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Early postoperative pancreatitis following pancreaticoduodenectomy: what is clinically relevant postoperative pancreatitis?

Birgin E, Reeg A, Téoule P, Rahbari NN, Post S, Reissfelder C, Rückert F.

HPB (Oxford). 2018 Dec 24. pii: S1365-182X(18)34555-6. doi: 10.1016/j.hpb.2018.11.006. [Epub ahead of print]


Use of Activity Tracking in Major Visceral Surgery-the Enhanced Perioperative Mobilization Trial: a Randomized Controlled Trial.

Wolk S, Linke S, Bogner A, Sturm D, Meißner T, Müssle B, Rahbari NN, Distler M, Weitz J, Welsch T.

J Gastrointest Surg. 2018 Oct 8. doi: 10.1007/s11605-018-3998-0. [Epub ahead of print]


Correction to: FDG-PET/MRI in patients with pelvic recurrence of rectal cancer: first clinical experiences.

Plodeck V, Rahbari NN, Weitz J, Radosa CG, Laniado M, Hoffmann RT, Zöphel K, Beuthien-Baumann B, Kotzerke J, van den Hoff J, Platzek I.

Eur Radiol. 2019 Feb;29(2):1064. doi: 10.1007/s00330-018-5677-7.


Randomized clinical trial of stapler hepatectomy versus LigaSure™ transection in elective hepatic resection.

Fritzmann J, Kirchberg J, Sturm D, Ulrich AB, Knebel P, Mehrabi A, Büchler MW, Weitz J, Reissfelder C, Rahbari NN.

Br J Surg. 2018 Aug;105(9):1119-1127. doi: 10.1002/bjs.10902.


FDG-PET/MRI in patients with pelvic recurrence of rectal cancer: first clinical experiences.

Plodeck V, Rahbari NN, Weitz J, Radosa CG, Laniado M, Hoffmann RT, Zöphel K, Beuthien-Baumann B, Kotzerke J, van den Hoff J, Platzek I.

Eur Radiol. 2019 Jan;29(1):422-428. doi: 10.1007/s00330-018-5589-6. Epub 2018 Jul 6. Erratum in: Eur Radiol. 2018 Aug 6;:.


Validation of prognostic risk scores for patients undergoing resection for pancreatic cancer.

Adamu M, Nitschke P, Petrov P, Rentsch A, Distler M, Reissfelder C, Welsch T, Saeger HD, Weitz J, Rahbari NN.

Pancreatology. 2018 May 21. pii: S1424-3903(18)30110-8. doi: 10.1016/j.pan.2018.05.005. [Epub ahead of print]


Pancreatoduodenectomy with or without prophylactic falciform ligament wrap around the gastroduodenal artery stump for prevention of pancreatectomy hemorrhage.

Müssle B, Zühlke L, Wierick A, Sturm D, Grählert X, Distler M, Rahbari NN, Weitz J, Welsch T.

Trials. 2018 Apr 12;19(1):222. doi: 10.1186/s13063-018-2580-0.


Obesity promotes resistance to anti-VEGF therapy in breast cancer by up-regulating IL-6 and potentially FGF-2.

Incio J, Ligibel JA, McManus DT, Suboj P, Jung K, Kawaguchi K, Pinter M, Babykutty S, Chin SM, Vardam TD, Huang Y, Rahbari NN, Roberge S, Wang D, Gomes-Santos IL, Puchner SB, Schlett CL, Hoffmman U, Ancukiewicz M, Tolaney SM, Krop IE, Duda DG, Boucher Y, Fukumura D, Jain RK.

Sci Transl Med. 2018 Mar 14;10(432). pii: eaag0945. doi: 10.1126/scitranslmed.aag0945.


Comparison of three classifications for lymph node evaluation in patients undergoing total mesorectal excision for rectal cancer.

Fritzmann J, Contin P, Reissfelder C, Büchler MW, Weitz J, Rahbari NN, Ulrich AB.

Langenbecks Arch Surg. 2018 Jun;403(4):451-462. doi: 10.1007/s00423-018-1662-5. Epub 2018 Mar 9.


Management of clinically relevant postpancreatectomy hemorrhage (PPH) over two decades - A comparative study of 1 450 consecutive patients undergoing pancreatic resection.

Wolk S, Grützmann R, Rahbari NN, Hoffmann RT, Plodeck V, Weitz J, Welsch T, Distler M.

Pancreatology. 2017 Nov - Dec;17(6):943-950. doi: 10.1016/j.pan.2017.10.006. Epub 2017 Oct 25.


Postoperative course and prognostic value of circulating angiogenic cytokines after pancreatic cancer resection.

Yang C, Bork U, Schölch S, Kulu Y, Kaderali L, Bolstorff UL, Kahlert C, Weitz J, Rahbari NN, Reissfelder C.

Oncotarget. 2017 Aug 17;8(42):72315-72323. doi: 10.18632/oncotarget.20315. eCollection 2017 Sep 22.


Time of Metastasis and Outcome in Colorectal Cancer.

Rahbari NN, Carr PR, Jansen L, Chang-Claude J, Weitz J, Hoffmeister M, Brenner H.

Ann Surg. 2017 Oct 23. doi: 10.1097/SLA.0000000000002564. [Epub ahead of print]


Targeting CXCR4-dependent immunosuppressive Ly6Clow monocytes improves antiangiogenic therapy in colorectal cancer.

Jung K, Heishi T, Incio J, Huang Y, Beech EY, Pinter M, Ho WW, Kawaguchi K, Rahbari NN, Chung E, Kim JK, Clark JW, Willett CG, Yun SH, Luster AD, Padera TP, Jain RK, Fukumura D.

Proc Natl Acad Sci U S A. 2017 Sep 26;114(39):10455-10460. doi: 10.1073/pnas.1710754114. Epub 2017 Sep 12.


Surgical salvage of recurrence after resection of colorectal liver metastases: incidence and outcomes.

Rahbari NN, D'Angelica MI.

Hepat Oncol. 2017 Aug 3. doi: 10.2217/hep-2017-0002. [Epub ahead of print]


Ly6Clo monocytes drive immunosuppression and confer resistance to anti-VEGFR2 cancer therapy.

Jung K, Heishi T, Khan OF, Kowalski PS, Incio J, Rahbari NN, Chung E, Clark JW, Willett CG, Luster AD, Yun SH, Langer R, Anderson DG, Padera TP, Jain RK, Fukumura D.

J Clin Invest. 2017 Aug 1;127(8):3039-3051. doi: 10.1172/JCI93182. Epub 2017 Jul 10.


Prognostic value of circulating endothelial cells in metastatic colorectal cancer.

Rahbari NN, Schölch S, Bork U, Kahlert C, Schneider M, Rahbari M, Büchler MW, Weitz J, Reissfelder C.

Oncotarget. 2017 Jun 6;8(23):37491-37501. doi: 10.18632/oncotarget.16397.


Inhibition of Six1 affects tumour invasion and the expression of cancer stem cell markers in pancreatic cancer.

Lerbs T, Bisht S, Schölch S, Pecqueux M, Kristiansen G, Schneider M, Hofmann BT, Welsch T, Reissfelder C, Rahbari NN, Fritzmann J, Brossart P, Weitz J, Feldmann G, Kahlert C.

BMC Cancer. 2017 Apr 7;17(1):249. doi: 10.1186/s12885-017-3225-5.


Use of activity tracking in major visceral surgery-the Enhanced Perioperative Mobilization (EPM) trial: study protocol for a randomized controlled trial.

Wolk S, Meißner T, Linke S, Müssle B, Wierick A, Bogner A, Sturm D, Rahbari NN, Distler M, Weitz J, Welsch T.

Trials. 2017 Feb 21;18(1):77. doi: 10.1186/s13063-017-1782-1.


Reply: What Is the Impact of Intraoperative Re-resection After a Positive Pancreatic Margin Frozen Section in the Era of Perioperative Therapies?

Nitschke P, Weitz J, Rahbari NN.

Ann Surg. 2018 Mar;267(3):e56. doi: 10.1097/SLA.0000000000002130. No abstract available.


Perioperative application of somatostatin analogs for pancreatic surgery-current status in Germany.

Volk A, Nitschke P, Johnscher F, Rahbari N, Welsch T, Reißfelder C, Weitz J, Distler M, Mees ST.

Langenbecks Arch Surg. 2016 Nov;401(7):1037-1044. Epub 2016 Sep 15.


A Comprehensive MicroRNA Expression Profile of Liver and Lung Metastases of Colorectal Cancer with Their Corresponding Host Tissue and Its Prognostic Impact on Survival.

Pecqueux M, Liebetrau I, Werft W, Dienemann H, Muley T, Pfannschmidt J, Müssle B, Rahbari N, Schölch S, Büchler MW, Weitz J, Reissfelder C, Kahlert C.

Int J Mol Sci. 2016 Oct 21;17(10). pii: E1755.


Anti-VEGF therapy induces ECM remodeling and mechanical barriers to therapy in colorectal cancer liver metastases.

Rahbari NN, Kedrin D, Incio J, Liu H, Ho WW, Nia HT, Edrich CM, Jung K, Daubriac J, Chen I, Heishi T, Martin JD, Huang Y, Maimon N, Reissfelder C, Weitz J, Boucher Y, Clark JW, Grodzinsky AJ, Duda DG, Jain RK, Fukumura D.

Sci Transl Med. 2016 Oct 12;8(360):360ra135.


LDB1 overexpression is a negative prognostic factor in colorectal cancer.

García SA, Swiersy A, Radhakrishnan P, Branchi V, Kanth Nanduri L, Győrffy B, Betzler AM, Bork U, Kahlert C, Reißfelder C, Rahbari NN, Weitz J, Schölch S.

Oncotarget. 2016 Dec 20;7(51):84258-84270. doi: 10.18632/oncotarget.12481.


Exosomes: novel implications in diagnosis and treatment of gastrointestinal cancer.

Rahbari M, Rahbari N, Reissfelder C, Weitz J, Kahlert C.

Langenbecks Arch Surg. 2016 Dec;401(8):1097-1110. Epub 2016 Jun 24. Review.


Impact of Intraoperative Re-resection to Achieve R0 Status on Survival in Patients With Pancreatic Cancer: A Single-center Experience With 483 Patients.

Nitschke P, Volk A, Welsch T, Hackl J, Reissfelder C, Rahbari M, Distler M, Saeger HD, Weitz J, Rahbari NN.

Ann Surg. 2017 Jun;265(6):1219-1225. doi: 10.1097/SLA.0000000000001808.


Obesity-Induced Inflammation and Desmoplasia Promote Pancreatic Cancer Progression and Resistance to Chemotherapy.

Incio J, Liu H, Suboj P, Chin SM, Chen IX, Pinter M, Ng MR, Nia HT, Grahovac J, Kao S, Babykutty S, Huang Y, Jung K, Rahbari NN, Han X, Chauhan VP, Martin JD, Kahn J, Huang P, Desphande V, Michaelson J, Michelakos TP, Ferrone CR, Soares R, Boucher Y, Fukumura D, Jain RK.

Cancer Discov. 2016 Aug;6(8):852-69. doi: 10.1158/2159-8290.CD-15-1177. Epub 2016 May 31.


The relationship between mindfulness, pain intensity, pain catastrophizing, depression, and quality of life among cancer survivors living with chronic neuropathic pain.

Poulin PA, Romanow HC, Rahbari N, Small R, Smyth CE, Hatchard T, Solomon BK, Song X, Harris CA, Kowal J, Nathan HJ, Wilson KG.

Support Care Cancer. 2016 Oct;24(10):4167-75. doi: 10.1007/s00520-016-3243-x. Epub 2016 May 18.


Circulating tumor cells exhibit stem cell characteristics in an orthotopic mouse model of colorectal cancer.

Schölch S, García SA, Iwata N, Niemietz T, Betzler AM, Nanduri LK, Bork U, Kahlert C, Thepkaysone ML, Swiersy A, Büchler MW, Reissfelder C, Weitz J, Rahbari NN.

Oncotarget. 2016 May 10;7(19):27232-42. doi: 10.18632/oncotarget.8373.


Impact of Bevacizumab on parenchymal damage and functional recovery of the liver in patients with colorectal liver metastases.

Volk AM, Fritzmann J, Reissfelder C, Weber GF, Weitz J, Rahbari NN.

BMC Cancer. 2016 Feb 10;16:84. doi: 10.1186/s12885-016-2095-6.


PlGF/VEGFR-1 Signaling Promotes Macrophage Polarization and Accelerated Tumor Progression in Obesity.

Incio J, Tam J, Rahbari NN, Suboj P, McManus DT, Chin SM, Vardam TD, Batista A, Babykutty S, Jung K, Khachatryan A, Hato T, Ligibel JA, Krop IE, Puchner SB, Schlett CL, Hoffmman U, Ancukiewicz M, Shibuya M, Carmeliet P, Soares R, Duda DG, Jain RK, Fukumura D.

Clin Cancer Res. 2016 Jun 15;22(12):2993-3004. doi: 10.1158/1078-0432.CCR-15-1839. Epub 2016 Feb 9.


Solid stress and elastic energy as measures of tumour mechanopathology.

Nia HT, Liu H, Seano G, Datta M, Jones D, Rahbari N, Incio J, Chauhan VP, Jung K, Martin JD, Askoxylakis V, Padera TP, Fukumura D, Boucher Y, Hornicek FJ, Grodzinsky AJ, Baish JW, Munn LL, Jain RK.

Nat Biomed Eng. 2016;1. pii: 0004. doi: 10.1038/s41551-016-0004. Epub 2016 Nov 28.


Metastatic Spread Emerging From Liver Metastases of Colorectal Cancer: Does the Seed Leave the Soil Again?

Rahbari NN, Bork U, Schölch S, Reissfelder C, Thorlund K, Betzler A, Kahlert C, Schneider M, Ulrich AB, Büchler MW, Weitz J, Koch M.

Ann Surg. 2016 Feb;263(2):345-52. doi: 10.1097/SLA.0000000000001341.


Free intraperitoneal tumor cells and outcome in gastric cancer patients: a systematic review and meta-analysis.

Pecqueux M, Fritzmann J, Adamu M, Thorlund K, Kahlert C, Reißfelder C, Weitz J, Rahbari NN.

Oncotarget. 2015 Nov 3;6(34):35564-78. doi: 10.18632/oncotarget.5595. Review.


Glypican-1 identifies cancer exosomes and detects early pancreatic cancer.

Melo SA, Luecke LB, Kahlert C, Fernandez AF, Gammon ST, Kaye J, LeBleu VS, Mittendorf EA, Weitz J, Rahbari N, Reissfelder C, Pilarsky C, Fraga MF, Piwnica-Worms D, Kalluri R.

Nature. 2015 Jul 9;523(7559):177-82. doi: 10.1038/nature14581. Epub 2015 Jun 24.


Staged resection of bilobar colorectal liver metastases: surgical strategies.

Yang C, Rahbari NN, Mees ST, Schaab F, Koch M, Weitz J, Reissfelder C.

Langenbecks Arch Surg. 2015 Aug;400(6):633-40. doi: 10.1007/s00423-015-1310-2. Epub 2015 Jun 8. Review.


Overexpression of SIX1 is an independent prognostic marker in stage I-III colorectal cancer.

Kahlert C, Lerbs T, Pecqueux M, Herpel E, Hoffmeister M, Jansen L, Brenner H, Chang-Claude J, Bläker H, Kloor M, Roth W, Pilarsky C, Rahbari NN, Schölch S, Bork U, Reissfelder C, Weitz J, Aust D, Koch M.

Int J Cancer. 2015 Nov 1;137(9):2104-13. doi: 10.1002/ijc.29596. Epub 2015 May 21.


Circulating tumour cells and outcome in non-metastatic colorectal cancer: a prospective study.

Bork U, Rahbari NN, Schölch S, Reissfelder C, Kahlert C, Büchler MW, Weitz J, Koch M.

Br J Cancer. 2015 Apr 14;112(8):1306-13. doi: 10.1038/bjc.2015.88. Epub 2015 Mar 31.


Interleukin-3 amplifies acute inflammation and is a potential therapeutic target in sepsis.

Weber GF, Chousterman BG, He S, Fenn AM, Nairz M, Anzai A, Brenner T, Uhle F, Iwamoto Y, Robbins CS, Noiret L, Maier SL, Zönnchen T, Rahbari NN, Schölch S, Klotzsche-von Ameln A, Chavakis T, Weitz J, Hofer S, Weigand MA, Nahrendorf M, Weissleder R, Swirski FK.

Science. 2015 Mar 13;347(6227):1260-5. doi: 10.1126/science.aaa4268.


Corrigendum. Tumor-specific cytotoxic T lymphocyte activity determines colorectal cancer patient prognosis.

Reissfelder C, Stamova S, Gossmann C, Braun M, Bonertz A, Walliczek U, Grimm M, Rahbari NN, Koch M, Saadati M, Benner A, Büchler MW, Jäger D, Halama N, Khazaie K, Weitz J, Beckhove P.

J Clin Invest. 2015 Mar 2;125(3):1364. doi: 10.1172/JCI81442. Epub 2015 Mar 2. No abstract available.


Radiotherapy combined with TLR7/8 activation induces strong immune responses against gastrointestinal tumors.

Schölch S, Rauber C, Tietz A, Rahbari NN, Bork U, Schmidt T, Kahlert C, Haberkorn U, Tomai MA, Lipson KE, Carretero R, Weitz J, Koch M, Huber PE.

Oncotarget. 2015 Mar 10;6(7):4663-76.


Influence of age on resection of colorectal liver metastases.

Schmidt T, Strowitzki MJ, Reissfelder C, Rahbari NN, Nienhueser H, Bruckner T, Rahäuser C, Keppler U, Schneider M, Büchler MW, Ulrich A.

J Surg Oncol. 2015 May;111(6):729-39. doi: 10.1002/jso.23872. Epub 2015 Jan 16.


Tumor-specific cytotoxic T lymphocyte activity determines colorectal cancer patient prognosis.

Reissfelder C, Stamova S, Gossmann C, Braun M, Bonertz A, Walliczek U, Grimm M, Rahbari NN, Koch M, Saadati M, Benner A, Büchler MW, Jäger D, Halama N, Khazaie K, Weitz J, Beckhove P.

J Clin Invest. 2015 Feb;125(2):739-51. doi: 10.1172/JCI74894. Epub 2014 Dec 22. Erratum in: J Clin Invest. 2015 Mar 2;125(3):1364.


[Lichtenstein's hernia repair].

Volk A, Rahbari NN, Koch M, Weitz J.

Zentralbl Chir. 2014 Dec;139(6):581-2. doi: 10.1055/s-0034-1383346. Epub 2014 Dec 22. German.


Prognostic impact of a compartment-specific angiogenic marker profile in patients with pancreatic cancer.

Kahlert C, Fiala M, Musso G, Halama N, Keim S, Mazzone M, Lasitschka F, Pecqueux M, Klupp F, Schmidt T, Rahbari N, Schölch S, Pilarsky C, Ulrich A, Schneider M, Weitz J, Koch M.

Oncotarget. 2014 Dec 30;5(24):12978-89.


Prognostic relevance of minimal residual disease in colorectal cancer.

Bork U, Grützmann R, Rahbari NN, Schölch S, Distler M, Reissfelder C, Koch M, Weitz J.

World J Gastroenterol. 2014 Aug 14;20(30):10296-304. doi: 10.3748/wjg.v20.i30.10296. Review.


A systematic review of localization, surgical treatment options, and outcome of insulinoma.

Mehrabi A, Fischer L, Hafezi M, Dirlewanger A, Grenacher L, Diener MK, Fonouni H, Golriz M, Garoussi C, Fard N, Rahbari NN, Werner J, Büchler MW.

Pancreas. 2014 Jul;43(5):675-86. doi: 10.1097/MPA.0000000000000110. Review.


Comparison of various surgical approaches for extensive bilateral colorectal liver metastases.

Reissfelder C, Rahbari NN, Bejarano LU, Schmidt T, Kortes N, Kauczor HU, Büchler MW, Weitz J, Koch M.

Langenbecks Arch Surg. 2014 Apr;399(4):481-91. doi: 10.1007/s00423-014-1177-7. Epub 2014 Mar 11.


Adjuvant therapy after resection of colorectal liver metastases: the predictive value of the MSKCC clinical risk score in the era of modern chemotherapy.

Rahbari NN, Reissfelder C, Schulze-Bergkamen H, Jäger D, Büchler MW, Weitz J, Koch M.

BMC Cancer. 2014 Mar 11;14:174. doi: 10.1186/1471-2407-14-174.


Immune escape and survival mechanisms in circulating tumor cells of colorectal cancer.

Steinert G, Schölch S, Niemietz T, Iwata N, García SA, Behrens B, Voigt A, Kloor M, Benner A, Bork U, Rahbari NN, Büchler MW, Stoecklein NH, Weitz J, Koch M.

Cancer Res. 2014 Mar 15;74(6):1694-704. doi: 10.1158/0008-5472.CAN-13-1885. Epub 2014 Mar 5.


Randomized clinical trial of stapler versus clamp-crushing transection in elective liver resection.

Rahbari NN, Elbers H, Koch M, Vogler P, Striebel F, Bruckner T, Mehrabi A, Schemmer P, Büchler MW, Weitz J.

Br J Surg. 2014 Feb;101(3):200-7. doi: 10.1002/bjs.9387. Epub 2014 Jan 8.


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