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Items: 1 to 50 of 154

1.

Fenretinide favorably affects mucins (MUC5AC/MUC5B) and fatty acid imbalance in a manner mimicking CFTR-induced correction.

Garić D, De Sanctis JB, Dumut DC, Shah J, Peña MJ, Youssef M, Petrof BJ, Kopriva F, Hanrahan JW, Hajduch M, Radzioch D.

Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Oct 31;1865(2):158538. doi: 10.1016/j.bbalip.2019.158538. [Epub ahead of print]

PMID:
31678518
2.

Biochemistry of very-long-chain and long-chain ceramides in cystic fibrosis and other diseases: The importance of side chain.

Garić D, De Sanctis JB, Shah J, Dumut DC, Radzioch D.

Prog Lipid Res. 2019 Aug 21:100998. doi: 10.1016/j.plipres.2019.100998. [Epub ahead of print] Review.

PMID:
31445070
3.

Biochemistry of very-long-chain and long-chain ceramides in cystic fibrosis and other diseases: The importance of side chain.

Garić D, De Sanctis JB, Shah J, Dumut DC, Radzioch D.

Prog Lipid Res. 2019 Apr;74:130-144. doi: 10.1016/j.plipres.2019.03.001. Epub 2019 Mar 12. Review.

PMID:
30876862
4.

Depletion of BAFF cytokine exacerbates infection in Pseudomonas aeruginosa infected mice.

Garić D, Tao S, Ahmed E, Youssef M, Kanagaratham C, Shah J, Mazer B, Radzioch D.

J Cyst Fibros. 2019 May;18(3):349-356. doi: 10.1016/j.jcf.2018.11.015. Epub 2018 Dec 7.

PMID:
30527891
5.

c-Src kinase is involved in the tyrosine phosphorylation and activity of SLC11A1 in differentiating macrophages.

Xu YZ, Thuraisingam T, Kanagaratham C, Tao S, Radzioch D.

PLoS One. 2018 May 3;13(5):e0196230. doi: 10.1371/journal.pone.0196230. eCollection 2018.

6.

[Delivery in hypoxic tumor regions of a chemotherapeutic agent encapsulated in nanoliposomes carried by magnetoaerotactic bacteria].

Felfoul O, Mohammadi M, Taherkhani S, de Lanauze D, Zhong Xu Y, Lafleur M, Gaboury L, Tabrizian M, Vuong T, Batist G, Beauchemin N, Radzioch D, Martel S.

Med Sci (Paris). 2018 Mar;34(3):197-199. doi: 10.1051/medsci/20183403002. Epub 2018 Mar 16. French. No abstract available.

7.

Loss of the zona pellucida-binding protein 2 (Zpbp2) gene in mice impacts airway hypersensitivity and lung lipid metabolism in a sex-dependent fashion.

Kanagaratham C, Chiwara V, Ho B, Moussette S, Youssef M, Venuto D, Jeannotte L, Bourque G, de Sanctis JB, Radzioch D, Naumova AK.

Mamm Genome. 2018 Apr;29(3-4):281-298. doi: 10.1007/s00335-018-9743-x. Epub 2018 Mar 13.

PMID:
29536159
8.

Toll-Like Receptor 7/8 Ligand, S28463, Suppresses Ascaris suum-induced Allergic Asthma in Nonhuman Primates.

Camateros P, Kanagaratham C, Najdekr L, Holub D, Vrbkova J, Coté L, Fournier J, Gourdon J, Creery D, Olivenstein R, Kopriva F, Adam T, Friedecký D, Džubák P, Hajdúch M, Radzioch D.

Am J Respir Cell Mol Biol. 2018 Jan;58(1):55-65. doi: 10.1165/rcmb.2017-0184OC.

PMID:
28850259
9.

Mouse Chromosome 4 Is Associated with the Baseline and Allergic IgE Phenotypes.

Kanagaratham C, Camateros P, Ren J, Sladek R, Vidal SM, Radzioch D.

G3 (Bethesda). 2017 Aug 7;7(8):2559-2564. doi: 10.1534/g3.117.042739.

10.

Fenretinide differentially modulates the levels of long- and very long-chain ceramides by downregulating Cers5 enzyme: evidence from bench to bedside.

Garić D, De Sanctis JB, Wojewodka G, Houle D, Cupri S, Abu-Arish A, Hanrahan JW, Hajduch M, Matouk E, Radzioch D.

J Mol Med (Berl). 2017 Oct;95(10):1053-1064. doi: 10.1007/s00109-017-1564-y. Epub 2017 Jul 10.

PMID:
28695226
11.

A prognostic model for development of significant liver fibrosis in HIV-hepatitis C co-infection.

Moqueet N, Kanagaratham C, Gill MJ, Hull M, Walmsley S, Radzioch D, Saeed S, Platt RW, Klein MB; Canadian Co-infection Cohort Study (CTN 222).

PLoS One. 2017 May 3;12(5):e0176282. doi: 10.1371/journal.pone.0176282. eCollection 2017.

12.

C-Reactive Protein in Stable Cystic Fibrosis: An Additional Indicator of Clinical Disease Activity and Risk of Future Pulmonary Exacerbations.

Matouk E, Nguyen D, Benedetti A, Bernier J, Gruber J, Landry J, Rousseau S, Ahlgren HG, Lands LC, Wojewodka G, Radzioch D.

J Pulm Respir Med. 2016 Oct 14;6(5):1000375. doi: 10.4172/2161-105X.1000375.

13.

Magneto-aerotactic bacteria deliver drug-containing nanoliposomes to tumour hypoxic regions.

Felfoul O, Mohammadi M, Taherkhani S, de Lanauze D, Zhong Xu Y, Loghin D, Essa S, Jancik S, Houle D, Lafleur M, Gaboury L, Tabrizian M, Kaou N, Atkin M, Vuong T, Batist G, Beauchemin N, Radzioch D, Martel S.

Nat Nanotechnol. 2016 Nov;11(11):941-947. doi: 10.1038/nnano.2016.137. Epub 2016 Aug 15.

14.

Correction of lung inflammation in a F508del CFTR murine cystic fibrosis model by the sphingosine-1-phosphate lyase inhibitor LX2931.

Veltman M, Stolarczyk M, Radzioch D, Wojewodka G, De Sanctis JB, Dik WA, Dzyubachyk O, Oravecz T, de Kleer I, Scholte BJ.

Am J Physiol Lung Cell Mol Physiol. 2016 Nov 1;311(5):L1000-L1014. doi: 10.1152/ajplung.00298.2016. Epub 2016 Sep 23.

15.

Allergic Asthma: A Summary from Genetic Basis, Mouse Studies, to Diagnosis and Treatment.

Kanagaratham C, Radzioch D.

Curr Pharm Des. 2016;22(41):6261-6272. doi: 10.2174/1381612822666160829141708. Review.

PMID:
27573930
16.

Cystic fibrosis-adapted Pseudomonas aeruginosa quorum sensing lasR mutants cause hyperinflammatory responses.

LaFayette SL, Houle D, Beaudoin T, Wojewodka G, Radzioch D, Hoffman LR, Burns JL, Dandekar AA, Smalley NE, Chandler JR, Zlosnik JE, Speert DP, Bernier J, Matouk E, Brochiero E, Rousseau S, Nguyen D.

Sci Adv. 2015 Jul;1(6). pii: e1500199. Epub 2015 Jul 31.

17.

Evolution of the Immune Response to Chronic Airway Colonization with Aspergillus fumigatus Hyphae.

Urb M, Snarr BD, Wojewodka G, Lehoux M, Lee MJ, Ralph B, Divangahi M, King IL, McGovern TK, Martin JG, Fraser R, Radzioch D, Sheppard DC.

Infect Immun. 2015 Sep;83(9):3590-600. doi: 10.1128/IAI.00359-15. Epub 2015 Jun 29.

18.

Clinical outcomes associated with Staphylococcus aureus and Pseudomonas aeruginosa airway infections in adult cystic fibrosis patients.

Ahlgren HG, Benedetti A, Landry JS, Bernier J, Matouk E, Radzioch D, Lands LC, Rousseau S, Nguyen D.

BMC Pulm Med. 2015 Jun 21;15:67. doi: 10.1186/s12890-015-0062-7.

19.

ZRBA1, a Mixed EGFR/DNA Targeting Molecule, Potentiates Radiation Response Through Delayed DNA Damage Repair Process in a Triple Negative Breast Cancer Model.

Heravi M, Kumala S, Rachid Z, Jean-Claude BJ, Radzioch D, Muanza TM.

Int J Radiat Oncol Biol Phys. 2015 Jun 1;92(2):399-406. doi: 10.1016/j.ijrobp.2015.01.026. Epub 2015 Mar 27.

PMID:
25823448
20.

Immunosuppressive Tryptophan Catabolism and Gut Mucosal Dysfunction Following Early HIV Infection.

Jenabian MA, El-Far M, Vyboh K, Kema I, Costiniuk CT, Thomas R, Baril JG, LeBlanc R, Kanagaratham C, Radzioch D, Allam O, Ahmad A, Lebouché B, Tremblay C, Ancuta P, Routy JP; Montreal Primary infection and Slow Progressor Study Groups.

J Infect Dis. 2015 Aug 1;212(3):355-66. doi: 10.1093/infdis/jiv037. Epub 2015 Jan 23.

PMID:
25616404
21.

Mapping of a chromosome 12 region associated with airway hyperresponsiveness in a recombinant congenic mouse strain and selection of potential candidate genes by expression and sequence variation analyses.

Kanagaratham C, Marino R, Camateros P, Ren J, Houle D, Sladek R, Vidal SM, Radzioch D.

PLoS One. 2014 Aug 11;9(8):e104234. doi: 10.1371/journal.pone.0104234. eCollection 2014.

22.

Soluble CD40-ligand (sCD40L, sCD154) plays an immunosuppressive role via regulatory T cell expansion in HIV infection.

Jenabian MA, Patel M, Kema I, Vyboh K, Kanagaratham C, Radzioch D, Thébault P, Lapointe R, Gilmore N, Ancuta P, Tremblay C, Routy JP.

Clin Exp Immunol. 2014 Oct;178(1):102-11. doi: 10.1111/cei.12396.

23.

Assessment of chloroquine as a modulator of immune activation to improve CD4 recovery in immune nonresponding HIV-infected patients receiving antiretroviral therapy.

Routy JP, Angel JB, Patel M, Kanagaratham C, Radzioch D, Kema I, Gilmore N, Ancuta P, Singer J, Jenabian MA.

HIV Med. 2015 Jan;16(1):48-56. doi: 10.1111/hiv.12171. Epub 2014 Jun 2.

24.

Fenretinide prevents inflammation and airway hyperresponsiveness in a mouse model of allergic asthma.

Kanagaratham C, Kalivodová A, Najdekr L, Friedecký D, Adam T, Hajduch M, De Sanctis JB, Radzioch D.

Am J Respir Cell Mol Biol. 2014 Dec;51(6):783-92. doi: 10.1165/rcmb.2014-0121OC.

PMID:
24885263
25.

A new era of targeting the ancient gatekeepers of the immune system: toll-like agonists in the treatment of allergic rhinitis and asthma.

Aryan Z, Holgate ST, Radzioch D, Rezaei N.

Int Arch Allergy Immunol. 2014;164(1):46-63. doi: 10.1159/000362553. Epub 2014 May 21. Review.

26.

Deregulated balance of omega-6 and omega-3 polyunsaturated fatty acids following infection by the zoonotic pathogen Streptococcus suis.

Lachance C, Segura M, Dominguez-Punaro MC, Wojewodka G, De Sanctis JB, Radzioch D, Gottschalk M.

Infect Immun. 2014 May;82(5):1778-85. doi: 10.1128/IAI.01524-13. Epub 2014 Feb 18.

27.

Candidate markers associated with the probability of future pulmonary exacerbations in cystic fibrosis patients.

Wojewodka G, De Sanctis JB, Bernier J, Bérubé J, Ahlgren HG, Gruber J, Landry J, Lands LC, Nguyen D, Rousseau S, Benedetti A, Matouk E, Radzioch D.

PLoS One. 2014 Feb 12;9(2):e88567. doi: 10.1371/journal.pone.0088567. eCollection 2014.

28.

Distinct tryptophan catabolism and Th17/Treg balance in HIV progressors and elite controllers.

Jenabian MA, Patel M, Kema I, Kanagaratham C, Radzioch D, Thébault P, Lapointe R, Tremblay C, Gilmore N, Ancuta P, Routy JP.

PLoS One. 2013 Oct 16;8(10):e78146. doi: 10.1371/journal.pone.0078146. eCollection 2013. Erratum in: PLoS One. 2014;9(1). doi:10.1371/annotation/11698dd2-0bc1-4fe0-ad92-b161b5594e81.

29.

Fenretinide corrects the imbalance between omega-6 to omega-3 polyunsaturated fatty acids and inhibits macrophage inflammatory mediators via the ERK pathway.

Lachance C, Wojewodka G, Skinner TA, Guilbault C, De Sanctis JB, Radzioch D.

PLoS One. 2013 Sep 12;8(9):e74875. doi: 10.1371/journal.pone.0074875. eCollection 2013.

30.

Gene-metabolite expression in blood can discriminate allergen-induced isolated early from dual asthmatic responses.

Singh A, Yamamoto M, Kam SH, Ruan J, Gauvreau GM, O'Byrne PM, FitzGerald JM, Schellenberg R, Boulet LP, Wojewodka G, Kanagaratham C, De Sanctis JB, Radzioch D, Tebbutt SJ.

PLoS One. 2013 Jul 2;8(7):e67907. doi: 10.1371/journal.pone.0067907. Print 2013.

31.

Induction of nitric oxide synthase expression by lipopolysaccharide is mediated by calcium-dependent PKCα-β1 in alveolar epithelial cells.

Boncoeur É, Bouvet GF, Migneault F, Tardif V, Ferraro P, Radzioch D, de Sanctis JB, Eidelman D, Govindaraju K, Dagenais A, Berthiaume Y.

Am J Physiol Lung Cell Mol Physiol. 2013 Jul 15;305(2):L175-84. doi: 10.1152/ajplung.00295.2012. Epub 2013 May 17.

32.

Lycopene improves the distorted ratio between AA/DHA in the seminal plasma of infertile males and increases the likelihood of successful pregnancy.

Filipcikova R, Oborna I, Brezinova J, Novotny J, Wojewodka G, De Sanctis JB, Radova L, Hajduch M, Radzioch D.

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015 Mar;159(1):77-82. doi: 10.5507/bp.2013.007. Epub 2013 Feb 25.

33.

Promoter deletion analysis using a dual-luciferase reporter system.

Xu YZ, Kanagaratham C, Jancik S, Radzioch D.

Methods Mol Biol. 2013;977:79-93. doi: 10.1007/978-1-62703-284-1_7.

PMID:
23436355
34.

A comparison of Direct sequencing, Pyrosequencing, High resolution melting analysis, TheraScreen DxS, and the K-ras StripAssay for detecting KRAS mutations in non small cell lung carcinomas.

Jancik S, Drabek J, Berkovcova J, Xu YZ, Stankova M, Klein J, Kolek V, Skarda J, Tichy T, Grygarkova I, Radzioch D, Hajduch M.

J Exp Clin Cancer Res. 2012 Sep 20;31:79. doi: 10.1186/1756-9966-31-79.

35.

Sorafenib in combination with ionizing radiation has a greater anti-tumour activity in a breast cancer model.

Heravi M, Tomic N, Liang L, Devic S, Holmes J, Deblois F, Radzioch D, Muanza T.

Anticancer Drugs. 2012 Jun;23(5):525-33. doi: 10.1097/CAD.0b013e32834ea5b3.

PMID:
22357220
36.

Critical role for phosphoinositide 3-kinase gamma in parasite invasion and disease progression of cutaneous leishmaniasis.

Cummings HE, Barbi J, Reville P, Oghumu S, Zorko N, Sarkar A, Keiser TL, Lu B, Rückle T, Varikuti S, Lezama-Davila C, Wewers MD, Whitacre C, Radzioch D, Rommel C, Seveau S, Satoskar AR.

Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):1251-6. doi: 10.1073/pnas.1110339109. Epub 2012 Jan 9.

37.

Fragile X related protein 1 clusters with ribosomes and messenger RNAs at a subset of dendritic spines in the mouse hippocampus.

Cook D, Sanchez-Carbente Mdel R, Lachance C, Radzioch D, Tremblay S, Khandjian EW, DesGroseillers L, Murai KK.

PLoS One. 2011;6(10):e26120. doi: 10.1371/journal.pone.0026120. Epub 2011 Oct 11.

38.

Distinct functions of the mitogen-activated protein kinase-activated protein (MAPKAP) kinases MK2 and MK3: MK2 mediates lipopolysaccharide-induced signal transducers and activators of transcription 3 (STAT3) activation by preventing negative regulatory effects of MK3.

Ehlting C, Ronkina N, Böhmer O, Albrecht U, Bode KA, Lang KS, Kotlyarov A, Radzioch D, Gaestel M, Häussinger D, Bode JG.

J Biol Chem. 2011 Jul 8;286(27):24113-24. doi: 10.1074/jbc.M111.235275. Epub 2011 May 17.

39.

Ceramide in cystic fibrosis: a potential new target for therapeutic intervention.

Wojewodka G, De Sanctis JB, Radzioch D.

J Lipids. 2011;2011:674968. doi: 10.1155/2011/674968. Epub 2010 Dec 28.

40.

Secretory leukocyte protease inhibitor plays an important role in the regulation of allergic asthma in mice.

Marino R, Thuraisingam T, Camateros P, Kanagaratham C, Xu YZ, Henri J, Yang J, He G, Ding A, Radzioch D.

J Immunol. 2011 Apr 1;186(7):4433-42. doi: 10.4049/jimmunol.1001539. Epub 2011 Feb 18.

41.

Recruitment of SWI/SNF complex is required for transcriptional activation of the SLC11A1 gene during macrophage differentiation of HL-60 cells.

Xu YZ, Thuraisingam T, Marino R, Radzioch D.

J Biol Chem. 2011 Apr 15;286(15):12839-49. doi: 10.1074/jbc.M110.185637. Epub 2011 Feb 7.

42.

Polymorphisms in TOLL-like receptor genes and their roles in allergic asthma and atopy.

Kanagaratham C, Camateros P, Flaczyk A, Radzioch D.

Recent Pat Inflamm Allergy Drug Discov. 2011 Jan;5(1):45-56. Review.

PMID:
21158736
43.

Mitogen-activated protein kinase-activated protein kinase 2 (MK2) contributes to secondary damage after spinal cord injury.

Ghasemlou N, Lopez-Vales R, Lachance C, Thuraisingam T, Gaestel M, Radzioch D, David S.

J Neurosci. 2010 Oct 13;30(41):13750-9. doi: 10.1523/JNEUROSCI.2998-10.2010.

44.

Brg-1 mediates the constitutive and fenretinide-induced expression of SPARC in mammary carcinoma cells via its interaction with transcription factor Sp1.

Xu YZ, Heravi M, Thuraisingam T, Di Marco S, Muanza T, Radzioch D.

Mol Cancer. 2010 Aug 5;9:210. doi: 10.1186/1476-4598-9-210.

45.

Clinical relevance of KRAS in human cancers.

Jancík S, Drábek J, Radzioch D, Hajdúch M.

J Biomed Biotechnol. 2010;2010:150960. doi: 10.1155/2010/150960. Epub 2010 Jun 7. Review.

46.

Fenretinide promotes functional recovery and tissue protection after spinal cord contusion injury in mice.

López-Vales R, Redensek A, Skinner TA, Rathore KI, Ghasemlou N, Wojewodka G, DeSanctis J, Radzioch D, David S.

J Neurosci. 2010 Mar 3;30(9):3220-6. doi: 10.1523/JNEUROSCI.5770-09.2010.

47.

Nuclear translocation of beta-actin is involved in transcriptional regulation during macrophage differentiation of HL-60 cells.

Xu YZ, Thuraisingam T, Morais DA, Rola-Pleszczynski M, Radzioch D.

Mol Biol Cell. 2010 Mar 1;21(5):811-20. doi: 10.1091/mbc.E09-06-0534. Epub 2010 Jan 6.

48.

Beneficial effects of secretory leukocyte protease inhibitor after spinal cord injury.

Ghasemlou N, Bouhy D, Yang J, López-Vales R, Haber M, Thuraisingam T, He G, Radzioch D, Ding A, David S.

Brain. 2010 Jan;133(Pt 1):126-38. doi: 10.1093/brain/awp304.

49.

Identification of novel chromosomal regions associated with airway hyperresponsiveness in recombinant congenic strains of mice.

Camateros P, Marino R, Fortin A, Martin JG, Skamene E, Sladek R, Radzioch D.

Mamm Genome. 2010 Feb;21(1-2):28-38. doi: 10.1007/s00335-009-9236-z. Epub 2009 Dec 15.

PMID:
20012967
50.

Increased lipid peroxidation and abnormal fatty acid profiles in seminal and blood plasma of normozoospermic males from infertile couples.

Oborna I, Wojewodka G, De Sanctis JB, Fingerova H, Svobodova M, Brezinova J, Hajduch M, Novotny J, Radova L, Radzioch D.

Hum Reprod. 2010 Feb;25(2):308-16. doi: 10.1093/humrep/dep416. Epub 2009 Nov 25.

PMID:
19942612

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