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Items: 1 to 50 of 288

1.

Detection and quantification of nitric oxide-derived oxidants in biological systems.

Möller MN, Rios N, Trujillo M, Radi R, Denicola A, Alvarez B.

J Biol Chem. 2019 Aug 12. pii: jbc.REV119.006136. doi: 10.1074/jbc.REV119.006136. [Epub ahead of print] Review.

2.

Kinetics of formation and reactivity of the persulfide in the one-cysteine peroxiredoxin from Mycobacterium tuberculosis.

Cuevasanta E, Reyes AM, Zeida A, Mastrogiovanni M, De Armas MI, Radi R, Alvarez B, Trujillo M.

J Biol Chem. 2019 Jul 16. pii: jbc.RA119.008883. doi: 10.1074/jbc.RA119.008883. [Epub ahead of print]

3.

Aconitases: Non-redox Iron-Sulfur Proteins Sensitive to Reactive Species.

Castro L, Tórtora V, Mansilla S, Radi R.

Acc Chem Res. 2019 Jul 9. doi: 10.1021/acs.accounts.9b00150. [Epub ahead of print]

PMID:
31287291
4.

Cytosolic Fe-superoxide dismutase safeguards Trypanosoma cruzi from macrophage-derived superoxide radical.

Martínez A, Prolo C, Estrada D, Rios N, Alvarez MN, Piñeyro MD, Robello C, Radi R, Piacenza L.

Proc Natl Acad Sci U S A. 2019 Apr 30;116(18):8879-8888. doi: 10.1073/pnas.1821487116. Epub 2019 Apr 12.

PMID:
30979807
5.

Free radical-dependent inhibition of prostaglandin endoperoxide H Synthase-2 by nitro-arachidonic acid.

Wood I, Trostchansky A, Xu Y, Qian S, Radi R, Rubbo H.

Free Radic Biol Med. 2019 Mar 25. pii: S0891-5849(19)30230-8. doi: 10.1016/j.freeradbiomed.2019.03.022. [Epub ahead of print] Review.

PMID:
30922958
6.

Lung nitroxidative stress in mechanically-ventilated septic patients: A pilot study.

Gorrasi J, Peluffo G, Botti H, Batthyany C, Naviliat M, Barrios E, Correa H, Radi R.

J Crit Care. 2019 Jun;51:204-212. doi: 10.1016/j.jcrc.2019.02.017. Epub 2019 Feb 20.

PMID:
30903936
7.

The origins of nitric oxide and peroxynitrite research in Uruguay: 25 years of contributions to the biochemical and biomedical sciences.

Radi R.

Nitric Oxide. 2019 Jun 1;87:83-89. doi: 10.1016/j.niox.2019.03.003. Epub 2019 Mar 11. Review.

PMID:
30872109
8.

Carbon dioxide-catalyzed peroxynitrite reactivity - The resilience of the radical mechanism after two decades of research.

Augusto O, Goldstein S, Hurst JK, Lind J, Lymar SV, Merenyi G, Radi R.

Free Radic Biol Med. 2019 May 1;135:210-215. doi: 10.1016/j.freeradbiomed.2019.02.026. Epub 2019 Feb 25. Review.

PMID:
30818056
9.

The alkaline transition of cytochrome c revisited: Effects of electrostatic interactions and tyrosine nitration on the reaction dynamics.

Oviedo-Rouco S, Castro MA, Alvarez-Paggi D, Spedalieri C, Tortora V, Tomasina F, Radi R, Murgida DH.

Arch Biochem Biophys. 2019 Apr 15;665:96-106. doi: 10.1016/j.abb.2019.02.016. Epub 2019 Feb 25.

PMID:
30817907
10.

Reactive species and pathogen antioxidant networks during phagocytosis.

Piacenza L, Trujillo M, Radi R.

J Exp Med. 2019 Mar 4;216(3):501-516. doi: 10.1084/jem.20181886. Epub 2019 Feb 21. Review.

PMID:
30792185
11.

A painful anal lesion.

Khodaee M, Radi RL.

J Family Med Prim Care. 2018 Sep-Oct;7(5):1139-1140. doi: 10.4103/jfmpc.jfmpc_150_17. No abstract available.

12.

Attitudes and barriers towards using complementary and alternative medicine among university students in Jordan.

Radi R, Isleem U, Al Omari L, Alimoğlu O, Ankarali H, Taha H.

Complement Ther Med. 2018 Dec;41:175-179. doi: 10.1016/j.ctim.2018.09.012. Epub 2018 Sep 24.

PMID:
30477835
13.

A computational investigation of the reactions of tyrosyl, tryptophanyl, and cysteinyl radicals with nitric oxide and molecular oxygen.

Pedron FN, Bartesaghi S, Estrin DA, Radi R, Zeida A.

Free Radic Res. 2019 Jan;53(1):18-25. doi: 10.1080/10715762.2018.1541322. Epub 2018 Nov 23.

PMID:
30468096
14.

DksA-DnaJ redox interactions provide a signal for the activation of bacterial RNA polymerase.

Kim JS, Liu L, Fitzsimmons LF, Wang Y, Crawford MA, Mastrogiovanni M, Trujillo M, Till JKA, Radi R, Dai S, Vázquez-Torres A.

Proc Natl Acad Sci U S A. 2018 Dec 11;115(50):E11780-E11789. doi: 10.1073/pnas.1813572115. Epub 2018 Nov 14.

15.

Rapid peroxynitrite reduction by human peroxiredoxin 3: Implications for the fate of oxidants in mitochondria.

De Armas MI, Esteves R, Viera N, Reyes AM, Mastrogiovanni M, Alegria TGP, Netto LES, Tórtora V, Radi R, Trujillo M.

Free Radic Biol Med. 2019 Jan;130:369-378. doi: 10.1016/j.freeradbiomed.2018.10.451. Epub 2018 Nov 2.

PMID:
30391677
16.

Erratum to "Manganese porphyrin redox state in endothelial cells: Resonance Raman studies and implications for antioxidant protection towards peroxynitrite" [Free Radic. Biol. Med. 126 (2018) 379-392].

Carballal S, Valez V, Alvarez-Paggi D, Tovmasyan A, Batinic-Haberle I, Ferrer-Sueta G, Murgida DH, Radi R.

Free Radic Biol Med. 2018 Dec;129:611. doi: 10.1016/j.freeradbiomed.2018.10.001. Epub 2018 Oct 11. No abstract available.

PMID:
30318140
17.

Diphenyl diselenide protects neuronal cells against oxidative stress and mitochondrial dysfunction: Involvement of the glutathione-dependent antioxidant system.

Quispe RL, Jaramillo ML, Galant LS, Engel D, Dafre AL, Teixeira da Rocha JB, Radi R, Farina M, de Bem AF.

Redox Biol. 2019 Jan;20:118-129. doi: 10.1016/j.redox.2018.09.014. Epub 2018 Sep 25.

18.

Foreword to the Free Radical Biology and Medicine Special Issue on ¨Current fluorescence and chemiluminescence approaches in free radical and redox biology¨.

Radi R, Denicola A, Morgan B, Zielonka J.

Free Radic Biol Med. 2018 Nov 20;128:1-2. doi: 10.1016/j.freeradbiomed.2018.09.027. No abstract available.

PMID:
30293645
19.

Early Trypanosoma cruzi Infection Triggers mTORC1-Mediated Respiration Increase and Mitochondrial Biogenesis in Human Primary Cardiomyocytes.

Libisch MG, Faral-Tello P, Garg NJ, Radi R, Piacenza L, Robello C.

Front Microbiol. 2018 Aug 16;9:1889. doi: 10.3389/fmicb.2018.01889. eCollection 2018.

20.

Manganese porphyrin redox state in endothelial cells: Resonance Raman studies and implications for antioxidant protection towards peroxynitrite.

Carballal S, Valez V, Alvarez-Paggi D, Tovmasyan A, Batinic-Haberle I, Ferrer-Sueta G, Murgida DH, Radi R.

Free Radic Biol Med. 2018 Oct;126:379-392. doi: 10.1016/j.freeradbiomed.2018.08.023. Epub 2018 Aug 23. Erratum in: Free Radic Biol Med. 2018 Dec;129:611.

PMID:
30144631
21.

Clinical Inquiries: Does prophylactic azithromycin reduce the number of COPD exacerbations or hospitalizations?

Lyon C, Radi R, Staff T, Nashelsky J.

J Fam Pract. 2018 Jun;67(6):384-385.

PMID:
29879240
22.

Oxygen radicals, nitric oxide, and peroxynitrite: Redox pathways in molecular medicine.

Radi R.

Proc Natl Acad Sci U S A. 2018 Jun 5;115(23):5839-5848. doi: 10.1073/pnas.1804932115. Epub 2018 May 25. Review.

23.

Human Mn-superoxide dismutase inactivation by peroxynitrite: a paradigm of metal-catalyzed tyrosine nitration in vitro and in vivo.

Demicheli V, Moreno DM, Radi R.

Metallomics. 2018 May 23;10(5):679-695. doi: 10.1039/c7mt00348j. Review.

PMID:
29737331
24.

Respiratory analysis of coupled mitochondria in cryopreserved liver biopsies.

García-Roche M, Casal A, Carriquiry M, Radi R, Quijano C, Cassina A.

Redox Biol. 2018 Jul;17:207-212. doi: 10.1016/j.redox.2018.03.008. Epub 2018 Mar 22.

25.

Fluorescence and chemiluminescence approaches for peroxynitrite detection.

Prolo C, Rios N, Piacenza L, Álvarez MN, Radi R.

Free Radic Biol Med. 2018 Nov 20;128:59-68. doi: 10.1016/j.freeradbiomed.2018.02.017. Epub 2018 Feb 15. Review.

PMID:
29454880
26.

Cardiomyocyte diffusible redox mediators control Trypanosoma cruzi infection: role of parasite mitochondrial iron superoxide dismutase.

Estrada D, Specker G, Martínez A, Dias PP, Hissa B, Andrade LO, Radi R, Piacenza L.

Biochem J. 2018 Apr 5;475(7):1235-1251. doi: 10.1042/BCJ20170698.

PMID:
29438066
27.

Biochemistry of Peroxynitrite and Protein Tyrosine Nitration.

Ferrer-Sueta G, Campolo N, Trujillo M, Bartesaghi S, Carballal S, Romero N, Alvarez B, Radi R.

Chem Rev. 2018 Feb 14;118(3):1338-1408. doi: 10.1021/acs.chemrev.7b00568. Epub 2018 Feb 5. Review.

PMID:
29400454
28.

Propagation of free-radical reactions in concentrated protein solutions.

Aicardo A, Mastrogiovanni M, Cassina A, Radi R.

Free Radic Res. 2018 Feb;52(2):159-170. doi: 10.1080/10715762.2017.1420905. Epub 2018 Jan 22.

PMID:
29278949
29.

Addition and Correction to Multifunctional Cytochrome c: Learning New Tricks from an Old Dog.

Alvarez-Paggi D, Hannibal L, Castro MA, Oviedo-Rouco S, Demicheli V, Tórtora V, Tomasina F, Radi R, Murgida DH.

Chem Rev. 2017 Dec 13;117(23):14014. doi: 10.1021/acs.chemrev.7b00706. Epub 2017 Dec 1. No abstract available.

PMID:
29192778
30.

Fundamentals on the biochemistry of peroxynitrite and protein tyrosine nitration.

Bartesaghi S, Radi R.

Redox Biol. 2018 Apr;14:618-625. doi: 10.1016/j.redox.2017.09.009. Epub 2017 Sep 19. Review.

31.

Redox-sensitive GFP fusions for monitoring the catalytic mechanism and inactivation of peroxiredoxins in living cells.

Staudacher V, Trujillo M, Diederichs T, Dick TP, Radi R, Morgan B, Deponte M.

Redox Biol. 2018 Apr;14:549-556. doi: 10.1016/j.redox.2017.10.017. Epub 2017 Oct 26.

32.

Selenocompounds in Cancer Therapy: An Overview.

Bartolini D, Sancineto L, Fabro de Bem A, Tew KD, Santi C, Radi R, Toquato P, Galli F.

Adv Cancer Res. 2017;136:259-302. doi: 10.1016/bs.acr.2017.07.007. Epub 2017 Sep 28. Review.

PMID:
29054421
33.

Multifunctional Cytochrome c: Learning New Tricks from an Old Dog.

Alvarez-Paggi D, Hannibal L, Castro MA, Oviedo-Rouco S, Demicheli V, Tórtora V, Tomasina F, Radi R, Murgida DH.

Chem Rev. 2017 Nov 8;117(21):13382-13460. doi: 10.1021/acs.chemrev.7b00257. Epub 2017 Oct 13. Review. Erratum in: Chem Rev. 2017 Dec 13;117(23):14014.

PMID:
29027792
34.

Cardiomyocyte oxidants production may signal to T. cruzi intracellular development.

Dias PP, Capila RF, do Couto NF, Estrada D, Gadelha FR, Radi R, Piacenza L, Andrade LO.

PLoS Negl Trop Dis. 2017 Aug 23;11(8):e0005852. doi: 10.1371/journal.pntd.0005852. eCollection 2017 Aug.

35.

Iron-sulfur glutaredoxin 2 protects oligodendrocytes against damage induced by nitric oxide release from activated microglia.

Lepka K, Volbracht K, Bill E, Schneider R, Rios N, Hildebrandt T, Ingwersen J, Prozorovski T, Lillig CH, van Horssen J, Steinman L, Hartung HP, Radi R, Holmgren A, Aktas O, Berndt C.

Glia. 2017 Sep;65(9):1521-1534. doi: 10.1002/glia.23178. Epub 2017 Jun 15.

PMID:
28618115
36.

Tyrosine oxidation and nitration in transmembrane peptides is connected to lipid peroxidation.

Bartesaghi S, Herrera D, Martinez DM, Petruk A, Demicheli V, Trujillo M, Martí MA, Estrín DA, Radi R.

Arch Biochem Biophys. 2017 May 15;622:9-25. doi: 10.1016/j.abb.2017.04.006. Epub 2017 Apr 13.

PMID:
28412156
37.

Chemistry and Redox Biology of Mycothiol.

Reyes AM, Pedre B, De Armas MI, Tossounian MA, Radi R, Messens J, Trujillo M.

Antioxid Redox Signal. 2018 Feb 20;28(6):487-504. doi: 10.1089/ars.2017.7074. Epub 2017 May 10. Review.

PMID:
28372502
38.

Kinetics, subcellular localization, and contribution to parasite virulence of a Trypanosoma cruzi hybrid type A heme peroxidase (TcAPx-CcP).

Hugo M, Martínez A, Trujillo M, Estrada D, Mastrogiovanni M, Linares E, Augusto O, Issoglio F, Zeida A, Estrín DA, Heijnen HF, Piacenza L, Radi R.

Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):E1326-E1335. doi: 10.1073/pnas.1618611114. Epub 2017 Feb 8.

39.

Worsening of memory deficit induced by energy-dense diet in a rat model of early-Alzheimer's disease is associated to neurotoxic Aβ species and independent of neuroinflammation.

Martino Adami PV, Galeano P, Wallinger ML, Quijano C, Rabossi A, Pagano ES, Olivar N, Reyes Toso C, Cardinali D, Brusco LI, Do Carmo S, Radi R, Gevorkian G, Castaño EM, Cuello AC, Morelli L.

Biochim Biophys Acta Mol Basis Dis. 2017 Mar;1863(3):731-743. doi: 10.1016/j.bbadis.2016.12.014. Epub 2016 Dec 27.

40.

Ohr plays a central role in bacterial responses against fatty acid hydroperoxides and peroxynitrite.

Alegria TG, Meireles DA, Cussiol JR, Hugo M, Trujillo M, de Oliveira MA, Miyamoto S, Queiroz RF, Valadares NF, Garratt RC, Radi R, Di Mascio P, Augusto O, Netto LE.

Proc Natl Acad Sci U S A. 2017 Jan 10;114(2):E132-E141. doi: 10.1073/pnas.1619659114. Epub 2016 Dec 27.

41.

PrxQ B from Mycobacterium tuberculosis is a monomeric, thioredoxin-dependent and highly efficient fatty acid hydroperoxide reductase.

Reyes AM, Vazquez DS, Zeida A, Hugo M, Piñeyro MD, De Armas MI, Estrin D, Radi R, Santos J, Trujillo M.

Free Radic Biol Med. 2016 Dec;101:249-260. doi: 10.1016/j.freeradbiomed.2016.10.005. Epub 2016 Oct 15.

PMID:
27751911
42.

Exploring the Catalytic Mechanism of Human Glutamine Synthetase by Computer Simulations.

Issoglio FM, Campolo N, Zeida A, Grune T, Radi R, Estrin DA, Bartesaghi S.

Biochemistry. 2016 Oct 25;55(42):5907-5916. doi: 10.1021/acs.biochem.6b00822. Epub 2016 Oct 13.

PMID:
27685475
43.

Sensitive detection and estimation of cell-derived peroxynitrite fluxes using fluorescein-boronate.

Rios N, Piacenza L, Trujillo M, Martínez A, Demicheli V, Prolo C, Álvarez MN, López GV, Radi R.

Free Radic Biol Med. 2016 Dec;101:284-295. doi: 10.1016/j.freeradbiomed.2016.08.033. Epub 2016 Sep 15.

PMID:
27641237
44.

Tyrosine-Nitrated Proteins: Proteomic and Bioanalytical Aspects.

Batthyány C, Bartesaghi S, Mastrogiovanni M, Lima A, Demicheli V, Radi R.

Antioxid Redox Signal. 2017 Mar 1;26(7):313-328. doi: 10.1089/ars.2016.6787. Epub 2016 Jul 22. Review.

45.

Mechanism of the Reaction of Human Manganese Superoxide Dismutase with Peroxynitrite: Nitration of Critical Tyrosine 34.

Demicheli V, Moreno DM, Jara GE, Lima A, Carballal S, Ríos N, Batthyany C, Ferrer-Sueta G, Quijano C, Estrı́n DA, Martí MA, Radi R.

Biochemistry. 2016 Jun 21;55(24):3403-17. doi: 10.1021/acs.biochem.6b00045. Epub 2016 Jun 10.

PMID:
27227512
46.

Role of nitrite, urate and pepsin in the gastroprotective effects of saliva.

Rocha BS, Lundberg JO, Radi R, Laranjinha J.

Redox Biol. 2016 Aug;8:407-14. doi: 10.1016/j.redox.2016.04.002. Epub 2016 Apr 8.

47.

Correction: Nitro-Arachidonic Acid Prevents Angiotensin II Induced Mitochondrial Dysfunction in Kidney Proximal Tubular Cells.

Sánchez-Calvo B, Cassina A, Rios N, Peluffo G, Boggia J, Radi R, Rubbo H, Trostchansky A.

PLoS One. 2016 Apr 26;11(4):e0154651. doi: 10.1371/journal.pone.0154651. eCollection 2016.

48.

Redox-Active Sensing by Bacterial DksA Transcription Factors Is Determined by Cysteine and Zinc Content.

Crawford MA, Tapscott T, Fitzsimmons LF, Liu L, Reyes AM, Libby SJ, Trujillo M, Fang FC, Radi R, Vázquez-Torres A.

MBio. 2016 Apr 19;7(2):e02161-15. doi: 10.1128/mBio.02161-15.

49.

Correction to Alternative Conformations of Cytochrome c: Structure, Function, and Detection.

Hannibal L, Tomasina F, Capdevila DA, Demicheli V, Tórtora V, Alvarez-Paggi D, Jemmerson R, Murgida DH, Radi R.

Biochemistry. 2016 Apr 5;55(13):2062. doi: 10.1021/acs.biochem.6b00236. Epub 2016 Mar 22. No abstract available.

PMID:
27003234
50.

Nitro-Arachidonic Acid Prevents Angiotensin II-Induced Mitochondrial Dysfunction in a Cell Line of Kidney Proximal Tubular Cells.

Sánchez-Calvo B, Cassina A, Rios N, Peluffo G, Boggia J, Radi R, Rubbo H, Trostchansky A.

PLoS One. 2016 Mar 4;11(3):e0150459. doi: 10.1371/journal.pone.0150459. eCollection 2016. Erratum in: PLoS One. 2016;11(4):e0154651.

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