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Items: 1 to 50 of 51

1.

OpEn-Tag-A Customizable Optogenetic Toolbox To Dissect Subcellular Signaling.

Mühlhäuser WWD, Weber W, Radziwill G.

ACS Synth Biol. 2019 Jul 19;8(7):1679-1684. doi: 10.1021/acssynbio.9b00059. Epub 2019 Jun 24.

PMID:
31185174
2.

Optogenetic control of integrin-matrix interaction.

Baaske J, Mühlhäuser WWD, Yousefi OS, Zanner S, Radziwill G, Hörner M, Schamel WWA, Weber W.

Commun Biol. 2019 Jan 8;2:15. doi: 10.1038/s42003-018-0264-7. eCollection 2019.

3.

Optogenetic control of focal adhesion kinase signaling.

Hörner M, Chatelle C, Mühlhäuser WWD, Stocker DR, Coats M, Weber W, Radziwill G.

Cell Signal. 2018 Jan;42:176-183. doi: 10.1016/j.cellsig.2017.10.012. Epub 2017 Oct 23.

PMID:
29074139
4.

Membrane localization of acetylated CNK1 mediates a positive feedback on RAF/ERK signaling.

Fischer A, Mühlhäuser WWD, Warscheid B, Radziwill G.

Sci Adv. 2017 Aug 11;3(8):e1700475. doi: 10.1126/sciadv.1700475. eCollection 2017 Aug.

5.

Light-Regulated Protein Kinases Based on the CRY2-CIB1 System.

Mühlhäuser WW, Hörner M, Weber W, Radziwill G.

Methods Mol Biol. 2017;1596:257-270. doi: 10.1007/978-1-4939-6940-1_16.

PMID:
28293892
6.

Myofibrillar Z-discs Are a Protein Phosphorylation Hot Spot with Protein Kinase C (PKCα) Modulating Protein Dynamics.

Reimann L, Wiese H, Leber Y, Schwäble AN, Fricke AL, Rohland A, Knapp B, Peikert CD, Drepper F, van der Ven PF, Radziwill G, Fürst DO, Warscheid B.

Mol Cell Proteomics. 2017 Mar;16(3):346-367. doi: 10.1074/mcp.M116.065425. Epub 2016 Dec 27.

7.

Optogenetic clustering of CNK1 reveals mechanistic insights in RAF and AKT signalling controlling cell fate decisions.

Fischer A, Warscheid B, Weber W, Radziwill G.

Sci Rep. 2016 Nov 30;6:38155. doi: 10.1038/srep38155.

8.

Optogenetics - Bringing light into the darkness of mammalian signal transduction.

Mühlhäuser WW, Fischer A, Weber W, Radziwill G.

Biochim Biophys Acta Mol Cell Res. 2017 Feb;1864(2):280-292. doi: 10.1016/j.bbamcr.2016.11.009. Epub 2016 Nov 11. Review.

9.

AKT-dependent phosphorylation of the SAM domain induces oligomerization and activation of the scaffold protein CNK1.

Fischer A, Weber W, Warscheid B, Radziwill G.

Biochim Biophys Acta Mol Cell Res. 2017 Jan;1864(1):89-100. doi: 10.1016/j.bbamcr.2016.10.009. Epub 2016 Oct 18.

10.

Optogenetically controlled RAF to characterize BRAF and CRAF protein kinase inhibitors.

Chatelle CV, Hövermann D, Müller A, Wagner HJ, Weber W, Radziwill G.

Sci Rep. 2016 Mar 30;6:23713. doi: 10.1038/srep23713.

11.

Differential tyrosine phosphorylation controls the function of CNK1 as a molecular switch in signal transduction.

Fischer A, Brummer T, Warscheid B, Radziwill G.

Biochim Biophys Acta. 2015 Nov;1853(11 Pt A):2847-55. doi: 10.1016/j.bbamcr.2015.08.014. Epub 2015 Aug 28.

12.

Modularized CRISPR/dCas9 effector toolkit for target-specific gene regulation.

Agne M, Blank I, Emhardt AJ, Gäbelein CG, Gawlas F, Gillich N, Gonschorek P, Juretschke TJ, Krämer SD, Louis N, Müller A, Rudorf A, Schäfer LM, Scheidmann MC, Schmunk LJ, Schwenk PM, Stammnitz MR, Warmer PM, Weber W, Fischer A, Kaufmann B, Wagner HJ, Radziwill G.

ACS Synth Biol. 2014 Dec 19;3(12):986-9. doi: 10.1021/sb500035y.

PMID:
25524106
13.

Quantitative phosphoproteomics reveals the protein tyrosine kinase Pyk2 as a central effector of olfactory receptor signaling in prostate cancer cells.

Wiese H, Gelis L, Wiese S, Reichenbach C, Jovancevic N, Osterloh M, Meyer HE, Neuhaus EM, Hatt HH, Radziwill G, Warscheid B.

Biochim Biophys Acta. 2015 Jun;1854(6):632-40. doi: 10.1016/j.bbapap.2014.09.002. Epub 2014 Sep 9.

PMID:
25219547
14.

Optogenetic control of signaling in mammalian cells.

Beyer HM, Naumann S, Weber W, Radziwill G.

Biotechnol J. 2015 Feb;10(2):273-83. doi: 10.1002/biot.201400077. Epub 2014 Sep 12. Review.

PMID:
25216399
15.

Small-molecule inhibitors of AF6 PDZ-mediated protein-protein interactions.

Vargas C, Radziwill G, Krause G, Diehl A, Keller S, Kamdem N, Czekelius C, Kreuchwig A, Schmieder P, Doyle D, Moelling K, Hagen V, Schade M, Oschkinat H.

ChemMedChem. 2014 Jul;9(7):1458-62. doi: 10.1002/cmdc.201300553. Epub 2014 Mar 25.

PMID:
24668962
16.

Optogenetic control of protein kinase activity in mammalian cells.

Wend S, Wagner HJ, Müller K, Zurbriggen MD, Weber W, Radziwill G.

ACS Synth Biol. 2014 May 16;3(5):280-5. doi: 10.1021/sb400090s. Epub 2013 Oct 4.

PMID:
24090449
17.

Pharmacologically controlled protein switch for ON-OFF regulation of growth factor activity.

Karlsson M, Rebmann B, Lienemann PS, Sprossmann N, Ehrbar M, Radziwill G, Weber W.

Sci Rep. 2013;3:2716. doi: 10.1038/srep02716.

18.

CNK1 and other scaffolds for Akt/FoxO signaling.

Fritz RD, Radziwill G.

Biochim Biophys Acta. 2011 Nov;1813(11):1971-7. doi: 10.1016/j.bbamcr.2011.02.008. Epub 2011 Feb 12. Review.

19.

CNK1 is a novel Akt interaction partner that promotes cell proliferation through the Akt-FoxO signalling axis.

Fritz RD, Varga Z, Radziwill G.

Oncogene. 2010 Jun 17;29(24):3575-82. doi: 10.1038/onc.2010.104. Epub 2010 Apr 12.

PMID:
20383191
20.

CNK1 promotes invasion of cancer cells through NF-kappaB-dependent signaling.

Fritz RD, Radziwill G.

Mol Cancer Res. 2010 Mar;8(3):395-406. doi: 10.1158/1541-7786.MCR-09-0296. Epub 2010 Mar 2.

21.

A short hairpin DNA analogous to miR-125b inhibits C-Raf expression, proliferation, and survival of breast cancer cells.

Hofmann MH, Heinrich J, Radziwill G, Moelling K.

Mol Cancer Res. 2009 Oct;7(10):1635-44. doi: 10.1158/1541-7786.MCR-09-0043. Epub 2009 Oct 13. Erratum in: Mol Cancer Res. 2010 Jun;8(6):935. Radziwil, Gerald [corrected to Radziwill, Gerald].

22.

c-Src-mediated epithelial cell migration and invasion regulated by PDZ binding site.

Baumgartner M, Radziwill G, Lorger M, Weiss A, Moelling K.

Mol Cell Biol. 2008 Jan;28(2):642-55. Epub 2007 Nov 26.

23.

Characterization of a putative phosphorylation switch: adaptation of SPOT synthesis to analyze PDZ domain regulation mechanisms.

Boisguerin P, Ay B, Radziwill G, Fritz RD, Moelling K, Volkmer R.

Chembiochem. 2007 Dec 17;8(18):2302-7.

PMID:
17973281
24.

Role of AF6 protein in cell-to-cell spread of Herpes simplex virus 1.

Keyser J, Lorger M, Pavlovic J, Radziwill G, Moelling K.

FEBS Lett. 2007 Nov 27;581(28):5349-54. Epub 2007 Oct 29.

25.

c-Src is a PDZ interaction partner and substrate of the E3 ubiquitin ligase Ligand-of-Numb protein X1.

Weiss A, Baumgartner M, Radziwill G, Dennler J, Moelling K.

FEBS Lett. 2007 Oct 30;581(26):5131-6. Epub 2007 Oct 8.

26.
27.

Regulation of c-Src by binding to the PDZ domain of AF-6.

Radziwill G, Weiss A, Heinrich J, Baumgartner M, Boisguerin P, Owada K, Moelling K.

EMBO J. 2007 Jun 6;26(11):2633-44. Epub 2007 May 10.

28.

Simultaneous positioning of cells into two-dimensional arrays using ultrasound.

Neild A, Oberti S, Radziwill G, Dual J.

Biotechnol Bioeng. 2007 Aug 1;97(5):1335-9.

PMID:
17187440
29.

The scaffold protein CNK1 interacts with the angiotensin II type 2 receptor.

Fritz RD, Radziwill G.

Biochem Biophys Res Commun. 2005 Dec 30;338(4):1906-12. Epub 2005 Nov 9.

PMID:
16289034
30.

Positioning, displacement, and localization of cells using ultrasonic forces.

Haake A, Neild A, Radziwill G, Dual J.

Biotechnol Bioeng. 2005 Oct 5;92(1):8-14.

PMID:
16094668
31.

CNK1 is a scaffold protein that regulates Src-mediated Raf-1 activation.

Ziogas A, Moelling K, Radziwill G.

J Biol Chem. 2005 Jun 24;280(25):24205-11. Epub 2005 Apr 21.

32.

An improved method for the synthesis of cellulose membrane-bound peptides with free C termini is useful for PDZ domain binding studies.

Boisguerin P, Leben R, Ay B, Radziwill G, Moelling K, Dong L, Volkmer-Engert R.

Chem Biol. 2004 Apr;11(4):449-59.

33.

The Bcr kinase downregulates Ras signaling by phosphorylating AF-6 and binding to its PDZ domain.

Radziwill G, Erdmann RA, Margelisch U, Moelling K.

Mol Cell Biol. 2003 Jul;23(13):4663-72.

34.

Retroviral gene transfer of dominant negative raf-1 mutants suppresses ha-ras-induced transformation and delays tumor formation.

Heinicke T, Radziwill G, Nawrath M, Rommel C, Pavlovic J, Moelling K.

Cancer Gene Ther. 2000 May;7(5):697-706.

35.

Host cell-virus cross talk: phosphorylation of a hepatitis B virus envelope protein mediates intracellular signaling.

Rothmann K, Schnölzer M, Radziwill G, Hildt E, Moelling K, Schaller H.

J Virol. 1998 Dec;72(12):10138-47.

36.

Mitotic Raf-1 is stimulated independently of Ras and is active in the cytoplasm.

Ziogas A, Lorenz IC, Moelling K, Radziwill G.

J Biol Chem. 1998 Sep 11;273(37):24108-14.

37.

MEK1 mediates a positive feedback on Raf-1 activity independently of Ras and Src.

Zimmermann S, Rommel C, Ziogas A, Lovric J, Moelling K, Radziwill G.

Oncogene. 1997 Sep 25;15(13):1503-11.

38.

Negative regulation of Raf activity by binding of 14-3-3 to the amino terminus of Raf in vivo.

Rommel C, Radziwill G, Moelling K, Hafen E.

Mech Dev. 1997 Jun;64(1-2):95-104.

39.

Inhibition of Raf/MAPK signaling in Xenopus oocyte extracts by Raf-1-specific peptides.

Radziwill G, Steinhusen U, Aitken A, Moelling K.

Biochem Biophys Res Commun. 1996 Oct 3;227(1):20-6.

PMID:
8858097
40.

Specific association of Mil/Raf proteins with a 34 kDa phosphoprotein.

Lovrić J, Radziwill G, Moelling K.

Oncogene. 1996 Mar 7;12(5):1145-51.

PMID:
8649807
41.

Activated Ras displaces 14-3-3 protein from the amino terminus of c-Raf-1.

Rommel C, Radziwill G, Lovrić J, Noeldeke J, Heinicke T, Jones D, Aitken A, Moelling K.

Oncogene. 1996 Feb 1;12(3):609-19.

PMID:
8637718
42.

Signal transduction as target of gene therapy.

Moelling K, Strack B, Radziwill G.

Recent Results Cancer Res. 1996;142:63-71. Review.

PMID:
8893335
43.

Direct interaction and N-terminal phosphorylation of c-Jun by c-Mil/Raf.

Radziwill G, Niehof M, Rommel C, Moelling K.

Proc Natl Acad Sci U S A. 1995 Feb 28;92(5):1421-5.

44.

A small peptide derived from the aminoterminus of c-Raf-1 inhibits c-Raf-1/Ras binding.

Niehof M, Radziwill G, Klauser S, Moelling K.

Biochem Biophys Res Commun. 1995 Jan 5;206(1):46-50.

PMID:
7818549
45.

The aminoterminus of c-Raf-1 binds a protein kinase phosphorylating Ser259.

Beimling P, Niehof M, Radziwill G, Moelling K.

Biochem Biophys Res Commun. 1994 Oct 28;204(2):841-8.

PMID:
7980551
46.

Phosphorylation of c-Raf-1 by protein kinase A interferes with activation.

Schramm K, Niehof M, Radziwill G, Rommel C, Moelling K.

Biochem Biophys Res Commun. 1994 Jun 15;201(2):740-7.

PMID:
8003010
47.

Complementation analysis of mutants defective in different steps of HBV reverse transcription.

Schaller H, Radziwill G.

Gastroenterol Jpn. 1990 Sep;25 Suppl 2:6-10.

PMID:
2227268
48.
49.
50.

The duck hepatitis B virus P-gene codes for protein strongly associated with the 5'-end of the viral DNA minus strand.

Bosch V, Bartenschlager R, Radziwill G, Schaller H.

Virology. 1988 Oct;166(2):475-85.

PMID:
3176342

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