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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1978 1
1979 5
1980 4
1981 1
1982 2
1983 4
1984 1
1987 1
1989 1
1990 1
1991 1
1992 6
1993 13
1994 19
1995 27
1996 44
1997 61
1998 84
1999 90
2000 91
2001 111
2002 129
2003 124
2004 166
2005 177
2006 217
2007 165
2008 212
2009 239
2010 228
2011 271
2012 248
2013 309
2014 326
2015 304
2016 348
2017 340
2018 304
2019 337
2020 359
2021 396
2022 357
2023 358
2024 115

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6,014 results

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Page 1
RAD51 Gene Family Structure and Function.
Bonilla B, Hengel SR, Grundy MK, Bernstein KA. Bonilla B, et al. Annu Rev Genet. 2020 Nov 23;54:25-46. doi: 10.1146/annurev-genet-021920-092410. Epub 2020 Jul 14. Annu Rev Genet. 2020. PMID: 32663049 Free PMC article. Review.
Its paralogs, which arose from ancient gene duplications of RAD51, have evolved to regulate and promote RAD51 function. Underscoring its importance, misregulation of RAD51, and its paralogs, is associated with diseases such as cancer and Fanconi anemia. ...We …
Its paralogs, which arose from ancient gene duplications of RAD51, have evolved to regulate and promote RAD51 function. Unders …
RAD51: Beyond the break.
Wassing IE, Esashi F. Wassing IE, et al. Semin Cell Dev Biol. 2021 May;113:38-46. doi: 10.1016/j.semcdb.2020.08.010. Epub 2020 Sep 13. Semin Cell Dev Biol. 2021. PMID: 32938550 Free PMC article. Review.
With recent advances in the understanding of RAD51 function extending beyond DSBs, the importance of RAD51 throughout DNA metabolism has become increasingly clear. Here we review the suggested roles of RAD51 beyond HR, specifically focusing on their interplay …
With recent advances in the understanding of RAD51 function extending beyond DSBs, the importance of RAD51 throughout DNA meta …
RAD51 protects human cells from transcription-replication conflicts.
Bhowmick R, Lerdrup M, Gadi SA, Rossetti GG, Singh MI, Liu Y, Halazonetis TD, Hickson ID. Bhowmick R, et al. Mol Cell. 2022 Sep 15;82(18):3366-3381.e9. doi: 10.1016/j.molcel.2022.07.010. Epub 2022 Aug 23. Mol Cell. 2022. PMID: 36002000 Free article.
Consistent with a role for RAD51 in protecting against transcription-replication conflicts, many of the adverse effects of RAD51 depletion are ameliorated by inhibiting early S-phase transcription. We propose a model whereby RAD51 suppresses fork breakage and …
Consistent with a role for RAD51 in protecting against transcription-replication conflicts, many of the adverse effects of RAD51 …
Noncanonical Roles of RAD51.
Thomas M, Dubacq C, Rabut E, Lopez BS, Guirouilh-Barbat J. Thomas M, et al. Cells. 2023 Apr 15;12(8):1169. doi: 10.3390/cells12081169. Cells. 2023. PMID: 37190078 Free PMC article. Review.
Surprisingly, despite its central role in HR, the invalidation of RAD51 is not classified as being cancer prone, constituting the "RAD51 paradox". ...RAD51 also exhibits noncanonical roles in RNA-mediated processes. ...
Surprisingly, despite its central role in HR, the invalidation of RAD51 is not classified as being cancer prone, constituting the " …
Rad51 filament dynamics and its antagonistic modulators.
Carver A, Zhang X. Carver A, et al. Semin Cell Dev Biol. 2021 May;113:3-13. doi: 10.1016/j.semcdb.2020.06.012. Epub 2020 Jul 3. Semin Cell Dev Biol. 2021. PMID: 32631783 Review.
Rad51 forms nucleoprotein filaments on single-stranded DNA, exposed by a double-strand break. ...In this review, we summarize our current understanding of the dynamics of Rad51 filaments, the roles of other factors and their modes of action in modulating key stages …
Rad51 forms nucleoprotein filaments on single-stranded DNA, exposed by a double-strand break. ...In this review, we summarize our cur …
RAD51 paralogs: Expanding roles in replication stress responses and repair.
Bhattacharya D, Sahoo S, Nagraj T, Dixit S, Dwivedi HK, Nagaraju G. Bhattacharya D, et al. Curr Opin Pharmacol. 2022 Dec;67:102313. doi: 10.1016/j.coph.2022.102313. Epub 2022 Nov 4. Curr Opin Pharmacol. 2022. PMID: 36343481 Review.
Mammalian RAD51 paralogs are essential for cell survival and are critical for RAD51-mediated repair of DNA double-strand breaks (DSBs) by homologous recombination (HR). However, the molecular mechanism by which RAD51 paralogs participate in HR is largely uncl …
Mammalian RAD51 paralogs are essential for cell survival and are critical for RAD51-mediated repair of DNA double-strand break …
Double-stranded DNA binding function of RAD51 in DNA protection and its regulation by BRCA2.
Halder S, Sanchez A, Ranjha L, Reginato G, Ceppi I, Acharya A, Anand R, Cejka P. Halder S, et al. Mol Cell. 2022 Oct 6;82(19):3553-3565.e5. doi: 10.1016/j.molcel.2022.08.014. Epub 2022 Sep 6. Mol Cell. 2022. PMID: 36070766 Free article.
Using reconstituted MRE11-, EXO1-, and DNA2-dependent nuclease reactions, we show that the protective function of RAD51 unexpectedly depends on its binding to dsDNA. The BRC4 repeat of BRCA2 abrogates RAD51 binding to dsDNA and accordingly impairs the function of …
Using reconstituted MRE11-, EXO1-, and DNA2-dependent nuclease reactions, we show that the protective function of RAD51 unexpectedly …
RAD51 paralog function in replicative DNA damage and tolerance.
Rein HL, Bernstein KA, Baldock RA. Rein HL, et al. Curr Opin Genet Dev. 2021 Dec;71:86-91. doi: 10.1016/j.gde.2021.06.010. Epub 2021 Jul 24. Curr Opin Genet Dev. 2021. PMID: 34311385 Free PMC article. Review.
RAD51 paralog gene mutations are observed in both hereditary breast and ovarian cancers. ...Several recent investigative advances have enabled characterization of non-canonical RAD51 paralog function during DNA replication. Here we discuss the role of the RAD51 …
RAD51 paralog gene mutations are observed in both hereditary breast and ovarian cancers. ...Several recent investigative advances hav …
Bre1/RNF20 promotes Rad51-mediated strand exchange and antagonizes the Srs2/FBH1 helicases.
Liu G, Li J, He B, Yan J, Zhao J, Wang X, Zhao X, Xu J, Wu Y, Zhang S, Gan X, Zhou C, Li X, Zhang X, Chen X. Liu G, et al. Nat Commun. 2023 May 25;14(1):3024. doi: 10.1038/s41467-023-38617-z. Nat Commun. 2023. PMID: 37230987 Free PMC article.
Central to homologous recombination (HR) is the assembly of Rad51 recombinase on single-strand DNA (ssDNA), forming the Rad51-ssDNA filament. ...We show that Bre1/RNF20 interacts with Rad51, directs Rad51 to ssDNA, and facilitates Rad51-ssDNA fi …
Central to homologous recombination (HR) is the assembly of Rad51 recombinase on single-strand DNA (ssDNA), forming the Rad51- …
BRCA2 chaperones RAD51 to single molecules of RPA-coated ssDNA.
Bell JC, Dombrowski CC, Plank JL, Jensen RB, Kowalczykowski SC. Bell JC, et al. Proc Natl Acad Sci U S A. 2023 Apr 4;120(14):e2221971120. doi: 10.1073/pnas.2221971120. Epub 2023 Mar 28. Proc Natl Acad Sci U S A. 2023. PMID: 36976771 Free PMC article.
BRCA2 accelerates nucleation of RAD51 to a rate that approaches the rapid association of RAD51 to naked ssDNA, thereby overcoming the kinetic block imposed by RPA. Furthermore, BRCA2 eliminates the need for the rate-limiting nucleation of RAD51 by chaperoning …
BRCA2 accelerates nucleation of RAD51 to a rate that approaches the rapid association of RAD51 to naked ssDNA, thereby overcom …
6,014 results