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Items: 1 to 50 of 192

1.

Hydrolytic pathway protects against ceramide-induced apoptosis in keratinocytes exposed to UVB.

Uchida Y, Houben E, Park K, Douangpanya S, Lee YM, Wu BX, Hannun YA, Radin NS, Elias PM, Holleran WM.

J Invest Dermatol. 2010 Oct;130(10):2472-80. doi: 10.1038/jid.2010.153. Epub 2010 Jun 3.

2.

New antitumor imidazo[2,1-b]thiazole guanylhydrazones and analogues.

Andreani A, Burnelli S, Granaiola M, Leoni A, Locatelli A, Morigi R, Rambaldi M, Varoli L, Calonghi N, Cappadone C, Farruggia G, Zini M, Stefanelli C, Masotti L, Radin NS, Shoemaker RH.

J Med Chem. 2008 Feb 28;51(4):809-16. doi: 10.1021/jm701246g. Epub 2008 Feb 6.

PMID:
18251494
3.

Allylic structures in cancer drugs and body metabolites that control cell life and death.

Radin NS.

Expert Opin Drug Discov. 2007 Jun;2(6):809-21. doi: 10.1517/17460441.2.6.809.

PMID:
23488999
4.

Meta-analysis of anticancer drug structures--significance of their polar allylic moieties.

Radin NS.

Anticancer Agents Med Chem. 2007 Mar;7(2):209-22. Review.

PMID:
17348828
5.

Preventing the binding of pathogens to the host by controlling sphingolipid metabolism.

Radin NS.

Microbes Infect. 2006 Mar;8(3):938-45. Epub 2006 Jan 13. Review.

PMID:
16460984
6.

Sphingolipids as coenzymes in anion transfer and tumor death.

Radin NS.

Bioorg Med Chem. 2004 Dec 1;12(23):6029-37. Review.

PMID:
15519148
7.

Poly-drug cancer therapy based on ceramide.

Radin NS.

Eksp Onkol. 2004 Mar;26(1):3-10. Review.

PMID:
15112572
8.

Designing anticancer drugs via the achilles heel: ceramide, allylic ketones, and mitochondria.

Radin NS.

Bioorg Med Chem. 2003 May 15;11(10):2123-42. Review.

PMID:
12713822
9.

Infections and glycolipids.

Radin NS.

Postgrad Med J. 2003 Mar;79(929):185. No abstract available.

10.

Killing tumours by ceramide-induced apoptosis: a critique of available drugs.

Radin NS.

Biochem J. 2003 Apr 15;371(Pt 2):243-56. Review.

11.

Cancer progression in the kidney and prostate: vital roles of sphingolipids in chemotherapy.

Radin NS.

Urology. 2002 Oct;60(4):562-8. Review. No abstract available.

PMID:
12385907
12.

The development of aggressive cancer: a possible role for sphingolipids.

Radin NS.

Cancer Invest. 2002;20(5-6):779-86. Review. No abstract available.

PMID:
12197236
13.

Apoptotic death by ceramide: will the real killer please stand up?

Radin NS.

Med Hypotheses. 2001 Jul;57(1):96-100.

PMID:
11421634
14.
15.
17.

Chemotherapy by slowing glucosphingolipid synthesis.

Radin NS.

Biochem Pharmacol. 1999 Mar 15;57(6):589-95. Review.

PMID:
10037442
18.

Effect of an inhibitor of glucosylceramide synthesis on cultured human keratinocytes.

Takami Y, Abe A, Matsuda T, Shayman JA, Radin NS, Walter RJ.

J Dermatol. 1998 Feb;25(2):73-7.

19.

Ceramide glycanase from rat mammary tissues: inhibition by PPMP(D-/L-) and its probable role in signal transduction.

Basu M, Girzadas M, Dastgheib S, Baker J, Rossi F, Radin NS, Basu S.

Indian J Biochem Biophys. 1997 Feb-Apr;34(1-2):142-9.

PMID:
9343942
20.
21.
22.

Treatment of Gaucher disease with an enzyme inhibitor.

Radin NS.

Glycoconj J. 1996 Apr;13(2):153-7. Review.

23.

Glycosphingolipid synthesis and proliferation in a renal cell line grown in high glucose.

el-Khatib M, Radin NS, Shayman JA.

Am J Physiol. 1996 Mar;270(3 Pt 2):F476-84.

PMID:
8780251
24.

Induction of glucosylceramide synthase by synthase inhibitors and ceramide.

Abe A, Radin NS, Shayman JA.

Biochim Biophys Acta. 1996 Feb 16;1299(3):333-41.

PMID:
8597588
25.

Structural and stereochemical studies of potent inhibitors of glucosylceramide synthase and tumor cell growth.

Abe A, Radin NS, Shayman JA, Wotring LL, Zipkin RE, Sivakumar R, Ruggieri JM, Carson KG, Ganem B.

J Lipid Res. 1995 Mar;36(3):611-21.

26.

Cell cycle arrest induced by an inhibitor of glucosylceramide synthase. Correlation with cyclin-dependent kinases.

Rani CS, Abe A, Chang Y, Rosenzweig N, Saltiel AR, Radin NS, Shayman JA.

J Biol Chem. 1995 Feb 10;270(6):2859-67.

27.

Epithelial glucosphingolipid expression as a determinant of bacterial adherence and cytokine production.

Svensson M, Lindstedt R, Radin NS, Svanborg C.

Infect Immun. 1994 Oct;62(10):4404-10.

28.

Abnormalities of glycosphingolipid, sulfatide, and ceramide in the polycystic (cpk/cpk) mouse.

Deshmukh GD, Radin NS, Gattone VH 2nd, Shayman JA.

J Lipid Res. 1994 Sep;35(9):1611-8.

29.

Glucosylceramide in the nervous system--a mini-review.

Radin NS.

Neurochem Res. 1994 May;19(5):533-40. Review. No abstract available.

30.
31.

A role for glycosphingolipid accumulation in the renal hypertrophy of streptozotocin-induced diabetes mellitus.

Zador IZ, Deshmukh GD, Kunkel R, Johnson K, Radin NS, Shayman JA.

J Clin Invest. 1993 Mar;91(3):797-803.

32.

Metabolic effects of inhibiting glucosylceramide synthesis with PDMP and other substances.

Radin NS, Shayman JA, Inokuchi J.

Adv Lipid Res. 1993;26:183-213. Review. No abstract available.

PMID:
8379450
33.

Metabolic effects of short-chain ceramide and glucosylceramide on sphingolipids and protein kinase C.

Abe A, Wu D, Shayman JA, Radin NS.

Eur J Biochem. 1992 Dec 15;210(3):765-73.

34.

Fluorescence assay of glucosylceramide glucosidase using NBD-cerebroside.

Abe A, Shayman JA, Radin NS.

Lipids. 1992 Dec;27(12):1052-4.

35.

Glycolipid depletion using a ceramide analogue (PDMP) alters growth, adhesion, and membrane lipid organization in human A431 cells.

Barbour S, Edidin M, Felding-Habermann B, Taylor-Norton J, Radin NS, Fenderson BA.

J Cell Physiol. 1992 Mar;150(3):610-9.

PMID:
1537889
36.

Decreased formation of inositol trisphosphate in Madin-Darby canine kidney cells under conditions of beta-glucosidase inhibition.

Mahdiyoun S, Deshmukh GD, Abe A, Radin NS, Shayman JA.

Arch Biochem Biophys. 1992 Feb 1;292(2):506-11.

37.

A ceramide analogue (PDMP) inhibits glycolipid synthesis in fish embryos.

Fenderson BA, Ostrander GK, Hausken Z, Radin NS, Hakomori S.

Exp Cell Res. 1992 Feb;198(2):362-6.

38.

Improved inhibitors of glucosylceramide synthase.

Abe A, Inokuchi J, Jimbo M, Shimeno H, Nagamatsu A, Shayman JA, Shukla GS, Radin NS.

J Biochem. 1992 Feb;111(2):191-6.

39.

Control of kidney size by sex hormones: possible involvement of glucosylceramide.

Shukla A, Shukla GS, Radin NS.

Am J Physiol. 1992 Jan;262(1 Pt 2):F24-9.

PMID:
1733293
40.

Modulation of renal epithelial cell growth by glucosylceramide. Association with protein kinase C, sphingosine, and diacylglycerol.

Shayman JA, Deshmukh GD, Mahdiyoun S, Thomas TP, Wu D, Barcelon FS, Radin NS.

J Biol Chem. 1991 Dec 5;266(34):22968-74.

41.

Ceramide stimulates epidermal growth factor receptor phosphorylation in A431 human epidermoid carcinoma cells. Evidence that ceramide may mediate sphingosine action.

Goldkorn T, Dressler KA, Muindi J, Radin NS, Mendelsohn J, Menaldino D, Liotta D, Kolesnick RN.

J Biol Chem. 1991 Aug 25;266(24):16092-7.

42.

Gangliosides inhibit glucosylceramide synthase: a possible role in ganglioside therapy.

Shukla GS, Shukla A, Radin NS.

J Neurochem. 1991 Jun;56(6):2125-32.

43.

Rapid kidney changes resulting from glycosphingolipid depletion by treatment with a glucosyltransferase inhibitor.

Shukla GS, Shukla A, Inokuchi J, Radin NS.

Biochim Biophys Acta. 1991 Apr 24;1083(1):101-8.

45.

Structure and function of renal glycosphingolipids.

Shayman JA, Radin NS.

Am J Physiol. 1991 Mar;260(3 Pt 2):F291-302. Review. No abstract available.

PMID:
2000947
46.

Ultrasonic baths as substitutes for shaking incubator baths.

Radin NS, Shukla GS.

Enzyme. 1991;45(1-2):67-70.

PMID:
1806368
47.
48.

Preparative scale isolation of sphingosine.

Radin NS.

J Lipid Res. 1990 Dec;31(12):2291-3.

49.
50.

Effect of an inhibitor of glucosylceramide synthesis on cultured rabbit skin fibroblasts.

Uemura K, Sugiyama E, Tamai C, Hara A, Taketomi T, Radin NS.

J Biochem. 1990 Oct;108(4):525-30.

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