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Items: 13

1.

Protease-activated receptor 2 deficiency mediates cardiac fibrosis and diastolic dysfunction.

Friebel J, Weithauser A, Witkowski M, Rauch BH, Savvatis K, Dörner A, Tabaraie T, Kasner M, Moos V, Bösel D, Gotthardt M, Radke MH, Wegner M, Bobbert P, Lassner D, Tschöpe C, Schutheiss HP, Felix SB, Landmesser U, Rauch U.

Eur Heart J. 2019 Apr 19. pii: ehz117. doi: 10.1093/eurheartj/ehz117. [Epub ahead of print]

PMID:
31004144
2.

Deleting Full Length Titin Versus the Titin M-Band Region Leads to Differential Mechanosignaling and Cardiac Phenotypes.

Radke MH, Polack C, Methawasin M, Fink C, Granzier HL, Gotthardt M.

Circulation. 2019 Apr 9;139(15):1813-1827. doi: 10.1161/CIRCULATIONAHA.118.037588.

PMID:
30700140
3.

Drug discovery with an RBM20 dependent titin splice reporter identifies cardenolides as lead structures to improve cardiac filling.

Liss M, Radke MH, Eckhard J, Neuenschwander M, Dauksaite V, von Kries JP, Gotthardt M.

PLoS One. 2018 Jun 11;13(6):e0198492. doi: 10.1371/journal.pone.0198492. eCollection 2018.

4.

Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat.

Park TJ, Reznick J, Peterson BL, Blass G, Omerbašić D, Bennett NC, Kuich PHJL, Zasada C, Browe BM, Hamann W, Applegate DT, Radke MH, Kosten T, Lutermann H, Gavaghan V, Eigenbrod O, Bégay V, Amoroso VG, Govind V, Minshall RD, Smith ESJ, Larson J, Gotthardt M, Kempa S, Lewin GR.

Science. 2017 Apr 21;356(6335):307-311. doi: 10.1126/science.aab3896.

PMID:
28428423
5.

Reducing RBM20 activity improves diastolic dysfunction and cardiac atrophy.

Hinze F, Dieterich C, Radke MH, Granzier H, Gotthardt M.

J Mol Med (Berl). 2016 Dec;94(12):1349-1358. Epub 2016 Nov 26.

6.

Deletion of the titin N2B region accelerates myofibrillar force development but does not alter relaxation kinetics.

Elhamine F, Radke MH, Pfitzer G, Granzier H, Gotthardt M, Stehle R.

J Cell Sci. 2014 Sep 1;127(Pt 17):3666-74. doi: 10.1242/jcs.141796. Epub 2014 Jun 30.

7.

RNA-binding protein RBM20 represses splicing to orchestrate cardiac pre-mRNA processing.

Maatz H, Jens M, Liss M, Schafer S, Heinig M, Kirchner M, Adami E, Rintisch C, Dauksaite V, Radke MH, Selbach M, Barton PJ, Cook SA, Rajewsky N, Gotthardt M, Landthaler M, Hubner N.

J Clin Invest. 2014 Aug;124(8):3419-30. doi: 10.1172/JCI74523. Epub 2014 Jun 24.

8.

RBM20, a gene for hereditary cardiomyopathy, regulates titin splicing.

Guo W, Schafer S, Greaser ML, Radke MH, Liss M, Govindarajan T, Maatz H, Schulz H, Li S, Parrish AM, Dauksaite V, Vakeel P, Klaassen S, Gerull B, Thierfelder L, Regitz-Zagrosek V, Hacker TA, Saupe KW, Dec GW, Ellinor PT, MacRae CA, Spallek B, Fischer R, Perrot A, Özcelik C, Saar K, Hubner N, Gotthardt M.

Nat Med. 2012 May;18(5):766-73. doi: 10.1038/nm.2693.

9.

Titin based viscosity in ventricular physiology: an integrative investigation of PEVK-actin interactions.

Chung CS, Methawasin M, Nelson OL, Radke MH, Hidalgo CG, Gotthardt M, Granzier HL.

J Mol Cell Cardiol. 2011 Sep;51(3):428-34. doi: 10.1016/j.yjmcc.2011.06.006. Epub 2011 Jun 16.

10.

Titin visualization in real time reveals an unexpected level of mobility within and between sarcomeres.

da Silva Lopes K, Pietas A, Radke MH, Gotthardt M.

J Cell Biol. 2011 May 16;193(4):785-98. doi: 10.1083/jcb.201010099. Epub 2011 May 9.

11.

Truncation of titin's elastic PEVK region leads to cardiomyopathy with diastolic dysfunction.

Granzier HL, Radke MH, Peng J, Westermann D, Nelson OL, Rost K, King NM, Yu Q, Tschöpe C, McNabb M, Larson DF, Labeit S, Gotthardt M.

Circ Res. 2009 Sep 11;105(6):557-64. doi: 10.1161/CIRCRESAHA.109.200964. Epub 2009 Aug 13.

12.

The tight junction protein CAR regulates cardiac conduction and cell-cell communication.

Lisewski U, Shi Y, Wrackmeyer U, Fischer R, Chen C, Schirdewan A, Jüttner R, Rathjen F, Poller W, Radke MH, Gotthardt M.

J Exp Med. 2008 Sep 29;205(10):2369-79. doi: 10.1084/jem.20080897. Epub 2008 Sep 15.

13.

Targeted deletion of titin N2B region leads to diastolic dysfunction and cardiac atrophy.

Radke MH, Peng J, Wu Y, McNabb M, Nelson OL, Granzier H, Gotthardt M.

Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3444-9. Epub 2007 Feb 20.

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