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Items: 1 to 50 of 208

1.

The RpoS Gatekeeper in Borrelia burgdorferi: An Invariant Regulatory Scheme That Promotes Spirochete Persistence in Reservoir Hosts and Niche Diversity.

Caimano MJ, Groshong AM, Belperron A, Mao J, Hawley KL, Luthra A, Graham DE, Earnhart CG, Marconi RT, Bockenstedt LK, Blevins JS, Radolf JD.

Front Microbiol. 2019 Aug 21;10:1923. doi: 10.3389/fmicb.2019.01923. eCollection 2019.

2.

Sequence Variation of Rare Outer Membrane Protein β-Barrel Domains in Clinical Strains Provides Insights into the Evolution of Treponema pallidum subsp. pallidum, the Syphilis Spirochete.

Kumar S, Caimano MJ, Anand A, Dey A, Hawley KL, LeDoyt ME, La Vake CJ, Cruz AR, Ramirez LG, Paštěková L, Bezsonova I, Šmajs D, Salazar JC, Radolf JD.

MBio. 2018 Jun 12;9(3). pii: e01006-18. doi: 10.1128/mBio.01006-18.

3.

Peptide Uptake Is Essential for Borrelia burgdorferi Viability and Involves Structural and Regulatory Complexity of its Oligopeptide Transporter.

Groshong AM, Dey A, Bezsonova I, Caimano MJ, Radolf JD.

MBio. 2017 Dec 19;8(6). pii: e02047-17. doi: 10.1128/mBio.02047-17.

4.

IFNγ Enhances CD64-Potentiated Phagocytosis of Treponema pallidum Opsonized with Human Syphilitic Serum by Human Macrophages.

Hawley KL, Cruz AR, Benjamin SJ, La Vake CJ, Cervantes JL, LeDoyt M, Ramirez LG, Mandich D, Fiel-Gan M, Caimano MJ, Radolf JD, Salazar JC.

Front Immunol. 2017 Oct 5;8:1227. doi: 10.3389/fimmu.2017.01227. eCollection 2017.

5.

The major outer sheath protein forms distinct conformers and multimeric complexes in the outer membrane and periplasm of Treponema denticola.

Puthenveetil R, Kumar S, Caimano MJ, Dey A, Anand A, Vinogradova O, Radolf JD.

Sci Rep. 2017 Oct 16;7(1):13260. doi: 10.1038/s41598-017-13550-6.

6.

Syphilis.

Peeling RW, Mabey D, Kamb ML, Chen XS, Radolf JD, Benzaken AS.

Nat Rev Dis Primers. 2017 Oct 12;3:17073. doi: 10.1038/nrdp.2017.73. Review.

7.

The Treponema pallidum Outer Membrane.

Radolf JD, Kumar S.

Curr Top Microbiol Immunol. 2018;415:1-38. doi: 10.1007/82_2017_44. Review.

8.

Two Distinct Mechanisms Govern RpoS-Mediated Repression of Tick-Phase Genes during Mammalian Host Adaptation by Borrelia burgdorferi, the Lyme Disease Spirochete.

Grove AP, Liveris D, Iyer R, Petzke M, Rudman J, Caimano MJ, Radolf JD, Schwartz I.

MBio. 2017 Aug 22;8(4). pii: e01204-17. doi: 10.1128/mBio.01204-17.

9.

Treponema pallidum, the syphilis spirochete: making a living as a stealth pathogen.

Radolf JD, Deka RK, Anand A, Šmajs D, Norgard MV, Yang XF.

Nat Rev Microbiol. 2016 Dec;14(12):744-759. doi: 10.1038/nrmicro.2016.141. Epub 2016 Oct 10. Review.

10.

Consensus computational network analysis for identifying candidate outer membrane proteins from Borrelia spirochetes.

Kenedy MR, Scott EJ 2nd, Shrestha B, Anand A, Iqbal H, Radolf JD, Dyer DW, Akins DR.

BMC Microbiol. 2016 Jul 11;16(1):141. doi: 10.1186/s12866-016-0762-z.

11.

Genomic insights into the Ixodes scapularis tick vector of Lyme disease.

Gulia-Nuss M, Nuss AB, Meyer JM, Sonenshine DE, Roe RM, Waterhouse RM, Sattelle DB, de la Fuente J, Ribeiro JM, Megy K, Thimmapuram J, Miller JR, Walenz BP, Koren S, Hostetler JB, Thiagarajan M, Joardar VS, Hannick LI, Bidwell S, Hammond MP, Young S, Zeng Q, Abrudan JL, Almeida FC, Ayllón N, Bhide K, Bissinger BW, Bonzon-Kulichenko E, Buckingham SD, Caffrey DR, Caimano MJ, Croset V, Driscoll T, Gilbert D, Gillespie JJ, Giraldo-Calderón GI, Grabowski JM, Jiang D, Khalil SMS, Kim D, Kocan KM, Koči J, Kuhn RJ, Kurtti TJ, Lees K, Lang EG, Kennedy RC, Kwon H, Perera R, Qi Y, Radolf JD, Sakamoto JM, Sánchez-Gracia A, Severo MS, Silverman N, Šimo L, Tojo M, Tornador C, Van Zee JP, Vázquez J, Vieira FG, Villar M, Wespiser AR, Yang Y, Zhu J, Arensburger P, Pietrantonio PV, Barker SC, Shao R, Zdobnov EM, Hauser F, Grimmelikhuijzen CJP, Park Y, Rozas J, Benton R, Pedra JHF, Nelson DR, Unger MF, Tubio JMC, Tu Z, Robertson HM, Shumway M, Sutton G, Wortman JR, Lawson D, Wikel SK, Nene VM, Fraser CM, Collins FH, Birren B, Nelson KE, Caler E, Hill CA.

Nat Commun. 2016 Feb 9;7:10507. doi: 10.1038/ncomms10507.

12.

A systematic review of syphilis serological treatment outcomes in HIV-infected and HIV-uninfected persons: rethinking the significance of serological non-responsiveness and the serofast state after therapy.

Seña AC, Zhang XH, Li T, Zheng HP, Yang B, Yang LG, Salazar JC, Cohen MS, Moody MA, Radolf JD, Tucker JD.

BMC Infect Dis. 2015 Oct 28;15:479. doi: 10.1186/s12879-015-1209-0.

13.

Treponema pallidum in Gel Microdroplets: A Method for Topological Analysis of BamA (TP0326) and Localization of Rare Outer Membrane Proteins.

Luthra A, Anand A, Radolf JD.

Methods Mol Biol. 2015;1329:67-75. doi: 10.1007/978-1-4939-2871-2_6.

PMID:
26427677
14.

Structural characterization and modeling of the Borrelia burgdorferi hybrid histidine kinase Hk1 periplasmic sensor: A system for sensing small molecules associated with tick feeding.

Bauer WJ, Luthra A, Zhu G, Radolf JD, Malkowski MG, Caimano MJ.

J Struct Biol. 2015 Oct;192(1):48-58. doi: 10.1016/j.jsb.2015.08.013. Epub 2015 Aug 28.

15.

Cyclic di-GMP modulates gene expression in Lyme disease spirochetes at the tick-mammal interface to promote spirochete survival during the blood meal and tick-to-mammal transmission.

Caimano MJ, Dunham-Ems S, Allard AM, Cassera MB, Kenedy M, Radolf JD.

Infect Immun. 2015 Aug;83(8):3043-60. doi: 10.1128/IAI.00315-15. Epub 2015 May 18.

16.

A Homology Model Reveals Novel Structural Features and an Immunodominant Surface Loop/Opsonic Target in the Treponema pallidum BamA Ortholog TP_0326.

Luthra A, Anand A, Hawley KL, LeDoyt M, La Vake CJ, Caimano MJ, Cruz AR, Salazar JC, Radolf JD.

J Bacteriol. 2015 Jun;197(11):1906-20. doi: 10.1128/JB.00086-15. Epub 2015 Mar 30.

17.

Bipartite Topology of Treponema pallidum Repeat Proteins C/D and I: OUTER MEMBRANE INSERTION, TRIMERIZATION, AND PORIN FUNCTION REQUIRE A C-TERMINAL β-BARREL DOMAIN.

Anand A, LeDoyt M, Karanian C, Luthra A, Koszelak-Rosenblum M, Malkowski MG, Puthenveetil R, Vinogradova O, Radolf JD.

J Biol Chem. 2015 May 8;290(19):12313-31. doi: 10.1074/jbc.M114.629188. Epub 2015 Mar 24.

18.

Stage-specific global alterations in the transcriptomes of Lyme disease spirochetes during tick feeding and following mammalian host adaptation.

Iyer R, Caimano MJ, Luthra A, Axline D Jr, Corona A, Iacobas DA, Radolf JD, Schwartz I.

Mol Microbiol. 2015 Feb;95(3):509-38. doi: 10.1111/mmi.12882. Epub 2014 Dec 30.

19.

Xenodiagnosis for posttreatment Lyme disease syndrome: resolving the conundrum or adding to it?

Bockenstedt LK, Radolf JD.

Clin Infect Dis. 2014 Apr;58(7):946-8. doi: 10.1093/cid/cit942. Epub 2014 Feb 11. No abstract available.

20.

Evaluation of the Borrelia burgdorferi BBA64 protein as a protective immunogen in mice.

Brandt KS, Patton TG, Allard AS, Caimano MJ, Radolf JD, Gilmore RD.

Clin Vaccine Immunol. 2014 Apr;21(4):526-33. doi: 10.1128/CVI.00824-13. Epub 2014 Feb 5.

21.

HrpA, an RNA helicase involved in RNA processing, is required for mouse infectivity and tick transmission of the Lyme disease spirochete.

Salman-Dilgimen A, Hardy PO, Radolf JD, Caimano MJ, Chaconas G.

PLoS Pathog. 2013;9(12):e1003841. doi: 10.1371/journal.ppat.1003841. Epub 2013 Dec 19.

22.

Structural modeling and physicochemical characterization provide evidence that P66 forms a β-barrel in the Borrelia burgdorferi outer membrane.

Kenedy MR, Luthra A, Anand A, Dunn JP, Radolf JD, Akins DR.

J Bacteriol. 2014 Feb;196(4):859-72. doi: 10.1128/JB.01236-13. Epub 2013 Dec 6.

23.

Viscous dynamics of Lyme disease and syphilis spirochetes reveal flagellar torque and drag.

Harman M, Vig DK, Radolf JD, Wolgemuth CW.

Biophys J. 2013 Nov 19;105(10):2273-80. doi: 10.1016/j.bpj.2013.10.004.

24.

MyD88 deficiency markedly worsens tissue inflammation and bacterial clearance in mice infected with Treponema pallidum, the agent of syphilis.

Silver AC, Dunne DW, Zeiss CJ, Bockenstedt LK, Radolf JD, Salazar JC, Fikrig E.

PLoS One. 2013 Aug 5;8(8):e71388. doi: 10.1371/journal.pone.0071388. Print 2013.

25.

The major outer sheath protein (Msp) of Treponema denticola has a bipartite domain architecture and exists as periplasmic and outer membrane-spanning conformers.

Anand A, Luthra A, Edmond ME, Ledoyt M, Caimano MJ, Radolf JD.

J Bacteriol. 2013 May;195(9):2060-71. doi: 10.1128/JB.00078-13. Epub 2013 Mar 1. Erratum in: J Bacteriol. 2014 Sep;196(18):3361.

26.

Pulling the trigger on lyme arthritis.

Radolf JD.

J Infect Dis. 2013 Mar 15;207(6):877-9. doi: 10.1093/infdis/jis931. Epub 2013 Jan 9. No abstract available. Erratum in: J Infect Dis.2013 Jul 15;208(2):366.

27.

Immune evasion and recognition of the syphilis spirochete in blood and skin of secondary syphilis patients: two immunologically distinct compartments.

Cruz AR, Ramirez LG, Zuluaga AV, Pillay A, Abreu C, Valencia CA, La Vake C, Cervantes JL, Dunham-Ems S, Cartun R, Mavilio D, Radolf JD, Salazar JC.

PLoS Negl Trop Dis. 2012;6(7):e1717. doi: 10.1371/journal.pntd.0001717. Epub 2012 Jul 17.

28.

TprC/D (Tp0117/131), a trimeric, pore-forming rare outer membrane protein of Treponema pallidum, has a bipartite domain structure.

Anand A, Luthra A, Dunham-Ems S, Caimano MJ, Karanian C, LeDoyt M, Cruz AR, Salazar JC, Radolf JD.

J Bacteriol. 2012 May;194(9):2321-33. doi: 10.1128/JB.00101-12. Epub 2012 Mar 2. Erratum in: J Bacteriol. 2014 Sep;196(18):3360.

29.

Borrelia burgdorferi requires the alternative sigma factor RpoS for dissemination within the vector during tick-to-mammal transmission.

Dunham-Ems SM, Caimano MJ, Eggers CH, Radolf JD.

PLoS Pathog. 2012 Feb;8(2):e1002532. doi: 10.1371/journal.ppat.1002532. Epub 2012 Feb 16.

30.

The heterogeneous motility of the Lyme disease spirochete in gelatin mimics dissemination through tissue.

Harman MW, Dunham-Ems SM, Caimano MJ, Belperron AA, Bockenstedt LK, Fu HC, Radolf JD, Wolgemuth CW.

Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):3059-64. doi: 10.1073/pnas.1114362109. Epub 2012 Feb 6.

31.

CD14 cooperates with complement receptor 3 to mediate MyD88-independent phagocytosis of Borrelia burgdorferi.

Hawley KL, Olson CM Jr, Iglesias-Pedraz JM, Navasa N, Cervantes JL, Caimano MJ, Izadi H, Ingalls RR, Pal U, Salazar JC, Radolf JD, Anguita J.

Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):1228-32. doi: 10.1073/pnas.1112078109. Epub 2012 Jan 9.

32.

Of ticks, mice and men: understanding the dual-host lifestyle of Lyme disease spirochaetes.

Radolf JD, Caimano MJ, Stevenson B, Hu LT.

Nat Rev Microbiol. 2012 Jan 9;10(2):87-99. doi: 10.1038/nrmicro2714. Review.

33.

The transition from closed to open conformation of Treponema pallidum outer membrane-associated lipoprotein TP0453 involves membrane sensing and integration by two amphipathic helices.

Luthra A, Zhu G, Desrosiers DC, Eggers CH, Mulay V, Anand A, McArthur FA, Romano FB, Caimano MJ, Heuck AP, Malkowski MG, Radolf JD.

J Biol Chem. 2011 Dec 2;286(48):41656-68. doi: 10.1074/jbc.M111.305284. Epub 2011 Sep 29.

34.

The coenzyme A disulphide reductase of Borrelia burgdorferi is important for rapid growth throughout the enzootic cycle and essential for infection of the mammalian host.

Eggers CH, Caimano MJ, Malizia RA, Kariu T, Cusack B, Desrosiers DC, Hazlett KR, Claiborne A, Pal U, Radolf JD.

Mol Microbiol. 2011 Nov;82(3):679-97. doi: 10.1111/j.1365-2958.2011.07845.x. Epub 2011 Oct 12.

35.

Serodiagnosis of syphilis in the recombinant era: reversal of fortune.

Hoover KW, Radolf JD.

J Infect Dis. 2011 Nov;204(9):1295-6. doi: 10.1093/infdis/jir528. Epub 2011 Sep 15. No abstract available.

36.

Borrelia burgdorferi requires glycerol for maximum fitness during the tick phase of the enzootic cycle.

Pappas CJ, Iyer R, Petzke MM, Caimano MJ, Radolf JD, Schwartz I.

PLoS Pathog. 2011 Jul;7(7):e1002102. doi: 10.1371/journal.ppat.1002102. Epub 2011 Jul 7.

37.

The hybrid histidine kinase Hk1 is part of a two-component system that is essential for survival of Borrelia burgdorferi in feeding Ixodes scapularis ticks.

Caimano MJ, Kenedy MR, Kairu T, Desrosiers DC, Harman M, Dunham-Ems S, Akins DR, Pal U, Radolf JD.

Infect Immun. 2011 Aug;79(8):3117-30. doi: 10.1128/IAI.05136-11. Epub 2011 May 23.

38.

TP0326, a Treponema pallidum β-barrel assembly machinery A (BamA) orthologue and rare outer membrane protein.

Desrosiers DC, Anand A, Luthra A, Dunham-Ems SM, LeDoyt M, Cummings MA, Eshghi A, Cameron CE, Cruz AR, Salazar JC, Caimano MJ, Radolf JD.

Mol Microbiol. 2011 Jun;80(6):1496-515. doi: 10.1111/j.1365-2958.2011.07662.x. Epub 2011 Apr 27.

39.

Treponema.

Radolf JD.

In: Baron S, editor. Medical Microbiology. 4th edition. Galveston (TX): University of Texas Medical Branch at Galveston; 1996. Chapter 36.

40.

Phagosomal signaling by Borrelia burgdorferi in human monocytes involves Toll-like receptor (TLR) 2 and TLR8 cooperativity and TLR8-mediated induction of IFN-beta.

Cervantes JL, Dunham-Ems SM, La Vake CJ, Petzke MM, Sahay B, Sellati TJ, Radolf JD, Salazar JC.

Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3683-8. doi: 10.1073/pnas.1013776108. Epub 2011 Feb 14.

41.

BB0844, an RpoS-regulated protein, is dispensable for Borrelia burgdorferi infectivity and maintenance in the mouse-tick infectious cycle.

Banik S, Terekhova D, Iyer R, Pappas CJ, Caimano MJ, Radolf JD, Schwartz I.

Infect Immun. 2011 Mar;79(3):1208-17. doi: 10.1128/IAI.01156-10. Epub 2010 Dec 20.

42.

A TFIIH-associated mediator head is a basal factor of small nuclear spliced leader RNA gene transcription in early-diverged trypanosomes.

Lee JH, Cai G, Panigrahi AK, Dunham-Ems S, Nguyen TN, Radolf JD, Asturias FJ, Günzl A.

Mol Cell Biol. 2010 Dec;30(23):5502-13. doi: 10.1128/MCB.00966-10. Epub 2010 Sep 27.

43.

Surface immunolabeling and consensus computational framework to identify candidate rare outer membrane proteins of Treponema pallidum.

Cox DL, Luthra A, Dunham-Ems S, Desrosiers DC, Salazar JC, Caimano MJ, Radolf JD.

Infect Immun. 2010 Dec;78(12):5178-94. doi: 10.1128/IAI.00834-10. Epub 2010 Sep 27.

44.

Role of acetyl-phosphate in activation of the Rrp2-RpoN-RpoS pathway in Borrelia burgdorferi.

Xu H, Caimano MJ, Lin T, He M, Radolf JD, Norris SJ, Gherardini F, Wolfe AJ, Yang XF.

PLoS Pathog. 2010 Sep 16;6(9):e1001104. doi: 10.1371/journal.ppat.1001104. Erratum in: PLoS Pathog. 2010 Dec 14;6(12). doi: 10.1371/annotation/88293342-3534-4b8b-8800-c63a8c86bf6d. Gheradini, Frank [corrected to Gherardini, Frank].

45.

Znu is the predominant zinc importer in Yersinia pestis during in vitro growth but is not essential for virulence.

Desrosiers DC, Bearden SW, Mier I Jr, Abney J, Paulley JT, Fetherston JD, Salazar JC, Radolf JD, Perry RD.

Infect Immun. 2010 Dec;78(12):5163-77. doi: 10.1128/IAI.00732-10. Epub 2010 Sep 20.

46.

Secondary syphilis in cali, Colombia: new concepts in disease pathogenesis.

Cruz AR, Pillay A, Zuluaga AV, Ramirez LG, Duque JE, Aristizabal GE, Fiel-Gan MD, Jaramillo R, Trujillo R, Valencia C, Jagodzinski L, Cox DL, Radolf JD, Salazar JC.

PLoS Negl Trop Dis. 2010 May 18;4(5):e690. doi: 10.1371/journal.pntd.0000690.

47.

Broad specificity AhpC-like peroxiredoxin and its thioredoxin reductant in the sparse antioxidant defense system of Treponema pallidum.

Parsonage D, Desrosiers DC, Hazlett KR, Sun Y, Nelson KJ, Cox DL, Radolf JD, Poole LB.

Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6240-5. doi: 10.1073/pnas.0910057107. Epub 2010 Mar 19.

48.

Identification of residues within ligand-binding domain 1 (LBD1) of the Borrelia burgdorferi OspC protein required for function in the mammalian environment.

Earnhart CG, Leblanc DV, Alix KE, Desrosiers DC, Radolf JD, Marconi RT.

Mol Microbiol. 2010 Apr;76(2):393-408. doi: 10.1111/j.1365-2958.2010.07103.x. Epub 2010 Feb 28.

49.

CD14 signaling restrains chronic inflammation through induction of p38-MAPK/SOCS-dependent tolerance.

Sahay B, Patsey RL, Eggers CH, Salazar JC, Radolf JD, Sellati TJ.

PLoS Pathog. 2009 Dec;5(12):e1000687. doi: 10.1371/journal.ppat.1000687. Epub 2009 Dec 11.

50.

Who is the BosR around here anyway?

Samuels DS, Radolf JD.

Mol Microbiol. 2009 Dec;74(6):1295-9. doi: 10.1111/j.1365-2958.2009.06971.x. Epub 2009 Nov 25.

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