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Items: 1 to 50 of 83

1.

Noninvasive Imaging of the Immune Checkpoint LAG-3 Using Nanobodies, from Development to Pre-Clinical Use.

Lecocq Q, Zeven K, De Vlaeminck Y, Martens S, Massa S, Goyvaerts C, Raes G, Keyaerts M, Breckpot K, Devoogdt N.

Biomolecules. 2019 Sep 29;9(10). pii: E548. doi: 10.3390/biom9100548.

2.

Single Domain Antibody-Mediated Blockade of Programmed Death-Ligand 1 on Dendritic Cells Enhances CD8 T-cell Activation and Cytokine Production.

Broos K, Lecocq Q, Keersmaecker B, Raes G, Corthals J, Lion E, Thielemans K, Devoogdt N, Keyaerts M, Breckpot K.

Vaccines (Basel). 2019 Aug 7;7(3). pii: E85. doi: 10.3390/vaccines7030085.

3.

NIRF-Molecular Imaging with Synovial Macrophages-Targeting Vsig4 Nanobody for Disease Monitoring in a Mouse Model of Arthritis.

Zheng F, Luo S, Ouyang Z, Zhou J, Mo H, Schoonooghe S, Muyldermans S, De Baetselier P, Raes G, Wen Y.

Int J Mol Sci. 2019 Jul 8;20(13). pii: E3347. doi: 10.3390/ijms20133347.

4.

Evaluating a Single Domain Antibody Targeting Human PD-L1 as a Nuclear Imaging and Therapeutic Agent.

Broos K, Lecocq Q, Xavier C, Bridoux J, Nguyen TT, Corthals J, Schoonooghe S, Lion E, Raes G, Keyaerts M, Devoogdt N, Breckpot K.

Cancers (Basel). 2019 Jun 21;11(6). pii: E872. doi: 10.3390/cancers11060872.

5.

Clinical Translation of [68Ga]Ga-NOTA-anti-MMR-sdAb for PET/CT Imaging of Protumorigenic Macrophages.

Xavier C, Blykers A, Laoui D, Bolli E, Vaneyken I, Bridoux J, Baudhuin H, Raes G, Everaert H, Movahedi K, Van Ginderachter JA, Devoogdt N, Caveliers V, Lahoutte T, Keyaerts M.

Mol Imaging Biol. 2019 Oct;21(5):898-906. doi: 10.1007/s11307-018-01302-5.

PMID:
30671739
6.

Targeting mannose receptor expression on macrophages in atherosclerotic plaques of apolipoprotein E-knockout mice using 68Ga-NOTA-anti-MMR nanobody: non-invasive imaging of atherosclerotic plaques.

Varasteh Z, Mohanta S, Li Y, López Armbruster N, Braeuer M, Nekolla SG, Habenicht A, Sager HB, Raes G, Weber W, Hernot S, Schwaiger M.

EJNMMI Res. 2019 Jan 21;9(1):5. doi: 10.1186/s13550-019-0474-0.

7.

Nanobody-Facilitated Multiparametric PET/MRI Phenotyping of Atherosclerosis.

Senders ML, Hernot S, Carlucci G, van de Voort JC, Fay F, Calcagno C, Tang J, Alaarg A, Zhao Y, Ishino S, Palmisano A, Boeykens G, Meerwaldt AE, Sanchez-Gaytan BL, Baxter S, Zendman L, Lobatto ME, Karakatsanis NA, Robson PM, Broisat A, Raes G, Lewis JS, Tsimikas S, Reiner T, Fayad ZA, Devoogdt N, Mulder WJM, Pérez-Medina C.

JACC Cardiovasc Imaging. 2019 Oct;12(10):2015-2026. doi: 10.1016/j.jcmg.2018.07.027. Epub 2018 Oct 17.

8.

Noninvasive imaging of the PD-1:PD-L1 immune checkpoint: Embracing nuclear medicine for the benefit of personalized immunotherapy.

Broos K, Lecocq Q, Raes G, Devoogdt N, Keyaerts M, Breckpot K.

Theranostics. 2018 Jun 7;8(13):3559-3570. doi: 10.7150/thno.24762. eCollection 2018. Review.

9.

The role of hepatic macrophages in liver metastasis.

Keirsse J, Van Damme H, Geeraerts X, Beschin A, Raes G, Van Ginderachter JA.

Cell Immunol. 2018 Aug;330:202-215. doi: 10.1016/j.cellimm.2018.03.010. Epub 2018 Apr 6. Review.

PMID:
29661474
10.

Novel half-life extended anti-MIF nanobodies protect against endotoxic shock.

Sparkes A, De Baetselier P, Brys L, Cabrito I, Sterckx YG, Schoonooghe S, Muyldermans S, Raes G, Bucala R, Vanlandschoot P, Van Ginderachter JA, Stijlemans B.

FASEB J. 2018 Jun;32(6):3411-3422. doi: 10.1096/fj.201701189R. Epub 2018 Jan 25.

11.

Development of an adenovirus vector vaccine platform for targeting dendritic cells.

Sharma PK, Dmitriev IP, Kashentseva EA, Raes G, Li L, Kim SW, Lu ZH, Arbeit JM, Fleming TP, Kaliberov SA, Goedegebuure SP, Curiel DT, Gillanders WE.

Cancer Gene Ther. 2018 Feb;25(1-2):27-38. doi: 10.1038/s41417-017-0002-1. Epub 2017 Dec 15.

12.

Evaluation of [99mTc]Radiolabeled Macrophage Mannose Receptor-Specific Nanobodies for Targeting of Atherosclerotic Lesions in Mice.

Bala G, Baudhuin H, Remory I, Gillis K, Debie P, Krasniqi A, Lahoutte T, Raes G, Devoogdt N, Cosyns B, Hernot S.

Mol Imaging Biol. 2018 Apr;20(2):260-267. doi: 10.1007/s11307-017-1117-3.

PMID:
28875290
13.

Beyond the M-CSF receptor - novel therapeutic targets in tumor-associated macrophages.

Bonelli S, Geeraerts X, Bolli E, Keirsse J, Kiss M, Pombo Antunes AR, Van Damme H, De Vlaminck K, Movahedi K, Laoui D, Raes G, Van Ginderachter JA.

FEBS J. 2018 Feb;285(4):777-787. doi: 10.1111/febs.14202. Epub 2017 Sep 6. Review.

14.

Al18F-Labeling Of Heat-Sensitive Biomolecules for Positron Emission Tomography Imaging.

Cleeren F, Lecina J, Ahamed M, Raes G, Devoogdt N, Caveliers V, McQuade P, Rubins DJ, Li W, Verbruggen A, Xavier C, Bormans G.

Theranostics. 2017 Jul 14;7(11):2924-2939. doi: 10.7150/thno.20094. eCollection 2017.

15.

131I-labeled Anti-HER2 Camelid sdAb as a Theranostic Tool in Cancer Treatment.

D'Huyvetter M, De Vos J, Xavier C, Pruszynski M, Sterckx YGJ, Massa S, Raes G, Caveliers V, Zalutsky MR, Lahoutte T, Devoogdt N.

Clin Cancer Res. 2017 Nov 1;23(21):6616-6628. doi: 10.1158/1078-0432.CCR-17-0310. Epub 2017 Jul 27.

16.

Reprint of: The non-mammalian MIF superfamily.

Sparkes A, De Baetselier P, Roelants K, De Trez C, Magez S, Van Ginderachter JA, Raes G, Bucala R, Stijlemans B.

Immunobiology. 2017 Jun;222(6):858-867. doi: 10.1016/j.imbio.2017.05.004. Epub 2017 May 26. Review.

PMID:
28552269
17.

Antigen-presenting cell-targeted lentiviral vectors do not support the development of productive T-cell effector responses: implications for in vivo targeted vaccine delivery.

Goyvaerts C, De Vlaeminck Y, Escors D, Lienenklaus S, Keyaerts M, Raes G, Breckpot K.

Gene Ther. 2017 Jun;24(6):370-375. doi: 10.1038/gt.2017.30. Epub 2017 May 25.

PMID:
28540936
18.

Non-invasive assessment of murine PD-L1 levels in syngeneic tumor models by nuclear imaging with nanobody tracers.

Broos K, Keyaerts M, Lecocq Q, Renmans D, Nguyen T, Escors D, Liston A, Raes G, Breckpot K, Devoogdt N.

Oncotarget. 2017 Jun 27;8(26):41932-41946. doi: 10.18632/oncotarget.16708.

19.

Structural evaluation of a nanobody targeting complement receptor Vsig4 and its cross reactivity.

Wen Y, Ouyang Z, Schoonooghe S, Luo S, De Baetselier P, Lu W, Muyldermans S, Raes G, Zheng F.

Immunobiology. 2017 Jun;222(6):807-813. doi: 10.1016/j.imbio.2016.11.008. Epub 2016 Nov 18.

PMID:
27889311
20.

The non-mammalian MIF superfamily.

Sparkes A, De Baetselier P, Roelants K, De Trez C, Magez S, Van Ginderachter JA, Raes G, Bucala R, Stijlemans B.

Immunobiology. 2017 Mar;222(3):473-482. doi: 10.1016/j.imbio.2016.10.006. Epub 2016 Oct 12. Review.

21.

Specificity Evaluation and Disease Monitoring in Arthritis Imaging with Complement Receptor of the Ig superfamily targeting Nanobodies.

Zheng F, Perlman H, Matthys P, Wen Y, Lahoutte T, Muyldermans S, Lu S, De Baetselier P, Schoonooghe S, Devoogdt N, Raes G.

Sci Rep. 2016 Oct 25;6:35966. doi: 10.1038/srep35966.

22.

Molecular Imaging with Kupffer Cell-Targeting Nanobodies for Diagnosis and Prognosis in Mouse Models of Liver Pathogenesis.

Zheng F, Sparkes A, De Baetselier P, Schoonooghe S, Stijlemans B, Muyldermans S, Flamand V, Van Ginderachter JA, Devoogdt N, Raes G, Beschin A.

Mol Imaging Biol. 2017 Feb;19(1):49-58. doi: 10.1007/s11307-016-0976-3.

PMID:
27339464
23.

Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells.

Scott CL, Zheng F, De Baetselier P, Martens L, Saeys Y, De Prijck S, Lippens S, Abels C, Schoonooghe S, Raes G, Devoogdt N, Lambrecht BN, Beschin A, Guilliams M.

Nat Commun. 2016 Jan 27;7:10321. doi: 10.1038/ncomms10321.

24.

Physiology and Acoustics of Inspiratory Phonation.

Vanhecke F, Lebacq J, Moerman M, Manfredi C, Raes GW, DeJonckere PH.

J Voice. 2016 Nov;30(6):769.e9-769.e18. doi: 10.1016/j.jvoice.2015.11.001. Epub 2015 Dec 22.

PMID:
26706750
25.

The transduction pattern of IL-12-encoding lentiviral vectors shapes the immunological outcome.

Goyvaerts C, Broos K, Escors D, Heirman C, Raes G, De Baetselier P, Thielemans K, Breckpot K.

Eur J Immunol. 2015 Dec;45(12):3351-61. doi: 10.1002/eji.201545559. Epub 2015 Oct 27.

26.

PET Imaging of Macrophage Mannose Receptor-Expressing Macrophages in Tumor Stroma Using 18F-Radiolabeled Camelid Single-Domain Antibody Fragments.

Blykers A, Schoonooghe S, Xavier C, D'hoe K, Laoui D, D'Huyvetter M, Vaneycken I, Cleeren F, Bormans G, Heemskerk J, Raes G, De Baetselier P, Lahoutte T, Devoogdt N, Van Ginderachter JA, Caveliers V.

J Nucl Med. 2015 Aug;56(8):1265-71. doi: 10.2967/jnumed.115.156828. Epub 2015 Jun 11.

27.

Monitoring liver macrophages using nanobodies targeting Vsig4: concanavalin A induced acute hepatitis as paradigm.

Zheng F, Devoogdt N, Sparkes A, Morias Y, Abels C, Stijlemans B, Lahoutte T, Muyldermans S, De Baetselier P, Schoonooghe S, Beschin A, Raes G.

Immunobiology. 2015 Feb;220(2):200-9. doi: 10.1016/j.imbio.2014.09.018. Epub 2014 Oct 2.

PMID:
25440182
28.

Functional Relationship between Tumor-Associated Macrophages and Macrophage Colony-Stimulating Factor as Contributors to Cancer Progression.

Laoui D, Van Overmeire E, De Baetselier P, Van Ginderachter JA, Raes G.

Front Immunol. 2014 Oct 7;5:489. doi: 10.3389/fimmu.2014.00489. eCollection 2014. Review.

29.

MIF contributes to Trypanosoma brucei associated immunopathogenicity development.

Stijlemans B, Leng L, Brys L, Sparkes A, Vansintjan L, Caljon G, Raes G, Van Den Abbeele J, Van Ginderachter JA, Beschin A, Bucala R, De Baetselier P.

PLoS Pathog. 2014 Sep 25;10(9):e1004414. doi: 10.1371/journal.ppat.1004414. eCollection 2014 Sep.

30.

Molecular imaging with macrophage CRIg-targeting nanobodies for early and preclinical diagnosis in a mouse model of rheumatoid arthritis.

Zheng F, Put S, Bouwens L, Lahoutte T, Matthys P, Muyldermans S, De Baetselier P, Devoogdt N, Raes G, Schoonooghe S.

J Nucl Med. 2014 May;55(5):824-9. doi: 10.2967/jnumed.113.130617. Epub 2014 Mar 31.

31.

Immunogenicity of targeted lentivectors.

Goyvaerts C, Kurt de G, Van Lint S, Heirman C, Van Ginderachter JA, De Baetselier P, Raes G, Thielemans K, Breckpot K.

Oncotarget. 2014 Feb 15;5(3):704-15.

32.

The role of monocytes in the development of Tuberculosis-associated Immune Reconstitution Inflammatory Syndrome.

Tran HT, Van den Bergh R, Vu TN, Laukens K, Worodria W, Loembé MM, Colebunders R, Kestens L, De Baetselier P, Raes G; TB-IRIS Study Group.

Immunobiology. 2014 Jan;219(1):37-44. doi: 10.1016/j.imbio.2013.07.004. Epub 2013 Jul 25.

PMID:
23958034
33.

Targeting of human antigen-presenting cell subsets.

Goyvaerts C, Dingemans J, De Groeve K, Heirman C, Van Gulck E, Vanham G, De Baetselier P, Thielemans K, Raes G, Breckpot K.

J Virol. 2013 Oct;87(20):11304-8. doi: 10.1128/JVI.01498-13. Epub 2013 Jul 17.

34.

Modulation of the complement system in monocytes contributes to tuberculosis-associated immune reconstitution inflammatory syndrome.

Tran HT, Van den Bergh R, Loembé MM, Worodria W, Mayanja-Kizza H, Colebunders R, Mascart F, Stordeur P, Kestens L, De Baetselier P, Raes G; TB-IRIS study group.

AIDS. 2013 Jul 17;27(11):1725-34. doi: 10.1097/QAD.0b013e328361648b.

PMID:
23807270
35.

SPECT imaging of joint inflammation with Nanobodies targeting the macrophage mannose receptor in a mouse model for rheumatoid arthritis.

Put S, Schoonooghe S, Devoogdt N, Schurgers E, Avau A, Mitera T, D'Huyvetter M, De Baetselier P, Raes G, Lahoutte T, Matthys P.

J Nucl Med. 2013 May;54(5):807-14. doi: 10.2967/jnumed.112.111781. Epub 2013 Feb 27.

36.

Plasticity of monocytes, macrophages and dendritic cells is reflected in distinct organs and tissues.

Raes G, De Baetselier P, Van Ginderachter JA.

Immunobiology. 2012 Dec;217(12):1223-4. doi: 10.1016/j.imbio.2012.10.001. Epub 2012 Oct 4. No abstract available.

PMID:
23084370
37.

Novel applications of nanobodies for in vivo bio-imaging of inflamed tissues in inflammatory diseases and cancer.

Schoonooghe S, Laoui D, Van Ginderachter JA, Devoogdt N, Lahoutte T, De Baetselier P, Raes G.

Immunobiology. 2012 Dec;217(12):1266-72. doi: 10.1016/j.imbio.2012.07.009. Epub 2012 Jul 21. Review.

PMID:
22884356
38.

Nanobody-based targeting of the macrophage mannose receptor for effective in vivo imaging of tumor-associated macrophages.

Movahedi K, Schoonooghe S, Laoui D, Houbracken I, Waelput W, Breckpot K, Bouwens L, Lahoutte T, De Baetselier P, Raes G, Devoogdt N, Van Ginderachter JA.

Cancer Res. 2012 Aug 15;72(16):4165-77. doi: 10.1158/0008-5472.CAN-11-2994. Epub 2012 Jun 19.

39.

Monocytes contribute to differential immune pressure on R5 versus X4 HIV through the adipocytokine visfatin/NAMPT.

Van den Bergh R, Morin S, Sass HJ, Grzesiek S, Vekemans M, Florence E, Tran HT, Imiru RG, Heyndrickx L, Vanham G, De Baetselier P, Raes G.

PLoS One. 2012;7(4):e35074. doi: 10.1371/journal.pone.0035074. Epub 2012 Apr 6.

40.

Claudin-1, claudin-2 and claudin-11 genes differentially associate with distinct types of anti-inflammatory macrophages in vitro and with parasite- and tumour-elicited macrophages in vivo.

Van den Bossche J, Laoui D, Morias Y, Movahedi K, Raes G, De Baetselier P, Van Ginderachter JA.

Scand J Immunol. 2012 Jun;75(6):588-98. doi: 10.1111/j.1365-3083.2012.02689.x.

41.

Development of the Nanobody display technology to target lentiviral vectors to antigen-presenting cells.

Goyvaerts C, De Groeve K, Dingemans J, Van Lint S, Robays L, Heirman C, Reiser J, Zhang XY, Thielemans K, De Baetselier P, Raes G, Breckpot K.

Gene Ther. 2012 Dec;19(12):1133-40. doi: 10.1038/gt.2011.206. Epub 2012 Jan 12.

42.

Clinical and fundamental aspects of monocyte, macrophage and dendritic cell plasticity.

Raes G, De Baetselier P, Van Ginderachter JA.

Eur J Immunol. 2012 Jan;42(1):13-6. doi: 10.1002/eji.201190081. No abstract available.

43.

Do-it-yourself: construction of a custom cDNA macroarray platform with high sensitivity and linear range.

Boonefaes T, Houthuys E, Van den Bergh R, Vander Beken S, Raes G, Brouckaert P, De Baetselier P, Grooten J.

BMC Biotechnol. 2011 Oct 25;11:97. doi: 10.1186/1472-6750-11-97.

44.

Heterogeneity of macrophage activation in fish.

Forlenza M, Fink IR, Raes G, Wiegertjes GF.

Dev Comp Immunol. 2011 Dec;35(12):1246-55. doi: 10.1016/j.dci.2011.03.008. Epub 2011 Mar 23. Review.

PMID:
21414343
45.

A novel soluble immune-type receptor (SITR) in teleost fish: carp SITR is involved in the nitric oxide-mediated response to a protozoan parasite.

Ribeiro CM, Bird S, Raes G, Ghassabeh GH, Schijns VE, Pontes MJ, Savelkoul HF, Wiegertjes GF.

PLoS One. 2011 Jan 31;6(1):e15986. doi: 10.1371/journal.pone.0015986.

46.

Myeloid-derived suppressor cells in parasitic infections.

Van Ginderachter JA, Beschin A, De Baetselier P, Raes G.

Eur J Immunol. 2010 Nov;40(11):2976-85. doi: 10.1002/eji.201040911. Review.

47.

In vitro analysis and in vivo tumor targeting of a humanized, grafted nanobody in mice using pinhole SPECT/micro-CT.

Vaneycken I, Govaert J, Vincke C, Caveliers V, Lahoutte T, De Baetselier P, Raes G, Bossuyt A, Muyldermans S, Devoogdt N.

J Nucl Med. 2010 Jul;51(7):1099-106. doi: 10.2967/jnumed.109.069823. Epub 2010 Jun 16.

48.

Transcriptome analysis of monocyte-HIV interactions.

Van den Bergh R, Florence E, Vlieghe E, Boonefaes T, Grooten J, Houthuys E, Tran HT, Gali Y, De Baetselier P, Vanham G, Raes G.

Retrovirology. 2010 Jun 14;7:53. doi: 10.1186/1742-4690-7-53.

49.

A novel promiscuous class of camelid single-domain antibody contributes to the antigen-binding repertoire.

Deschacht N, De Groeve K, Vincke C, Raes G, De Baetselier P, Muyldermans S.

J Immunol. 2010 May 15;184(10):5696-704. doi: 10.4049/jimmunol.0903722. Epub 2010 Apr 19.

50.

Nanobodies as tools for in vivo imaging of specific immune cell types.

De Groeve K, Deschacht N, De Koninck C, Caveliers V, Lahoutte T, Devoogdt N, Muyldermans S, De Baetselier P, Raes G.

J Nucl Med. 2010 May;51(5):782-9. doi: 10.2967/jnumed.109.070078. Epub 2010 Apr 15.

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