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Items: 1 to 50 of 56

1.

Mechanisms of amiodarone and desethylamiodarone cytotoxicity in nontransformed human peripheral lung epithelial cells.

Mulder JE, Brien JF, Racz WJ, Takahashi T, Massey TE.

J Pharmacol Exp Ther. 2011 Feb;336(2):551-9. doi: 10.1124/jpet.110.173120. Epub 2010 Nov 15.

PMID:
21078785
2.

Direct mitochondrial dysfunction precedes reactive oxygen species production in amiodarone-induced toxicity in human peripheral lung epithelial HPL1A cells.

Nicolescu AC, Ji Y, Comeau JL, Hill BC, Takahashi T, Brien JF, Racz WJ, Massey TE.

Toxicol Appl Pharmacol. 2008 Mar 15;227(3):370-9. doi: 10.1016/j.taap.2007.12.009. Epub 2007 Dec 15.

PMID:
18191165
3.

Aryl radical involvement in amiodarone-induced pulmonary toxicity: investigation of protection by spin-trapping nitrones.

Nicolescu AC, Comeau JL, Hill BC, Bedard LL, Takahashi T, Brien JF, Racz WJ, Massey TE.

Toxicol Appl Pharmacol. 2007 Apr 1;220(1):60-71. Epub 2007 Jan 9.

PMID:
17316728
4.

On-line sources of toxicological information in Canada.

Racz WJ, Ecobichon DJ, Baril M.

Toxicology. 2003 Aug 21;190(1-2):3-14.

PMID:
12909394
5.

Differential effects of pirfenidone on acute pulmonary injury and ensuing fibrosis in the hamster model of amiodarone-induced pulmonary toxicity.

Card JW, Racz WJ, Brien JF, Margolin SB, Massey TE.

Toxicol Sci. 2003 Sep;75(1):169-80. Epub 2003 Jun 27.

PMID:
12832656
7.

Mitochondrial dysfunction is an early manifestation of 1,1-dichloroethylene-induced hepatotoxicity in mice.

Martin EJ, Racz WJ, Forkert PG.

J Pharmacol Exp Ther. 2003 Jan;304(1):121-9.

PMID:
12490582
8.

Induction of c-jun and TGF-beta 1 in Fischer 344 rats during amiodarone-induced pulmonary fibrosis.

Chung WH, Bennett BM, Racz WJ, Brien JF, Massey TE.

Am J Physiol Lung Cell Mol Physiol. 2001 Nov;281(5):L1180-8.

9.

Effects of vitamin E on cytotoxicity of amiodarone and N-desethylamiodarone in isolated hamster lung cells.

Bolt MW, Racz WJ, Brien JF, Massey TE.

Toxicology. 2001 Sep 25;166(3):109-18.

PMID:
11543907
10.
11.

The role of mitochondrial injury in bromobenzene and furosemide induced hepatotoxicity.

Wong SG, Card JW, Racz WJ.

Toxicol Lett. 2000 Aug 16;116(3):171-81.

PMID:
10996478
12.

Effects of an environmental anti-androgen on erectile function in an animal penile erection model.

Brien SE, Heaton JP, Racz WJ, Adams MA.

J Urol. 2000 Apr;163(4):1315-21.

PMID:
10737536
13.

Effects of dietary vitamin E supplementation on pulmonary morphology and collagen deposition in amiodarone- and vehicle-treated hamsters.

Card JW, Leeder RG, Racz WJ, Brien JF, Bray TM, Massey TE.

Toxicology. 1999 Apr 15;133(2-3):75-84.

PMID:
10378474
14.

Differential susceptibilities of isolated hamster lung cell types to amiodarone toxicity.

Bolt MW, Racz WJ, Brien JF, Bray TM, Massey TE.

Can J Physiol Pharmacol. 1998 Jul-Aug;76(7-8):721-7.

PMID:
10030452
15.

Amiodarone-induced disruption of hamster lung and liver mitochondrial function: lack of association with thiobarbituric acid-reactive substance production.

Card JW, Lalonde BR, Rafeiro E, Tam AS, Racz WJ, Brien JF, Bray TM, Massey TE.

Toxicol Lett. 1998 Sep 1;98(1-2):41-50.

PMID:
9776560
16.

The effects of methylmercury on endogenous dopamine efflux from mouse striatal slices.

Kalisch BE, Racz WJ.

Toxicol Lett. 1996 Dec;89(1):43-9.

PMID:
8952710
17.

Bromobenzene and furosemide hepatotoxicity: alterations in glutathione, protein thiols, and calcium.

Grewal KK, Rafeiro E, Racz WJ.

Can J Physiol Pharmacol. 1996 Mar;74(3):257-64.

PMID:
8773404
19.
20.

Intracellular calcium disruption as a secondary event in acetaminophen-induced hepatotoxicity.

Grewal KK, Racz WJ.

Can J Physiol Pharmacol. 1993 Jan;71(1):26-33.

PMID:
8513431
21.

Alternative methods of selecting rat hepatocellular nodules resistant to 2-acetylaminofluorene.

Semple-Roberts E, Hayes MA, Armstrong D, Becker RA, Racz WJ, Farber E.

Int J Cancer. 1987 Nov 15;40(5):643-5.

PMID:
3679591
22.
23.

Metabolic activation of 1,1-dichloroethylene by mouse lung and liver microsomes.

Forkert PG, Hofley M, Racz WJ.

Can J Physiol Pharmacol. 1987 Jul;65(7):1496-9.

PMID:
3664363
24.
25.

Furosemide toxicity in isolated mouse hepatocyte suspensions.

Massey TE, Walker RM, McElligott TF, Racz WJ.

Toxicology. 1987 Feb;43(2):149-60.

PMID:
3810658
26.

Effects of mercury compounds on the spontaneous and potassium-evoked release of [3H]dopamine from mouse striatal slices.

McKay SJ, Reynolds JN, Racz WJ.

Can J Physiol Pharmacol. 1986 Dec;64(12):1507-14.

PMID:
2435391
28.
30.

Acetaminophen-induced hepatotoxic congestion in mice.

Walker RM, Racz WJ, McElligott TF.

Hepatology. 1985 Mar-Apr;5(2):233-40.

PMID:
3979955
31.

Effects of N-acetylcysteine on acetaminophen covalent binding and hepatic necrosis in mice.

Corcoran GB, Racz WJ, Smith CV, Mitchell JR.

J Pharmacol Exp Ther. 1985 Mar;232(3):864-72.

PMID:
3973835
32.

Effects of N-acetylcysteine on the disposition and metabolism of acetaminophen in mice.

Corcoran GB, Todd EL, Racz WJ, Hughes H, Smith CV, Mitchell JR.

J Pharmacol Exp Ther. 1985 Mar;232(3):857-63.

PMID:
3973834
33.

The disposition and the liver and thymus gland toxicity of 3,3',4,4'-tetrachlorobiphenyl in the female rat.

Clarke DW, Brien JF, Racz WJ, Nakatsu K, Marks GS.

Can J Physiol Pharmacol. 1984 Oct;62(10):1253-60.

PMID:
6439399
34.

Methylmercury distribution, metabolism, and neurotoxicity in the mouse brain.

Vandewater LJ, Racz WJ, Norris AR, Buncel E.

Can J Physiol Pharmacol. 1983 Dec;61(12):1487-93.

PMID:
6671161
35.
36.

Ultrastructural effects of acetaminophen in isolated mouse hepatocytes.

Walker RM, McElligott TF, Massey TE, Racz WJ.

Exp Mol Pathol. 1983 Oct;39(2):163-75.

PMID:
6617825
37.

Gas-liquid chromatographic determination of the distribution of 3,3',4,4'-tetrachlorobiphenyl in the adult female rat following short-term oral administration.

Clarke DW, Brien JF, Nakatsu K, Taub H, Racz WJ, Marks GS.

Can J Physiol Pharmacol. 1983 Oct;61(10):1093-100.

PMID:
6416658
38.

Increased acetaminophen-induced hepatotoxicity after chronic ethanol consumption in mice.

Walker RM, McElligott TF, Power EM, Massey TE, Racz WJ.

Toxicology. 1983;28(3):193-206.

PMID:
6636205
39.

Perspectives on the central nervous system toxicity of methylmercury.

Racz WJ, Vandewater LJ.

Can J Physiol Pharmacol. 1982 Jul;60(7):1037-45.

PMID:
7127207
40.

Acetaminophen toxicity in fed and fasted mice.

Walker RM, Massey TE, McElligott TF, Racz WJ.

Can J Physiol Pharmacol. 1982 Mar;60(3):399-404.

PMID:
6804076
41.

Acetaminophen-induced hypothermia in mice: evidence for a central action of the parent compound.

Massey TE, Walker RM, McElligott TF, Racz WJ.

Toxicology. 1982;25(2-3):187-200.

PMID:
7157399
42.

Effects of porphyrin-inducing drugs on ferrochelatase activity in isolated mouse hepatocytes.

Cole SP, Massey TE, Marks GS, Racz WJ.

Can J Physiol Pharmacol. 1981 Nov;59(11):1155-8.

PMID:
7317839
43.

Effects of N-acetylcysteine on metabolism, covalent binding, and toxicity of acetaminophen in isolated mouse hepatocytes.

Massey TE, Racz WJ.

Toxicol Appl Pharmacol. 1981 Sep 15;60(2):220-8. No abstract available.

PMID:
7281185
44.

Acetaminophen-induced hypothermia, hepatic congestion, and modification by N-acetylcysteine in mice.

Walker RM, Massey TE, McElligott TF, Racz WJ.

Toxicol Appl Pharmacol. 1981 Jul;59(3):500-7. No abstract available.

PMID:
7268773
45.

Drug interactions of amitriptyline and nortriptyline with warfarin in the rat.

Loomis CW, Racz WJ.

Res Commun Chem Pathol Pharmacol. 1980 Oct;30(1):41-58.

PMID:
7433768
46.

Acetaminophen-induced hepatotoxicity in mice.

Walker RM, Racz WJ, McElligott TF.

Lab Invest. 1980 Feb;42(2):181-9. No abstract available.

PMID:
7354612
47.

The contribution of propranolol metabolites to the fluorometric assay of propranolol in human plasma.

Pritchard JF, Schneck DW, Racz WJ, Hayes AH Jr.

Clin Biochem. 1978 Jun;11(3):121-5.

PMID:
688593
48.

Drug metabolism in cell culture. II. Studies on the metabolic route of DDC analogues.

Racz WJ, Hunter L, Wanless RG, McDonald MV, Moffat JA.

Can J Physiol Pharmacol. 1977 Jun;55(3):552-9. No abstract available.

PMID:
884611
49.

Drug metabolism in cell culture. I. Importance of steric factors for activity in porphyrin-inducing drugs.

Racz WJ, Moffat JA.

Biochem Pharmacol. 1974 Jan 15;23(2):215-21. No abstract available.

PMID:
4855916
50.

Drug-induced porphyrin biosynthesis. VI. Uptake and biotransformation of DDC and an inactive analogue.

Racz WJ, Marks GS.

Biochem Pharmacol. 1972 May 15;21(10):1511-4. No abstract available.

PMID:
5063837

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