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Items: 24

1.

Intrinsic cell-penetrating activity propels Omomyc from proof of concept to viable anti-MYC therapy.

Beaulieu ME, Jauset T, Massó-Vallés D, Martínez-Martín S, Rahl P, Maltais L, Zacarias-Fluck MF, Casacuberta-Serra S, Serrano Del Pozo E, Fiore C, Foradada L, Cano VC, Sánchez-Hervás M, Guenther M, Romero Sanz E, Oteo M, Tremblay C, Martín G, Letourneau D, Montagne M, Morcillo Alonso MÁ, Whitfield JR, Lavigne P, Soucek L.

Sci Transl Med. 2019 Mar 20;11(484). pii: eaar5012. doi: 10.1126/scitranslmed.aar5012.

2.

BET bromodomain proteins regulate enhancer function during adipogenesis.

Brown JD, Feldman ZB, Doherty SP, Reyes JM, Rahl PB, Lin CY, Sheng Q, Duan Q, Federation AJ, Kung AL, Haldar SM, Young RA, Plutzky J, Bradner JE.

Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):2144-2149. doi: 10.1073/pnas.1711155115. Epub 2018 Feb 14.

3.

Targeting transcription regulation in cancer with a covalent CDK7 inhibitor.

Kwiatkowski N, Zhang T, Rahl PB, Abraham BJ, Reddy J, Ficarro SB, Dastur A, Amzallag A, Ramaswamy S, Tesar B, Jenkins CE, Hannett NM, McMillin D, Sanda T, Sim T, Kim ND, Look T, Mitsiades CS, Weng AP, Brown JR, Benes CH, Marto JA, Young RA, Gray NS.

Nature. 2014 Jul 31;511(7511):616-20. doi: 10.1038/nature13393. Epub 2014 Jun 22.

4.

Small-molecule RORγt antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms.

Xiao S, Yosef N, Yang J, Wang Y, Zhou L, Zhu C, Wu C, Baloglu E, Schmidt D, Ramesh R, Lobera M, Sundrud MS, Tsai PY, Xiang Z, Wang J, Xu Y, Lin X, Kretschmer K, Rahl PB, Young RA, Zhong Z, Hafler DA, Regev A, Ghosh S, Marson A, Kuchroo VK.

Immunity. 2014 Apr 17;40(4):477-89. doi: 10.1016/j.immuni.2014.04.004.

5.

MYC and transcription elongation.

Rahl PB, Young RA.

Cold Spring Harb Perspect Med. 2014 Jan 1;4(1):a020990. doi: 10.1101/cshperspect.a020990. Review.

6.

Genome-wide localization of small molecules.

Anders L, Guenther MG, Qi J, Fan ZP, Marineau JJ, Rahl PB, Lovén J, Sigova AA, Smith WB, Lee TI, Bradner JE, Young RA.

Nat Biotechnol. 2014 Jan;32(1):92-6. doi: 10.1038/nbt.2776. Epub 2013 Dec 15.

7.

Discovery and characterization of super-enhancer-associated dependencies in diffuse large B cell lymphoma.

Chapuy B, McKeown MR, Lin CY, Monti S, Roemer MG, Qi J, Rahl PB, Sun HH, Yeda KT, Doench JG, Reichert E, Kung AL, Rodig SJ, Young RA, Shipp MA, Bradner JE.

Cancer Cell. 2013 Dec 9;24(6):777-90. doi: 10.1016/j.ccr.2013.11.003. Erratum in: Cancer Cell. 2014 Apr 14;25(4):545-6.

8.

Let-7 represses Nr6a1 and a mid-gestation developmental program in adult fibroblasts.

Gurtan AM, Ravi A, Rahl PB, Bosson AD, JnBaptiste CK, Bhutkar A, Whittaker CA, Young RA, Sharp PA.

Genes Dev. 2013 Apr 15;27(8):941-54. doi: 10.1101/gad.215376.113.

9.

Master transcription factors and mediator establish super-enhancers at key cell identity genes.

Whyte WA, Orlando DA, Hnisz D, Abraham BJ, Lin CY, Kagey MH, Rahl PB, Lee TI, Young RA.

Cell. 2013 Apr 11;153(2):307-19. doi: 10.1016/j.cell.2013.03.035.

10.

Revisiting global gene expression analysis.

Lovén J, Orlando DA, Sigova AA, Lin CY, Rahl PB, Burge CB, Levens DL, Lee TI, Young RA.

Cell. 2012 Oct 26;151(3):476-82. doi: 10.1016/j.cell.2012.10.012. Review.

11.

Transcriptional amplification in tumor cells with elevated c-Myc.

Lin CY, Lovén J, Rahl PB, Paranal RM, Burge CB, Bradner JE, Lee TI, Young RA.

Cell. 2012 Sep 28;151(1):56-67. doi: 10.1016/j.cell.2012.08.026.

12.

Functional association of Gdown1 with RNA polymerase II poised on human genes.

Cheng B, Li T, Rahl PB, Adamson TE, Loudas NB, Guo J, Varzavand K, Cooper JJ, Hu X, Gnatt A, Young RA, Price DH.

Mol Cell. 2012 Jan 13;45(1):38-50. doi: 10.1016/j.molcel.2011.10.022.

13.

Aire unleashes stalled RNA polymerase to induce ectopic gene expression in thymic epithelial cells.

Giraud M, Yoshida H, Abramson J, Rahl PB, Young RA, Mathis D, Benoist C.

Proc Natl Acad Sci U S A. 2012 Jan 10;109(2):535-40. doi: 10.1073/pnas.1119351109. Epub 2011 Dec 27.

14.

BET bromodomain inhibition as a therapeutic strategy to target c-Myc.

Delmore JE, Issa GC, Lemieux ME, Rahl PB, Shi J, Jacobs HM, Kastritis E, Gilpatrick T, Paranal RM, Qi J, Chesi M, Schinzel AC, McKeown MR, Heffernan TP, Vakoc CR, Bergsagel PL, Ghobrial IM, Richardson PG, Young RA, Hahn WC, Anderson KC, Kung AL, Bradner JE, Mitsiades CS.

Cell. 2011 Sep 16;146(6):904-17. doi: 10.1016/j.cell.2011.08.017. Epub 2011 Sep 1.

15.

DHODH modulates transcriptional elongation in the neural crest and melanoma.

White RM, Cech J, Ratanasirintrawoot S, Lin CY, Rahl PB, Burke CJ, Langdon E, Tomlinson ML, Mosher J, Kaufman C, Chen F, Long HK, Kramer M, Datta S, Neuberg D, Granter S, Young RA, Morrison S, Wheeler GN, Zon LI.

Nature. 2011 Mar 24;471(7339):518-22. doi: 10.1038/nature09882.

16.

Mediator and cohesin connect gene expression and chromatin architecture.

Kagey MH, Newman JJ, Bilodeau S, Zhan Y, Orlando DA, van Berkum NL, Ebmeier CC, Goossens J, Rahl PB, Levine SS, Taatjes DJ, Dekker J, Young RA.

Nature. 2010 Sep 23;467(7314):430-5. doi: 10.1038/nature09380. Epub 2010 Aug 18. Erratum in: Nature. 2011 Apr 14;472(7342):247.

17.

c-Myc regulates transcriptional pause release.

Rahl PB, Lin CY, Seila AC, Flynn RA, McCuine S, Burge CB, Sharp PA, Young RA.

Cell. 2010 Apr 30;141(3):432-45. doi: 10.1016/j.cell.2010.03.030.

18.

SetDB1 contributes to repression of genes encoding developmental regulators and maintenance of ES cell state.

Bilodeau S, Kagey MH, Frampton GM, Rahl PB, Young RA.

Genes Dev. 2009 Nov 1;23(21):2484-9. doi: 10.1101/gad.1837309.

19.

Divergent transcription from active promoters.

Seila AC, Calabrese JM, Levine SS, Yeo GW, Rahl PB, Flynn RA, Young RA, Sharp PA.

Science. 2008 Dec 19;322(5909):1849-51. doi: 10.1126/science.1162253. Epub 2008 Dec 4.

20.

Analysis of the Elp complex and its role in regulating exocytosis.

Rahl PB, Collins RN.

Methods Enzymol. 2008;439:315-25. doi: 10.1016/S0076-6879(07)00423-5.

PMID:
18374174
21.

Mutational analysis of betaCOP (Sec26p) identifies an appendage domain critical for function.

DeRegis CJ, Rahl PB, Hoffman GR, Cerione RA, Collins RN.

BMC Cell Biol. 2008 Jan 22;9:3. doi: 10.1186/1471-2121-9-3.

22.

Bioinformatic and comparative localization of Rab proteins reveals functional insights into the uncharacterized GTPases Ypt10p and Ypt11p.

Buvelot Frei S, Rahl PB, Nussbaum M, Briggs BJ, Calero M, Janeczko S, Regan AD, Chen CZ, Barral Y, Whittaker GR, Collins RN.

Mol Cell Biol. 2006 Oct;26(19):7299-317.

24.

Conserved structural motifs in intracellular trafficking pathways: structure of the gammaCOP appendage domain.

Hoffman GR, Rahl PB, Collins RN, Cerione RA.

Mol Cell. 2003 Sep;12(3):615-25.

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