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Items: 1 to 50 of 101

1.

Sulfation Patterns of Saccharides and Heavy Metal Ions Binding.

Alshanski I, Blaszkiewicz J, Mervinetsky E, Rademann J, Yitzchaik S, Hurevich M.

Chemistry. 2019 Jun 2. doi: 10.1002/chem.201901538. [Epub ahead of print]

PMID:
31155776
2.

An Intrinsic Hydrophobicity Scale for Amino Acids and Its Application to Fluorinated Compounds.

Hoffmann W, Langenhan J, Huhmann S, Moschner J, Chang R, Accorsi M, Seo J, Rademann J, Meijer G, Koksch B, Bowers MT, von Helden G, Pagel K.

Angew Chem Int Ed Engl. 2019 Jun 11;58(24):8216-8220. doi: 10.1002/anie.201813954. Epub 2019 May 10.

PMID:
30958917
3.

Syntheses of defined sulfated oligohyaluronans reveal structural effects, diversity and thermodynamics of GAG-protein binding.

Köhling S, Blaszkiewicz J, Ruiz-Gómez G, Fernández-Bachiller MI, Lemmnitzer K, Panitz N, Beck-Sickinger AG, Schiller J, Pisabarro MT, Rademann J.

Chem Sci. 2018 Nov 1;10(3):866-878. doi: 10.1039/c8sc03649g. eCollection 2019 Jan 21.

4.

Hyaluronan/collagen hydrogels containing sulfated hyaluronan improve wound healing by sustained release of heparin-binding EGF-like growth factor.

Thönes S, Rother S, Wippold T, Blaszkiewicz J, Balamurugan K, Moeller S, Ruiz-Gómez G, Schnabelrauch M, Scharnweber D, Saalbach A, Rademann J, Pisabarro MT, Hintze V, Anderegg U.

Acta Biomater. 2019 Mar 1;86:135-147. doi: 10.1016/j.actbio.2019.01.029. Epub 2019 Jan 17.

PMID:
30660005
5.

The transcription factor STAT5 catalyzes Mannich ligation reactions yielding inhibitors of leukemic cell proliferation.

Wong EL, Nawrotzky E, Arkona C, Kim BG, Beligny S, Wang X, Wagner S, Lisurek M, Carstanjen D, Rademann J.

Nat Commun. 2019 Jan 8;10(1):66. doi: 10.1038/s41467-018-07923-2.

6.

Structural Basis for Binding of Fluorescent CMP-Neu5Ac Mimetics to Enzymes of the Human ST8Sia Family.

Volkers G, Lizak C, Niesser J, Rosell FI, Preidl J, Gnanapragassam VS, Horstkorte R, Rademann J, Strynadka NCJ.

ACS Chem Biol. 2018 Aug 17;13(8):2320-2328. doi: 10.1021/acschembio.8b00478. Epub 2018 Jul 26.

PMID:
30015474
7.

Identification of a pyrogallol derivative as a potent and selective human TLR2 antagonist by structure-based virtual screening.

Grabowski M, Murgueitio MS, Bermudez M, Rademann J, Wolber G, Weindl G.

Biochem Pharmacol. 2018 Aug;154:148-160. doi: 10.1016/j.bcp.2018.04.018. Epub 2018 Apr 22.

PMID:
29684378
8.

Phenylthiomethyl Ketone-Based Fragments Show Selective and Irreversible Inhibition of Enteroviral 3C Proteases.

Schulz R, Atef A, Becker D, Gottschalk F, Tauber C, Wagner S, Arkona C, Abdel-Hafez AA, Farag HH, Rademann J, Wolber G.

J Med Chem. 2018 Feb 8;61(3):1218-1230. doi: 10.1021/acs.jmedchem.7b01440. Epub 2018 Jan 27.

PMID:
29328649
9.

Benzyl Mono-P-Fluorophosphonate and Benzyl Penta-P-Fluorophosphate Anions Are Physiologically Stable Phosphotyrosine Mimetics and Inhibitors of Protein Tyrosine Phosphatases.

Wagner S, Accorsi M, Rademann J.

Chemistry. 2017 Nov 2;23(61):15387-15395. doi: 10.1002/chem.201701204. Epub 2017 Oct 11.

PMID:
29024172
10.

Pharmacological inhibition of focal segmental glomerulosclerosis-related, gain of function mutants of TRPC6 channels by semi-synthetic derivatives of larixol.

Urban N, Neuser S, Hentschel A, Köhling S, Rademann J, Schaefer M.

Br J Pharmacol. 2017 Nov;174(22):4099-4122. doi: 10.1111/bph.13977. Epub 2017 Oct 15. Erratum in: Br J Pharmacol. 2019 Apr;176(7):981.

11.

Sulfated Hyaluronan Derivatives Modulate TGF-β1:Receptor Complex Formation: Possible Consequences for TGF-β1 Signaling.

Koehler L, Samsonov S, Rother S, Vogel S, Köhling S, Moeller S, Schnabelrauch M, Rademann J, Hempel U, Pisabarro MT, Scharnweber D, Hintze V.

Sci Rep. 2017 Apr 26;7(1):1210. doi: 10.1038/s41598-017-01264-8.

12.

Biotransformation of 2,4-toluenediamine in human skin and reconstructed tissues.

Grohmann L, Becker D, Rademann J, Ma N, Schäfer-Korting M, Weindl G.

Arch Toxicol. 2017 Oct;91(10):3307-3316. doi: 10.1007/s00204-017-1954-5. Epub 2017 Mar 23.

PMID:
28337504
13.

Sulfated Hyaluronan Alters Endothelial Cell Activation in Vitro by Controlling the Biological Activity of the Angiogenic Factors Vascular Endothelial Growth Factor-A and Tissue Inhibitor of Metalloproteinase-3.

Rother S, Samsonov SA, Moeller S, Schnabelrauch M, Rademann J, Blaszkiewicz J, Köhling S, Waltenberger J, Pisabarro MT, Scharnweber D, Hintze V.

ACS Appl Mater Interfaces. 2017 Mar 22;9(11):9539-9550. doi: 10.1021/acsami.7b01300. Epub 2017 Mar 13.

PMID:
28248081
14.

Protein-Templated Formation of an Inhibitor of the Blood Coagulation Factor Xa through a Background-Free Amidation Reaction.

Jaegle M, Steinmetzer T, Rademann J.

Angew Chem Int Ed Engl. 2017 Mar 20;56(13):3718-3722. doi: 10.1002/anie.201611547. Epub 2017 Feb 15.

15.

Protein-Templated Fragment Ligations-From Molecular Recognition to Drug Discovery.

Jaegle M, Wong EL, Tauber C, Nawrotzky E, Arkona C, Rademann J.

Angew Chem Int Ed Engl. 2017 Jun 19;56(26):7358-7378. doi: 10.1002/anie.201610372. Epub 2017 May 31. Review.

PMID:
28117936
16.

C-type lectin receptor DCIR modulates immunity to tuberculosis by sustaining type I interferon signaling in dendritic cells.

Troegeler A, Mercier I, Cougoule C, Pietretti D, Colom A, Duval C, Vu Manh TP, Capilla F, Poincloux R, Pingris K, Nigou J, Rademann J, Dalod M, Verreck FA, Al Saati T, Lugo-Villarino G, Lepenies B, Hudrisier D, Neyrolles O.

Proc Natl Acad Sci U S A. 2017 Jan 24;114(4):E540-E549. doi: 10.1073/pnas.1613254114. Epub 2017 Jan 9.

17.

Rhamnolipids form drug-loaded nanoparticles for dermal drug delivery.

Müller F, Hönzke S, Luthardt WO, Wong EL, Unbehauen M, Bauer J, Haag R, Hedtrich S, Rühl E, Rademann J.

Eur J Pharm Biopharm. 2017 Jul;116:31-37. doi: 10.1016/j.ejpb.2016.12.013. Epub 2016 Dec 21.

PMID:
28012989
18.

One-Pot Synthesis of Unprotected Anomeric Glycosyl Thiols in Water for Glycan Ligation Reactions with Highly Functionalized Sugars.

Köhling S, Exner MP, Nojoumi S, Schiller J, Budisa N, Rademann J.

Angew Chem Int Ed Engl. 2016 Dec 12;55(50):15510-15514. doi: 10.1002/anie.201607228. Epub 2016 Nov 11.

PMID:
27860027
19.

Structural and functional insights into the interaction of sulfated glycosaminoglycans with tissue inhibitor of metalloproteinase-3 - A possible regulatory role on extracellular matrix homeostasis.

Rother S, Samsonov SA, Hofmann T, Blaszkiewicz J, Köhling S, Moeller S, Schnabelrauch M, Rademann J, Kalkhof S, von Bergen M, Pisabarro MT, Scharnweber D, Hintze V.

Acta Biomater. 2016 Nov;45:143-154. doi: 10.1016/j.actbio.2016.08.030. Epub 2016 Aug 18.

PMID:
27545813
20.

Irreversible inhibitors of the 3C protease of Coxsackie virus through templated assembly of protein-binding fragments.

Becker D, Kaczmarska Z, Arkona C, Schulz R, Tauber C, Wolber G, Hilgenfeld R, Coll M, Rademann J.

Nat Commun. 2016 Sep 28;7:12761. doi: 10.1038/ncomms12761.

21.

Sulfated Hyaluronan Alters the Interaction Profile of TIMP-3 with the Endocytic Receptor LRP-1 Clusters II and IV and Increases the Extracellular TIMP-3 Level of Human Bone Marrow Stromal Cells.

Rother S, Samsonov SA, Hempel U, Vogel S, Moeller S, Blaszkiewicz J, Köhling S, Schnabelrauch M, Rademann J, Pisabarro MT, Hintze V, Scharnweber D.

Biomacromolecules. 2016 Oct 10;17(10):3252-3261. Epub 2016 Sep 20.

PMID:
27610455
22.

The structural investigation of glycosaminoglycan binding to CXCL12 displays distinct interaction sites.

Panitz N, Theisgen S, Samsonov SA, Gehrcke JP, Baumann L, Bellmann-Sickert K, Köhling S, Pisabarro MT, Rademann J, Huster D, Beck-Sickinger AG.

Glycobiology. 2016 Nov;26(11):1209-1221. doi: 10.1093/glycob/cww059. Epub 2016 Jun 24.

PMID:
27496764
23.

Mapping Protein-Protein Interactions of the Resistance-Related Bacterial Zeta Toxin-Epsilon Antitoxin Complex (ε₂ζ₂) with High Affinity Peptide Ligands Using Fluorescence Polarization.

Fernández-Bachiller MI, Brzozowska I, Odolczyk N, Zielenkiewicz U, Zielenkiewicz P, Rademann J.

Toxins (Basel). 2016 Jul 16;8(7). pii: E222. doi: 10.3390/toxins8070222.

24.

Incorporation of Amino Acids with Long-Chain Terminal Olefins into Proteins.

Exner MP, Köhling S, Rivollier J, Gosling S, Srivastava P, Palyancheva ZI, Herdewijn P, Heck MP, Rademann J, Budisa N.

Molecules. 2016 Feb 29;21(3):287. doi: 10.3390/molecules21030287.

25.

Chemoenzymatic Synthesis of Nonasulfated Tetrahyaluronan with a Paramagnetic Tag for Studying Its Complex with Interleukin-10.

Köhling S, Künze G, Lemmnitzer K, Bermudez M, Wolber G, Schiller J, Huster D, Rademann J.

Chemistry. 2016 Apr 11;22(16):5563-74. doi: 10.1002/chem.201504459. Epub 2016 Feb 25.

PMID:
26918733
26.

Cholesteryl esters stabilize human CD1c conformations for recognition by self-reactive T cells.

Mansour S, Tocheva AS, Cave-Ayland C, Machelett MM, Sander B, Lissin NM, Molloy PE, Baird MS, Stübs G, Schröder NW, Schumann RR, Rademann J, Postle AD, Jakobsen BK, Marshall BG, Gosain R, Elkington PT, Elliott T, Skylaris CK, Essex JW, Tews I, Gadola SD.

Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):E1266-75. doi: 10.1073/pnas.1519246113. Epub 2016 Feb 16.

27.

Identification of the Glycosaminoglycan Binding Site of Interleukin-10 by NMR Spectroscopy.

Künze G, Köhling S, Vogel A, Rademann J, Huster D.

J Biol Chem. 2016 Feb 5;291(6):3100-13. doi: 10.1074/jbc.M115.681759. Epub 2015 Dec 16.

28.

Identification and Validation of Larixyl Acetate as a Potent TRPC6 Inhibitor.

Urban N, Wang L, Kwiek S, Rademann J, Kuebler WM, Schaefer M.

Mol Pharmacol. 2016 Jan;89(1):197-213. doi: 10.1124/mol.115.100792. Epub 2015 Oct 23.

PMID:
26500253
29.

Peptide-polymer ligands for a tandem WW-domain, an adaptive multivalent protein-protein interaction: lessons on the thermodynamic fitness of flexible ligands.

Koschek K, Durmaz V, Krylova O, Wieczorek M, Gupta S, Richter M, Bujotzek A, Fischer C, Haag R, Freund C, Weber M, Rademann J.

Beilstein J Org Chem. 2015 May 18;11:837-47. doi: 10.3762/bjoc.11.93. eCollection 2015.

30.

Light-switched inhibitors of protein tyrosine phosphatase PTP1B based on phosphonocarbonyl phenylalanine as photoactive phosphotyrosine mimetic.

Wagner S, Schütz A, Rademann J.

Bioorg Med Chem. 2015 Jun 15;23(12):2839-47. doi: 10.1016/j.bmc.2015.03.074. Epub 2015 Apr 4.

PMID:
25907367
31.

Selective inhibitors of the protein tyrosine phosphatase SHP2 block cellular motility and growth of cancer cells in vitro and in vivo.

Grosskopf S, Eckert C, Arkona C, Radetzki S, Böhm K, Heinemann U, Wolber G, von Kries JP, Birchmeier W, Rademann J.

ChemMedChem. 2015 May;10(5):815-26. doi: 10.1002/cmdc.201500015. Epub 2015 Apr 15.

PMID:
25877780
32.

Shp2 signaling suppresses senescence in PyMT-induced mammary gland cancer in mice.

Lan L, Holland JD, Qi J, Grosskopf S, Rademann J, Vogel R, Györffy B, Wulf-Goldenberg A, Birchmeier W.

EMBO J. 2015 Jun 3;34(11):1493-508. doi: 10.15252/embj.201489004. Epub 2015 Mar 3. Erratum in: EMBO J. 2015 Sep 14;34(18):2383. Rademann, Jörg [added].

33.

Catalytic activation of pre-substrates via dynamic fragment assembly on protein templates.

Burda E, Rademann J.

Nat Commun. 2014 Nov 18;5:5170. doi: 10.1038/ncomms6170.

PMID:
25403979
34.

Flexible, polymer-supported synthesis of sphingosine derivatives provides ceramides with enhanced biological activity.

El-Dahshan A, Al-Gharabli SI, Radetzki S, Al-Tel TH, Kumar P, Rademann J.

Bioorg Med Chem. 2014 Oct 1;22(19):5506-12. doi: 10.1016/j.bmc.2014.07.024. Epub 2014 Jul 24.

PMID:
25172146
35.

Chemoselective Wittig and Michael ligations of unprotected peptidyl phosphoranes in water furnish potent inhibitors of caspase-3.

Holland-Nell K, Fernández-Bachiller MI, Ahsanullah, Rademann J.

Org Lett. 2014 Sep 5;16(17):4428-31. doi: 10.1021/ol501910x. Epub 2014 Aug 20.

PMID:
25141292
36.

Multivalent presentation of the cell-penetrating peptide nona-arginine on a linear scaffold strongly increases its membrane-perturbing capacity.

Chakrabarti A, Witsenburg JJ, Sinzinger MD, Richter M, Wallbrecher R, Cluitmans JC, Verdurmen WP, Tanis S, Adjobo-Hermans MJ, Rademann J, Brock R.

Biochim Biophys Acta. 2014 Dec;1838(12):3097-106. doi: 10.1016/j.bbamem.2014.08.001. Epub 2014 Aug 7.

37.

Fluorescent mimetics of CMP-Neu5Ac are highly potent, cell-permeable polarization probes of eukaryotic and bacterial sialyltransferases and inhibit cellular sialylation.

Preidl JJ, Gnanapragassam VS, Lisurek M, Saupe J, Horstkorte R, Rademann J.

Angew Chem Int Ed Engl. 2014 May 26;53(22):5700-5. doi: 10.1002/anie.201400394. Epub 2014 Apr 15. Erratum in: Angew Chem Int Ed Engl. 2014 Jul 28;53(31):7977.

PMID:
24737687
38.

Highly functionalized terpyridines as competitive inhibitors of AKAP-PKA interactions.

Schäfer G, Milić J, Eldahshan A, Götz F, Zühlke K, Schillinger C, Kreuchwig A, Elkins JM, Abdul Azeez KR, Oder A, Moutty MC, Masada N, Beerbaum M, Schlegel B, Niquet S, Schmieder P, Krause G, von Kries JP, Cooper DM, Knapp S, Rademann J, Rosenthal W, Klussmann E.

Angew Chem Int Ed Engl. 2013 Nov 11;52(46):12187-91. doi: 10.1002/anie.201304686. Epub 2013 Sep 23. No abstract available.

39.

Effects of charge and charge distribution on the cellular uptake of multivalent arginine-containing peptide-polymer conjugates.

Koschek K, Dathe M, Rademann J.

Chembiochem. 2013 Oct 11;14(15):1982-90. doi: 10.1002/cbic.201300365. Epub 2013 Sep 24.

PMID:
24115335
40.

Propargyl amides as irreversible inhibitors of cysteine proteases--a lesson on the biological reactivity of alkynes.

Arkona C, Rademann J.

Angew Chem Int Ed Engl. 2013 Aug 5;52(32):8210-2. doi: 10.1002/anie.201303544. Epub 2013 Jun 21. No abstract available.

PMID:
23794491
41.

Alzheimer's disease: identification and development of β-secretase (BACE-1) binding fragments and inhibitors by dynamic ligation screening (DLS).

Fernández-Bachiller MI, Horatscheck A, Lisurek M, Rademann J.

ChemMedChem. 2013 Jul;8(7):1041-56. doi: 10.1002/cmdc.201300078. Epub 2013 Jun 11.

PMID:
23757181
42.

Multivalent design of apoptosis-inducing bid-BH3 peptide-oligosaccharides boosts the intracellular activity at identical overall peptide concentrations.

Richter M, Chakrabarti A, Ruttekolk IR, Wiesner B, Beyermann M, Brock R, Rademann J.

Chemistry. 2012 Dec 21;18(52):16708-15. doi: 10.1002/chem.201202276. Epub 2012 Nov 4.

PMID:
23124530
43.

Fmoc-based synthesis of peptide thioacids for azide ligations via 2-cyanoethyl thioesters.

Raz R, Rademann J.

Org Lett. 2012 Oct 5;14(19):5038-41. doi: 10.1021/ol302247h. Epub 2012 Sep 19.

PMID:
22991969
44.

Extra- and intracellular imaging of human matrix metalloprotease 11 (hMMP-11) with a cell-penetrating FRET substrate.

Meyer BS, Rademann J.

J Biol Chem. 2012 Nov 2;287(45):37857-67. doi: 10.1074/jbc.M112.371500. Epub 2012 Aug 27.

45.

High yield expression of catalytically active USP18 (UBP43) using a Trigger Factor fusion system.

Basters A, Ketscher L, Deuerling E, Arkona C, Rademann J, Knobeloch KP, Fritz G.

BMC Biotechnol. 2012 Aug 23;12:56. doi: 10.1186/1472-6750-12-56.

46.

Benzoylphosphonate-based photoactive phosphopeptide mimetics for modulation of protein tyrosine phosphatases and highly specific labeling of SH2 domains.

Horatscheck A, Wagner S, Ortwein J, Kim BG, Lisurek M, Beligny S, Schütz A, Rademann J.

Angew Chem Int Ed Engl. 2012 Sep 10;51(37):9441-7. doi: 10.1002/anie.201201475. Epub 2012 Aug 21. No abstract available.

PMID:
22907897
47.

New tacrine-4-oxo-4H-chromene hybrids as multifunctional agents for the treatment of Alzheimer's disease, with cholinergic, antioxidant, and β-amyloid-reducing properties.

Fernández-Bachiller MI, Pérez C, Monjas L, Rademann J, Rodríguez-Franco MI.

J Med Chem. 2012 Feb 9;55(3):1303-17. doi: 10.1021/jm201460y. Epub 2012 Jan 27.

PMID:
22243648
48.

Soluble peptidyl phosphoranes for metal-free, stereoselective ligations in organic and aqueous solution.

Ahsanullah, Al-Gharabli SI, Rademann J.

Org Lett. 2012 Jan 6;14(1):14-7. doi: 10.1021/ol202627h. Epub 2011 Dec 2.

PMID:
22136619
49.

Dynamic substrate enhancement for the identification of specific, second-site-binding fragments targeting a set of protein tyrosine phosphatases.

Schmidt MF, Groves MR, Rademann J.

Chembiochem. 2011 Nov 25;12(17):2640-6. doi: 10.1002/cbic.201100414. Epub 2011 Nov 3.

PMID:
22052725
50.

Peptide aldehyde inhibitors challenge the substrate specificity of the SARS-coronavirus main protease.

Zhu L, George S, Schmidt MF, Al-Gharabli SI, Rademann J, Hilgenfeld R.

Antiviral Res. 2011 Nov;92(2):204-12. doi: 10.1016/j.antiviral.2011.08.001. Epub 2011 Aug 11.

PMID:
21854807

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