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Items: 31


Accelerating Gene Discovery by Phenotyping Whole-Genome Sequenced Multi-mutation Strains and Using the Sequence Kernel Association Test (SKAT).

Timbers TA, Garland SJ, Mohan S, Flibotte S, Edgley M, Muncaster Q, Au V, Li-Leger E, Rosell FI, Cai J, Rademakers S, Jansen G, Moerman DG, Leroux MR.

PLoS Genet. 2016 Aug 10;12(8):e1006235. doi: 10.1371/journal.pgen.1006235. eCollection 2016 Aug.


DLK-1/p38 MAP Kinase Signaling Controls Cilium Length by Regulating RAB-5 Mediated Endocytosis in Caenorhabditis elegans.

van der Vaart A, Rademakers S, Jansen G.

PLoS Genet. 2015 Dec 11;11(12):e1005733. doi: 10.1371/journal.pgen.1005733. eCollection 2015 Dec.


Hypoxia, metabolism, and growth factor signaling in head and neck squamous cell carcinoma: correlation between primary and xenograft tumors.

Stegeman H, Rademakers SE, Span PN, Takes RP, van der Kogel AJ, Kaanders JH, Bussink J.

Head Neck. 2014 Sep;36(9):1288-95. doi: 10.1002/hed.23446. Epub 2013 Nov 6.


Improved recurrence-free survival with ARCON for anemic patients with laryngeal cancer.

Janssens GO, Rademakers SE, Terhaard CH, Doornaert PA, Bijl HP, van den Ende P, Chin A, Takes RP, de Bree R, Hoogsteen IJ, Bussink J, Span PN, Kaanders JH.

Clin Cancer Res. 2014 Mar 1;20(5):1345-54. doi: 10.1158/1078-0432.CCR-13-1730. Epub 2014 Jan 22.


Prognostic value of the proliferation marker Ki-67 in laryngeal carcinoma: results of the accelerated radiotherapy with carbogen breathing and nicotinamide phase III randomized trial.

Rademakers SE, Hoogsteen IJ, Rijken PF, Terhaard CH, Doornaert PA, Langendijk JA, van den Ende P, van der Kogel AJ, Bussink J, Kaanders JH.

Head Neck. 2015 Feb;37(2):171-6. doi: 10.1002/hed.23569. Epub 2014 Feb 12.


Pattern of CAIX expression is prognostic for outcome and predicts response to ARCON in patients with laryngeal cancer treated in a phase III randomized trial.

Rademakers SE, Hoogsteen IJ, Rijken PF, Oosterwijk E, Terhaard CH, Doornaert PA, Langendijk JA, van den Ende P, Takes R, De Bree R, van der Kogel AJ, Bussink J, Kaanders JH.

Radiother Oncol. 2013 Sep;108(3):517-22. doi: 10.1016/j.radonc.2013.04.022. Epub 2013 May 26.


SQL-1, homologue of the Golgi protein GMAP210, modulates intraflagellar transport in C. elegans.

Broekhuis JR, Rademakers S, Burghoorn J, Jansen G.

J Cell Sci. 2013 Apr 15;126(Pt 8):1785-95. doi: 10.1242/jcs.116640. Epub 2013 Feb 26.


Vasopressin/oxytocin-related signaling regulates gustatory associative learning in C. elegans.

Beets I, Janssen T, Meelkop E, Temmerman L, Suetens N, Rademakers S, Jansen G, Schoofs L.

Science. 2012 Oct 26;338(6106):543-5. doi: 10.1126/science.1226860.


Accelerated radiotherapy with carbogen and nicotinamide for laryngeal cancer: results of a phase III randomized trial.

Janssens GO, Rademakers SE, Terhaard CH, Doornaert PA, Bijl HP, van den Ende P, Chin A, Marres HA, de Bree R, van der Kogel AJ, Hoogsteen IJ, Bussink J, Span PN, Kaanders JH.

J Clin Oncol. 2012 May 20;30(15):1777-83. doi: 10.1200/JCO.2011.35.9315. Epub 2012 Apr 16.


Differences in metabolism between adeno- and squamous cell non-small cell lung carcinomas: spatial distribution and prognostic value of GLUT1 and MCT4.

Meijer TW, Schuurbiers OC, Kaanders JH, Looijen-Salamon MG, de Geus-Oei LF, Verhagen AF, Lok J, van der Heijden HF, Rademakers SE, Span PN, Bussink J.

Lung Cancer. 2012 Jun;76(3):316-23. doi: 10.1016/j.lungcan.2011.11.006. Epub 2011 Dec 6.


Metabolic markers in relation to hypoxia; staining patterns and colocalization of pimonidazole, HIF-1α, CAIX, LDH-5, GLUT-1, MCT1 and MCT4.

Rademakers SE, Lok J, van der Kogel AJ, Bussink J, Kaanders JH.

BMC Cancer. 2011 May 12;11:167. doi: 10.1186/1471-2407-11-167.


Parametric mapping of immunohistochemically stained tissue sections; a method to quantify the colocalization of tumor markers.

Rademakers SE, Rijken PF, Peeters WJ, Nijkamp MM, Barber PR, van der Laak J, van de Kogel AJ, Bussink J, Kaanders JH.

Cell Oncol (Dordr). 2011 Apr;34(2):119-29. doi: 10.1007/s13402-010-0008-2. Epub 2011 Feb 8.


Dauer pheromone and G-protein signaling modulate the coordination of intraflagellar transport kinesin motor proteins in C. elegans.

Burghoorn J, Dekkers MP, Rademakers S, de Jong T, Willemsen R, Swoboda P, Jansen G.

J Cell Sci. 2010 Jun 15;123(Pt 12):2077-84. doi: 10.1242/jcs.062885. Epub 2010 May 25.


Discovery and characterization of a conserved pigment dispersing factor-like neuropeptide pathway in Caenorhabditis elegans.

Janssen T, Husson SJ, Meelkop E, Temmerman L, Lindemans M, Verstraelen K, Rademakers S, Mertens I, Nitabach M, Jansen G, Schoofs L.

J Neurochem. 2009 Oct;111(1):228-41. doi: 10.1111/j.1471-4159.2009.06323.x. Epub 2009 Aug 3.


Molecular aspects of tumour hypoxia.

Rademakers SE, Span PN, Kaanders JH, Sweep FC, van der Kogel AJ, Bussink J.

Mol Oncol. 2008 Jun;2(1):41-53. doi: 10.1016/j.molonc.2008.03.006. Epub 2008 Mar 27. Review.


Gustatory plasticity in C. elegans involves integration of negative cues and NaCl taste mediated by serotonin, dopamine, and glutamate.

Hukema RK, Rademakers S, Jansen G.

Learn Mem. 2008 Oct 30;15(11):829-36. doi: 10.1101/lm.994408. Print 2008 Nov.


Functional characterization of three G protein-coupled receptors for pigment dispersing factors in Caenorhabditis elegans.

Janssen T, Husson SJ, Lindemans M, Mertens I, Rademakers S, Ver Donck K, Geysen J, Jansen G, Schoofs L.

J Biol Chem. 2008 May 30;283(22):15241-9. doi: 10.1074/jbc.M709060200. Epub 2008 Apr 4.


Mutation of the MAP kinase DYF-5 affects docking and undocking of kinesin-2 motors and reduces their speed in the cilia of Caenorhabditis elegans.

Burghoorn J, Dekkers MP, Rademakers S, de Jong T, Willemsen R, Jansen G.

Proc Natl Acad Sci U S A. 2007 Apr 24;104(17):7157-62. Epub 2007 Apr 9.


Expression of mammalian GPCRs in C. elegans generates novel behavioural responses to human ligands.

Teng MS, Dekkers MP, Ng BL, Rademakers S, Jansen G, Fraser AG, McCafferty J.

BMC Biol. 2006 Jul 20;4:22.


Antagonistic sensory cues generate gustatory plasticity in Caenorhabditis elegans.

Hukema RK, Rademakers S, Dekkers MP, Burghoorn J, Jansen G.

EMBO J. 2006 Jan 25;25(2):312-22. Epub 2006 Jan 12.


Xeroderma pigmentosum group A protein loads as a separate factor onto DNA lesions.

Rademakers S, Volker M, Hoogstraten D, Nigg AL, Moné MJ, Van Zeeland AA, Hoeijmakers JH, Houtsmuller AB, Vermeulen W.

Mol Cell Biol. 2003 Aug;23(16):5755-67.


A temperature-sensitive disorder in basal transcription and DNA repair in humans.

Vermeulen W, Rademakers S, Jaspers NG, Appeldoorn E, Raams A, Klein B, Kleijer WJ, Hansen LK, Hoeijmakers JH.

Nat Genet. 2001 Mar;27(3):299-303.


Sublimiting concentration of TFIIH transcription/DNA repair factor causes TTD-A trichothiodystrophy disorder.

Vermeulen W, Bergmann E, Auriol J, Rademakers S, Frit P, Appeldoorn E, Hoeijmakers JH, Egly JM.

Nat Genet. 2000 Nov;26(3):307-13.


XAB2, a novel tetratricopeptide repeat protein involved in transcription-coupled DNA repair and transcription.

Nakatsu Y, Asahina H, Citterio E, Rademakers S, Vermeulen W, Kamiuchi S, Yeo JP, Khaw MC, Saijo M, Kodo N, Matsuda T, Hoeijmakers JH, Tanaka K.

J Biol Chem. 2000 Nov 10;275(45):34931-7.


Action of DNA repair endonuclease ERCC1/XPF in living cells.

Houtsmuller AB, Rademakers S, Nigg AL, Hoogstraten D, Hoeijmakers JH, Vermeulen W.

Science. 1999 May 7;284(5416):958-61.


Biochemical and biological characterization of wild-type and ATPase-deficient Cockayne syndrome B repair protein.

Citterio E, Rademakers S, van der Horst GT, van Gool AJ, Hoeijmakers JH, Vermeulen W.

J Biol Chem. 1998 May 8;273(19):11844-51.


Two human homologs of Rad23 are functionally interchangeable in complex formation and stimulation of XPC repair activity.

Sugasawa K, Ng JM, Masutani C, Maekawa T, Uchida A, van der Spek PJ, Eker AP, Rademakers S, Visser C, Aboussekhra A, Wood RD, Hanaoka F, Bootsma D, Hoeijmakers JH.

Mol Cell Biol. 1997 Dec;17(12):6924-31.


The Cockayne syndrome B protein, involved in transcription-coupled DNA repair, resides in an RNA polymerase II-containing complex.

van Gool AJ, Citterio E, Rademakers S, van Os R, Vermeulen W, Constantinou A, Egly JM, Bootsma D, Hoeijmakers JH.

EMBO J. 1997 Oct 1;16(19):5955-65.


Xeroderma pigmentosum group F caused by a defect in a structure-specific DNA repair endonuclease.

Sijbers AM, de Laat WL, Ariza RR, Biggerstaff M, Wei YF, Moggs JG, Carter KC, Shell BK, Evans E, de Jong MC, Rademakers S, de Rooij J, Jaspers NG, Hoeijmakers JH, Wood RD.

Cell. 1996 Sep 6;86(5):811-22.


XPC and human homologs of RAD23: intracellular localization and relationship to other nucleotide excision repair complexes.

van der Spek PJ, Eker A, Rademakers S, Visser C, Sugasawa K, Masutani C, Hanaoka F, Bootsma D, Hoeijmakers JH.

Nucleic Acids Res. 1996 Jul 1;24(13):2551-9.

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