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Am J Reprod Immunol. 2013 Dec;70(6):448-53. doi: 10.1111/aji.12157. Epub 2013 Oct 10.

Cutting edge: IL-10-producing regulatory B cells in early human pregnancy.

Author information

1
Experimental Obstetrics and Gynaecology, Medical Faculty, Otto-von-Guericke-University, Magdeburg, Germany.

Abstract

PROBLEM:

The function of IL-10 producing regulatory B cells (Breg) during gestation is unknown. Here, we aimed to understand their participation in early pregnancy.

METHOD:

CD19(+) CD24(hi) CD27(+) B cell frequency, measured by flow cytometry, increased with pregnancy onset but not in the case of spontaneous abortions.

RESULTS:

B cells from non-pregnant women cultured with serum from normal pregnant women produced higher IL-10 levels than those cultured with serum from spontaneous abortion patients or autologous serum. CD19(+) -activated B cells from pregnant women strongly suppressed TNF-a production by CD4(+) T cells when cocultured. We identified hCG as an important factor regulating the number and function of Breg during pregnancy.

CONCLUSIONS:

Breg emerge as important players in pregnancy; they suppress undesired immune responses from maternal T cells and are therefore important for tolerance acquisition.

KEYWORDS:

Abortion; Breg; IL-10; TNF-alpha; hCG; pregnancy

PMID:
24118333
DOI:
10.1111/aji.12157
[Indexed for MEDLINE]

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