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Evidence that a positive feedback loop drives centrosome maturation in fly embryos.

Alvarez-Rodrigo I, Steinacker TL, Saurya S, Conduit PT, Baumbach J, Novak ZA, Aydogan MG, Wainman A, Raff JW.

Elife. 2019 Sep 9;8. pii: e50130. doi: 10.7554/eLife.50130.


Phase Separation and the Centrosome: A Fait Accompli?

Raff JW.

Trends Cell Biol. 2019 Aug;29(8):612-622. doi: 10.1016/j.tcb.2019.04.001. Epub 2019 May 7. Review.


Lessons learned: eight years at the helm of Biology Open.

Raff JW.

Biol Open. 2018 Aug 28;7(8). pii: bio037317. doi: 10.1242/bio.037317. No abstract available.


A homeostatic clock sets daughter centriole size in flies.

Aydogan MG, Wainman A, Saurya S, Steinacker TL, Caballe A, Novak ZA, Baumbach J, Muschalik N, Raff JW.

J Cell Biol. 2018 Apr 2;217(4):1233-1248. doi: 10.1083/jcb.201801014. Epub 2018 Mar 2.


Drosophila PLP assembles pericentriolar clouds that promote centriole stability, cohesion and MT nucleation.

Roque H, Saurya S, Pratt MB, Johnson E, Raff JW.

PLoS Genet. 2018 Feb 9;14(2):e1007198. doi: 10.1371/journal.pgen.1007198. eCollection 2018 Feb.


Patricia Keely (1963-2017).

Raff JW.

Biol Open. 2017 Oct 15;6(10):1403. doi: 10.1242/bio.030098. No abstract available.


A combined 3D-SIM/SMLM approach allows centriole proteins to be localized with a precision of ∼4-5 nm.

Gartenmann L, Wainman A, Qurashi M, Kaufmann R, Schubert S, Raff JW, Dobbie IM.

Curr Biol. 2017 Oct 9;27(19):R1054-R1055. doi: 10.1016/j.cub.2017.08.009.


Happy 5th Birthday Biology Open.

Raff JW, Hackett R.

Biol Open. 2017 Jul 15;6(7):929-930. doi: 10.1242/bio.027508. No abstract available.


Structural Basis for Mitotic Centrosome Assembly in Flies.

Feng Z, Caballe A, Wainman A, Johnson S, Haensele AFM, Cottee MA, Conduit PT, Lea SM, Raff JW.

Cell. 2017 Jun 1;169(6):1078-1089.e13. doi: 10.1016/j.cell.2017.05.030.


A key centriole assembly interaction interface between human PLK4 and STIL appears to not be conserved in flies.

Cottee MA, Johnson S, Raff JW, Lea SM.

Biol Open. 2017 Mar 15;6(3):381-389. doi: 10.1242/bio.024661.


Centrosome Amplification and Cancer: A Question of Sufficiency.

Raff JW, Basto R.

Dev Cell. 2017 Feb 6;40(3):217-218. doi: 10.1016/j.devcel.2017.01.009.


Drosophila sensory cilia lacking MKS proteins exhibit striking defects in development but only subtle defects in adults.

Pratt MB, Titlow JS, Davis I, Barker AR, Dawe HR, Raff JW, Roque H.

J Cell Sci. 2016 Oct 15;129(20):3732-3743. Epub 2016 Aug 30.


Cdk1 Phosphorylates Drosophila Sas-4 to Recruit Polo to Daughter Centrioles and Convert Them to Centrosomes.

Novak ZA, Wainman A, Gartenmann L, Raff JW.

Dev Cell. 2016 Jun 20;37(6):545-57. doi: 10.1016/j.devcel.2016.05.022.


Drosophila Ana1 is required for centrosome assembly and centriole elongation.

Saurya S, Roque H, Novak ZA, Wainman A, Aydogan MG, Volanakis A, Sieber B, Pinto DM, Raff JW.

J Cell Sci. 2016 Jul 1;129(13):2514-25. doi: 10.1242/jcs.186460. Epub 2016 May 20.


Thanking our peer reviewers.

Hackett R, Raff JW.

Biol Open. 2016 Feb 15;5(2):91. doi: 10.1242/bio.017053. No abstract available.


Expression of Concern: Fructose sensitizes pancreatic beta cells to TNFα-induced necroptosis by Nataly Shulga and John G. Pastorino. Biol Open doi: 10.1242/bio.014712.

Hackett R, Raff JW.

Biol Open. 2016 Jan 21. pii: bio.017046. doi: 10.1242/bio.017046. [Epub ahead of print] No abstract available.


Biology Open: evaluating impact.

Hackett R, Moulton OC, Raff JW.

Biol Open. 2015 Dec 16;4(12):1609-13. doi: 10.1242/bio.016147. No abstract available.


Re-examining the role of Drosophila Sas-4 in centrosome assembly using two-colour-3D-SIM FRAP.

Conduit PT, Wainman A, Novak ZA, Weil TT, Raff JW.

Elife. 2015 Nov 4;4. pii: e08483. doi: 10.7554/eLife.08483.


Centrosome function and assembly in animal cells.

Conduit PT, Wainman A, Raff JW.

Nat Rev Mol Cell Biol. 2015 Oct;16(10):611-24. doi: 10.1038/nrm4062. Epub 2015 Sep 16. Review.


Different Drosophila cell types exhibit differences in mitotic centrosome assembly dynamics.

Conduit PT, Raff JW.

Curr Biol. 2015 Aug 3;25(15):R650-1. doi: 10.1016/j.cub.2015.05.061. No abstract available.


The Drosophila Pericentrin-like-protein (PLP) cooperates with Cnn to maintain the integrity of the outer PCM.

Richens JH, Barros TP, Lucas EP, Peel N, Pinto DM, Wainman A, Raff JW.

Biol Open. 2015 Jul 8;4(8):1052-61. doi: 10.1242/bio.012914.


Dissecting the function and assembly of acentriolar microtubule organizing centers in Drosophila cells in vivo.

Baumbach J, Novak ZA, Raff JW, Wainman A.

PLoS Genet. 2015 May 28;11(5):e1005261. doi: 10.1371/journal.pgen.1005261. eCollection 2015 May.


The homo-oligomerisation of both Sas-6 and Ana2 is required for efficient centriole assembly in flies.

Cottee MA, Muschalik N, Johnson S, Leveson J, Raff JW, Lea SM.

Elife. 2015 May 23;4:e07236. doi: 10.7554/eLife.07236.


Biology Open: The story so far….

Raff JW, Hackett R.

Biol Open. 2015 Feb 15;4(2):105-8. doi: 10.1242/bio.201511643. No abstract available.


A molecular mechanism of mitotic centrosome assembly in Drosophila.

Conduit PT, Richens JH, Wainman A, Holder J, Vicente CC, Pratt MB, Dix CI, Novak ZA, Dobbie IM, Schermelleh L, Raff JW.

Elife. 2014 Aug 22;3:e03399. doi: 10.7554/eLife.03399.


Asterless licenses daughter centrioles to duplicate for the first time in Drosophila embryos.

Novak ZA, Conduit PT, Wainman A, Raff JW.

Curr Biol. 2014 Jun 2;24(11):1276-82. doi: 10.1016/j.cub.2014.04.023. Epub 2014 May 15.


The centrosome-specific phosphorylation of Cnn by Polo/Plk1 drives Cnn scaffold assembly and centrosome maturation.

Conduit PT, Feng Z, Richens JH, Baumbach J, Wainman A, Bakshi SD, Dobbelaere J, Johnson S, Lea SM, Raff JW.

Dev Cell. 2014 Mar 31;28(6):659-69. doi: 10.1016/j.devcel.2014.02.013. Epub 2014 Mar 20.


CP110 exhibits novel regulatory activities during centriole assembly in Drosophila.

Franz A, Roque H, Saurya S, Dobbelaere J, Raff JW.

J Cell Biol. 2013 Dec 9;203(5):785-99. doi: 10.1083/jcb.201305109. Epub 2013 Dec 2.


Passing the test.

Hackett R, Moulton OC, Raff JW.

Biol Open. 2013 Oct 30;2(11):1091-2. doi: 10.1242/bio.20136940. eCollection 2013. No abstract available.


Crystal structures of the CPAP/STIL complex reveal its role in centriole assembly and human microcephaly.

Cottee MA, Muschalik N, Wong YL, Johnson CM, Johnson S, Andreeva A, Oegema K, Lea SM, Raff JW, van Breugel M.

Elife. 2013 Sep 17;2:e01071. doi: 10.7554/eLife.01071.


The san francisco declaration on research assessment.

Raff JW.

Biol Open. 2013 May 17;2(6):533-4. doi: 10.1242/bio.20135330. Print 2013 Jun 15. No abstract available.


Dgp71WD is required for the assembly of the acentrosomal Meiosis I spindle, and is not a general targeting factor for the γ-TuRC.

Reschen RF, Colombie N, Wheatley L, Dobbelaere J, St Johnston D, Ohkura H, Raff JW.

Biol Open. 2012 May 15;1(5):422-9. doi: 10.1242/bio.2012596. Epub 2012 Mar 6.


Publishing in the biomedical sciences: if it's broken, fix it!

Raff JW.

Biol Open. 2012 Nov 15;1(11):1055-7. doi: 10.1242/bio.20122477. Epub 2012 Aug 31. No abstract available.


Centrosome loss or amplification does not dramatically perturb global gene expression in Drosophila.

Baumbach J, Levesque MP, Raff JW.

Biol Open. 2012 Oct 15;1(10):983-93. doi: 10.1242/bio.20122238. Epub 2012 Aug 17.


Drosophila Cep135/Bld10 maintains proper centriole structure but is dispensable for cartwheel formation.

Roque H, Wainman A, Richens J, Kozyrska K, Franz A, Raff JW.

J Cell Sci. 2012 Dec 1;125(Pt 23):5881-6. doi: 10.1242/jcs.113506. Epub 2012 Sep 12.


SAS-6 oligomerization: the key to the centriole?

Cottee MA, Raff JW, Lea SM, Roque H.

Nat Chem Biol. 2011 Sep 19;7(10):650-3. doi: 10.1038/nchembio.660. No abstract available.


Cnn dynamics drive centrosome size asymmetry to ensure daughter centriole retention in Drosophila neuroblasts.

Conduit PT, Raff JW.

Curr Biol. 2010 Dec 21;20(24):2187-92. doi: 10.1016/j.cub.2010.11.055. Epub 2010 Dec 9.


Centrioles regulate centrosome size by controlling the rate of Cnn incorporation into the PCM.

Conduit PT, Brunk K, Dobbelaere J, Dix CI, Lucas EP, Raff JW.

Curr Biol. 2010 Dec 21;20(24):2178-86. doi: 10.1016/j.cub.2010.11.011. Epub 2010 Dec 9.


DSas-6 and Ana2 coassemble into tubules to promote centriole duplication and engagement.

Stevens NR, Roque H, Raff JW.

Dev Cell. 2010 Dec 14;19(6):913-9. doi: 10.1016/j.devcel.2010.11.010.


Drosophila Ana2 is a conserved centriole duplication factor.

Stevens NR, Dobbelaere J, Brunk K, Franz A, Raff JW.

J Cell Biol. 2010 Feb 8;188(3):313-23. doi: 10.1083/jcb.200910016. Epub 2010 Feb 1.


Ana3 is a conserved protein required for the structural integrity of centrioles and basal bodies.

Stevens NR, Dobbelaere J, Wainman A, Gergely F, Raff JW.

J Cell Biol. 2009 Nov 2;187(3):355-63. doi: 10.1083/jcb.200905031. Epub 2009 Oct 26.


Centrioles, centrosomes, and cilia in health and disease.

Nigg EA, Raff JW.

Cell. 2009 Nov 13;139(4):663-78. doi: 10.1016/j.cell.2009.10.036. Review.


Centrosome amplification can initiate tumorigenesis in flies.

Basto R, Brunk K, Vinadogrova T, Peel N, Franz A, Khodjakov A, Raff JW.

Cell. 2008 Jun 13;133(6):1032-42. doi: 10.1016/j.cell.2008.05.039.


From stem cell to embryo without centrioles.

Stevens NR, Raposo AA, Basto R, St Johnston D, Raff JW.

Curr Biol. 2007 Sep 4;17(17):1498-503. Epub 2007 Aug 23.


Overexpressing centriole-replication proteins in vivo induces centriole overduplication and de novo formation.

Peel N, Stevens NR, Basto R, Raff JW.

Curr Biol. 2007 May 15;17(10):834-43. Epub 2007 May 3.


Hsp90 is required to localise cyclin B and Msps/ch-TOG to the mitotic spindle in Drosophila and humans.

Basto R, Gergely F, Draviam VM, Ohkura H, Liley K, Raff JW.

J Cell Sci. 2007 Apr 1;120(Pt 7):1278-87.


Flies without centrioles.

Basto R, Lau J, Vinogradova T, Gardiol A, Woods CG, Khodjakov A, Raff JW.

Cell. 2006 Jun 30;125(7):1375-86.


Aurora A activates D-TACC-Msps complexes exclusively at centrosomes to stabilize centrosomal microtubules.

Barros TP, Kinoshita K, Hyman AA, Raff JW.

J Cell Biol. 2005 Sep 26;170(7):1039-46.

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