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A new hyperpolarized 13C ketone body probe reveals an increase in acetoacetate utilization in the diabetic rat heart.

Abdurrachim D, Woo CC, Teo XQ, Chan WX, Radda GK, Lee PTH.

Sci Rep. 2019 Apr 2;9(1):5532. doi: 10.1038/s41598-019-39378-w.


Loss of BCAA Catabolism during Carcinogenesis Enhances mTORC1 Activity and Promotes Tumor Development and Progression.

Ericksen RE, Lim SL, McDonnell E, Shuen WH, Vadiveloo M, White PJ, Ding Z, Kwok R, Lee P, Radda GK, Toh HC, Hirschey MD, Han W.

Cell Metab. 2019 May 7;29(5):1151-1165.e6. doi: 10.1016/j.cmet.2018.12.020. Epub 2019 Jan 17.


Downregulating serine hydroxymethyltransferase 2 (SHMT2) suppresses tumorigenesis in human hepatocellular carcinoma.

Woo CC, Chen WC, Teo XQ, Radda GK, Lee PT.

Oncotarget. 2016 Aug 16;7(33):53005-53017. doi: 10.18632/oncotarget.10415.


Robust hyperpolarized (13)C metabolic imaging with selective non-excitation of pyruvate (SNEP).

Chen WC, Teo XQ, Lee MY, Radda GK, Lee P.

NMR Biomed. 2015 Aug;28(8):1021-30. doi: 10.1002/nbm.3346. Epub 2015 Jun 28.


FoxO1 negatively regulates leptin-induced POMC transcription through its direct interaction with STAT3.

Ma W, Fuentes G, Shi X, Verma C, Radda GK, Han W.

Biochem J. 2015 Mar 1;466(2):291-8. doi: 10.1042/BJ20141109.


Impaired in vivo mitochondrial Krebs cycle activity after myocardial infarction assessed using hyperpolarized magnetic resonance spectroscopy.

Dodd MS, Atherton HJ, Carr CA, Stuckey DJ, West JA, Griffin JL, Radda GK, Clarke K, Heather LC, Tyler DJ.

Circ Cardiovasc Imaging. 2014 Nov;7(6):895-904. doi: 10.1161/CIRCIMAGING.114.001857. Epub 2014 Sep 8.


Transposon mutagenesis identifies genes driving hepatocellular carcinoma in a chronic hepatitis B mouse model.

Bard-Chapeau EA, Nguyen AT, Rust AG, Sayadi A, Lee P, Chua BQ, New LS, de Jong J, Ward JM, Chin CK, Chew V, Toh HC, Abastado JP, Benoukraf T, Soong R, Bard FA, Dupuy AJ, Johnson RL, Radda GK, Chan EC, Wessels LF, Adams DJ, Jenkins NA, Copeland NG.

Nat Genet. 2014 Jan;46(1):24-32. doi: 10.1038/ng.2847. Epub 2013 Dec 8.


Neonatal overnutrition in mice exacerbates high-fat diet-induced metabolic perturbations.

Liu Z, Lim CY, Su MY, Soh SL, Shui G, Wenk MR, Grove KL, Radda GK, Han W, Xiao X.

J Endocrinol. 2013 Oct 4;219(2):131-43. doi: 10.1530/JOE-13-0111. Print 2013 Nov.


Gastrointestinal transit measurements in mice with 99mTc-DTPA-labeled activated charcoal using NanoSPECT-CT.

Padmanabhan P, Grosse J, Asad AB, Radda GK, Golay X.

EJNMMI Res. 2013 Aug 2;3(1):60. doi: 10.1186/2191-219X-3-60.


Visualization and isolation of Langerhans islets by a fluorescent probe PiY.

Kang NY, Lee SC, Park SJ, Ha HH, Yun SW, Kostromina E, Gustavsson N, Ali Y, Chandran Y, Chun HS, Bae M, Ahn JH, Han W, Radda GK, Chang YT.

Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8557-60. doi: 10.1002/anie.201302149. Epub 2013 May 28. No abstract available.


Suppression of adipogenesis by pathogenic seipin mutant is associated with inflammatory response.

Qiu W, Wee K, Takeda K, Lim X, Sugii S, Radda GK, Han W.

PLoS One. 2013;8(3):e57874. doi: 10.1371/journal.pone.0057874. Epub 2013 Mar 8.


Motor neuron degeneration in a mouse model of seipinopathy.

Guo J, Qiu W, Soh SL, Wei S, Radda GK, Ong WY, Pang ZP, Han W.

Cell Death Dis. 2013 Mar 7;4:e535. doi: 10.1038/cddis.2013.64.


Seipin differentially regulates lipogenesis and adipogenesis through a conserved core sequence and an evolutionarily acquired C-terminus.

Yang W, Thein S, Guo X, Xu F, Venkatesh B, Sugii S, Radda GK, Han W.

Biochem J. 2013 May 15;452(1):37-44. doi: 10.1042/BJ20121870.


Nuclear factor κB (NF-κB) suppresses food intake and energy expenditure in mice by directly activating the Pomc promoter.

Shi X, Wang X, Li Q, Su M, Chew E, Wong ET, Lacza Z, Radda GK, Tergaonkar V, Han W.

Diabetologia. 2013 Apr;56(4):925-36. doi: 10.1007/s00125-013-2831-2. Epub 2013 Jan 31.


Regulation of adipogenesis by cytoskeleton remodelling is facilitated by acetyltransferase MEC-17-dependent acetylation of α-tubulin.

Yang W, Guo X, Thein S, Xu F, Sugii S, Baas PW, Radda GK, Han W.

Biochem J. 2013 Feb 1;449(3):605-12. doi: 10.1042/BJ20121121.


In vivo hyperpolarized carbon-13 magnetic resonance spectroscopy reveals increased pyruvate carboxylase flux in an insulin-resistant mouse model.

Lee P, Leong W, Tan T, Lim M, Han W, Radda GK.

Hepatology. 2013 Feb;57(2):515-24. doi: 10.1002/hep.26028. Epub 2013 Jan 10.


The cycling of acetyl-coenzyme A through acetylcarnitine buffers cardiac substrate supply: a hyperpolarized 13C magnetic resonance study.

Schroeder MA, Atherton HJ, Dodd MS, Lee P, Cochlin LE, Radda GK, Clarke K, Tyler DJ.

Circ Cardiovasc Imaging. 2012 Mar;5(2):201-9. doi: 10.1161/CIRCIMAGING.111.969451. Epub 2012 Jan 11.


Increased lipolysis and energy expenditure in a mouse model with severely impaired glucagon secretion.

Lou PH, Gustavsson N, Wang Y, Radda GK, Han W.

PLoS One. 2011;6(10):e26671. doi: 10.1371/journal.pone.0026671. Epub 2011 Oct 27.


Role of pyruvate dehydrogenase inhibition in the development of hypertrophy in the hyperthyroid rat heart: a combined magnetic resonance imaging and hyperpolarized magnetic resonance spectroscopy study.

Atherton HJ, Dodd MS, Heather LC, Schroeder MA, Griffin JL, Radda GK, Clarke K, Tyler DJ.

Circulation. 2011 Jun 7;123(22):2552-61. doi: 10.1161/CIRCULATIONAHA.110.011387. Epub 2011 May 23.


Synaptotagmin-7 as a positive regulator of glucose-induced glucagon-like peptide-1 secretion in mice.

Gustavsson N, Wang Y, Kang Y, Seah T, Chua S, Radda GK, Han W.

Diabetologia. 2011 Jul;54(7):1824-30. doi: 10.1007/s00125-011-2119-3. Epub 2011 Mar 22.


Determining the in vivo regulation of cardiac pyruvate dehydrogenase based on label flux from hyperpolarised [1-13C]pyruvate.

Schroeder MA, Atherton HJ, Heather LC, Griffin JL, Clarke K, Radda GK, Tyler DJ.

NMR Biomed. 2011 Oct;24(8):980-987. doi: 10.1002/nbm.1668. Epub 2011 Mar 8.


Neuronal calcium sensor synaptotagmin-9 is not involved in the regulation of glucose homeostasis or insulin secretion.

Gustavsson N, Wang X, Wang Y, Seah T, Xu J, Radda GK, Südhof TC, Han W.

PLoS One. 2010 Nov 9;5(11):e15414. doi: 10.1371/journal.pone.0015414.


Delayed onset of hyperglycaemia in a mouse model with impaired glucagon secretion demonstrates that dysregulated glucagon secretion promotes hyperglycaemia and type 2 diabetes.

Gustavsson N, Seah T, Lao Y, Radda GK, Südhof TC, Han W.

Diabetologia. 2011 Feb;54(2):415-22. doi: 10.1007/s00125-010-1950-2. Epub 2010 Oct 27.


Validation of the in vivo assessment of pyruvate dehydrogenase activity using hyperpolarised 13C MRS.

Atherton HJ, Schroeder MA, Dodd MS, Heather LC, Carter EE, Cochlin LE, Nagel S, Sibson NR, Radda GK, Clarke K, Tyler DJ.

NMR Biomed. 2011 Feb;24(2):201-208. doi: 10.1002/nbm.1573. Epub 2010 Aug 26.


Reduced body weight and increased energy expenditure in transgenic mice over-expressing soluble leptin receptor.

Lou PH, Yang G, Huang L, Cui Y, Pourbahrami T, Radda GK, Li C, Han W.

PLoS One. 2010 Jul 20;5(7):e11669. doi: 10.1371/journal.pone.0011669.


Imaging metabolic syndrome.

Han W, Chuang KH, Chang YT, Olivo M, Velan SS, Bhakoo K, Townsend D, Radda GK.

EMBO Mol Med. 2010 Jun;2(6):196-210. doi: 10.1002/emmm.201000074. Review.


Glucose intolerance and impaired insulin secretion in pancreas-specific signal transducer and activator of transcription-3 knockout mice are associated with microvascular alterations in the pancreas.

Kostromina E, Gustavsson N, Wang X, Lim CY, Radda GK, Li C, Han W.

Endocrinology. 2010 May;151(5):2050-9. doi: 10.1210/en.2009-1199. Epub 2010 Mar 9.


Measuring intracellular pH in the heart using hyperpolarized carbon dioxide and bicarbonate: a 13C and 31P magnetic resonance spectroscopy study.

Schroeder MA, Swietach P, Atherton HJ, Gallagher FA, Lee P, Radda GK, Clarke K, Tyler DJ.

Cardiovasc Res. 2010 Apr 1;86(1):82-91. doi: 10.1093/cvr/cvp396. Epub 2009 Dec 15.


Real-time assessment of Krebs cycle metabolism using hyperpolarized 13C magnetic resonance spectroscopy.

Schroeder MA, Atherton HJ, Ball DR, Cole MA, Heather LC, Griffin JL, Clarke K, Radda GK, Tyler DJ.

FASEB J. 2009 Aug;23(8):2529-38. doi: 10.1096/fj.09-129171. Epub 2009 Mar 27.


The effect of hyperpolarized tracer concentration on myocardial uptake and metabolism.

Schroeder MA, Atherton HJ, Cochlin LE, Clarke K, Radda GK, Tyler DJ.

Magn Reson Med. 2009 May;61(5):1007-14. doi: 10.1002/mrm.21934.


Synaptotagmin-7 is a principal Ca2+ sensor for Ca2+ -induced glucagon exocytosis in pancreas.

Gustavsson N, Wei SH, Hoang DN, Lao Y, Zhang Q, Radda GK, Rorsman P, Südhof TC, Han W.

J Physiol. 2009 Mar 15;587(Pt 6):1169-78. doi: 10.1113/jphysiol.2008.168005. Epub 2009 Jan 26.


FoxO1 inhibits leptin regulation of pro-opiomelanocortin promoter activity by blocking STAT3 interaction with specificity protein 1.

Yang G, Lim CY, Li C, Xiao X, Radda GK, Li C, Cao X, Han W.

J Biol Chem. 2009 Feb 6;284(6):3719-27. doi: 10.1074/jbc.M804965200. Epub 2008 Dec 2.


Abnormal cardiac morphology, function and energy metabolism in the dystrophic mdx mouse: an MRI and MRS study.

Zhang W, ten Hove M, Schneider JE, Stuckey DJ, Sebag-Montefiore L, Bia BL, Radda GK, Davies KE, Neubauer S, Clarke K.

J Mol Cell Cardiol. 2008 Dec;45(6):754-60. doi: 10.1016/j.yjmcc.2008.09.125. Epub 2008 Sep 27.


In vivo assessment of pyruvate dehydrogenase flux in the heart using hyperpolarized carbon-13 magnetic resonance.

Schroeder MA, Cochlin LE, Heather LC, Clarke K, Radda GK, Tyler DJ.

Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):12051-6. doi: 10.1073/pnas.0805953105. Epub 2008 Aug 8.


Remembering John Newsom-Davis' contribution to human imaging in Oxford.

Matthews PM, Radda GK, Johansen-Berg H, Tracey I, Cowey A.

J Neuroimmunol. 2008 Sep 15;201-202:250-4. doi: 10.1016/j.jneuroim.2008.05.035. Epub 2008 Aug 3.


Bone marrow-derived stromal cells home to and remain in the infarcted rat heart but fail to improve function: an in vivo cine-MRI study.

Carr CA, Stuckey DJ, Tatton L, Tyler DJ, Hale SJ, Sweeney D, Schneider JE, Martin-Rendon E, Radda GK, Harding SE, Watt SM, Clarke K.

Am J Physiol Heart Circ Physiol. 2008 Aug;295(2):H533-42. doi: 10.1152/ajpheart.00094.2008. Epub 2008 Jun 6.


Impaired insulin secretion and glucose intolerance in synaptotagmin-7 null mutant mice.

Gustavsson N, Lao Y, Maximov A, Chuang JC, Kostromina E, Repa JJ, Li C, Radda GK, Südhof TC, Han W.

Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3992-7. doi: 10.1073/pnas.0711700105. Epub 2008 Feb 28.


Molecular imaging perspectives.

Cassidy PJ, Radda GK.

J R Soc Interface. 2005 Jun 22;2(3):133-44. Review.


Iron particles for noninvasive monitoring of bone marrow stromal cell engraftment into, and isolation of viable engrafted donor cells from, the heart.

Stuckey DJ, Carr CA, Martin-Rendon E, Tyler DJ, Willmott C, Cassidy PJ, Hale SJ, Schneider JE, Tatton L, Harding SE, Radda GK, Watt S, Clarke K.

Stem Cells. 2006 Aug;24(8):1968-75. Epub 2006 Apr 20.


Insulin resistance, abnormal energy metabolism and increased ischemic damage in the chronically infarcted rat heart.

Murray AJ, Lygate CA, Cole MA, Carr CA, Radda GK, Neubauer S, Clarke K.

Cardiovasc Res. 2006 Jul 1;71(1):149-57. Epub 2006 Mar 10.


PPAR-alpha activation required for decreased glucose uptake and increased susceptibility to injury during ischemia.

Panagia M, Gibbons GF, Radda GK, Clarke K.

Am J Physiol Heart Circ Physiol. 2005 Jun;288(6):H2677-83. Epub 2005 Jan 21.


Uncoupling proteins in human heart.

Murray AJ, Anderson RE, Watson GC, Radda GK, Clarke K.

Lancet. 2004 Nov 13-19;364(9447):1786-8.


Gender differences in hypertrophy, insulin resistance and ischemic injury in the aging type 2 diabetic rat heart.

Desrois M, Sidell RJ, Gauguier D, Davey CL, Radda GK, Clarke K.

J Mol Cell Cardiol. 2004 Aug;37(2):547-55.


Initial steps of insulin signaling and glucose transport are defective in the type 2 diabetic rat heart.

Desrois M, Sidell RJ, Gauguier D, King LM, Radda GK, Clarke K.

Cardiovasc Res. 2004 Feb 1;61(2):288-96.


From gene function to improved health: genome research in the United Kingdom.

Radda GK, Viney I.

J Mol Med (Berl). 2004 Feb;82(2):74-90. Epub 2004 Jan 8. Review.


Brain bioenergetics and cognitive ability.

Rae C, Scott RB, Lee M, Simpson JM, Hines N, Paul C, Anderson M, Karmiloff-Smith A, Styles P, Radda GK.

Dev Neurosci. 2003 Sep-Oct;25(5):324-31.


Abnormal cardiac and skeletal muscle energy metabolism in patients with type 2 diabetes.

Scheuermann-Freestone M, Madsen PL, Manners D, Blamire AM, Buckingham RE, Styles P, Radda GK, Neubauer S, Clarke K.

Circulation. 2003 Jun 24;107(24):3040-6. Epub 2003 Jun 16.


The mechanism underlying the positive inotropic effect of angiotensin II in the isolated perfused rabbit heart: a 31P NMR study.

Mielke M, Paterson DJ, Sang AE, Radda GK, Clarke K.

Int J Biochem Cell Biol. 2003 Jun;35(6):984-91.


Simultaneous determination of low free Mg2+ and pH in human sickle cells using 31P NMR spectroscopy.

Willcocks JP, Mulquiney PJ, Ellory JC, Veech RL, Radda GK, Clarke K.

J Biol Chem. 2002 Dec 20;277(51):49911-20. Epub 2002 Sep 23.

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