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Items: 19


Mutations in the NPxxY motif stabilize pharmacologically distinct conformational states of the α1B- and β2-adrenoceptors.

Ragnarsson L, Andersson Å, Thomas WG, Lewis RJ.

Sci Signal. 2019 Mar 12;12(572). pii: eaas9485. doi: 10.1126/scisignal.aas9485.


Synthesis of Pseudellone Analogs and Characterization as Novel T-type Calcium Channel Blockers.

Wang D, Neupane P, Ragnarsson L, Capon RJ, Lewis RJ.

Mar Drugs. 2018 Nov 28;16(12). pii: E475. doi: 10.3390/md16120475.


Insight into T-type calcium channel structure, function and modulation.

Wang D, Ragnarsson L, Lewis RJ.

Curr Med Chem. 2018 Oct 1. doi: 10.2174/0929867325666181001112821. [Epub ahead of print]


Novel analgesic ω-conotoxins from the vermivorous cone snail Conus moncuri provide new insights into the evolution of conopeptides.

Sousa SR, McArthur JR, Brust A, Bhola RF, Rosengren KJ, Ragnarsson L, Dutertre S, Alewood PF, Christie MJ, Adams DJ, Vetter I, Lewis RJ.

Sci Rep. 2018 Sep 7;8(1):13397. doi: 10.1038/s41598-018-31245-4.


Subtle modifications to oxytocin produce ligands that retain potency and improved selectivity across species.

Muttenthaler M, Andersson Å, Vetter I, Menon R, Busnelli M, Ragnarsson L, Bergmayr C, Arrowsmith S, Deuis JR, Chiu HS, Palpant NJ, O'Brien M, Smith TJ, Wray S, Neumann ID, Gruber CW, Lewis RJ, Alewood PF.

Sci Signal. 2017 Dec 5;10(508). pii: eaan3398. doi: 10.1126/scisignal.aan3398.


Discovery and mode of action of a novel analgesic β-toxin from the African spider Ceratogyrus darlingi.

Sousa SR, Wingerd JS, Brust A, Bladen C, Ragnarsson L, Herzig V, Deuis JR, Dutertre S, Vetter I, Zamponi GW, King GF, Alewood PF, Lewis RJ.

PLoS One. 2017 Sep 7;12(9):e0182848. doi: 10.1371/journal.pone.0182848. eCollection 2017.


Structural mechanisms for α-conotoxin activity at the human α3β4 nicotinic acetylcholine receptor.

Abraham N, Healy M, Ragnarsson L, Brust A, Alewood PF, Lewis RJ.

Sci Rep. 2017 Mar 31;7:45466. doi: 10.1038/srep45466.


Escherichia coli Protein Expression System for Acetylcholine Binding Proteins (AChBPs).

Abraham N, Paul B, Ragnarsson L, Lewis RJ.

PLoS One. 2016 Jun 15;11(6):e0157363. doi: 10.1371/journal.pone.0157363. eCollection 2016.


Conopeptide-Derived κ-Opioid Agonists (Conorphins): Potent, Selective, and Metabolic Stable Dynorphin A Mimetics with Antinociceptive Properties.

Brust A, Croker DE, Colless B, Ragnarsson L, Andersson Å, Jain K, Garcia-Caraballo S, Castro J, Brierley SM, Alewood PF, Lewis RJ.

J Med Chem. 2016 Mar 24;59(6):2381-95. doi: 10.1021/acs.jmedchem.5b00911. Epub 2016 Feb 22.


Extracellular surface residues of the α1B-adrenoceptor critical for G protein-coupled receptor function.

Ragnarsson L, Andersson Å, Thomas WG, Lewis RJ.

Mol Pharmacol. 2015 Jan;87(1):121-9. doi: 10.1124/mol.114.094557. Epub 2014 Oct 28.


Sidewall crystalline orientation effect of post-treatments for a replacement metal gate bulk fin field effect transistor.

Lee JW, Simoen E, Veloso A, Cho MJ, Boccardi G, Ragnarsson LÅ, Chiarella T, Horiguchi N, Groeseneken G, Thean A.

ACS Appl Mater Interfaces. 2013 Sep 25;5(18):8865-8. doi: 10.1021/am403270m. Epub 2013 Sep 11.


Expression and pharmacology of endogenous Cav channels in SH-SY5Y human neuroblastoma cells.

Sousa SR, Vetter I, Ragnarsson L, Lewis RJ.

PLoS One. 2013;8(3):e59293. doi: 10.1371/journal.pone.0059293. Epub 2013 Mar 25.


Conopeptide ρ-TIA defines a new allosteric site on the extracellular surface of the α1B-adrenoceptor.

Ragnarsson L, Wang CI, Andersson Å, Fajarningsih D, Monks T, Brust A, Rosengren KJ, Lewis RJ.

J Biol Chem. 2013 Jan 18;288(3):1814-27. doi: 10.1074/jbc.M112.430785. Epub 2012 Nov 26.


Glycerotoxin stimulates neurotransmitter release from N-type Ca2+ channel expressing neurons.

Schenning M, Proctor DT, Ragnarsson L, Barbier J, Lavidis NA, Molgó JJ, Zamponi GW, Schiavo G, Meunier FA.

J Neurochem. 2006 Aug;98(3):894-904. Epub 2006 Jun 2.


NMDA receptor subunit-dependent modulation by conantokin-G and Ala7-conantokin-G.

Ragnarsson L, Yasuda T, Lewis RJ, Dodd PR, Adams DJ.

J Neurochem. 2006 Jan;96(1):283-91. Epub 2005 Nov 29.


Multiple myeloma cells are killed by syndecan-1-directed superantigen-activated T cells.

Ragnarsson L, Strömberg T, Wijdenes J, Tötterman TH, Weigelt C.

Cancer Immunol Immunother. 2001 Sep;50(7):382-90.


Targeted superantigens for immunotherapy of haematopoietic tumours.

Tötterman TH, Gidlöf C, Ragnarsson L, Högbom E, Lindeberg M, von der Lehr N, Einarsson A, Soegaard M, Kristensson K, Kalland T, Dohlsten M.

Vox Sang. 1998;74 Suppl 2:483-7. Review.


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