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Items: 1 to 50 of 122

1.

Protein tyrosine phosphatase 1b deficiency protects against hepatic fibrosis by modulating nadph oxidases.

García-Ruiz I, Blanes Ruiz N, Rada P, Pardo V, Ruiz L, Blas-García A, Valdecantos MP, Grau Sanz M, Solís Herruzo JA, Valverde ÁM.

Redox Biol. 2019 Jun 29;26:101263. doi: 10.1016/j.redox.2019.101263. [Epub ahead of print]

2.

Insulin receptor substrate 2 (IRS2) deficiency delays liver fibrosis associated with cholestatic injury.

Villar-Lorenzo A, Rada P, Rey E, Marañón P, Arroba AI, Santamaría B, Sáiz J, Rupérez FJ, Barbas C, García-Monzón C, Valverde ÁM, González-Rodríguez Á.

Dis Model Mech. 2019 Jul 16;12(7). pii: dmm038810. doi: 10.1242/dmm.038810.

3.

Investigation of the Secretory Pathway in Trichomonas vaginalis Argues against a Moonlighting Function of Hydrogenosomal Enzymes.

Rada P, Kellerová P, Verner Z, Tachezy J.

J Eukaryot Microbiol. 2019 May 11. doi: 10.1111/jeu.12741. [Epub ahead of print]

PMID:
31077495
4.

p38α deficiency restrains liver regeneration after partial hepatectomy triggering oxidative stress and liver injury.

Rius-Pérez S, Tormos AM, Pérez S, Finamor I, Rada P, Valverde ÁM, Nebreda AR, Sastre J, Taléns-Visconti R.

Sci Rep. 2019 Mar 7;9(1):3775. doi: 10.1038/s41598-019-39428-3.

5.

Triplet-pore structure of a highly divergent TOM complex of hydrogenosomes in Trichomonas vaginalis.

Makki A, Rada P, Žárský V, Kereïche S, Kováčik L, Novotný M, Jores T, Rapaport D, Tachezy J.

PLoS Biol. 2019 Jan 4;17(1):e3000098. doi: 10.1371/journal.pbio.3000098. eCollection 2019 Jan.

6.

Targeting of tail-anchored proteins to Trichomonas vaginalis hydrogenosomes.

Rada P, Makki A, Žárský V, Tachezy J.

Mol Microbiol. 2019 Mar;111(3):588-603. doi: 10.1111/mmi.14175. Epub 2019 Jan 8.

PMID:
30506591
7.

Sugar Addiction: From Evolution to Revolution.

Wiss DA, Avena N, Rada P.

Front Psychiatry. 2018 Nov 7;9:545. doi: 10.3389/fpsyt.2018.00545. eCollection 2018. Review.

8.

Differential effects of metformin glycinate and hydrochloride in glucose production, AMPK phosphorylation and insulin sensitivity in hepatocytes from non-diabetic and diabetic mice.

Rada P, Mosquera A, Muntané J, Ferrandiz F, Rodriguez-Mañas L, de Pablo F, González-Canudas J, Valverde ÁM.

Food Chem Toxicol. 2019 Jan;123:470-480. doi: 10.1016/j.fct.2018.11.019. Epub 2018 Nov 9.

PMID:
30414960
9.

Involvement of G protein-coupled receptor kinase 2 (GRK2) in the development of non-alcoholic steatosis and steatohepatitis in mice and humans.

Cruces-Sande M, Vila-Bedmar R, Arcones AC, González-Rodríguez Á, Rada P, Gutiérrez-de-Juan V, Vargas-Castrillón J, Iruzubieta P, Sánchez-González C, Formentini L, Crespo J, García-Monzón C, Martínez-Chantar ML, Valverde ÁM, Mayor F Jr, Murga C.

Biochim Biophys Acta Mol Basis Dis. 2018 Dec;1864(12):3655-3667. doi: 10.1016/j.bbadis.2018.09.027. Epub 2018 Sep 24.

PMID:
30261289
10.

Protection against gamma-radiation injury by protein tyrosine phosphatase 1B.

Mojena M, Pimentel-Santillana M, Povo-Retana A, Fernández-García V, González-Ramos S, Rada P, Tejedor A, Rico D, Martín-Sanz P, Valverde AM, Boscá L.

Redox Biol. 2018 Jul;17:213-223. doi: 10.1016/j.redox.2018.04.018. Epub 2018 Apr 21.

11.

Micellar electrokinetic chromatography with laser induced fluorescence detection shows increase of putrescine in erythrocytes of Parkinson's disease patients.

Betancourt L, Rada P, Hernandez L, Araujo H, Ceballos GA, Hernandez LE, Tucci P, Mari Z, De Pasquale M, Paredes DA.

J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Apr 1;1081-1082:51-57. doi: 10.1016/j.jchromb.2018.02.015. Epub 2018 Feb 13.

PMID:
29502029
12.

Hepatic regulation of VLDL receptor by PPARβ/δ and FGF21 modulates non-alcoholic fatty liver disease.

Zarei M, Barroso E, Palomer X, Dai J, Rada P, Quesada-López T, Escolà-Gil JC, Cedó L, Zali MR, Molaei M, Dabiri R, Vázquez S, Pujol E, Valverde ÁM, Villarroya F, Liu Y, Wahli W, Vázquez-Carrera M.

Mol Metab. 2018 Feb;8:117-131. doi: 10.1016/j.molmet.2017.12.008. Epub 2017 Dec 19.

13.

Dynamic secretome of Trichomonas vaginalis: Case study of β-amylases.

Štáfková J, Rada P, Meloni D, Žárský V, Smutná T, Zimmann N, Harant K, Pompach P, Hrdý I, Tachezy J.

Mol Cell Proteomics. 2018 Feb;17(2):304-320. doi: 10.1074/mcp.RA117.000434. Epub 2017 Dec 12.

14.

Dual role of protein tyrosine phosphatase 1B in the progression and reversion of non-alcoholic steatohepatitis.

González-Rodríguez Á, Valdecantos MP, Rada P, Addante A, Barahona I, Rey E, Pardo V, Ruiz L, Laiglesia LM, Moreno-Aliaga MJ, García-Monzón C, Sánchez A, Valverde ÁM.

Mol Metab. 2018 Jan;7:132-146. doi: 10.1016/j.molmet.2017.10.008. Epub 2017 Oct 31.

15.

SIRT1 Controls Acetaminophen Hepatotoxicity by Modulating Inflammation and Oxidative Stress.

Rada P, Pardo V, Mobasher MA, García-Martínez I, Ruiz L, González-Rodríguez Á, Sanchez-Ramos C, Muntané J, Alemany S, James LP, Simpson KJ, Monsalve M, Valdecantos MP, Valverde ÁM.

Antioxid Redox Signal. 2018 May 1;28(13):1187-1208. doi: 10.1089/ars.2017.7373. Epub 2017 Dec 11.

PMID:
29084443
16.

NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology.

Rojo AI, Pajares M, Rada P, Nuñez A, Nevado-Holgado AJ, Killik R, Van Leuven F, Ribe E, Lovestone S, Yamamoto M, Cuadrado A.

Redox Biol. 2017 Oct;13:444-451. doi: 10.1016/j.redox.2017.07.006. Epub 2017 Jul 5.

17.

A ketogenic diet modifies glutamate, gamma-aminobutyric acid and agmatine levels in the hippocampus of rats: A microdialysis study.

Calderón N, Betancourt L, Hernández L, Rada P.

Neurosci Lett. 2017 Mar 6;642:158-162. doi: 10.1016/j.neulet.2017.02.014. Epub 2017 Feb 8.

PMID:
28189745
18.

Correlation between plasma levels of arginine and citrulline in preterm and full-term neonates: Therapeutical implications.

Contreras MT, Gallardo MJ, Betancourt LR, Rada PV, Ceballos GA, Hernandez LE, Hernandez LF.

J Clin Lab Anal. 2017 Nov;31(6). doi: 10.1002/jcla.22134. Epub 2017 Feb 7.

PMID:
28169465
19.

p38α regulates actin cytoskeleton and cytokinesis in hepatocytes during development and aging.

Tormos AM, Rius-Pérez S, Jorques M, Rada P, Ramirez L, Valverde ÁM, Nebreda ÁR, Sastre J, Taléns-Visconti R.

PLoS One. 2017 Feb 6;12(2):e0171738. doi: 10.1371/journal.pone.0171738. eCollection 2017.

20.

N-Terminal Presequence-Independent Import of Phosphofructokinase into Hydrogenosomes of Trichomonas vaginalis.

Rada P, Makki AR, Zimorski V, Garg S, Hampl V, Hrdý I, Gould SB, Tachezy J.

Eukaryot Cell. 2015 Dec;14(12):1264-75. doi: 10.1128/EC.00104-15. Epub 2015 Oct 16.

21.

Conservation of Transit Peptide-Independent Protein Import into the Mitochondrial and Hydrogenosomal Matrix.

Garg S, Stölting J, Zimorski V, Rada P, Tachezy J, Martin WF, Gould SB.

Genome Biol Evol. 2015 Sep 2;7(9):2716-26. doi: 10.1093/gbe/evv175.

22.

Resveratrol treatment restores peripheral insulin sensitivity in diabetic mice in a sirt1-independent manner.

González-Rodríguez Á, Santamaría B, Mas-Gutierrez JA, Rada P, Fernández-Millán E, Pardo V, Álvarez C, Cuadrado A, Ros M, Serrano M, Valverde ÁM.

Mol Nutr Food Res. 2015 Aug;59(8):1431-42. doi: 10.1002/mnfr.201400933. Epub 2015 Apr 28.

PMID:
25808216
23.

Melatonin-sulforaphane hybrid ITH12674 induces neuroprotection in oxidative stress conditions by a 'drug-prodrug' mechanism of action.

Egea J, Buendia I, Parada E, Navarro E, Rada P, Cuadrado A, López MG, García AG, León R.

Br J Pharmacol. 2015 Apr;172(7):1807-21. doi: 10.1111/bph.13025. Epub 2015 Feb 10.

24.

WNT-3A regulates an Axin1/NRF2 complex that regulates antioxidant metabolism in hepatocytes.

Rada P, Rojo AI, Offergeld A, Feng GJ, Velasco-Martín JP, González-Sancho JM, Valverde ÁM, Dale T, Regadera J, Cuadrado A.

Antioxid Redox Signal. 2015 Mar 1;22(7):555-71. doi: 10.1089/ars.2014.6040. Epub 2014 Dec 9.

25.

Agmatine induces Nrf2 and protects against corticosterone effects in hippocampal neuronal cell line.

Freitas AE, Egea J, Buendía I, Navarro E, Rada P, Cuadrado A, Rodrigues AL, López MG.

Mol Neurobiol. 2015;51(3):1504-19. doi: 10.1007/s12035-014-8827-1. Epub 2014 Aug 2.

PMID:
25084759
26.

The PTEN/NRF2 axis promotes human carcinogenesis.

Rojo AI, Rada P, Mendiola M, Ortega-Molina A, Wojdyla K, Rogowska-Wrzesinska A, Hardisson D, Serrano M, Cuadrado A.

Antioxid Redox Signal. 2014 Dec 20;21(18):2498-514. doi: 10.1089/ars.2014.5843. Epub 2014 Jul 31.

27.

Redox control of microglial function: molecular mechanisms and functional significance.

Rojo AI, McBean G, Cindric M, Egea J, López MG, Rada P, Zarkovic N, Cuadrado A.

Antioxid Redox Signal. 2014 Oct 20;21(12):1766-801. doi: 10.1089/ars.2013.5745. Epub 2014 May 5. Review.

28.

Iron-induced changes in the proteome of Trichomonas vaginalis hydrogenosomes.

Beltrán NC, Horváthová L, Jedelský PL, Sedinová M, Rada P, Marcinčiková M, Hrdý I, Tachezy J.

PLoS One. 2013 May 31;8(5):e65148. doi: 10.1371/journal.pone.0065148. Print 2013.

29.

Protein tyrosine phosphatase 1B modulates GSK3β/Nrf2 and IGFIR signaling pathways in acetaminophen-induced hepatotoxicity.

Mobasher MA, González-Rodriguez A, Santamaría B, Ramos S, Martín MÁ, Goya L, Rada P, Letzig L, James LP, Cuadrado A, Martín-Pérez J, Simpson KJ, Muntané J, Valverde AM.

Cell Death Dis. 2013 May 9;4:e626. doi: 10.1038/cddis.2013.150.

30.

Physical exercise prevents stress-induced activation of granule neurons and enhances local inhibitory mechanisms in the dentate gyrus.

Schoenfeld TJ, Rada P, Pieruzzini PR, Hsueh B, Gould E.

J Neurosci. 2013 May 1;33(18):7770-7. doi: 10.1523/JNEUROSCI.5352-12.2013.

31.

Nuclear import and export signals control the subcellular localization of Nurr1 protein in response to oxidative stress.

García-Yagüe ÁJ, Rada P, Rojo AI, Lastres-Becker I, Cuadrado A.

J Biol Chem. 2013 Feb 22;288(8):5506-17. doi: 10.1074/jbc.M112.439190. Epub 2013 Jan 2.

32.

Listeria monocytogenes septic arthritis in a patient treated with mycophenolate mofetil for polyarteritis nodosa: a case report and review of the literature.

Del Pozo JL, de la Garza RG, de Rada PD, Ornilla E, Yuste JR.

Int J Infect Dis. 2013 Feb;17(2):e132-3. doi: 10.1016/j.ijid.2012.11.005. Epub 2012 Dec 5. Review.

33.

Amino acid profile of plasma and cerebrospinal fluid in preeclampsia.

Terán Y, Ponce O, Betancourt L, Hernández L, Rada P.

Pregnancy Hypertens. 2012 Oct;2(4):416-22. doi: 10.1016/j.preghy.2012.05.001. Epub 2012 May 20.

PMID:
26105613
34.

Structural and functional characterization of Nrf2 degradation by the glycogen synthase kinase 3/β-TrCP axis.

Rada P, Rojo AI, Evrard-Todeschi N, Innamorato NG, Cotte A, Jaworski T, Tobón-Velasco JC, Devijver H, García-Mayoral MF, Van Leuven F, Hayes JD, Bertho G, Cuadrado A.

Mol Cell Biol. 2012 Sep;32(17):3486-99. doi: 10.1128/MCB.00180-12. Epub 2012 Jul 2.

35.

Cholinergic modulation of food and drug satiety and withdrawal.

Avena NM, Rada PV.

Physiol Behav. 2012 Jun 6;106(3):332-6. doi: 10.1016/j.physbeh.2012.03.020. Epub 2012 Mar 28. Review.

36.

Corticotropin-releasing factor in the nucleus accumbens shell induces swim depression, anxiety, and anhedonia along with changes in local dopamine/acetylcholine balance.

Chen YW, Rada PV, Bützler BP, Leibowitz SF, Hoebel BG.

Neuroscience. 2012 Mar 29;206:155-66. doi: 10.1016/j.neuroscience.2011.12.009. Epub 2012 Jan 5.

PMID:
22245501
37.

A high-fat meal, or intraperitoneal administration of a fat emulsion, increases extracellular dopamine in the nucleus accumbens.

Rada P, Avena NM, Barson JR, Hoebel BG, Leibowitz SF.

Brain Sci. 2012 Jun 11;2(2):242-53. doi: 10.3390/brainsci2020242.

38.

Signaling pathways activated by the phytochemical nordihydroguaiaretic acid contribute to a Keap1-independent regulation of Nrf2 stability: Role of glycogen synthase kinase-3.

Rojo AI, Medina-Campos ON, Rada P, Zúñiga-Toalá A, López-Gazcón A, Espada S, Pedraza-Chaverri J, Cuadrado A.

Free Radic Biol Med. 2012 Jan 15;52(2):473-87. doi: 10.1016/j.freeradbiomed.2011.11.003. Epub 2011 Nov 12.

PMID:
22142471
39.

In vivo monitoring of cerebral agmatine by microdialysis and capillary electrophoresis.

Betancourt L, Rada P, Paredes D, Hernández L.

J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Jan 1;880(1):58-65. doi: 10.1016/j.jchromb.2011.11.016. Epub 2011 Nov 18.

PMID:
22134038
40.

The core components of organelle biogenesis and membrane transport in the hydrogenosomes of Trichomonas vaginalis.

Rada P, Doležal P, Jedelský PL, Bursac D, Perry AJ, Šedinová M, Smíšková K, Novotný M, Beltrán NC, Hrdý I, Lithgow T, Tachezy J.

PLoS One. 2011;6(9):e24428. doi: 10.1371/journal.pone.0024428. Epub 2011 Sep 15.

41.

Enhanced GABAergic tone in the ventral pallidum: memory of unpleasant experiences?

Skirzewski M, López W, Mosquera E, Betancourt L, Catlow B, Chiurillo M, Loureiro N, Hernández L, Rada P.

Neuroscience. 2011 Nov 24;196:131-46. doi: 10.1016/j.neuroscience.2011.08.058. Epub 2011 Aug 30.

PMID:
21914462
42.

Feeding behavior as seen through the prism of brain microdialysis.

Hernández L, Paredes D, Rada P.

Physiol Behav. 2011 Jul 25;104(1):47-56. doi: 10.1016/j.physbeh.2011.04.031. Epub 2011 Apr 28. Review.

PMID:
21549733
43.

Fluoxetine alleviates behavioral depression while decreasing acetylcholine release in the nucleus accumbens shell.

Chau DT, Rada PV, Kim K, Kosloff RA, Hoebel BG.

Neuropsychopharmacology. 2011 Jul;36(8):1729-37. doi: 10.1038/npp.2011.54. Epub 2011 Apr 27. Erratum in: Neuropsychopharmacology. 2012 Sep;37(10):2346. Dosage error in article text.

44.

The minimal proteome in the reduced mitochondrion of the parasitic protist Giardia intestinalis.

Jedelský PL, Doležal P, Rada P, Pyrih J, Smíd O, Hrdý I, Sedinová M, Marcinčiková M, Voleman L, Perry AJ, Beltrán NC, Lithgow T, Tachezy J.

PLoS One. 2011 Feb 24;6(2):e17285. doi: 10.1371/journal.pone.0017285.

45.

SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner.

Rada P, Rojo AI, Chowdhry S, McMahon M, Hayes JD, Cuadrado A.

Mol Cell Biol. 2011 Mar;31(6):1121-33. doi: 10.1128/MCB.01204-10. Epub 2011 Jan 18.

46.

Reduced accumbens dopamine in Sprague-Dawley rats prone to overeating a fat-rich diet.

Rada P, Bocarsly ME, Barson JR, Hoebel BG, Leibowitz SF.

Physiol Behav. 2010 Oct 5;101(3):394-400. doi: 10.1016/j.physbeh.2010.07.005. Epub 2010 Jul 16.

47.

Acute lecozotan administration increases learning and memory in rats without affecting anxiety or behavioral depression.

Skirzewski M, Hernandez L, Schechter LE, Rada P.

Pharmacol Biochem Behav. 2010 May;95(3):325-30. doi: 10.1016/j.pbb.2010.02.008. Epub 2010 Feb 17.

PMID:
20170670
48.

Opioids in the hypothalamic paraventricular nucleus stimulate ethanol intake.

Barson JR, Carr AJ, Soun JE, Sobhani NC, Rada P, Leibowitz SF, Hoebel BG.

Alcohol Clin Exp Res. 2010 Feb;34(2):214-22. doi: 10.1111/j.1530-0277.2009.01084.x. Epub 2009 Nov 24.

49.

Opioids in the hypothalamus control dopamine and acetylcholine levels in the nucleus accumbens.

Rada P, Barson JR, Leibowitz SF, Hoebel BG.

Brain Res. 2010 Feb 2;1312:1-9. doi: 10.1016/j.brainres.2009.11.055. Epub 2009 Nov 27.

50.

The monothiol single-domain glutaredoxin is conserved in the highly reduced mitochondria of Giardia intestinalis.

Rada P, Smíd O, Sutak R, Dolezal P, Pyrih J, Zársky V, Montagne JJ, Hrdy I, Camadro JM, Tachezy J.

Eukaryot Cell. 2009 Oct;8(10):1584-91. doi: 10.1128/EC.00181-09. Epub 2009 Aug 28.

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