Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 121


A new crystal form of human acetylcholinesterase for exploratory room-temperature crystallography studies.

Gerlits O, Ho KY, Cheng X, Blumenthal D, Taylor P, Kovalevsky A, Radić Z.

Chem Biol Interact. 2019 Jun 7;309:108698. doi: 10.1016/j.cbi.2019.06.011. [Epub ahead of print]


Productive reorientation of a bound oxime reactivator revealed in room temperature X-ray structures of native and VX-inhibited human acetylcholinesterase.

Gerlits O, Kong X, Cheng X, Wymore T, Blumenthal DK, Taylor P, Radić Z, Kovalevsky A.

J Biol Chem. 2019 Jul 5;294(27):10607-10618. doi: 10.1074/jbc.RA119.008725. Epub 2019 May 28.


Assessment of ionizable, zwitterionic oximes as reactivating antidotal agents for organophosphate exposure.

Taylor P, Yan-Jye S, Momper J, Hou W, Camacho-Hernandez GA, Radic' Z, Rosenberg Y, Kovarik Z, Sit R, Sharpless KB.

Chem Biol Interact. 2019 Aug 1;308:194-197. doi: 10.1016/j.cbi.2019.05.015. Epub 2019 May 14. Review.


Counteracting tabun inhibition by reactivation by pyridinium aldoximes that interact with active center gorge mutants of acetylcholinesterase.

Kovarik Z, Maček Hrvat N, Kalisiak J, Katalinić M, Sit RK, Zorbaz T, Radić Z, Fokin VV, Sharpless KB, Taylor P.

Toxicol Appl Pharmacol. 2019 Jun 1;372:40-46. doi: 10.1016/j.taap.2019.04.007. Epub 2019 Apr 9.


Reversal of Tabun Toxicity Enabled by a Triazole-Annulated Oxime Library-Reactivators of Acetylcholinesterase.

Kovarik Z, Kalisiak J, Hrvat NM, Katalinić M, Zorbaz T, Žunec S, Green C, Radić Z, Fokin VV, Sharpless KB, Taylor P.

Chemistry. 2019 Mar 15;25(16):4100-4114. doi: 10.1002/chem.201805051. Epub 2019 Feb 14.


Pharmacology, Pharmacokinetics, and Tissue Disposition of Zwitterionic Hydroxyiminoacetamido Alkylamines as Reactivating Antidotes for Organophosphate Exposure.

Sit RK, Kovarik Z, Maček Hrvat N, Žunec S, Green C, Fokin VV, Sharpless KB, Radić Z, Taylor P.

J Pharmacol Exp Ther. 2018 Nov;367(2):363-372. doi: 10.1124/jpet.118.249383. Epub 2018 Sep 6.


Planarian cholinesterase: molecular and functional characterization of an evolutionarily ancient enzyme to study organophosphorus pesticide toxicity.

Hagstrom D, Zhang S, Ho A, Tsai ES, Radić Z, Jahromi A, Kaj KJ, He Y, Taylor P, Collins ES.

Arch Toxicol. 2018 Mar;92(3):1161-1176. doi: 10.1007/s00204-017-2130-7. Epub 2017 Nov 22.


Post-exposure treatment with the oxime RS194B rapidly reverses early and advanced symptoms in macaques exposed to sarin vapor.

Rosenberg YJ, Mao L, Jiang X, Lees J, Zhang L, Radic Z, Taylor P.

Chem Biol Interact. 2017 Aug 25;274:50-57. doi: 10.1016/j.cbi.2017.07.003. Epub 2017 Jul 8.


Planarian cholinesterase: in vitro characterization of an evolutionarily ancient enzyme to study organophosphorus pesticide toxicity and reactivation.

Hagstrom D, Hirokawa H, Zhang L, Radic Z, Taylor P, Collins ES.

Arch Toxicol. 2017 Aug;91(8):2837-2847. doi: 10.1007/s00204-016-1908-3. Epub 2016 Dec 18.


Limitations in current acetylcholinesterase structure-based design of oxime antidotes for organophosphate poisoning.

Kovalevsky A, Blumenthal DK, Cheng X, Taylor P, Radić Z.

Ann N Y Acad Sci. 2016 Aug;1378(1):41-49. doi: 10.1111/nyas.13128. Epub 2016 Jul 2. Review.


Mechanistic studies of new oximes reactivators of human butyryl cholinesterase inhibited by cyclosarin and sarin.

de Lima WE, Francisco A, da Cunha EF, Radic Z, Taylor P, França TC, Ramalho TC.

J Biomol Struct Dyn. 2017 May;35(6):1272-1282. doi: 10.1080/07391102.2016.1178173. Epub 2016 Jun 7.


HI-6 assisted catalytic scavenging of VX by acetylcholinesterase choline binding site mutants.

Maček Hrvat N, Žunec S, Taylor P, Radić Z, Kovarik Z.

Chem Biol Interact. 2016 Nov 25;259(Pt B):148-153. doi: 10.1016/j.cbi.2016.04.023. Epub 2016 Apr 12.


Butyrylcholinesterase identification in a phenylvalerate esterase-enriched fraction sensitive to low mipafox concentrations in chicken brain.

Mangas I, Radić Z, Taylor P, Ghassemian M, Candela H, Vilanova E, Estévez J.

Arch Toxicol. 2017 Feb;91(2):909-919. doi: 10.1007/s00204-016-1670-6. Epub 2016 Feb 2.


Marine Macrocyclic Imines, Pinnatoxins A and G: Structural Determinants and Functional Properties to Distinguish Neuronal α7 from Muscle α1(2)βγδ nAChRs.

Bourne Y, Sulzenbacher G, Radić Z, Aráoz R, Reynaud M, Benoit E, Zakarian A, Servent D, Molgó J, Taylor P, Marchot P.

Structure. 2015 Jun 2;23(6):1106-15. doi: 10.1016/j.str.2015.04.009. Epub 2015 May 21.


Catalytic Soman Scavenging by the Y337A/F338A Acetylcholinesterase Mutant Assisted with Novel Site-Directed Aldoximes.

Kovarik Z, Maček Hrvat N, Katalinić M, Sit RK, Paradyse A, Žunec S, Musilek K, Fokin VV, Taylor P, Radić Z.

Chem Res Toxicol. 2015 May 18;28(5):1036-44. doi: 10.1021/acs.chemrestox.5b00060. Epub 2015 Apr 16.


Resolving pathways of interaction of mipafox and a sarin analog with human acetylcholinesterase by kinetics, mass spectrometry and molecular modeling approaches.

Mangas I, Taylor P, Vilanova E, Estévez J, França TC, Komives E, Radić Z.

Arch Toxicol. 2016 Mar;90(3):603-16. doi: 10.1007/s00204-015-1481-1. Epub 2015 Mar 6.


Quaternary and tertiary aldoxime antidotes for organophosphate exposure in a zebrafish model system.

Schmidt HR, Radić Z, Taylor P, Fradinger EA.

Toxicol Appl Pharmacol. 2015 Apr 15;284(2):197-203. doi: 10.1016/j.taap.2015.02.011. Epub 2015 Feb 17.


Structural basis for cooperative interactions of substituted 2-aminopyrimidines with the acetylcholine binding protein.

Kaczanowska K, Harel M, Radić Z, Changeux JP, Finn MG, Taylor P.

Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):10749-54. doi: 10.1073/pnas.1410992111. Epub 2014 Jul 8.


Imidazole aldoximes effective in assisting butyrylcholinesterase catalysis of organophosphate detoxification.

Sit RK, Fokin VV, Amitai G, Sharpless KB, Taylor P, Radić Z.

J Med Chem. 2014 Feb 27;57(4):1378-89. doi: 10.1021/jm401650z. Epub 2014 Feb 7.


Gene transfer of mutant mouse cholinesterase provides high lifetime expression and reduced cocaine responses with no evident toxicity.

Geng L, Gao Y, Chen X, Hou S, Zhan CG, Radic Z, Parks RJ, Russell SJ, Pham L, Brimijoin S.

PLoS One. 2013 Jun 28;8(6):e67446. doi: 10.1371/journal.pone.0067446. Print 2013.


Automated docking with protein flexibility in the design of femtomolar "click chemistry" inhibitors of acetylcholinesterase.

Morris GM, Green LG, Radić Z, Taylor P, Sharpless KB, Olson AJ, Grynszpan F.

J Chem Inf Model. 2013 Apr 22;53(4):898-906. doi: 10.1021/ci300545a. Epub 2013 Mar 29.


Catalytic detoxification of nerve agent and pesticide organophosphates by butyrylcholinesterase assisted with non-pyridinium oximes.

Radić Z, Dale T, Kovarik Z, Berend S, Garcia E, Zhang L, Amitai G, Green C, Radić B, Duggan BM, Ajami D, Rebek J, Taylor P.

Biochem J. 2013 Feb 15;450(1):231-42. doi: 10.1042/BJ20121612.


Mechanism of interaction of novel uncharged, centrally active reactivators with OP-hAChE conjugates.

Radić Z, Sit RK, Garcia E, Zhang L, Berend S, Kovarik Z, Amitai G, Fokin VV, Barry Sharpless K, Taylor P.

Chem Biol Interact. 2013 Mar 25;203(1):67-71. doi: 10.1016/j.cbi.2012.08.014. Epub 2012 Sep 4.


Centrally acting oximes in reactivation of tabun-phosphoramidated AChE.

Kovarik Z, Maček N, Sit RK, Radić Z, Fokin VV, Barry Sharpless K, Taylor P.

Chem Biol Interact. 2013 Mar 25;203(1):77-80. doi: 10.1016/j.cbi.2012.08.019. Epub 2012 Sep 7.


Refinement of structural leads for centrally acting oxime reactivators of phosphylated cholinesterases.

Radić Z, Sit RK, Kovarik Z, Berend S, Garcia E, Zhang L, Amitai G, Green C, Radić B, Fokin VV, Sharpless KB, Taylor P.

J Biol Chem. 2012 Apr 6;287(15):11798-809. doi: 10.1074/jbc.M111.333732. Epub 2012 Feb 16. Erratum in: J Biol Chem. 2012 Jun 1;287(23):19337.


Oxime-assisted acetylcholinesterase catalytic scavengers of organophosphates that resist aging.

Cochran R, Kalisiak J, Küçükkilinç T, Radic Z, Garcia E, Zhang L, Ho KY, Amitai G, Kovarik Z, Fokin VV, Sharpless KB, Taylor P.

J Biol Chem. 2011 Aug 26;286(34):29718-24. doi: 10.1074/jbc.M111.264739. Epub 2011 Jul 5.


Naturally occurring variations in the human cholinesterase genes: heritability and association with cardiovascular and metabolic traits.

Valle AM, Radic Z, Rana BK, Mahboubi V, Wessel J, Shih PA, Rao F, O'Connor DT, Taylor P.

J Pharmacol Exp Ther. 2011 Jul;338(1):125-33. doi: 10.1124/jpet.111.180091. Epub 2011 Apr 14.


New structural scaffolds for centrally acting oxime reactivators of phosphylated cholinesterases.

Sit RK, Radić Z, Gerardi V, Zhang L, Garcia E, Katalinić M, Amitai G, Kovarik Z, Fokin VV, Sharpless KB, Taylor P.

J Biol Chem. 2011 Jun 3;286(22):19422-30. doi: 10.1074/jbc.M111.230656. Epub 2011 Apr 4.


Conformational remodeling of femtomolar inhibitor-acetylcholinesterase complexes in the crystalline state.

Bourne Y, Radić Z, Taylor P, Marchot P.

J Am Chem Soc. 2010 Dec 29;132(51):18292-300. doi: 10.1021/ja106820e. Epub 2010 Nov 19.


Interaction kinetics of oximes with native, phosphylated and aged human acetylcholinesterase.

Radić Z, Kalisiak J, Fokin VV, Sharpless KB, Taylor P.

Chem Biol Interact. 2010 Sep 6;187(1-3):163-6. doi: 10.1016/j.cbi.2010.04.014. Epub 2010 Apr 20.


Investigating the structural influence of surface mutations on acetylcholinesterase inhibition by organophosphorus compounds and oxime reactivation.

Küçükkilinç T, Cochran R, Kalisiak J, Garcia E, Valle A, Amitai G, Radić Z, Taylor P.

Chem Biol Interact. 2010 Sep 6;187(1-3):238-40. doi: 10.1016/j.cbi.2010.03.050. Epub 2010 Apr 9.


Structural determinants in phycotoxins and AChBP conferring high affinity binding and nicotinic AChR antagonism.

Bourne Y, Radic Z, Aráoz R, Talley TT, Benoit E, Servent D, Taylor P, Molgó J, Marchot P.

Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):6076-81. doi: 10.1073/pnas.0912372107. Epub 2010 Mar 11.


Probing the carbohydrate recognition domain of E-selectin: the importance of the acid orientation in sLex mimetics.

Titz A, Patton J, Smiesko M, Radic Z, Schwardt O, Magnani JL, Ernst B.

Bioorg Med Chem. 2010 Jan 1;18(1):19-27. doi: 10.1016/j.bmc.2009.11.024. Epub 2009 Nov 13.


Acetylcholinesterase: mechanisms of covalent inhibition of H447I mutant determined by computational analyses.

Cheng YH, Cheng XL, Radić Z, McCammon JA.

Chem Biol Interact. 2008 Sep 25;175(1-3):196-9. doi: 10.1016/j.cbi.2008.04.044. Epub 2008 May 7.


Probing gorge dimensions of cholinesterases by freeze-frame click chemistry.

Radić Z, Manetsch R, Fournier D, Sharpless KB, Taylor P.

Chem Biol Interact. 2008 Sep 25;175(1-3):161-5. doi: 10.1016/j.cbi.2008.04.048. Epub 2008 May 8.


The cholinesterases: analysis by pharmacogenomics in man.

Valle AM, Radić Z, Rana BK, Whitfield JB, O'Connor DT, Martin NG, Taylor P.

Chem Biol Interact. 2008 Sep 25;175(1-3):343-5. doi: 10.1016/j.cbi.2008.04.042. Epub 2008 May 4.


Atomic interactions of neonicotinoid agonists with AChBP: molecular recognition of the distinctive electronegative pharmacophore.

Talley TT, Harel M, Hibbs RE, Radic Z, Tomizawa M, Casida JE, Taylor P.

Proc Natl Acad Sci U S A. 2008 May 27;105(21):7606-11. doi: 10.1073/pnas.0802197105. Epub 2008 May 13.


Application of recombinant DNA methods for production of cholinesterases as organophosphate antidotes and detectors.

Taylor P, Reiner E, Kovarik Z, Radić Z.

Arh Hig Rada Toksikol. 2007 Sep;58(3):339-45. Review.


Mechanisms of organophosphate toxicity and detoxication with emphasis on studies in Croatia.

Reiner E, Radić Z, Simeon-Rudolf V.

Arh Hig Rada Toksikol. 2007 Sep;58(3):329-38. Review.


Structure-guided drug design: conferring selectivity among neuronal nicotinic receptor and acetylcholine-binding protein subtypes.

Taylor P, Talley TT, Radic' Z, Hansen SB, Hibbs RE, Shi J.

Biochem Pharmacol. 2007 Oct 15;74(8):1164-71. Epub 2007 Aug 3. Review.


Acetylcholinesterase: mechanisms of covalent inhibition of wild-type and H447I mutant determined by computational analyses.

Cheng Y, Cheng X, Radić Z, McCammon JA.

J Am Chem Soc. 2007 May 23;129(20):6562-70. Epub 2007 Apr 27.


Protein folding determinants: structural features determining alternative disulfide pairing in alpha- and chi/lambda-conotoxins.

Kang TS, Radić Z, Talley TT, Jois SD, Taylor P, Kini RM.

Biochemistry. 2007 Mar 20;46(11):3338-55. Epub 2007 Feb 22.


Continuum simulations of acetylcholine diffusion with reaction-determined boundaries in neuromuscular junction models.

Cheng Y, Suen JK, Radić Z, Bond SD, Holst MJ, McCammon JA.

Biophys Chem. 2007 May;127(3):129-39. Epub 2007 Jan 19.


Acetylcholinesterase: converting a vulnerable target to a template for antidotes and detection of inhibitor exposure.

Taylor P, Kovarik Z, Reiner E, Radić Z.

Toxicology. 2007 Apr 20;233(1-3):70-8. Epub 2006 Nov 24.


Influence of agonists and antagonists on the segmental motion of residues near the agonist binding pocket of the acetylcholine-binding protein.

Hibbs RE, Radic Z, Taylor P, Johnson DA.

J Biol Chem. 2006 Dec 22;281(51):39708-18. Epub 2006 Oct 26.


Mutation of acetylcholinesterase to enhance oxime-assisted catalytic turnover of methylphosphonates.

Kovarik Z, Radić Z, Berman HA, Taylor P.

Toxicology. 2007 Apr 20;233(1-3):79-84. Epub 2006 Sep 1.


Substrate and product trafficking through the active center gorge of acetylcholinesterase analyzed by crystallography and equilibrium binding.

Bourne Y, Radic Z, Sulzenbacher G, Kim E, Taylor P, Marchot P.

J Biol Chem. 2006 Sep 29;281(39):29256-67. Epub 2006 Jul 12.


Active site mutant acetylcholinesterase interactions with 2-PAM, HI-6, and DDVP.

Kovarik Z, Ciban N, Radić Z, Simeon-Rudolf V, Taylor P.

Biochem Biophys Res Commun. 2006 Apr 14;342(3):973-8.


Conformational transitions in protein-protein association: binding of fasciculin-2 to acetylcholinesterase.

Bui JM, Radic Z, Taylor P, McCammon JA.

Biophys J. 2006 May 1;90(9):3280-7. Epub 2006 Feb 10.


A mutation linked with autism reveals a common mechanism of endoplasmic reticulum retention for the alpha,beta-hydrolase fold protein family.

De Jaco A, Comoletti D, Kovarik Z, Gaietta G, Radic Z, Lockridge O, Ellisman MH, Taylor P.

J Biol Chem. 2006 Apr 7;281(14):9667-76. Epub 2006 Jan 24.

Supplemental Content

Support Center