Feigelson HS, Goddard KA, Johnson MA, Funk KC, Rahm AK, Kauffman TL, Chitale DA, Le Marchand L, Richards CS.

BMC Res Notes. 2012 Apr 25;5:196. doi: 10.1186/1756-0500-5-196.


Perception of direct-to-consumer genetic testing and direct-to-consumer advertising of genetic tests among members of a large managed care organization.

Rahm AK, Feigelson HS, Wagner N, Le AQ, Halterman E, Cornish N, Dearing JW.

J Genet Couns. 2012 Jun;21(3):448-61. doi: 10.1007/s10897-011-9477-3. Epub 2012 Jan 26.


The importance of P wave morphology on the ECG.

Rahm AK, Looi KL, Fynn S.

Heart Asia. 2012 Jan 1;4(1):23-4. doi: 10.1136/heartasia-2011-010088. eCollection 2012. No abstract available.


PKC-dependent activation of human K(2P) 18.1 K(+) channels.

Rahm AK, Gierten J, Kisselbach J, Staudacher I, Staudacher K, Schweizer PA, Becker R, Katus HA, Thomas D.

Br J Pharmacol. 2012 May;166(2):764-73. doi: 10.1111/j.1476-5381.2011.01813.x.


Alternative splicing determines mRNA translation initiation and function of human K(2P)10.1 K+ channels.

Staudacher K, Baldea I, Kisselbach J, Staudacher I, Rahm AK, Schweizer PA, Becker R, Katus HA, Thomas D.

J Physiol. 2011 Aug 1;589(Pt 15):3709-20. doi: 10.1113/jphysiol.2011.210666. Epub 2011 Jun 13.


Barriers in identification and referral to genetic counseling for familial cancer risk: the perspective of genetic service providers.

Rolnick SJ, Rahm AK, Jackson JM, Nekhlyudov L, Goddard KA, Field T, McCarty C, Nakasato C, Roblin D, Anderson CP, Valdez R.

J Genet Couns. 2011 Jun;20(3):314-22. doi: 10.1007/s10897-011-9351-3. Epub 2011 Apr 19.


Carvedilol targets human K2P 3.1 (TASK1) K+ leak channels.

Staudacher K, Staudacher I, Ficker E, Seyler C, Gierten J, Kisselbach J, Rahm AK, Trappe K, Schweizer PA, Becker R, Katus HA, Thomas D.

Br J Pharmacol. 2011 Jul;163(5):1099-110. doi: 10.1111/j.1476-5381.2011.01319.x.


Assessment of barriers to changing practice as CME outcomes.

Price DW, Miller EK, Rahm AK, Brace NE, Larson RS.

J Contin Educ Health Prof. 2010 Fall;30(4):237-45. doi: 10.1002/chp.20088.


The use of internet-based technology to tailor well-child care encounters.

Bergman DA, Beck A, Rahm AK.

Pediatrics. 2009 Jul;124(1):e37-43. doi: 10.1542/peds.2008-3385.


Increasing utilization of cancer genetic counseling services using a patient navigator model.

Rahm AK, Sukhanova A, Ellis J, Mouchawar J.

J Genet Couns. 2007 Apr;16(2):171-7.


Robustness of a computer-assisted diabetes self-management intervention across patient characteristics, healthcare settings, and intervention staff.

Glasgow RE, Strycker LA, King DK, Toobert DJ, Rahm AK, Jex M, Nutting PA.

Am J Manag Care. 2006 Mar;12(3):137-45.


Randomized effectiveness trial of a computer-assisted intervention to improve diabetes care.

Glasgow RE, Nutting PA, King DK, Nelson CC, Cutter G, Gaglio B, Rahm AK, Whitesides H.

Diabetes Care. 2005 Jan;28(1):33-9.


A practical randomized trial to improve diabetes care.

Glasgow RE, Nutting PA, King DK, Nelson CC, Cutter G, Gaglio B, Rahm AK, Whitesides H, Amthauer H.

J Gen Intern Med. 2004 Dec;19(12):1167-74.


Impact of BRCA1 testing on women with cancer: a pilot study.

Wood ME, Mullineaux L, Rahm AK, Fairclough D, Wenzel L.

Genet Test. 2000;4(3):265-72.


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