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Items: 37

1.

Higher order structures of Adalimumab, Infliximab and their complexes with TNFα revealed by electron microscopy.

Tran BN, Chan SL, Ng C, Shi J, Correia I, Radziejewski C, Matsudaira P.

Protein Sci. 2017 Dec;26(12):2392-2398. doi: 10.1002/pro.3306. Epub 2017 Nov 14.

2.

When Good Intentions Go Awry: Modification of a Recombinant Monoclonal Antibody in Chemically Defined Cell Culture by Xylosone, an Oxidative Product of Ascorbic Acid.

Chumsae C, Hossler P, Raharimampionona H, Zhou Y, McDermott S, Racicot C, Radziejewski C, Zhou ZS.

Anal Chem. 2015 Aug 4;87(15):7529-34. doi: 10.1021/acs.analchem.5b00801. Epub 2015 Jul 21.

PMID:
26151084
3.

Discovery of a chemical modification by citric acid in a recombinant monoclonal antibody.

Chumsae C, Zhou LL, Shen Y, Wohlgemuth J, Fung E, Burton R, Radziejewski C, Zhou ZS.

Anal Chem. 2014 Sep 16;86(18):8932-6. doi: 10.1021/ac502179m. Epub 2014 Aug 27.

4.

Arginine modifications by methylglyoxal: discovery in a recombinant monoclonal antibody and contribution to acidic species.

Chumsae C, Gifford K, Lian W, Liu H, Radziejewski CH, Zhou ZS.

Anal Chem. 2013 Dec 3;85(23):11401-9. doi: 10.1021/ac402384y. Epub 2013 Nov 18.

5.

Comparison of the in vitro and in vivo stability of a succinimide intermediate observed on a therapeutic IgG1 molecule.

Ouellette D, Chumsae C, Clabbers A, Radziejewski C, Correia I.

MAbs. 2013 May-Jun;5(3):432-44. doi: 10.4161/mabs.24458. Epub 2013 Apr 22.

6.

The structure of dual-variable-domain immunoglobulin molecules alone and bound to antigen.

Correia I, Sung J, Burton R, Jakob CG, Carragher B, Ghayur T, Radziejewski C.

MAbs. 2013 May-Jun;5(3):364-72. doi: 10.4161/mabs.24258. Epub 2013 Apr 9.

7.

Increased serum clearance of oligomannose species present on a human IgG1 molecule.

Alessandri L, Ouellette D, Acquah A, Rieser M, Leblond D, Saltarelli M, Radziejewski C, Fujimori T, Correia I.

MAbs. 2012 Jul-Aug;4(4):509-20. doi: 10.4161/mabs.20450. Epub 2012 Jul 1.

8.

A high throughput capillary electrophoresis method to obtain pharmacokinetics and quality attributes of a therapeutic molecule in circulation.

Piparia R, Ouellette D, Stine WB, Grinnell C, Tarcsa E, Radziejewski C, Correia I.

MAbs. 2012 Jul-Aug;4(4):521-31. doi: 10.4161/mabs.20099. Epub 2012 Jul 1.

9.

Comparability analysis of protein therapeutics by bottom-up LC-MS with stable isotope-tagged reference standards.

Manuilov AV, Radziejewski CH, Lee DH.

MAbs. 2011 Jul-Aug;3(4):387-95. Epub 2011 Jul 1.

10.

Effect of the light chain C-terminal serine residue on disulfide bond susceptibility of human immunoglobulin G1λ.

Liu H, Zhong S, Chumsae C, Radziejewski C, Hsieh CM.

Anal Biochem. 2011 Jan 15;408(2):277-83. doi: 10.1016/j.ab.2010.09.025. Epub 2010 Oct 8.

PMID:
20869344
11.

Ranking the susceptibility of disulfide bonds in human IgG1 antibodies by reduction, differential alkylation, and LC-MS analysis.

Liu H, Chumsae C, Gaza-Bulseco G, Hurkmans K, Radziejewski CH.

Anal Chem. 2010 Jun 15;82(12):5219-26. doi: 10.1021/ac100575n.

PMID:
20491447
12.

Studies in serum support rapid formation of disulfide bond between unpaired cysteine residues in the VH domain of an immunoglobulin G1 molecule.

Ouellette D, Alessandri L, Chin A, Grinnell C, Tarcsa E, Radziejewski C, Correia I.

Anal Biochem. 2010 Feb 1;397(1):37-47. doi: 10.1016/j.ab.2009.09.027. Epub 2009 Sep 18.

PMID:
19766583
13.

Elevated cleavage of human immunoglobulin gamma molecules containing a lambda light chain mediated by iron and histidine.

Ouellette D, Alessandri L, Piparia R, Aikhoje A, Chin A, Radziejewski C, Correia I.

Anal Biochem. 2009 Jun 15;389(2):107-17. doi: 10.1016/j.ab.2009.03.027. Epub 2009 Mar 24.

PMID:
19318085
14.

Mass spectrometry analysis of in vitro nitration of a recombinant human IgG1 monoclonal antibody.

Liu H, Gaza-Bulseco G, Chumsae C, Radziejewski CH.

Rapid Commun Mass Spectrom. 2008;22(1):1-10.

PMID:
18041795
15.

Monoclonal antibody classification based on epitope-binding using differential antigen disruption.

Shi E, Fury W, Li W, Mikulka W, Aldrich T, Rafique A, Chen G, Hoffenberg S, Daly TJ, Radziejewski C.

J Immunol Methods. 2006 Jul 31;314(1-2):9-20. Epub 2006 Jun 27.

PMID:
16831443
16.

VEGF-A stimulates lymphangiogenesis and hemangiogenesis in inflammatory neovascularization via macrophage recruitment.

Cursiefen C, Chen L, Borges LP, Jackson D, Cao J, Radziejewski C, D'Amore PA, Dana MR, Wiegand SJ, Streilein JW.

J Clin Invest. 2004 Apr;113(7):1040-50.

17.

Cytokine traps: multi-component, high-affinity blockers of cytokine action.

Economides AN, Carpenter LR, Rudge JS, Wong V, Koehler-Stec EM, Hartnett C, Pyles EA, Xu X, Daly TJ, Young MR, Fandl JP, Lee F, Carver S, McNay J, Bailey K, Ramakanth S, Hutabarat R, Huang TT, Radziejewski C, Yancopoulos GD, Stahl N.

Nat Med. 2003 Jan;9(1):47-52. Epub 2002 Dec 16.

PMID:
12483208
18.

Angiopoietins have distinct modular domains essential for receptor binding, dimerization and superclustering.

Davis S, Papadopoulos N, Aldrich TH, Maisonpierre PC, Huang T, Kovac L, Xu A, Leidich R, Radziejewska E, Rafique A, Goldberg J, Jain V, Bailey K, Karow M, Fandl J, Samuelsson SJ, Ioffe E, Rudge JS, Daly TJ, Radziejewski C, Yancopoulos GD.

Nat Struct Biol. 2003 Jan;10(1):38-44. Erratum in: Nat Struct Biol. 2003 Feb;10(2):146.

PMID:
12469114
19.

Binding of discoidin domain receptor 2 to collagen I: an atomic force microscopy investigation.

Agarwal G, Kovac L, Radziejewski C, Samuelsson SJ.

Biochemistry. 2002 Sep 17;41(37):11091-8.

PMID:
12220173
20.

VEGF-Trap: a VEGF blocker with potent antitumor effects.

Holash J, Davis S, Papadopoulos N, Croll SD, Ho L, Russell M, Boland P, Leidich R, Hylton D, Burova E, Ioffe E, Huang T, Radziejewski C, Bailey K, Fandl JP, Daly T, Wiegand SJ, Yancopoulos GD, Rudge JS.

Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11393-8. Epub 2002 Aug 12.

21.

The structures of the neurotrophin 4 homodimer and the brain-derived neurotrophic factor/neurotrophin 4 heterodimer reveal a common Trk-binding site.

Robinson RC, Radziejewski C, Spraggon G, Greenwald J, Kostura MR, Burtnick LD, Stuart DI, Choe S, Jones EY.

Protein Sci. 1999 Dec;8(12):2589-97.

22.

Antiangiogenic gene therapy targeting the endothelium-specific receptor tyrosine kinase Tie2.

Lin P, Buxton JA, Acheson A, Radziejewski C, Maisonpierre PC, Yancopoulos GD, Channon KM, Hale LP, Dewhirst MW, George SE, Peters KG.

Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8829-34.

23.

An orphan receptor tyrosine kinase family whose members serve as nonintegrin collagen receptors.

Shrivastava A, Radziejewski C, Campbell E, Kovac L, McGlynn M, Ryan TE, Davis S, Goldfarb MP, Glass DJ, Lemke G, Yancopoulos GD.

Mol Cell. 1997 Dec;1(1):25-34.

24.

Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis.

Maisonpierre PC, Suri C, Jones PF, Bartunkova S, Wiegand SJ, Radziejewski C, Compton D, McClain J, Aldrich TH, Papadopoulos N, Daly TJ, Davis S, Sato TN, Yancopoulos GD.

Science. 1997 Jul 4;277(5322):55-60.

25.

Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning.

Davis S, Aldrich TH, Jones PF, Acheson A, Compton DL, Jain V, Ryan TE, Bruno J, Radziejewski C, Maisonpierre PC, Yancopoulos GD.

Cell. 1996 Dec 27;87(7):1161-9.

26.

Agrin acts via a MuSK receptor complex.

Glass DJ, Bowen DC, Stitt TN, Radziejewski C, Bruno J, Ryan TE, Gies DR, Shah S, Mattsson K, Burden SJ, DiStefano PS, Valenzuela DM, DeChiara TM, Yancopoulos GD.

Cell. 1996 May 17;85(4):513-23.

27.

Crystals of the neurotrophins.

Robinson RC, Radziejewski C, Stuart DI, Jones EY.

Protein Sci. 1996 May;5(5):973-7.

28.

Structure of the brain-derived neurotrophic factor/neurotrophin 3 heterodimer.

Robinson RC, Radziejewski C, Stuart DI, Jones EY.

Biochemistry. 1995 Apr 4;34(13):4139-46.

PMID:
7703225
29.

The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases.

Stitt TN, Conn G, Gore M, Lai C, Bruno J, Radziejewski C, Mattsson K, Fisher J, Gies DR, Jones PF, et al.

Cell. 1995 Feb 24;80(4):661-70.

30.

Heterodimers of the neurotrophic factors: formation, isolation, and differential stability.

Radziejewski C, Robinson RC.

Biochemistry. 1993 Dec 7;32(48):13350-6.

PMID:
8241191
31.

Dimeric structure and conformational stability of brain-derived neurotrophic factor and neurotrophin-3.

Radziejewski C, Robinson RC, DiStefano PS, Taylor JW.

Biochemistry. 1992 May 12;31(18):4431-6.

PMID:
1581298
32.

The neurotrophins BDNF, NT-3, and NGF display distinct patterns of retrograde axonal transport in peripheral and central neurons.

DiStefano PS, Friedman B, Radziejewski C, Alexander C, Boland P, Schick CM, Lindsay RM, Wiegand SJ.

Neuron. 1992 May;8(5):983-93.

PMID:
1375039
33.

Recombinant human and rat ciliary neurotrophic factors.

Masiakowski P, Liu HX, Radziejewski C, Lottspeich F, Oberthuer W, Wong V, Lindsay RM, Furth ME, Panayotatos N.

J Neurochem. 1991 Sep;57(3):1003-12.

PMID:
1861138
34.

trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor.

Squinto SP, Stitt TN, Aldrich TH, Davis S, Bianco SM, Radziejewski C, Glass DJ, Masiakowski P, Furth ME, Valenzuela DM, et al.

Cell. 1991 May 31;65(5):885-93.

PMID:
1710174
35.

Characterization of the in vitro sensitivity of human lymphoid and hematopoietic progenitors to L-leucyl-L-leucine methyl ester.

Pecora AL, Bordignon C, Fumagalli L, Radziejewski C, Small TN, Pekle K, O'Reilly RJ, Keever CA.

Transplantation. 1991 Feb;51(2):524-31.

PMID:
1994549
36.

Purification of recombinant pp60v-src protein tyrosine kinase and phosphorylation of peptides with different secondary structure preference.

Radziejewski C, Miller WT, Mobashery S, Goldberg AR, Kaiser ET.

Biochemistry. 1989 Nov 14;28(23):9047-52.

PMID:
2481500
37.

The design of new enzyme active sites for the catalysis of specific chemical reactions.

Kaiser ET, Radziejewski C.

Ciba Found Symp. 1985;111:219-30.

PMID:
3860367

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