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Items: 1 to 50 of 315

1.

Structure guided design of an antibacterial peptide that targets UDP-N-acetylglucosamine acyltransferase.

Dangkulwanich M, Raetz CRH, Williams AH.

Sci Rep. 2019 Mar 8;9(1):3947. doi: 10.1038/s41598-019-40418-8.

2.

Biochemical and Structural Insights into an Fe(II)/α-Ketoglutarate/O2-Dependent Dioxygenase, Kdo 3-Hydroxylase (KdoO).

Joo SH, Pemble CW 4th, Yang EG, Raetz CRH, Chung HS.

J Mol Biol. 2018 Oct 19;430(21):4036-4048. doi: 10.1016/j.jmb.2018.07.029. Epub 2018 Aug 7.

3.

Kdo hydroxylase is an inner core assembly enzyme in the Ko-containing lipopolysaccharide biosynthesis.

Chung HS, Yang EG, Hwang D, Lee JE, Guan Z, Raetz CR.

Biochem Biophys Res Commun. 2014 Sep 26;452(3):789-94. doi: 10.1016/j.bbrc.2014.08.153. Epub 2014 Sep 6.

4.

In vitro assembly of the outer core of the lipopolysaccharide from Escherichia coli K-12 and Salmonella typhimurium.

Qian J, Garrett TA, Raetz CR.

Biochemistry. 2014 Mar 4;53(8):1250-62. doi: 10.1021/bi4015665. Epub 2014 Feb 21.

5.

Chasing acyl carrier protein through a catalytic cycle of lipid A production.

Masoudi A, Raetz CR, Zhou P, Pemble CW 4th.

Nature. 2014 Jan 16;505(7483):422-6. doi: 10.1038/nature12679. Epub 2013 Nov 6.

6.

25-Hydroxycholesterol activates the integrated stress response to reprogram transcription and translation in macrophages.

Shibata N, Carlin AF, Spann NJ, Saijo K, Morello CS, McDonald JG, Romanoski CE, Maurya MR, Kaikkonen MU, Lam MT, Crotti A, Reichart D, Fox JN, Quehenberger O, Raetz CR, Sullards MC, Murphy RC, Merrill AH Jr, Brown HA, Dennis EA, Fahy E, Subramaniam S, Cavener DR, Spector DH, Russell DW, Glass CK.

J Biol Chem. 2013 Dec 13;288(50):35812-23. doi: 10.1074/jbc.M113.519637. Epub 2013 Nov 4.

7.

The calcium-stimulated lipid A 3-O deacylase from Rhizobium etli is not essential for plant nodulation.

Sohlenkamp C, Raetz CR, Ingram BO.

Biochim Biophys Acta. 2013 Jul;1831(7):1250-9.

PMID:
24046865
8.

Complex transcriptional and post-transcriptional regulation of an enzyme for lipopolysaccharide modification.

Moon K, Six DA, Lee HJ, Raetz CR, Gottesman S.

Mol Microbiol. 2013 Jul;89(1):52-64. doi: 10.1111/mmi.12257. Epub 2013 May 31.

9.

The calcium-stimulated lipid A 3-O deacylase from Rhizobium etli is not essential for plant nodulation.

Sohlenkamp C, Raetz CR, Ingram BO.

Biochim Biophys Acta. 2012 Jul;1831(7):1250-9. doi: 10.1016/j.bbalip.2013.04.002. Epub 2013 Apr 12.

10.

Mechanistic characterization of the tetraacyldisaccharide-1-phosphate 4'-kinase LpxK involved in lipid A biosynthesis.

Emptage RP, Pemble CW 4th, York JD, Raetz CR, Zhou P.

Biochemistry. 2013 Apr 2;52(13):2280-90. doi: 10.1021/bi400097z. Epub 2013 Mar 19.

11.

The origin of 8-amino-3,8-dideoxy-D-manno-octulosonic acid (Kdo8N) in the lipopolysaccharide of Shewanella oneidensis.

Gattis SG, Chung HS, Trent MS, Raetz CR.

J Biol Chem. 2013 Mar 29;288(13):9216-25. doi: 10.1074/jbc.M113.453324. Epub 2013 Feb 14.

12.

Pathogenicity of Yersinia pestis synthesis of 1-dephosphorylated lipid A.

Sun W, Six DA, Reynolds CM, Chung HS, Raetz CR, Curtiss R 3rd.

Infect Immun. 2013 Apr;81(4):1172-85. doi: 10.1128/IAI.01403-12. Epub 2013 Jan 28.

13.

Mutants resistant to LpxC inhibitors by rebalancing cellular homeostasis.

Zeng D, Zhao J, Chung HS, Guan Z, Raetz CR, Zhou P.

J Biol Chem. 2013 Feb 22;288(8):5475-86. doi: 10.1074/jbc.M112.447607. Epub 2013 Jan 11.

14.

LpxI structures reveal how a lipid A precursor is synthesized.

Metzger LE 4th, Lee JK, Finer-Moore JS, Raetz CR, Stroud RM.

Nat Struct Mol Biol. 2012 Nov;19(11):1132-8. doi: 10.1038/nsmb.2393. Epub 2012 Oct 7.

15.

Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses.

Spann NJ, Garmire LX, McDonald JG, Myers DS, Milne SB, Shibata N, Reichart D, Fox JN, Shaked I, Heudobler D, Raetz CR, Wang EW, Kelly SL, Sullards MC, Murphy RC, Merrill AH Jr, Brown HA, Dennis EA, Li AC, Ley K, Tsimikas S, Fahy E, Subramaniam S, Quehenberger O, Russell DW, Glass CK.

Cell. 2012 Sep 28;151(1):138-52. doi: 10.1016/j.cell.2012.06.054.

16.

Discovery of a cardiolipin synthase utilizing phosphatidylethanolamine and phosphatidylglycerol as substrates.

Tan BK, Bogdanov M, Zhao J, Dowhan W, Raetz CR, Guan Z.

Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16504-9. doi: 10.1073/pnas.1212797109. Epub 2012 Sep 17.

17.

NaxD is a deacetylase required for lipid A modification and Francisella pathogenesis.

Llewellyn AC, Zhao J, Song F, Parvathareddy J, Xu Q, Napier BA, Laroui H, Merlin D, Bina JE, Cotter PA, Miller MA, Raetz CR, Weiss DS.

Mol Microbiol. 2012 Nov;86(3):611-27. doi: 10.1111/mmi.12004. Epub 2012 Sep 11.

18.

Lipid diversity among botulinum neurotoxin-producing clostridia.

Guan Z, Johnston NC, Raetz CRH, Johnson EA, Goldfine H.

Microbiology. 2012 Oct;158(Pt 10):2577-2584. doi: 10.1099/mic.0.060707-0. Epub 2012 Jul 26.

19.

Crystal structure of LpxK, the 4'-kinase of lipid A biosynthesis and atypical P-loop kinase functioning at the membrane interface.

Emptage RP, Daughtry KD, Pemble CW 4th, Raetz CR.

Proc Natl Acad Sci U S A. 2012 Aug 7;109(32):12956-61. doi: 10.1073/pnas.1206072109. Epub 2012 Jul 23.

20.

Phosphate groups of lipid A are essential for Salmonella enterica serovar Typhimurium virulence and affect innate and adaptive immunity.

Kong Q, Six DA, Liu Q, Gu L, Wang S, Alamuri P, Raetz CR, Curtiss R 3rd.

Infect Immun. 2012 Sep;80(9):3215-24. doi: 10.1128/IAI.00123-12. Epub 2012 Jul 2.

21.

LPS remodeling is an evolved survival strategy for bacteria.

Li Y, Powell DA, Shaffer SA, Rasko DA, Pelletier MR, Leszyk JD, Scott AJ, Masoudi A, Goodlett DR, Wang X, Raetz CR, Ernst RK.

Proc Natl Acad Sci U S A. 2012 May 29;109(22):8716-21. doi: 10.1073/pnas.1202908109. Epub 2012 May 14. Erratum in: Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13877.

22.

Density gradient enrichment of Escherichia coli lpxL mutants.

Six DA, Lambert B, Raetz CR, Doerrler WT.

Biochim Biophys Acta. 2012 Jul;1821(7):989-93. doi: 10.1016/j.bbalip.2012.04.003. Epub 2012 Apr 14.

PMID:
22554681
23.

Activity and crystal structure of Arabidopsis thaliana UDP-N-acetylglucosamine acyltransferase.

Joo SH, Chung HS, Raetz CR, Garrett TA.

Biochemistry. 2012 May 29;51(21):4322-30. doi: 10.1021/bi3002242. Epub 2012 May 14.

24.

Life with too much polyprenol: polyprenol reductase deficiency.

Gründahl JE, Guan Z, Rust S, Reunert J, Müller B, Du Chesne I, Zerres K, Rudnik-Schöneborn S, Ortiz-Brüchle N, Häusler MG, Siedlecka J, Swiezewska E, Raetz CR, Marquardt T.

Mol Genet Metab. 2012 Apr;105(4):642-51. doi: 10.1016/j.ymgme.2011.12.017. Epub 2011 Dec 29.

25.

Role of Francisella lipid A phosphate modification in virulence and long-term protective immune responses.

Kanistanon D, Powell DA, Hajjar AM, Pelletier MR, Cohen IE, Way SS, Skerrett SJ, Wang X, Raetz CR, Ernst RK.

Infect Immun. 2012 Mar;80(3):943-51. doi: 10.1128/IAI.06109-11. Epub 2012 Jan 3.

26.

Palmitoylation state impacts induction of innate and acquired immunity by the Salmonella enterica serovar typhimurium msbB mutant.

Kong Q, Six DA, Liu Q, Gu L, Roland KL, Raetz CR, Curtiss R 3rd.

Infect Immun. 2011 Dec;79(12):5027-38. doi: 10.1128/IAI.05524-11. Epub 2011 Sep 19. Erratum in: Infect Immun. 2012 Mar;80(3):1302.

27.

Non-enzymatically derived minor lipids found in Escherichia coli lipid extracts.

Garrett TA, Raetz CR, Son JD, Richardson TD, Bartling C, Guan Z.

Biochim Biophys Acta. 2011 Nov;1811(11):827-37. doi: 10.1016/j.bbalip.2011.08.012. Epub 2011 Aug 24.

28.

Identification of self-lipids presented by CD1c and CD1d proteins.

Haig NA, Guan Z, Li D, McMichael A, Raetz CR, Xu XN.

J Biol Chem. 2011 Oct 28;286(43):37692-701. doi: 10.1074/jbc.M111.267948. Epub 2011 Sep 7.

29.

Pathway for lipid A biosynthesis in Arabidopsis thaliana resembling that of Escherichia coli.

Li C, Guan Z, Liu D, Raetz CR.

Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11387-92. doi: 10.1073/pnas.1108840108. Epub 2011 Jun 27.

30.

Mitochondrial phosphatase PTPMT1 is essential for cardiolipin biosynthesis.

Zhang J, Guan Z, Murphy AN, Wiley SE, Perkins GA, Worby CA, Engel JL, Heacock P, Nguyen OK, Wang JH, Raetz CR, Dowhan W, Dixon JE.

Cell Metab. 2011 Jun 8;13(6):690-700. doi: 10.1016/j.cmet.2011.04.007.

31.

Salmonella synthesizing 1-dephosphorylated [corrected] lipopolysaccharide exhibits low endotoxic activity while retaining its immunogenicity.

Kong Q, Six DA, Roland KL, Liu Q, Gu L, Reynolds CM, Wang X, Raetz CR, Curtiss R 3rd.

J Immunol. 2011 Jul 1;187(1):412-23. doi: 10.4049/jimmunol.1100339. Epub 2011 Jun 1. Erratum in: J Immunol. 2011 Sep 15;187(6):3449.

32.

Lipooligosaccharide is required for the generation of infectious elementary bodies in Chlamydia trachomatis.

Nguyen BD, Cunningham D, Liang X, Chen X, Toone EJ, Raetz CR, Zhou P, Valdivia RH.

Proc Natl Acad Sci U S A. 2011 Jun 21;108(25):10284-9. doi: 10.1073/pnas.1107478108. Epub 2011 May 31.

33.

A live attenuated strain of Yersinia pestis KIM as a vaccine against plague.

Sun W, Six D, Kuang X, Roland KL, Raetz CR, Curtiss R 3rd.

Vaccine. 2011 Apr 5;29(16):2986-98. doi: 10.1016/j.vaccine.2011.01.099. Epub 2011 Feb 12. Erratum in: Vaccine. 2011 Aug 5;29(34):5820.

34.

Structural characterization of the polar lipids of Clostridium novyi NT. Further evidence for a novel anaerobic biosynthetic pathway to plasmalogens.

Guan Z, Johnston NC, Aygun-Sunar S, Daldal F, Raetz CR, Goldfine H.

Biochim Biophys Acta. 2011 Mar;1811(3):186-93. doi: 10.1016/j.bbalip.2010.12.010. Epub 2010 Dec 30.

35.

Syntheses, structures and antibiotic activities of LpxC inhibitors based on the diacetylene scaffold.

Liang X, Lee CJ, Chen X, Chung HS, Zeng D, Raetz CR, Li Y, Zhou P, Toone EJ.

Bioorg Med Chem. 2011 Jan 15;19(2):852-60. doi: 10.1016/j.bmc.2010.12.017. Epub 2010 Dec 9.

36.

Dioxygenases in Burkholderia ambifaria and Yersinia pestis that hydroxylate the outer Kdo unit of lipopolysaccharide.

Chung HS, Raetz CR.

Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):510-5. doi: 10.1073/pnas.1016462108. Epub 2010 Dec 22.

37.

Species-specific and inhibitor-dependent conformations of LpxC: implications for antibiotic design.

Lee CJ, Liang X, Chen X, Zeng D, Joo SH, Chung HS, Barb AW, Swanson SM, Nicholas RA, Li Y, Toone EJ, Raetz CR, Zhou P.

Chem Biol. 2011 Jan 28;18(1):38-47. doi: 10.1016/j.chembiol.2010.11.011. Epub 2010 Dec 16.

38.

Three phosphatidylglycerol-phosphate phosphatases in the inner membrane of Escherichia coli.

Lu YH, Guan Z, Zhao J, Raetz CR.

J Biol Chem. 2011 Feb 18;286(7):5506-18. doi: 10.1074/jbc.M110.199265. Epub 2010 Dec 9.

39.

Identification of a chloroform-soluble membrane miniprotein in Escherichia coli and its homolog in Salmonella typhimurium.

Guan Z, Wang X, Raetz CR.

Anal Biochem. 2011 Feb 15;409(2):284-9. doi: 10.1016/j.ab.2010.10.035. Epub 2010 Nov 2.

40.

A mouse macrophage lipidome.

Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, Myers DS, Glass CK, Hardiman G, Reichart D, Merrill AH Jr, Sullards MC, Wang E, Murphy RC, Raetz CR, Garrett TA, Guan Z, Ryan AC, Russell DW, McDonald JG, Thompson BM, Shaw WA, Sud M, Zhao Y, Gupta S, Maurya MR, Fahy E, Subramaniam S.

J Biol Chem. 2010 Dec 17;285(51):39976-85. doi: 10.1074/jbc.M110.182915. Epub 2010 Oct 5.

41.

AglJ adds the first sugar of the N-linked pentasaccharide decorating the Haloferax volcanii S-layer glycoprotein.

Kaminski L, Abu-Qarn M, Guan Z, Naparstek S, Ventura VV, Raetz CR, Hitchen PG, Dell A, Eichler J.

J Bacteriol. 2010 Nov;192(21):5572-9. doi: 10.1128/JB.00705-10. Epub 2010 Aug 27.

42.

Escherichia coli mutants that synthesize dephosphorylated lipid A molecules.

Ingram BO, Masoudi A, Raetz CR.

Biochemistry. 2010 Sep 28;49(38):8325-37. doi: 10.1021/bi101253s.

43.

Expression of functional bacterial undecaprenyl pyrophosphate synthase in the yeast rer2{Delta} mutant and CHO cells.

Rush JS, Matveev S, Guan Z, Raetz CR, Waechter CJ.

Glycobiology. 2010 Dec;20(12):1585-93. doi: 10.1093/glycob/cwq107. Epub 2010 Aug 4.

44.

Lipidomics reveals a remarkable diversity of lipids in human plasma.

Quehenberger O, Armando AM, Brown AH, Milne SB, Myers DS, Merrill AH, Bandyopadhyay S, Jones KN, Kelly S, Shaner RL, Sullards CM, Wang E, Murphy RC, Barkley RM, Leiker TJ, Raetz CR, Guan Z, Laird GM, Six DA, Russell DW, McDonald JG, Subramaniam S, Fahy E, Dennis EA.

J Lipid Res. 2010 Nov;51(11):3299-305. doi: 10.1194/jlr.M009449. Epub 2010 Jul 29.

45.

A two-component Kdo hydrolase in the inner membrane of Francisella novicida.

Zhao J, Raetz CR.

Mol Microbiol. 2010 Nov;78(4):820-36. doi: 10.1111/j.1365-2958.2010.07305.x.

46.

Removal of the outer Kdo from Helicobacter pylori lipopolysaccharide and its impact on the bacterial surface.

Stead CM, Zhao J, Raetz CR, Trent MS.

Mol Microbiol. 2010 Nov;78(4):837-52. doi: 10.1111/j.1365-2958.2010.07304.x.

47.

SRD5A3 is required for converting polyprenol to dolichol and is mutated in a congenital glycosylation disorder.

Cantagrel V, Lefeber DJ, Ng BG, Guan Z, Silhavy JL, Bielas SL, Lehle L, Hombauer H, Adamowicz M, Swiezewska E, De Brouwer AP, Blümel P, Sykut-Cegielska J, Houliston S, Swistun D, Ali BR, Dobyns WB, Babovic-Vuksanovic D, van Bokhoven H, Wevers RA, Raetz CR, Freeze HH, Morava E, Al-Gazali L, Gleeson JG.

Cell. 2010 Jul 23;142(2):203-17. doi: 10.1016/j.cell.2010.06.001. Epub 2010 Jul 15.

48.

An alternative route for UDP-diacylglucosamine hydrolysis in bacterial lipid A biosynthesis.

Metzger LE 4th, Raetz CR.

Biochemistry. 2010 Aug 10;49(31):6715-26. doi: 10.1021/bi1008744.

49.

Subcellular organelle lipidomics in TLR-4-activated macrophages.

Andreyev AY, Fahy E, Guan Z, Kelly S, Li X, McDonald JG, Milne S, Myers D, Park H, Ryan A, Thompson BM, Wang E, Zhao Y, Brown HA, Merrill AH, Raetz CR, Russell DW, Subramaniam S, Dennis EA.

J Lipid Res. 2010 Sep;51(9):2785-97. doi: 10.1194/jlr.M008748. Epub 2010 Jun 23.

50.

Antimicrobial activity of CHIR-090, an inhibitor of lipopolysaccharide biosynthesis, against the Burkholderia cepacia complex.

Bodewits K, Raetz CR, Govan JR, Campopiano DJ.

Antimicrob Agents Chemother. 2010 Aug;54(8):3531-3. doi: 10.1128/AAC.01600-09. Epub 2010 Jun 1. No abstract available.

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