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Identification of the periplasmic DNA receptor for natural transformation of Helicobacter pylori.

Damke PP, Di Guilmi AM, Varela PF, Velours C, Marsin S, Veaute X, Machouri M, Gunjal GV, Rao DN, Charbonnier JB, Radicella JP.

Nat Commun. 2019 Nov 25;10(1):5357. doi: 10.1038/s41467-019-13352-6.


Prion protein deficiency impairs hematopoietic stem cells determination and sensitizes myeloid progenitors to irradiation.

Siberchicot C, Gault N, Déchamps N, Barroca V, Aguzzi A, Roméo PH, Radicella JP, Bravard A, Bernardino-Sgherri J.

Haematologica. 2019 Aug 1. pii: haematol.2018.205716. doi: 10.3324/haematol.2018.205716. [Epub ahead of print]


Identification of an XRCC1 DNA binding activity essential for retention at sites of DNA damage.

Mok MCY, Campalans A, Pillon MC, Guarné A, Radicella JP, Junop MS.

Sci Rep. 2019 Feb 28;9(1):3095. doi: 10.1038/s41598-019-39543-1.


The C-terminal domain of HpDprA is a DNA-binding winged helix domain that does not bind double-stranded DNA.

Lisboa J, Celma L, Sanchez D, Marquis M, Andreani J, Guérois R, Ochsenbein F, Durand D, Marsin S, Cuniasse P, Radicella JP, Quevillon-Cheruel S.

FEBS J. 2019 May;286(10):1941-1958. doi: 10.1111/febs.14788. Epub 2019 Mar 6.


The transcription-coupled DNA repair-initiating protein CSB promotes XRCC1 recruitment to oxidative DNA damage.

Menoni H, Wienholz F, Theil AF, Janssens RC, Lans H, Campalans A, Radicella JP, Marteijn JA, Vermeulen W.

Nucleic Acids Res. 2018 Sep 6;46(15):7747-7756. doi: 10.1093/nar/gky579.


Mitochondrial maintenance under oxidative stress depends on mitochondrially localised α-OGG1.

Lia D, Reyes A, de Melo Campos JTA, Piolot T, Baijer J, Radicella JP, Campalans A.

J Cell Sci. 2018 Jun 25;131(12). pii: jcs213538. doi: 10.1242/jcs.213538.


Structural basis for the substrate selectivity of Helicobacter pylori NucT nuclease activity.

Celma L, Corbinais C, Vercruyssen J, Veaute X, de la Sierra-Gallay IL, Guérois R, Busso D, Mathieu A, Marsin S, Quevillon-Cheruel S, Radicella JP.

PLoS One. 2017 Dec 4;12(12):e0189049. doi: 10.1371/journal.pone.0189049. eCollection 2017.


Incorporating interaction networks into the determination of functionally related hit genes in genomic experiments with Markov random fields.

Robinson S, Nevalainen J, Pinna G, Campalans A, Radicella JP, Guyon L.

Bioinformatics. 2017 Jul 15;33(14):i170-i179. doi: 10.1093/bioinformatics/btx244.


ComB proteins expression levels determine Helicobacter pylori competence capacity.

Corbinais C, Mathieu A, Damke PP, Kortulewski T, Busso D, Prado-Acosta M, Radicella JP, Marsin S.

Sci Rep. 2017 Jan 27;7:41495. doi: 10.1038/srep41495.


A threshold of endogenous stress is required to engage cellular response to protect against mutagenesis.

Saintigny Y, Chevalier F, Bravard A, Dardillac E, Laurent D, Hem S, Dépagne J, Radicella JP, Lopez BS.

Sci Rep. 2016 Jul 11;6:29412. doi: 10.1038/srep29412.


Following transforming DNA in Helicobacter pylori from uptake to expression.

Corbinais C, Mathieu A, Kortulewski T, Radicella JP, Marsin S.

Mol Microbiol. 2016 Sep;101(6):1039-53. doi: 10.1111/mmi.13440. Epub 2016 Jul 8.


XPC deficiency is related to APE1 and OGG1 expression and function.

de Melo JT, de Souza Timoteo AR, Lajus TB, Brandão JA, de Souza-Pinto NC, Menck CF, Campalans A, Radicella JP, Vessoni AT, Muotri AR, Agnez-Lima LF.

Mutat Res. 2016 Feb-Mar;784-785:25-33. doi: 10.1016/j.mrfmmm.2016.01.004. Epub 2016 Jan 16.


Φ-score: A cell-to-cell phenotypic scoring method for sensitive and selective hit discovery in cell-based assays.

Guyon L, Lajaunie C, Fer F, Bhajun R, Sulpice E, Pinna G, Campalans A, Radicella JP, Rouillier P, Mary M, Combe S, Obeid P, Vert JP, Gidrol X.

Sci Rep. 2015 Sep 18;5:14221. doi: 10.1038/srep14221.


E2F1 and E2F2 induction in response to DNA damage preserves genomic stability in neuronal cells.

Castillo DS, Campalans A, Belluscio LM, Carcagno AL, Radicella JP, Cánepa ET, Pregi N.

Cell Cycle. 2015;14(8):1300-14. doi: 10.4161/15384101.2014.985031.


The nuclease activities of both the Smr domain and an additional LDLK motif are required for an efficient anti-recombination function of Helicobacter pylori MutS2.

Damke PP, Dhanaraju R, Marsin S, Radicella JP, Rao DN.

Mol Microbiol. 2015 Jun;96(6):1240-56. doi: 10.1111/mmi.13003. Epub 2015 Apr 23.


Interaction with OGG1 is required for efficient recruitment of XRCC1 to base excision repair and maintenance of genetic stability after exposure to oxidative stress.

Campalans A, Moritz E, Kortulewski T, Biard D, Epe B, Radicella JP.

Mol Cell Biol. 2015 May;35(9):1648-58. doi: 10.1128/MCB.00134-15. Epub 2015 Mar 2.


The prion protein is critical for DNA repair and cell survival after genotoxic stress.

Bravard A, Auvré F, Fantini D, Bernardino-Sgherri J, Sissoëff L, Daynac M, Xu Z, Etienne O, Dehen C, Comoy E, Boussin FD, Tell G, Deslys JP, Radicella JP.

Nucleic Acids Res. 2015 Jan;43(2):904-16. doi: 10.1093/nar/gku1342. Epub 2014 Dec 24.


Nuclear translocation of p19INK4d in response to oxidative DNA damage promotes chromatin relaxation.

Sonzogni SV, Ogara MF, Castillo DS, Sirkin PF, Radicella JP, Cánepa ET.

Mol Cell Biochem. 2015 Jan;398(1-2):63-72. doi: 10.1007/s11010-014-2205-1. Epub 2014 Sep 10.


hOGG1-Cys326 variant cells are hypersensitive to DNA repair inhibition by nitric oxide.

Moritz E, Pauly K, Bravard A, Hall J, Radicella JP, Epe B.

Carcinogenesis. 2014 Jun;35(6):1426-33. doi: 10.1093/carcin/bgu066. Epub 2014 Mar 14.


Replication fork collapse is a major cause of the high mutation frequency at three-base lesion clusters.

Sedletska Y, Radicella JP, Sage E.

Nucleic Acids Res. 2013 Nov;41(20):9339-48. doi: 10.1093/nar/gkt731. Epub 2013 Aug 13.


Distinct spatiotemporal patterns and PARP dependence of XRCC1 recruitment to single-strand break and base excision repair.

Campalans A, Kortulewski T, Amouroux R, Menoni H, Vermeulen W, Radicella JP.

Nucleic Acids Res. 2013 Mar 1;41(5):3115-29. doi: 10.1093/nar/gkt025. Epub 2013 Jan 25.


Rapid inactivation and proteasome-mediated degradation of OGG1 contribute to the synergistic effect of hyperthermia on genotoxic treatments.

Fantini D, Moritz E, Auvré F, Amouroux R, Campalans A, Epe B, Bravard A, Radicella JP.

DNA Repair (Amst). 2013 Mar 1;12(3):227-37. doi: 10.1016/j.dnarep.2012.12.006. Epub 2013 Jan 15.


Biochemical and cellular characterization of Helicobacter pylori RecA, a protein with high-level constitutive expression.

Orillard E, Radicella JP, Marsin S.

J Bacteriol. 2011 Dec;193(23):6490-7. doi: 10.1128/JB.05646-11. Epub 2011 Sep 23.


Unexpected role for Helicobacter pylori DNA polymerase I as a source of genetic variability.

García-Ortíz MV, Marsin S, Arana ME, Gasparutto D, Guérois R, Kunkel TA, Radicella JP.

PLoS Genet. 2011 Jun;7(6):e1002152. doi: 10.1371/journal.pgen.1002152. Epub 2011 Jun 23.


Genetic dissection of Helicobacter pylori AddAB role in homologous recombination.

Marsin S, Lopes A, Mathieu A, Dizet E, Orillard E, Guérois R, Radicella JP.

FEMS Microbiol Lett. 2010 Oct;311(1):44-50. doi: 10.1111/j.1574-6968.2010.02077.x. Epub 2010 Aug 16.


Critical lysine residues within the overlooked N-terminal domain of human APE1 regulate its biological functions.

Fantini D, Vascotto C, Marasco D, D'Ambrosio C, Romanello M, Vitagliano L, Pedone C, Poletto M, Cesaratto L, Quadrifoglio F, Scaloni A, Radicella JP, Tell G.

Nucleic Acids Res. 2010 Dec;38(22):8239-56. doi: 10.1093/nar/gkq691. Epub 2010 Aug 10.


HO* radicals induce an unexpected high proportion of tandem base lesions refractory to repair by DNA glycosylases.

Bergeron F, Auvré F, Radicella JP, Ravanat JL.

Proc Natl Acad Sci U S A. 2010 Mar 23;107(12):5528-33. doi: 10.1073/pnas.1000193107. Epub 2010 Mar 8.


Oxidative stress triggers the preferential assembly of base excision repair complexes on open chromatin regions.

Amouroux R, Campalans A, Epe B, Radicella JP.

Nucleic Acids Res. 2010 May;38(9):2878-90. doi: 10.1093/nar/gkp1247. Epub 2010 Jan 13.


Inactivation by oxidation and recruitment into stress granules of hOGG1 but not APE1 in human cells exposed to sub-lethal concentrations of cadmium.

Bravard A, Campalans A, Vacher M, Gouget B, Levalois C, Chevillard S, Radicella JP.

Mutat Res. 2010 Mar 1;685(1-2):61-9. doi: 10.1016/j.mrfmmm.2009.09.013. Epub 2009 Oct 2.


Expression of 8-oxoguanine DNA glycosylase (Ogg1) in mouse retina.

Bigot K, Leemput J, Vacher M, Campalans A, Radicella JP, Lacassagne E, Provost A, Masson C, Menasche M, Abitbol M.

Mol Vis. 2009 Jun 5;15:1139-52.


Oxidation status of human OGG1-S326C polymorphic variant determines cellular DNA repair capacity.

Bravard A, Vacher M, Moritz E, Vaslin L, Hall J, Epe B, Radicella JP.

Cancer Res. 2009 Apr 15;69(8):3642-9. doi: 10.1158/0008-5472.CAN-08-3943. Epub 2009 Apr 7.


APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process.

Vascotto C, Fantini D, Romanello M, Cesaratto L, Deganuto M, Leonardi A, Radicella JP, Kelley MR, D'Ambrosio C, Scaloni A, Quadrifoglio F, Tell G.

Mol Cell Biol. 2009 Apr;29(7):1834-54. doi: 10.1128/MCB.01337-08. Epub 2009 Feb 2.


Unveiling novel RecO distant orthologues involved in homologous recombination.

Marsin S, Mathieu A, Kortulewski T, Guérois R, Radicella JP.

PLoS Genet. 2008 Aug 1;4(8):e1000146. doi: 10.1371/journal.pgen.1000146.


Oxidative stress impairs the repair of oxidative DNA base modifications in human skin fibroblasts and melanoma cells.

Eiberger W, Volkmer B, Amouroux R, Dhérin C, Radicella JP, Epe B.

DNA Repair (Amst). 2008 Jun 1;7(6):912-21. doi: 10.1016/j.dnarep.2008.03.002. Epub 2008 Apr 23.


Study of interaction of XRCC1 with DNA and proteins of base excision repair by photoaffinity labeling technique.

Nazarkina ZhK, Khodyreva SN, Marsin S, Radicella JP, Lavrik OI.

Biochemistry (Mosc). 2007 Aug;72(8):878-86.


Is the repair of oxidative DNA base modifications inducible by a preceding DNA damage induction?

Bercht M, Flohr-Beckhaus C, Osterod M, Rünger TM, Radicella JP, Epe B.

DNA Repair (Amst). 2007 Mar 1;6(3):367-73. Epub 2006 Dec 29.


UVA irradiation induces relocalisation of the DNA repair protein hOGG1 to nuclear speckles.

Campalans A, Amouroux R, Bravard A, Epe B, Radicella JP.

J Cell Sci. 2007 Jan 1;120(Pt 1):23-32. Epub 2006 Dec 5.


XRCC1 interactions with base excision repair DNA intermediates.

Nazarkina ZK, Khodyreva SN, Marsin S, Lavrik OI, Radicella JP.

DNA Repair (Amst). 2007 Feb 4;6(2):254-64. Epub 2006 Nov 21.


Helicobacter pylori genes involved in avoidance of mutations induced by 8-oxoguanine.

Mathieu A, O'Rourke EJ, Radicella JP.

J Bacteriol. 2006 Nov;188(21):7464-9. Epub 2006 Aug 25.


Redox regulation of human OGG1 activity in response to cellular oxidative stress.

Bravard A, Vacher M, Gouget B, Coutant A, de Boisferon FH, Marsin S, Chevillard S, Radicella JP.

Mol Cell Biol. 2006 Oct;26(20):7430-6. Epub 2006 Aug 21.


8-oxoguanine DNA glycosylase, but not Kin17 protein, is translocated and differentially regulated by estrogens in rat brain cells.

Araneda S, Pelloux S, Radicella JP, Angulo J, Kitahama K, Gysling K, Forray MI.

Neuroscience. 2005;136(1):135-46. Epub 2005 Sep 21.


XRCC1 interactions with multiple DNA glycosylases: a model for its recruitment to base excision repair.

Campalans A, Marsin S, Nakabeppu Y, O'connor TR, Boiteux S, Radicella JP.

DNA Repair (Amst). 2005 Jul 12;4(7):826-35.


APE1 overexpression in XRCC1-deficient cells complements the defective repair of oxidative single strand breaks but increases genomic instability.

Sossou M, Flohr-Beckhaus C, Schulz I, Daboussi F, Epe B, Radicella JP.

Nucleic Acids Res. 2005 Jan 12;33(1):298-306. Print 2005.


Suppression of homologous and homeologous recombination by the bacterial MutS2 protein.

Pinto AV, Mathieu A, Marsin S, Veaute X, Ielpi L, Labigne A, Radicella JP.

Mol Cell. 2005 Jan 7;17(1):113-20.


Crystal structures of 3-methyladenine DNA glycosylase MagIII and the recognition of alkylated bases.

Eichman BF, O'Rourke EJ, Radicella JP, Ellenberger T.

EMBO J. 2003 Oct 1;22(19):4898-909.


Poly(ADP-ribosyl)ation accelerates DNA repair in a pathway dependent on Cockayne syndrome B protein.

Flohr C, Bürkle A, Radicella JP, Epe B.

Nucleic Acids Res. 2003 Sep 15;31(18):5332-7.


Role of XRCC1 in the coordination and stimulation of oxidative DNA damage repair initiated by the DNA glycosylase hOGG1.

Marsin S, Vidal AE, Sossou M, Ménissier-de Murcia J, Le Page F, Boiteux S, de Murcia G, Radicella JP.

J Biol Chem. 2003 Nov 7;278(45):44068-74. Epub 2003 Aug 21.

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