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Items: 1 to 50 of 207

1.

Effects of functionalized silver nanoparticles on aggregation of human blood platelets.

Hajtuch J, Hante N, Tomczyk E, Wojcik M, Radomski MW, Santos-Martinez MJ, Inkielewicz-Stepniak I.

Int J Nanomedicine. 2019 Sep 11;14:7399-7417. doi: 10.2147/IJN.S213499. eCollection 2019.

2.

New Oxidovanadium(IV) Coordination Complex Containing 2-Methylnitrilotriacetate Ligands Induces Cell Cycle Arrest and Autophagy in Human Pancreatic Ductal Adenocarcinoma Cell Lines.

Kowalski S, Wyrzykowski D, Hac S, Rychlowski M, Radomski MW, Inkielewicz-Stepniak I.

Int J Mol Sci. 2019 Jan 10;20(2). pii: E261. doi: 10.3390/ijms20020261.

3.

The Role of Mucin in the Toxicological Impact of Polystyrene Nanoparticles.

Inkielewicz-Stepniak I, Tajber L, Behan G, Zhang H, Radomski MW, Medina C, Santos-Martinez MJ.

Materials (Basel). 2018 May 3;11(5). pii: E724. doi: 10.3390/ma11050724.

4.

Role of matrix metalloproteinases 2 and 9, toll-like receptor 4 and platelet-leukocyte aggregate formation in sepsis-associated thrombocytopenia.

Larkin CM, Hante NK, Breen EP, Tomaszewski KA, Eisele S, Radomski MW, Ryan TA, Santos-Martinez MJ.

PLoS One. 2018 May 7;13(5):e0196478. doi: 10.1371/journal.pone.0196478. eCollection 2018.

5.

Platelet microaggregation in sepsis examined by quartz crystal microbalance with dissipation technology.

Larkin CM, Breen EP, Tomaszewski KA, Eisele S, Radomski MW, Ryan TA, Santos-Martinez MJ.

Platelets. 2018 May;29(3):301-304. doi: 10.1080/09537104.2017.1371686. Epub 2017 Nov 9.

PMID:
29120698
6.

Differential eNOS-signalling by platelet subpopulations regulates adhesion and aggregation.

Radziwon-Balicka A, Lesyk G, Back V, Fong T, Loredo-Calderon EL, Dong B, El-Sikhry H, El-Sherbeni AA, El-Kadi A, Ogg S, Siraki A, Seubert JM, Santos-Martinez MJ, Radomski MW, Velazquez-Martinez CA, Winship IR, Jurasz P.

Cardiovasc Res. 2017 Dec 1;113(14):1719-1731. doi: 10.1093/cvr/cvx179. Review.

7.

Metal nanoparticles in dermatology and cosmetology: Interactions with human skin cells.

Niska K, Zielinska E, Radomski MW, Inkielewicz-Stepniak I.

Chem Biol Interact. 2018 Nov 1;295:38-51. doi: 10.1016/j.cbi.2017.06.018. Epub 2017 Jun 19. Review.

PMID:
28641964
8.

Molecular Mechanism of Silver Nanoparticles-Induced Human Osteoblast Cell Death: Protective Effect of Inducible Nitric Oxide Synthase Inhibitor.

Zielinska E, Tukaj C, Radomski MW, Inkielewicz-Stepniak I.

PLoS One. 2016 Oct 7;11(10):e0164137. doi: 10.1371/journal.pone.0164137. eCollection 2016.

9.

Sepsis-associated thrombocytopenia.

Larkin CM, Santos-Martinez MJ, Ryan T, Radomski MW.

Thromb Res. 2016 May;141:11-6. doi: 10.1016/j.thromres.2016.02.022. Epub 2016 Mar 2. Review. No abstract available.

PMID:
26953822
10.

The Nanopharmacology and Nanotoxicology of Nanomaterials: New Opportunities and Challenges.

Radomska A, Leszczyszyn J, Radomski MW.

Adv Clin Exp Med. 2016 Jan-Feb;25(1):151-62. doi: 10.17219/acem/60879. Review.

11.

Pharmacokinetics and bio-distribution of novel super paramagnetic iron oxide nanoparticles (SPIONs) in the anaesthetized pig.

Edge D, Shortt CM, Gobbo OL, Teughels S, Prina-Mello A, Volkov Y, MacEneaney P, Radomski MW, Markos F.

Clin Exp Pharmacol Physiol. 2016 Mar;43(3):319-26. doi: 10.1111/1440-1681.12533.

PMID:
26707795
12.

miR-134 in extracellular vesicles reduces triple-negative breast cancer aggression and increases drug sensitivity.

O'Brien K, Lowry MC, Corcoran C, Martinez VG, Daly M, Rani S, Gallagher WM, Radomski MW, MacLeod RA, O'Driscoll L.

Oncotarget. 2015 Oct 20;6(32):32774-89. doi: 10.18632/oncotarget.5192.

13.

Magnetic Nanoparticles in Cancer Theranostics.

Gobbo OL, Sjaastad K, Radomski MW, Volkov Y, Prina-Mello A.

Theranostics. 2015 Sep 1;5(11):1249-63. doi: 10.7150/thno.11544. eCollection 2015. Review.

14.

Pharmacological characterization of nanoparticle-induced platelet microaggregation using quartz crystal microbalance with dissipation: comparison with light aggregometry.

Santos-Martinez MJ, Tomaszewski KA, Medina C, Bazou D, Gilmer JF, Radomski MW.

Int J Nanomedicine. 2015 Aug 13;10:5107-19. doi: 10.2147/IJN.S84305. eCollection 2015.

15.

Biodistribution and pharmacokinetic studies of SPION using particle electron paramagnetic resonance, MRI and ICP-MS.

Gobbo OL, Wetterling F, Vaes P, Teughels S, Markos F, Edge D, Shortt CM, Crosbie-Staunton K, Radomski MW, Volkov Y, Prina-Mello A.

Nanomedicine (Lond). 2015;10(11):1751-60. doi: 10.2217/nnm.15.22.

PMID:
26080697
16.

Nanodiagnostics, nanopharmacology and nanotoxicology of platelet-vessel wall interactions.

Tomaszewski KA, Radomski MW, Santos-Martinez MJ.

Nanomedicine (Lond). 2015 May;10(9):1451-75. doi: 10.2217/nnm.14.232. Review.

PMID:
25996119
17.

CdTe quantum dots induce activation of human platelets: implications for nanoparticle hemocompatibility.

Samuel SP, Santos-Martinez MJ, Medina C, Jain N, Radomski MW, Prina-Mello A, Volkov Y.

Int J Nanomedicine. 2015 Apr 2;10:2723-34. doi: 10.2147/IJN.S78281. eCollection 2015.

18.

Titanium dioxide nanoparticles enhance production of superoxide anion and alter the antioxidant system in human osteoblast cells.

Niska K, Pyszka K, Tukaj C, Wozniak M, Radomski MW, Inkielewicz-Stepniak I.

Int J Nanomedicine. 2015 Feb 4;10:1095-107. doi: 10.2147/IJN.S73557. eCollection 2015.

19.

CuO nanoparticles induce apoptosis by impairing the antioxidant defense and detoxification systems in the mouse hippocampal HT22 cell line: protective effect of crocetin.

Niska K, Santos-Martinez MJ, Radomski MW, Inkielewicz-Stepniak I.

Toxicol In Vitro. 2015 Jun;29(4):663-71. doi: 10.1016/j.tiv.2015.02.004. Epub 2015 Feb 17.

PMID:
25701151
20.

Blood biocompatibility of surface-bound multi-walled carbon nanotubes.

Gaffney AM, Santos-Martinez MJ, Satti A, Major TC, Wynne KJ, Gun'ko YK, Annich GM, Elia G, Radomski MW.

Nanomedicine. 2015 Jan;11(1):39-46. doi: 10.1016/j.nano.2014.07.005. Epub 2014 Jul 27.

PMID:
25072378
21.

Pegylation increases platelet biocompatibility of gold nanoparticles.

Santos-Martinez MJ, Rahme K, Corbalan JJ, Faulkner C, Holmes JD, Tajber L, Medina C, Radomski MW.

J Biomed Nanotechnol. 2014 Jun;10(6):1004-15.

PMID:
24749395
22.

Pharmacological and toxicological effects of co-exposure of human gingival fibroblasts to silver nanoparticles and sodium fluoride.

Inkielewicz-Stepniak I, Santos-Martinez MJ, Medina C, Radomski MW.

Int J Nanomedicine. 2014 Apr 2;9:1677-87. doi: 10.2147/IJN.S59172. eCollection 2014.

23.

Nitric oxide-matrix metaloproteinase-9 interactions: biological and pharmacological significance--NO and MMP-9 interactions.

O'Sullivan S, Medina C, Ledwidge M, Radomski MW, Gilmer JF.

Biochim Biophys Acta. 2014 Mar;1843(3):603-17. Review.

24.

Mechanisms of platelet-stimulated colon cancer invasion: role of clusterin and thrombospondin 1 in regulation of the P38MAPK-MMP-9 pathway.

Radziwon-Balicka A, Santos-Martinez MJ, Corbalan JJ, O'Sullivan S, Treumann A, Gilmer JF, Radomski MW, Medina C.

Carcinogenesis. 2014 Feb;35(2):324-32. doi: 10.1093/carcin/bgt332. Epub 2013 Oct 1.

PMID:
24085798
25.

Platelets, photosensitizers, and PDT.

Senge MO, Radomski MW.

Photodiagnosis Photodyn Ther. 2013 Feb;10(1):1-16. doi: 10.1016/j.pdpdt.2012.08.004. Epub 2012 Sep 18. Review.

PMID:
23465367
26.

Exosomes from triple-negative breast cancer cells can transfer phenotypic traits representing their cells of origin to secondary cells.

O'Brien K, Rani S, Corcoran C, Wallace R, Hughes L, Friel AM, McDonnell S, Crown J, Radomski MW, O'Driscoll L.

Eur J Cancer. 2013 May;49(8):1845-59. doi: 10.1016/j.ejca.2013.01.017. Epub 2013 Feb 27.

PMID:
23453937
27.

Pharmacologic protein kinase Cα inhibition uncouples human platelet-stimulated angiogenesis from collagen-induced aggregation.

Moncada de la Rosa C, Radziwon-Balicka A, El-Sikhry H, Seubert J, Ruvolo PP, Radomski MW, Jurasz P.

J Pharmacol Exp Ther. 2013 Apr;345(1):15-24. doi: 10.1124/jpet.112.200881. Epub 2013 Feb 5.

PMID:
23386249
28.

Nanoparticle adhesion to the cell membrane and its effect on nanoparticle uptake efficiency.

Lesniak A, Salvati A, Santos-Martinez MJ, Radomski MW, Dawson KA, Åberg C.

J Am Chem Soc. 2013 Jan 30;135(4):1438-44. doi: 10.1021/ja309812z. Epub 2013 Jan 22.

PMID:
23301582
29.

MMP inhibition by barbiturate homodimers.

Wang J, Radomski MW, Medina C, Gilmer JF.

Bioorg Med Chem Lett. 2013 Jan 15;23(2):444-7. doi: 10.1016/j.bmcl.2012.11.063. Epub 2012 Nov 29.

PMID:
23246356
30.

Mechanisms of toxicity of amorphous silica nanoparticles on human lung submucosal cells in vitro: protective effects of fisetin.

McCarthy J, Inkielewicz-Stępniak I, Corbalan JJ, Radomski MW.

Chem Res Toxicol. 2012 Oct 15;25(10):2227-35. doi: 10.1021/tx3002884. Epub 2012 Sep 19.

PMID:
22931364
31.

Targeted delivery of transferrin-conjugated liposomes to an orthotopic model of lung cancer in nude rats.

Gaspar MM, Radomska A, Gobbo OL, Bakowsky U, Radomski MW, Ehrhardt C.

J Aerosol Med Pulm Drug Deliv. 2012 Dec;25(6):310-8. doi: 10.1089/jamp.2011.0928. Epub 2012 Aug 2.

PMID:
22857016
32.

Platelets increase survival of adenocarcinoma cells challenged with anticancer drugs: mechanisms and implications for chemoresistance.

Radziwon-Balicka A, Medina C, O'Driscoll L, Treumann A, Bazou D, Inkielewicz-Stepniak I, Radomski A, Jow H, Radomski MW.

Br J Pharmacol. 2012 Oct;167(4):787-804. doi: 10.1111/j.1476-5381.2012.01991.x.

33.

Amorphous silica nanoparticles aggregate human platelets: potential implications for vascular homeostasis.

Corbalan JJ, Medina C, Jacoby A, Malinski T, Radomski MW.

Int J Nanomedicine. 2012;7:631-9. doi: 10.2147/IJN.S28293. Epub 2012 Feb 7.

34.

The use of quartz crystal microbalance with dissipation (QCM-D) for studying nanoparticle-induced platelet aggregation.

Santos-Martinez MJ, Inkielewicz-Stepniak I, Medina C, Rahme K, D'Arcy DM, Fox D, Holmes JD, Zhang H, Radomski MW.

Int J Nanomedicine. 2012;7:243-55. doi: 10.2147/IJN.S26679. Epub 2012 Jan 13.

35.

Design of barbiturate-nitrate hybrids that inhibit MMP-9 activity and secretion.

Wang J, O'Sullivan S, Harmon S, Keaveny R, Radomski MW, Medina C, Gilmer JF.

J Med Chem. 2012 Mar 8;55(5):2154-62. doi: 10.1021/jm201352k. Epub 2012 Feb 23.

PMID:
22248361
36.

Fisetin prevents fluoride- and dexamethasone-induced oxidative damage in osteoblast and hippocampal cells.

Inkielewicz-Stepniak I, Radomski MW, Wozniak M.

Food Chem Toxicol. 2012 Mar;50(3-4):583-9. doi: 10.1016/j.fct.2011.12.015. Epub 2011 Dec 17.

PMID:
22198064
37.

Mechanisms of aggregation inhibition by aspirin and nitrate-aspirin prodrugs in human platelets.

Harmon S, Inkielewicz-Stepniak I, Jones M, Ledwidge M, Santos-Martinez MJ, Medina C, Radomski MW, Gilmer JF.

J Pharm Pharmacol. 2012 Jan;64(1):77-89. doi: 10.1111/j.2042-7158.2011.01380.x. Epub 2011 Nov 10.

PMID:
22150675
38.

Amorphous silica nanoparticles trigger nitric oxide/peroxynitrite imbalance in human endothelial cells: inflammatory and cytotoxic effects.

Corbalan JJ, Medina C, Jacoby A, Malinski T, Radomski MW.

Int J Nanomedicine. 2011;6:2821-35. doi: 10.2147/IJN.S25071. Epub 2011 Nov 9.

39.

Differential inhibition of tumour cell-induced platelet aggregation by the nicotinate aspirin prodrug (ST0702) and aspirin.

Medina C, Harmon S, Inkielewicz I, Santos-Martinez MJ, Jones M, Cantwell P, Bazou D, Ledwidge M, Radomski MW, Gilmer JF.

Br J Pharmacol. 2012 Jun;166(3):938-49. doi: 10.1111/j.1476-5381.2011.01794.x.

40.

Analysis of platelet function: role of microfluidics and nanodevices.

Santos-Martínez MJ, Prina-Mello A, Medina C, Radomski MW.

Analyst. 2011 Dec 21;136(24):5120-6. doi: 10.1039/c1an15445a. Epub 2011 Oct 26. Review.

PMID:
22029043
41.

Isolation of exosomes for subsequent mRNA, MicroRNA, and protein profiling.

Rani S, O'Brien K, Kelleher FC, Corcoran C, Germano S, Radomski MW, Crown J, O'Driscoll L.

Methods Mol Biol. 2011;784:181-95. doi: 10.1007/978-1-61779-289-2_13.

PMID:
21898221
42.

N-substituted homopiperazine barbiturates as gelatinase inhibitors.

Wang J, Medina C, Radomski MW, Gilmer JF.

Bioorg Med Chem. 2011 Aug 15;19(16):4985-99. doi: 10.1016/j.bmc.2011.06.055. Epub 2011 Jun 25.

PMID:
21764590
43.

Polystyrene nanoparticles activate ion transport in human airway epithelial cells.

McCarthy J, Gong X, Nahirney D, Duszyk M, Radomski M.

Int J Nanomedicine. 2011;6:1343-56. doi: 10.2147/IJN.S21145. Epub 2011 Jun 28.

44.

Elucidation of flow-mediated tumour cell-induced platelet aggregation using an ultrasound standing wave trap.

Bazou D, Santos-Martinez MJ, Medina C, Radomski MW.

Br J Pharmacol. 2011 Apr;162(7):1577-89. doi: 10.1111/j.1476-5381.2010.01182.x.

45.

Extracorporeal life support.

Gaffney AM, Wildhirt SM, Griffin MJ, Annich GM, Radomski MW.

BMJ. 2010 Nov 2;341:c5317. doi: 10.1136/bmj.c5317. Review. No abstract available.

PMID:
21045023
46.

Platelet compatibility of PLGA, chitosan and PLGA-chitosan nanoparticles.

Li X, Radomski A, Corrigan OI, Tajber L, De Sousa Menezes F, Endter S, Medina C, Radomski MW.

Nanomedicine (Lond). 2009 Oct;4(7):735-46. doi: 10.2217/nnm.09.65.

PMID:
19839810
47.

Isosorbide-based aspirin prodrugs: integration of nitric oxide releasing groups.

Jones M, Inkielewicz I, Medina C, Santos-Martinez MJ, Radomski A, Radomski MW, Lally MN, Moriarty LM, Gaynor J, Carolan CG, Khan D, O'Byrne P, Harmon S, Holland V, Clancy JM, Gilmer JF.

J Med Chem. 2009 Nov 12;52(21):6588-98. doi: 10.1021/jm900561s.

PMID:
19821574
48.

Characterisation of the R3/1 cell line as an alveolar epithelial cell model for drug disposition studies.

Horálková L, Radziwon A, Endter S, Andersen R, Koslowski R, Radomski MW, Dolezal P, Ehrhardt C.

Eur J Pharm Sci. 2009 Mar 2;36(4-5):444-50. doi: 10.1016/j.ejps.2008.11.010. Epub 2008 Dec 3.

PMID:
19103287
49.

Ceramide promotes apoptosis in chronic myelogenous leukemia-derived K562 cells by a mechanism involving caspase-8 and JNK.

Nica AF, Tsao CC, Watt JC, Jiffar T, Kurinna S, Jurasz P, Konopleva M, Andreeff M, Radomski MW, Ruvolo PP.

Cell Cycle. 2008 Nov 1;7(21):3362-70. Epub 2008 Nov 2.

50.

Long-term doxycycline is more effective than atenolol to prevent thoracic aortic aneurysm in marfan syndrome through the inhibition of matrix metalloproteinase-2 and -9.

Chung AW, Yang HH, Radomski MW, van Breemen C.

Circ Res. 2008 Apr 25;102(8):e73-85. doi: 10.1161/CIRCRESAHA.108.174367. Epub 2008 Apr 3.

PMID:
18388324

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